Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone.

Abstract:

:This study investigated the relative contributions of pore size and pore density (number of pores per mm2) to porosity in the midshaft of the human femur. Cross-sections were obtained from 168 individuals from a modern Australian population (mostly Anglo-Celtic). The study group comprised 73 females and 95 males, aged from 20 to 97 years. Microradiographs were made of 100-microm sections and porosity, pore areas and pore densities determined using image processing software. The cortex was divided into three rings radially and into octants circumferentially, and the porosity, pore area and pore density of each segment were calculated. Results show that 81% of the variance in porosity can be explained by changes in mean pore area with only a further 12-16% explained by changes in pore density. These effects were found to be constant across all areas of the cortex and in both sexes. These results are significant in their consistency and ordered gradation and indicate a well-regulated and systematic process of bone removal with ageing. The results show a regular progression from less porous to more porous bone; this is a uniform process that occurs in all individuals, and factors such as sex and rate of ageing determine where on this continuum any individual is at a particular time.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Thomas CD,Feik SA,Clement JG

doi

10.1111/j.1469-7580.2006.00589.x

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

219-30

issue

2

eissn

0021-8782

issn

1469-7580

pii

JOA589

journal_volume

209

pub_type

杂志文章
  • Megadontia, striae periodicity and patterns of enamel secretion in Plio-Pleistocene fossil hominins.

    abstract::Early hominins formed large and thick-enamelled cheek-teeth within relatively short growth periods as compared with modern humans. To understand better the developmental basis of this process, we measured daily enamel increments, or cross striations, in 17 molars of Plio-Pleistocene hominins representing seven differe...

    journal_title:Journal of anatomy

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1469-7580.2008.00938.x

    authors: Lacruz RS,Dean MC,Ramirez-Rozzi F,Bromage TG

    更新日期:2008-08-01 00:00:00

  • The ultrastructure of human abdominal mesothelium.

    abstract::Fresh specimens of human peritoneum collected from heart-beating cadaver organ donors have been examined by transmission electron microscopy. Samples were taken from the anterior abdominal wall and from the surfaces of the liver, stomach and diaphragm. The mesothelium consisted of a single layer of flattened cells gen...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Slater NJ,Raftery AT,Cope GH

    更新日期:1989-12-01 00:00:00

  • The moment arms of the muscles spanning the glenohumeral joint: a systematic review.

    abstract::The moment arm of a muscle represents its leverage or torque-producing capacity, and is indicative of the role of the muscle in joint actuation. The objective of this study was to undertake a systematic review of the moment arms of the major muscles spanning the glenohumeral joint during abduction, flexion and axial r...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12903

    authors: Hik F,Ackland DC

    更新日期:2019-01-01 00:00:00

  • Development of the chondrocranium of two caiman species, Caiman latirostris and Caiman yacare.

    abstract::Little is known about the embryonic development and variation of the chondrocranium in Crocodylia and there are no works on any Caiman species. Due to the importance of cranial features in the systematics of this clade, investigating the development of the skull in embryonic stages is essential. In this study, we pres...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12968

    authors: Fernandez Blanco MV

    更新日期:2019-06-01 00:00:00

  • The bony horncore of the common eland (Taurotragus oryx): composition and mechanical properties of a spiral fighting structure.

    abstract::Horns are permanent structures projecting from the head of bovids, consisting of a bony horncore covered with a layer of skin and then a sheath of keratinous material showing variability of growth intensity based on nutrition. From the point of view of the horn's mechanical properties, the keratin sheath has been wide...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12708

    authors: Cappelli J,García AJ,Kotrba R,Gambín Pozo P,Landete-Castillejos T,Gallego L,Ceacero F

    更新日期:2018-01-01 00:00:00

  • Comparative growth in the olfactory system of the developing chick with considerations for evolutionary studies.

