Abstract：
:Connective tissue function is defined as the formation and maintenance of shape, without which centralised physiologies (circulatory, digestive or nervous) could not have evolved. Two elements, inextensible (collagenous) fibrils and compression-resistant interfibrillar soluble polymers (proteoglycans), cope with all usual stresses. Relationships between the two are highly specific, as demonstrated by electron histochemistry based on Cupromeronic blue and critical electrolyte concentration (CEC) methodologies. Recent ideas on (1) the protofibrillar or modular structure of collagen fibrils, (2) the nature of specific binding sites for proteoglycans on fibrils, and (3) fundamental similarities in secondary and tertiary structures of the glycosaminoglycans (hyaluronan, chondroitin, keratan and dermatan sulphates) are described. They have greatly illuminated the study of extracellular matrix structure and function in normal, pathological (osteogenesis imperfecta) and ageing tissues. The small proteoglycans are proposed to be tissue organisers, orienting and ordering the collagen fibrils--thus shaping the tissue at a molecular and ultimately macro level. These interfibrillar structures are based on their bifunctional character, the protein parts binding to collagen fibrils at specific sites and the glycosaminoglycans duplexing and aggregating to hold the proteins and hence the collagen fibrils at defined distances from each other, rather like yardsticks. Examples of the way these functions work in specific tissues are drawn from the cornea and vitreous humour of the eye and developing tendon.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Scott JEsubject
Has Abstractpub_date
1995-10-01 00:00:00pages
259-69eissn
0021-8782issn
1469-7580journal_volume
187 ( Pt 2)pub_type
杂志文章,评审abstract：:A total histological grade does not necessarily distinguish between different manifestations of cartilage damage or degeneration. An accurate and reliable histological assessment method is required to separate normal and pathological tissue within a joint during treatment of degenerative joint conditions and to sub-cl...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2012.01513.x
更新日期：2012-07-01 00:00:00
abstract：:We investigated the occurrence and anatomy of the vomeronasal system (VNS) in tadpoles of 13 different anuran species. All of the species possessed a morphologically fully developed VNS with a highly conserved anatomical organisation. We found that a bean-shaped vomeronasal organ (VNO) developed early in the tadpoles,...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2012.01543.x
更新日期：2012-10-01 00:00:00
abstract：:This study was done in order to investigate the normal ultrastructure of well-preserved mouse spinal canal ependyma using light, scanning and transmission electron microscopy. The ependymal lining was found to consist of a simple, cuboidal epithelium essentially similar to the unspecialized cuboidal ependyma of the br...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:Kokartus honorarius from the Middle Jurassic (Bathonian) of Kyrgyzstan is one of the oldest salamanders in the fossil record, characterized by a mixture of plesiomorphic morphological features and characters shared with crown-group salamanders. Here we present a detailed histological analysis of its long bones. The an...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12281
更新日期：2015-04-01 00:00:00
abstract：:In this study we investigated immunohistochemically the distribution of VIP in ampullary and isthmic segments of the rabbit oviduct at different hormonal stages in order to correlate the presence of VIP with the morphological and functional differences between the two oviduct segments. Noticeable changes in the VIP-po...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:There is need for a consistent definition of structures caudal to the testis that variously are termed 'gubernaculum testis' as a basis for understanding the emergence and sexually dimorphic further growth and differentiation of this specifically mammalian structure. Rodent fetuses undergo a stage of development durin...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:Schwann cells are excluded from the CNS during development by the glial limiting membrane, an area of astrocytic specialisation present at the nerve root transitional zone, and at blood vessels in the neuropil. This barrier, however, can be disrupted and, with the highly migratory nature of Schwann cells, can result i...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.1997.19010035.x
更新日期：1997-01-01 00:00:00
abstract：:The sensory and motor innervation of a sample of 202 muscle spindles from the dorsolateral tail muscles of eight cats were studied by silver and gold staining techniques. The range of diameters of Group Ia afferent nerve fibres to primary (P) sensory endings was 2.0-14.0 micron with a peak at 8.5 micron. The range of ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:Exposure of male Albino Swiss rats to the nonsteroidal antiandrogen flutamide during the period from gestational day (d) 10 to birth resulted in feminisation of the external genitalia and the suppression of growth of the male reproductive tract. In adulthood, testes were found to be located in diverse positions. True ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19040577.x
更新日期：1997-05-01 00:00:00
abstract：:Elastic fibres, which are intimately associated with collagen, a major component of the urethra, have been assumed to contribute to the resting urethral closure pressure. The Miller stain for elastin was used to demonstrate elastic fibres in cryostat sections of guinea pig bladder base, vesicourethral junction (VUJ) a...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1999.19530447.x
更新日期：1999-10-01 00:00:00
abstract：:The sacroiliac joint (SIJ) is responsible for weight transmission between the spine and lower extremity. However, details of the structure and function of the SIJ remain unclear. In a previous study, we devised a method of quantitatively evaluating the level of degeneration of the SIJ using an age estimation procedure...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12765
更新日期：2018-02-01 00:00:00
abstract：:The pulmonary intravascular macrophages (PIMs) of domestic ungulates are recognised by their specific surface coat, consisting of linearly arranged globules along the external leaf of the plasma membrane. The coat is sensitive to in vitro digestion with lipolytic lipase (LPL), intravenous heparin and clinical exposure...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19850611.x
更新日期：2001-05-01 00:00:00
