Abstract:
:The dogma that cutaneous wound healing is impaired as a function of age is largely unsubstantiated. This can be attributed to poor experimental design of human studies, the lack of subject characterisation with the exclusion of disease processes, and the study of inappropriate animal models. Structural and functional changes in skin with age have been reported, such as a decrease in dermal thickness, decline in collagen content, a subtle alteration in the glycosaminoglycan profile, and a loss of elasticity, but these reports are subject to the above criticisms in addition to the often-neglected requirement for site specificity. Wound repair can be thought of as a culmination of three major overlapping phases: inflammation, proliferation and remodelling. The inflammatory process has not been studied systematically with respect to age, and despite a reported decline in cellular function and number, there is a confounding increase in the production of specific cytokines involved in the process of repair. The proliferative phase is associated with a loss of cellular responsiveness to specific cytokines with a decline in motility and proliferation; however caution in interpreting these findings is important as, for example, the definition of 'ageing' is used rather loosely with the result that neonatal versus young adult cells are compared instead of young versus old adults. During remodelling, fibronectin and collagen production may increase with age, as may wound contraction; the deposition of elastin has not been assessed and the resulting mechanical properties of the scar are controversial, not least because human in vivo studies have been ignored. The absence of a critical review on the effects of advancing age on wound healing has conspired to permit the perpetuation of the belief that well defined tenets exist. This review aims to redress this imbalance and to highlight the need for well designed research into an increasingly important field.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Ashcroft GS,Horan MA,Ferguson MWsubject
Has Abstractpub_date
1995-08-01 00:00:00pages
1-26eissn
0021-8782issn
1469-7580journal_volume
187 ( Pt 1)pub_type
杂志文章,评审abstract::The sheep is a commonly used animal model for human lumbar spine surgery, but only in vitro investigations comparing the human and ovine spine exist. Spinal musculature has previously not been compared between man and sheep. This additional knowledge could further indicate to what extent these species are biomechanica...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12354
更新日期:2015-10-01 00:00:00
abstract::The gross and microscopic anatomy of the Cape fur seal heart, lung, liver, spleen, stomach, intestine and kidneys (n = 31 seals) is described. Absolute and relative size of organs from 30 male seals are presented, with histological examination conducted on 7 animals. The relationship between log body weight, log organ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19520235.x
更新日期:1999-08-01 00:00:00
abstract::Mouse immunoglobulin G (IgG) was iodinated with 125iodine (I) and injected intravenously into pregnant mice in order to examine whether mouse granulated metrial gland (GMG) cells are able to take up IgG in vivo. The mice were injected intravenously on days 8, 12 or 16 of pregnancy and killed either 5 min, 2 h or 24 h ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Surgical interruption of the gastrointestinal tract is widely used for investigating the structure of the enteric nervous system and in the treatment of certain pathological conditions of the gastrointestinal tract. The effects of transection and end-to-end anastomosis and myotomy on nerve cells of the myenteric plexu...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Development of the neural crest involves a remarkable feat of coordinated cell migration in which cells detach from the neural tube, take varying routes of migration through the embryonic tissues and then differentiate at the end of their journey to participate in the formation of a number of organ systems. In general...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1046/j.1469-7580.1997.19140507.x
更新日期:1997-11-01 00:00:00
abstract::Alpha (greater than 40 microns) and gamma (less than 30 microns) motoneurons in inspiratory motor nuclei of the thoracic spinal cord of the adult cat were labelled retrogradely by the intramuscular injection of HRP. Small (less than 30 microns) unlabelled neurons within 200-300 microns of labelled motoneurons were ana...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Arguably, the gold standard of biological repair of articular cartilage lesions is autologous chondrocyte transplantation. Although the clinical outcomes appear to range between good and excellent in most cases, there are, nevertheless, both clinical and biological challenges that remain to improve rehabilitation and ...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2006.00624.x
更新日期:2006-10-01 00:00:00
abstract::The distribution and form of amoeboid microglia in the brain of neonatal rats have been studied with the light and electron microscope. With the silver carbonate method of Rio-Hortega, two major 'colonies' of amoeboid microglia are identified: (1) in the supraventricular corpus callosum in which the nerve fibres are w...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract::Abstract The skull and the face are directly related, and skeletal morphology influences the facial proportions, muscle structure, feature formation and hence detailed facial appearance. Each face is unique and we are each capable of perceiving very subtle differences between faces in order to carry out personal recog...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.00972.x
更新日期:2008-11-27 00:00:00
abstract::In an attempt to clarify the nature of the human cemento-dentinal junction, ground sections of incompletely formed and fully formed extracted teeth were prepared and their histology compared with their microradiographic appearances. The results showed that incompletely formed teeth possess distinctive surface layers o...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract::The morphological features of odontoblast processes in young kitten odontoblasts were studied by thin section and freeze-fracture electron microscopy. Freeze-fracture replication revealed depressions with particles on the plasma membranes of the proximal parts of odontoblast processes. Comparison with thin sections su...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract::Small clusters of extra large muscle fibres were identified in hindlimb muscles of neonatal mice (strain C57BL/10ScSn). At two days of age they had a significantly greater cross-sectional area than their normal counterparts (P less than 0.01). Fibre typing methods (NADH-tetrazolium reductase, ATPase and phosphorylase)...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::There is evidence for lymphatic drainage of interstitial fluid from the brain along perivascular spaces in a number of mammalian species. Ultrastructural studies suggest that there are similar drainage pathways in the human cerebral cortex. Perivascular spaces in the basal ganglia, however, differ from those in the co...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1997.19130337.x