    abstract::Despite the long-held assumption that olfaction plays a relatively minor role in the behavioral ecology of birds, crown-group avians exhibit marked phylogenetic variation in the size and form of the olfactory apparatus. As part of a larger effort to better understand the role of olfaction and olfactory tissues in the ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.13197

    authors: Hogan AVC,Watanabe A,Balanoff AM,Bever GS

    更新日期:2020-08-01 00:00:00

  • A study of weight transmission through the cervical and upper thoracic regions of the vertebral column in man.

    abstract::The role of the neural arch in weight transmission in the cervical and upper thoracic regions of the vertebral column has been investigated. Measurements at the levels of C2, C4, C6, C7, T1 and T5 vertebrae were made in 44 adult male vertebral columns. At each level, the area of the inferior surface of the body was co...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Pal GP,Routal RV

    更新日期:1986-10-01 00:00:00

  • 3D geometry analysis of the medial meniscus--a statistical shape modeling approach.

    abstract::The geometry-dependent functioning of the meniscus indicates that detailed knowledge on 3D meniscus geometry and its inter-subject variation is essential to design well functioning anatomically shaped meniscus replacements. Therefore, the aim of this study was to quantify 3D meniscus geometry and to determine whether ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12223

    authors: Vrancken AC,Crijns SP,Ploegmakers MJ,O'Kane C,van Tienen TG,Janssen D,Buma P,Verdonschot N

    更新日期:2014-10-01 00:00:00

  • Insulin and the IGF system in the human placenta of normal and diabetic pregnancies.

    abstract::The insulin/insulin-like growth factor (IGF) system regulates fetal and placental growth and development. In maternal diabetes, components of this system including insulin, IGF1, IGF2 and various IGF-binding proteins are deregulated in the maternal or fetal circulation, or in the placenta. The placenta expresses consi...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-7580.2008.01035.x

    authors: Hiden U,Glitzner E,Hartmann M,Desoye G

    更新日期:2009-07-01 00:00:00

  • Musculoskeletal anatomy of the pelvic fin of Polypterus: implications for phylogenetic distribution and homology of pre- and postaxial pelvic appendicular muscles.

    abstract::As a member of the most basal clade of extant ray-finned fishes (actinopterygians) and of one of the most basal clades of osteichthyans (bony fishes + tetrapods), Polypterus can provide insights into the ancestral anatomy of both ray-finned and lobe-finned fishes, including those that gave rise to tetrapods. The pecto...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12573

    authors: Molnar JL,Johnston PS,Esteve-Altava B,Diogo R

    更新日期:2017-04-01 00:00:00

  • Age related changes in neuron number in the mouse lateral vestibular nucleus.

    abstract::The number of large neurons in the lateral vestibular nucleus of the mouse brain decreases in number after 25 months of age, from 488 at 25 months to 298 at 31 months. The number of small neurons in the nucleus remains constant up to 31 months of age. Large neurons accumulate lipofuscin from 25 months and their mean n...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Sturrock RR

    更新日期:1989-10-01 00:00:00

  • Algorithms for radiological image registration and their clinical application.

    abstract::This paper reviews recent work in radiological image registration and provides a classification of image registration by type of transformation and by methods employed to compute the transformation. The former includes transformation of 2D images to 2D images of the same individual, transformation of 3D images to 3D i...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1046/j.1469-7580.1998.19330347.x

    authors: Hawkes DJ

    更新日期:1998-10-01 00:00:00

  • Blood supply to the cranial venae cavae and the heart in the laboratory shrew (Suncus murinus).

    abstract::The blood supply to the cranial venae cavae on both sides and to the heart was studied macroscopically in 40 adult laboratory shrews (Suncus murinus) of both sexes injected either with Neoprene latex into the abdominal aorta (25 animals) or with Mercox into the left ventricle (15 animals). The 1st branch of the left s...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Isomura G

    更新日期:1993-12-01 00:00:00

  • The impact of obesity on skeletal muscle architecture in untrained young vs. old women.