abstract：:Homoplastic grafts of re-orientated unsegmented paraxial mesoderm transplanted from stage 20 Xenopus embryos into host embryos of the same age resulted in segmentation and the formation of somites in the same axis as if they had been left in situ. Because grafts transplanted with various orientations came under the st...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
abstract：:The collagen in the endoneurium is present as argyrophilic reticular fibres, which show up as thin, weakly birefringent greenish fibres when studied by aid of the Picrosirius-polarization method, and are composed of loosely arranged thin collagen fibrils. The epineurium consists of thick non-argyrophilic collagen fibr...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
abstract：:It is well established that many tissue-derived factors are involved in blood vessel formation, but evidence is now emerging that endothelial cells themselves represent a crucial source of instructive signals to non-vascular tissue cells during organ development. Thus, endothelial cell signalling is currently believed...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2007.00790.x
更新日期：2007-10-01 00:00:00
abstract：:The present study investigated, by immunohistochemistry, the postnatal occurrence and anatomical localisation of some bone and cartilage proteins and proteoglycans in the rat coronal sutural region. Thirty two Sprague-Dawley rats, four in each group, were killed at ages 3, 5, 8, 10, 15, 30, 50 and 100 days and the sut...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:The morphology of the epididymal duct and, in particular, the epididymal microvasculature was examined at the light microscope level in young sexually-mature rats (3-5 months) and aged rats (18 months) to investigate the structural changes that may occur within the organ as a result of ageing, and which may predispose...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:A quantitative analysis of the motor innervation of intrafusal muscle fibres is described, based on teased silver-impregnated spindles of the tenuissimus muscle of the cat. Included in the analysis are the number and distribution of intrafusal branches of both skeletofusimotor (beta) and purely fusimotor (gamma) axons...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Current surgical treatments for degenerative intervertebral disc disease do not restore full normal spinal movement. Tissue engineering a functional disc replacement may be one way to circumvent this limitation, but will require an integration of the different tissues making up the disc for this approach to be success...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2012.01537.x
更新日期：2012-12-01 00:00:00
abstract：:The anatomy of the hypothalamus includes many nuclei and a complex network of neurocircuits. In this context, some hypothalamic nuclei reside closer to the blood-brain barrier, allowing communication with the peripheral organs through some molecules, such as leptin. Leptin is considered the main adipokine for energy h...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13342
更新日期：2020-10-22 00:00:00
abstract：:The canine's olfactory acuity is legendary, but neither its main olfactory system nor its vomeronasal system has been described in much detail. We used immunohistochemistry on paraffin-embedded sections of male and female adult dog vomeronasal organ (VNO) to characterize the expression of proteins known to be expresse...
journal_title：Journal of anatomy
pub_type： 更正并重新发布的文章,杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric proteins, such as alpha myosin heavy chain and cardiac alpha actin, have no...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12486
更新日期：2016-09-01 00:00:00
abstract：:Scanning microinterferometric measurements were made of matrix dry mass in the intermediate layer of normal rabbit patellar articular cartilage and in the area surrounding standard, experimental, full-thickness lesions of 1-5 mm diameter. The lesions were created in 1 kg animals and were allowed to heal for up to 3 we...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
abstract：:The fine structure of the elastic cartilage of the pinna has been examined in young rabbits aged from 1 day to 1108 days. Changes associated with growth and development are related not only to age but also to the actual situation in the pinna. In the midline, progressive changes are seen from the tip to the base. The ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:The paraspinal compartment acts as a bone-muscle composite beam of the spine. The elastic properties of the paraspinal muscles play a critical role in spine stabilization. These properties depend on the subjects' posture, and they may be drastically altered by low back pain. Supersonic shear wave elastography can be u...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12978
更新日期：2019-06-01 00:00:00
abstract：:The urethra is the main place of entry for sexually transmitted pathogens. However, there is little literature on the morphology of the urogenital system, principally the urethra and ducts of the sex accessory glands. The Mongolian gerbil is an insectivorous, herbivorous and monogamous rodent with nocturnal habits; it...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00181.x
更新日期：2003-05-01 00:00:00
abstract：:This study investigated the relative contributions of pore size and pore density (number of pores per mm2) to porosity in the midshaft of the human femur. Cross-sections were obtained from 168 individuals from a modern Australian population (mostly Anglo-Celtic). The study group comprised 73 females and 95 males, aged...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00589.x
更新日期：2006-08-01 00:00:00
abstract：:The microvascular anatomy of discrete knee ligaments in adult rabbits is described. Epiligamentous plexuses give rise to a limited number of vessels which penetrate deeply into ligament substance. Intraligamentous vessels are usually longitudinally orientated, widely separated linear anastomoses but occasionally compl...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Mobilisation of the latissimus dorsi muscle as a functional graft necessarily involves division of perforating arteries that enter the distal portion of the muscle, rendering it vulnerable to ischaemic damage when the muscle is stimulated electrically. Using a fluorescent microsphere technique we showed that the blood...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1998.19310093.x
更新日期：1998-07-01 00:00:00
abstract：:The neurotropic effect of the distal stump of transected sciatic nerve on regenerating axons emerging from the proximal stump was investigated in rats by the coculture of excised neonatal dorsal root ganglia and segments of degenerated and nondegenerated sciatic nerves. In all cultures, neurites from the ganglion exte...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
