Effects of angiotensin II on the zona fasciculata of the rat adrenal cortex: an ultrastructural stereologic study.

Abstract:

:The effects of a chronic administration of angiotensin II on the zona fasciculata of rats treated with dexamethasone and maintenance doses of ACTH were investigated by morphometric methods applied to electron microscopy. It was found that angiotensin induced a significant increase in the volume of cells, nuclei, mitochondrial and lipid compartments as well as in the surface area of smooth endoplasmic reticulum and mitochondrial cristae. Noticeable also were the hypertrophy of the Golgi apparatus and the increase in the number of acid phosphatase-positive dense bodies. These findings are interpreted as indicating that the renin-angiotensin system is involved in the stimulation of the growth and steroidogenic capacity of the rat zona fasciculata.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Nussdorfer GG,Robba C,Mazzochi G,Rebuffat P

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

235-42

issue

Pt 2

eissn

0021-8782

issn

1469-7580

journal_volume

132

pub_type

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