    abstract::It is unknown whether loading of the lower limbs through additional storage of fat mass as evident in obesity would promote muscular adaptations similar to those seen with resistance exercise. It is also unclear whether ageing modulates any such adjustments. This study aimed to examine the relationships between adipos...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12248

    authors: Tomlinson DJ,Erskine RM,Winwood K,Morse CI,Onambélé GL

    更新日期:2014-12-01 00:00:00

  • Surface morphology of the ducts of the epididymal region of the drake (Anas platyrhynchos) as revealed by scanning and transmission electron microscopy.

    abstract::Both scanning (SEM) and transmission (TEM) electron microscopic studies of the major ductules and ducts of the perfused epididymal region of the drake were reported. The SEM correlated with TEM studies and confirmed some previous observations that the non-ciliated Types I and II cells in the proximal and distal effere...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Aire TA

    更新日期:1982-10-01 00:00:00

  • Purkinje cell complements in mammalian cerebella and the biases incurred by counting nucleoli.

    abstract::An unbiased stereological counting device (the fractionator) was used to count Purkinje neurons in mammalian cerebella of known weights in order to define the relationship between weight and number. Nucleoli were chosen as the counting unit and numbers were estimated from uniform random samples of wax-embedded tissue ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Mwamengele GL,Mayhew TM,Dantzer V

    更新日期:1993-08-01 00:00:00

  • Enhancing tissue integration in cartilage repair procedures.

    abstract::Arguably, the gold standard of biological repair of articular cartilage lesions is autologous chondrocyte transplantation. Although the clinical outcomes appear to range between good and excellent in most cases, there are, nevertheless, both clinical and biological challenges that remain to improve rehabilitation and ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-7580.2006.00624.x

    authors: Archer CW,Redman S,Khan I,Bishop J,Richardson K

    更新日期:2006-10-01 00:00:00

  • Variations in the composition of the human rectus sheath: a study of the anterior abdominal wall.

    abstract::Three modes of construction of the rectus sheath above the arcuate line were found in a study of 40 cadavers. The classical description occurred most frequently, in 24 cases. The other constructions conformed to those described in earlier studies although the incidences were different. The accessory internal oblique m...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Monkhouse WS,Khalique A

    更新日期:1986-04-01 00:00:00

  • Development of articular cartilage and the metaphyseal growth plate: the localization of TRAP cells, VEGF, and endostatin.

    abstract::During long bone development the original cartilaginous model in mammals is replaced by bone, but at the long bone endings the avascular articular cartilage remains. Before the articular cartilage attains structural maturity it undergoes reorganization, and molecules such as vascular endothelial growth factor (VEGF) a...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/j.1469-7580.2011.01377.x

    authors: Stempel J,Fritsch H,Pfaller K,Blumer MJ

    更新日期:2011-06-01 00:00:00

  • The Harderian gland, its secretory duct and porphyrin content in the mongolian gerbil (Meriones unguiculatus).

    abstract::The Harderian gland, its secretory duct and porphyrin content were examined in the mongolian gerbil (Meriones unguiculatus). The gland consisted of tubules lined by a single layer of epithelial cells and a myoepithelial network. The tubule cells were often binucleate and possessed lipid vacuoles in the apical half of ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Johnston HS,McGadey J,Thompson GG,Moore MR,Payne AP

    更新日期:1983-10-01 00:00:00

  • A collagen and elastic network in the wing of the bat.

    abstract::Bundles of collagen fibrils, elastic fibres and fibroblasts are organized into a network that lies in the plane of a large portion of the bat wing. By ultrastructural (TEM and SEM) and biochemical analyses it was found that individual bundles of the net are similar to elastic ligaments. Although elastic fibres predomi...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Holbrook KA,Odland GF

    更新日期:1978-05-01 00:00:00

  • The dermal arteries of the human thumb pad.

    abstract::The arteries of the skin have been postulated to form a profound plexus at the dermal/hypodermal junction and a superficial plexus in the papillary dermis. Our article aims to rebut this concept and to provide an alternative description of the arrangement of the dermal arteries. Employing a novel technique, we produce...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12113

    authors: Geyer SH,Nöhammer MM,Tinhofer IE,Weninger WJ

    更新日期:2013-12-01 00:00:00

  • Slit-Robo interactions during cortical development.