更新日期:1997-10-01 00:00:00
abstract::The primary cilium is a ubiquitous cytoplasmic organelle of unknown function. Ultrastructural evidence of primary cilia in chondrocytes, and their colocalisation with the Golgi apparatus, has led to speculation that these structures are functionally linked. To investigate the relationship between these organelles, we ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19940393.x
更新日期:2001-10-01 00:00:00
abstract::The type and number of cell contacts between fibroblasts were studied in three structurally distinct varieties of periodontal connective tissue in the rat mandible (periodontal ligament of the incisor, enamel-related connective tissue of the incisor and periodontal ligament of the molar). Three types of cell contact w...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract::The astroglial lineage consists of heterogeneous cells instrumental for normal brain development, function and repair. Unfortunately, this heterogeneity complicates research in the field, which suffers from lack of truly specific and sensitive astroglial markers. Nevertheless, single astroglial markers are often used ...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/joa.12948
更新日期:2019-09-01 00:00:00
abstract::The ultrastructure of the tammar placenta was studied throughout pregnancy. The uterine epithelium grows from a columnar to an enlarged, undulating epithelium between early gestation and mid-gestation when the shell coat that surrounds the marsupial conceptus ruptures. Trophectoderm and uterine epithelium do not form ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2002.00084.x
更新日期:2002-08-01 00:00:00
abstract::Guinea-pig ovarian follicles were studied by light and electron microscopy. All freshly ruptured follicles showed small blood vessels within the stratum granulosum as well as amongst the cells of the theca interna. The evidence suggests that the marked increase in the size of the preovulatory follicle stretches the ba...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::There is an accumulating body of evidence that highlights the fact that one can identify convergence in programmes of cellular differentiation. That is, that a particular differentiated cell/tissue type can be generated via non-identical paths. Convergence is also seen in evolution and here it is termed homoplasy, thu...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2010.01232.x
更新日期:2010-06-01 00:00:00
abstract::An autoradiographic study of neuronal and glial production was carried out in the indusium griseum of mice. Most neurons were produced between 13 and 15 days post-conception. One part of the glial population underwent its last or second-last divisions between 14 and 16 days post-conception, while the other continued t...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::On the basis of its internal structure, the ball of the foot can be divided into three transverse areas, each with a different mechanical function: (1) an area proximal to the heads of the metatarsals in which the retinacula cutis are developed into a series of transverse bands, and in which the deep fibres of the pla...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract::The retinal vasculature of postmortem normal human and diabetic eyes was studied using an immunohistochemical technique in conjunction with confocal laser scanning microscopy. The technique, which stained for von Willebrand factor, allowed both large areas of the retinal vasculature to be visualised and abnormalities ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19410089.x
更新日期:1999-01-01 00:00:00
abstract::The translocation of mitochondria towards the primitive inner segment of the cones in the tree shrew Tupaia belangeri was investigated by transmission electron microscopy. Throughout ontogeny the migrating mitochondria were codistributed with cytoplasmic microtubules which were preserved after the application of conve...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::The paraspinal compartment acts as a bone-muscle composite beam of the spine. The elastic properties of the paraspinal muscles play a critical role in spine stabilization. These properties depend on the subjects' posture, and they may be drastically altered by low back pain. Supersonic shear wave elastography can be u...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12978
更新日期:2019-06-01 00:00:00
abstract::Ceratopsidae represents a group of quadrupedal herbivorous dinosaurs that inhabited western North America and eastern Asia during the Late Cretaceous. Although horns and frills of the cranium are highly variable across species, the lower jaw historically has been considered to be relatively conservative in morphology....
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12374
更新日期:2015-11-01 00:00:00
abstract::Rodents are defined by a uniquely specialized dentition and a highly complex arrangement of jaw-closing muscles. Finite element analysis (FEA) is an ideal technique to investigate the biomechanical implications of these specializations, but it is essential to understand fully the degree of influence of the different i...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2011.01436.x
更新日期:2011-12-01 00:00:00
abstract::This study was prompted by the prospect of transgenic pigs providing donor hearts for transplantation in human recipients. Autonomic innervation is important for the control of cardiac dynamics, especially in the conduction system. Our objective was to assess the relative distribution of autonomic nerves in the pig he...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19530341.x
更新日期:1999-10-01 00:00:00
abstract::Knowledge of the pattern of human craniofacial development in the fetal period is important for understanding the mechanisms underlying the emergence of variations in human craniofacial morphology. However, the precise character of the prenatal ontogenetic development of the human cranium has yet to be fully establish...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.00884.x
更新日期:2008-05-01 00:00:00
abstract::The vomeronasal system (VNS) has been extensively studied within specific animal families, such as Rodentia. However, the study of the VNS in other families, such as Canidae, has long been neglected. Among canids, the vomeronasal organ (VNO) has only been studied in detail in the dog, and no studies have examined the ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13254
更新日期:2020-11-01 00:00:00
abstract::This study examined NADPH-d and nNOS expression in the SCG of hamsters. By light microscopy, numerous NADPH-d/NOS positive processes were widely distributed in the ganglion. Ultrastructurally, the NADPH-d reaction product was associated with the membranous organelles of neuronal soma, dendrites, myelinated fibres, sma...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2000.19730461.x
更新日期:2000-10-01 00:00:00