Abstract：
:Angiogenesis is essential for the replacement of cartilage by bone during growth and repair. In order to obtain a better understanding of the mechanisms regulating vascular invasion at sites of endochondral ossification we have investigated the expression of the endothelial cell-specific mitogen, vascular endothelial growth factor (VEGF), by chondrocytes in human neonatal growth plates. VEGF was absent from chondrocytes in the resting zone and only weakly expressed by occasional chondrocytes in the proliferating region. In the hypertrophic zone the number of chondrocytes stained and the intensity of staining for VEGF increased with chondrocyte hypertrophy, maximum expression of VEGF being observed in chondrocytes in the lower hypertrophic and mineralised regions of the cartilage. These observations provide the first demonstration of the presence of VEGF in situ in developing human bone and are consistent with in vitro observations demonstrating the upregulation of proangiogenic growth factor production with increasing chondrocyte hypertrophy. The presence of numerous small blood vessels and vascular structures in the subchondral region where VEGF expression was maximal indicates that VEGF produced by hypertrophic chondrocytes may play a key role in the regulation of vascular invasion of the growth plate.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Horner A,Bishop NJ,Bord S,Beeton C,Kelsall AW,Coleman N,Compston JEdoi
10.1046/j.1469-7580.1999.19440519.xkeywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
519-24eissn
0021-8782issn
1469-7580journal_volume
194 ( Pt 4)pub_type
杂志文章abstract：:Decline of tactile sensation associated with ageing depends on modifications in skin and both central and peripheral nervous systems. At present, age-related changes in the periphery of the somatosensory system, particularly concerning the effects on mechanoreceptors, remain unknown. Here we used immunohistochemistry ...
journal_title：Journal of anatomy
pub_type： 杂志文章
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abstract：:Taurodontism (i.e. enlarged pulp chamber with concomitant apical displacement of the root bi/trifurcation) is considered a dental anomaly with relatively low incidence in contemporary societies, but it represents a typical trait frequently found in Neandertal teeth. Four hypotheses can be envisioned to explain the hig...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12260
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abstract：:We report a magnetic resonance imaging study which developed a consistent hierarchy of imaging planes for examination of the origins, courses and principal branches of the main coronary arteries of prepared human cadaveric hearts. The reference longitudinal axis was chosen between the aortic valve and the apex of the ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
abstract：:This pre-embedding electron-immunocytochemical study investigated the localisation of endothelial (type III) and neuronal (type I) isoforms of nitric oxide synthase, substance P, endothelin-1 and 5-hydroxytryptamine in the human middle cerebral artery taken up to 40 h postmortem. To ¿recover' from the anoxic period so...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
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abstract：:This paper describes a qualitative and quantitative investigation into the location of the motoneurons innervating the extra-ocular muscles of the rat. Injections of horseradish peroxidase, bisbenzimide, propidium iodide and DAPI-primuline were made either in one or simultaneously in two muscles. Unlike those of the c...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00523.x
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00682.x
更新日期：2007-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00884.x
更新日期：2008-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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更新日期：1997-11-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2007.00761.x
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13198
更新日期：2020-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00615.x
更新日期：2006-09-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13091
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
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