    abstract::Interneurons are an integral part of cortical neuronal circuits. During the past decade, numerous studies have shown that these cells, unlike their pyramidal counterparts that are derived from the neuroepithelium along the lumen of the lateral ventricles, are generated in the ganglionic eminences in the subpallium. Th...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-7580.2007.00750.x

    authors: Andrews WD,Barber M,Parnavelas JG

    更新日期:2007-08-01 00:00:00

  • Observations on the sinuatrial nodal artery of the rat.

    abstract::The structure of the sinuatrial nodal artery has been investigated in young and old rats. The nodal artery is derived from the internal thoracic artery, runs centrally though the node and supplies it by several branches. An extensive cuff of nodal cells is seen within the adventitia of the artery and its branches adja...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Taylor IM

    更新日期:1980-06-01 00:00:00

  • Reconstructing phylogenies and phenotypes: a molecular view of human evolution.

    abstract::This review broadly summarizes how molecular biology has contributed to our understanding of human evolution. Molecular anthropology began in the 1960s with immunological comparisons indicating that African apes and humans were closely related and, indeed, shared a common ancestor as recently as 5 million years ago. A...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-7580.2007.00840.x

    authors: Bradley BJ

    更新日期:2008-04-01 00:00:00

  • The existence of the vomeronasal organ in postnatal chimpanzees and evidence for its homology with that of humans.

    abstract::It is currently thought that New World monkeys, prosimians, and humans are the only primates to possess vomeronasal organs (VNOs) as adults. Recent studies of the human VNO suggest that previous investigations on Old World primates may have missed the VNO. We examined nasal septa from the chimpanzee (Pan troglodytes) ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1046/j.1469-7580.2001.19810077.x

    authors: Smith TD,Siegel MI,Bonar CJ,Bhatnagar KP,Mooney MP,Burrows AM,Smith MA,Maico LM

    更新日期:2001-01-01 00:00:00

  • Extracellular matrix, supramolecular organisation and shape.

    abstract::Connective tissue function is defined as the formation and maintenance of shape, without which centralised physiologies (circulatory, digestive or nervous) could not have evolved. Two elements, inextensible (collagenous) fibrils and compression-resistant interfibrillar soluble polymers (proteoglycans), cope with all u...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:

    authors: Scott JE

    更新日期:1995-10-01 00:00:00

  • How to measure the increase in elastic system fibres in the lamina propria of the uterine cervix of pregnant rats.

    abstract::As the uterus enlarges to accommodate the growing fetus during pregnancy, the cervix behaves essentially as a barrier. During ripening and delivery, it needs to become soft and distensible to allow dilation and the passage of the conceptus. As the transformations of the collagen-containing fibres are known to be essen...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1046/j.1469-7580.2003.00227.x

    authors: Battlehner CN,Caldini EG,Pereira JC,Luque EH,Montes GS

    更新日期:2003-10-01 00:00:00

  • Ultrastructure of the zinc iodide-osmic acid stained cells in guinea pig small intestine.

    abstract::This study has demonstrated that cells stained using the zinc iodide-osmic acid (ZIO) method have the same fine structural features as those of fibroblasts. They have a well developed Golgi apparatus, granular endoplasmic reticulum and many mitochondria. They have no basal lamina. They are distributed in association w...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Zhou DS,Komuro T

    更新日期:1995-10-01 00:00:00

  • Aspects of PET imaging relevant to the assessment of striatal transplantation in Huntington's disease.

    abstract::Proper assessment of outcome in clinical trials of neural transplantation requires both biochemical and imaging indices of graft survival, and behavioural and physiological indices of graft function. For transplantation in Huntington's disease, a variety of ligands that are selective for striatal degeneration and graf...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1046/j.1469-7580.2000.19640597.x

    authors: Besret L,Kendall AL,Dunnett SB

    更新日期:2000-05-01 00:00:00