Cell proliferation and osteogenic differentiation of growing pig cranial sutures.

Abstract:

:Bone growth at the cranial sutures relies on proliferation of osteogenic progenitor cells and/or differentiation of osteoblasts. The current study was undertaken to assess these events in relation to suture growth and fusion. A total of 21 pigs, divided into three age groups (0.5-1.5 months, 3-4 months and 5-7 months), were used for immunohistochemical evaluation of cell proliferation (BrdU) and osteogenic differentiation (Cbfa1/Runx2) in the interfrontal and interparietal sutures. Proliferation and osteogenic differentiation were both more prominent near the bone fronts than in the central zone. With age, both proliferation and osteogenic differentiation diminished. Proliferation ceased on the endocranial (dura mater) side by the age of 3-4 months. Proliferation on the pericranial side was accompanied by active bone formation and initiation of suture fusion from this side. In conclusion, (1) decreased suture bone growth with age reflects decreased cell proliferation and probably also osteogenic differentiation, and (2) suture fusion occurs from the pericranial side where activity remains relatively high.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Sun Z,Lee E,Herring SW

doi

10.1111/j.1469-7580.2007.00761.x

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

280-9

issue

3

eissn

0021-8782

issn

1469-7580

pii

JOA761

journal_volume

211

pub_type

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