Abstract：
:Stem cells hold great promise for regenerative medicine but remain elusive in many tissues, including the small intestine, where it is well accepted that the epithelium is maintained by intestinal stem cells located in the crypts. The lack of established markers to prospectively identify intestinal stem cells has necessitated the use of indirect analysis, e.g. long-term label retention, which is based on the hypothesis that intestinal stem cells are slow-cycling. Several intestinal stem cell markers have been proposed, including Musashi-1, BMPR1alpha, phospho-PTEN, DCAMKL1, Eph receptors and integrins, but their validity, using functional and/or lineage tracing assays, has yet to be confirmed. Recently, Lgr5 has been identified by lineage tracing as an intestinal stem cell marker. In this review we summarize what is known about the currently reported intestinal stem cell markers and provide a rationale for developing model systems whereby intestinal stem cells can be functionally validated.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Montgomery RK,Breault DTdoi
10.1111/j.1469-7580.2008.00925.xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
52-8issue
1eissn
0021-8782issn
1469-7580pii
JOA925journal_volume
213pub_type
杂志文章,评审abstract：:In zoology it is well known that birds are characterized by the presence of feathers, and mammals by hairs. Another common point of view is that avian scales are directly related to reptilian scales. As a skin embryologist, I have been fascinated by the problem of regionalization of skin appendages in amniotes through...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2008.01041.x
更新日期：2009-04-01 00:00:00
abstract：:The proposal that the cytoplasmic granules of glomerular peripolar cells (PPCs) of the adult sheep and lamb contain a kallikrein-like substance has been re-examined. After extensive characterisation and purification of anti-kallikrein antibodies, it was concluded that PPCs do not contain immunohistochemically detectab...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:The Harderian gland, its secretory duct and porphyrin content were examined in the mongolian gerbil (Meriones unguiculatus). The gland consisted of tubules lined by a single layer of epithelial cells and a myoepithelial network. The tubule cells were often binucleate and possessed lipid vacuoles in the apical half of ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:The paraspinal compartment acts as a bone-muscle composite beam of the spine. The elastic properties of the paraspinal muscles play a critical role in spine stabilization. These properties depend on the subjects' posture, and they may be drastically altered by low back pain. Supersonic shear wave elastography can be u...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12978
更新日期：2019-06-01 00:00:00
abstract：:Fluorescence microscopy and transmission electron microscopy were used to study peribronchial ganglia of cats. An osmiophilic substance that is selectively taken up into the synaptic vesicles of adrenergic nerves (5-hydroxydopamine) was used to help differentiate adrenergic and non-adrenergic terminals. Peribronchial ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:The structure of the cardiac foramen ovale from 17 species representing six cetacean families, the Monodontidae, Phocoenidae, Delphinidae, Ziphiidae, Balaenidae and the Balaenopteridae, was studied using the scanning electron microscope. Eight white whale fetuses (Delphinapterus leucas) and a narwhal fetus (Monodon mo...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2007.00743.x
更新日期：2007-07-01 00:00:00
abstract：:The juxtaoral organ was studied using light microscopy in 55 human embryos and 90 fetuses at different stages of development. The juxtaoral organ arises from the epithelium at the bottom of the transverse opening of the primitive mouth during O'Rahilly stage 16 and becomes detached from the epithelium after O'Rahilly ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2005.00377.x
更新日期：2005-02-01 00:00:00
abstract：:The three kinds of keratinized epithelium evident on gross examination of the soft palate of Wistar albino rats were studied by scanning and transmission electron microscopy. Scanning indicated a central area where the epithelium showed numerous fine folds and papillae, more lateral areas which were smooth, and most l...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：:Four forelimbs of 3 platypuses and 3 forelimbs of 2 echidnas were examined to study the precise form of the brachial plexus and to clarify the structural characteristics of the brachial plexus in phylogeny. The spinal components contributing to the plexus (C4-T2) and the formation patterns of the 3 trunks of the plexu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19030447.x
更新日期：1997-04-01 00:00:00
abstract：:At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidu...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2008.01036.x
更新日期：2009-07-01 00:00:00
abstract：:We studied the cerebellar connections to the reticular nucleus thalamus (RNT) by means of retrograde axonal transport of horseradish peroxidase (HRP) in the rat. Specific HRP pressure injections to the rostral RNT (1.6-1.8 mm caudal to bregma) resulted in retrograde labelling of neurones in the cerebellar nuclei. The ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2002.00119.x
更新日期：2002-12-01 00:00:00
abstract：:Surgical interruption of the gastrointestinal tract is widely used for investigating the structure of the enteric nervous system and in the treatment of certain pathological conditions of the gastrointestinal tract. The effects of transection and end-to-end anastomosis and myotomy on nerve cells of the myenteric plexu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Mechanisms for passively coordinating forelimb movements and flight feather abduction and adduction have been described separately from both in vivo and ex vivo studies. Skeletal coordination has been identified as a way for birds to simplify the neuromotor task of controlling flight stroke, but an understanding of th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12511
更新日期：2016-11-01 00:00:00
abstract：:A quantitative comparison of the internal diameters of cerebral feeder arteries (internal carotid and vertebral) and the aorta in developing non-human eutherians, metatherians and monotremes has been made, with the aim of determining if there are differences in cerebral arterial flow between the three infraclasses of ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12422
更新日期：2016-03-01 00:00:00
abstract：:The koala has an inguinoaxillary lymph trunk on either side of the ventral midline, and this carries efferent lymph from the superficial inguinal lymph node directly to the deep axillary lymph node. The superficial lymph nodes are large and soft compared with those of the domestic species, and each lymph centre usuall...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:This study addresses the effects of increased mechanical load on the vertebral bone of post-smolt Atlantic salmon by forcing them to swim at controlled speeds. The fish swam continuously in four circular tanks for 9 weeks, two groups at 0.47 body lengths (bl) × s(-1) (non-exercised group) and two groups at 2 bl × s(-1...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01399.x
更新日期：2011-10-01 00:00:00
abstract：:In experimental studies addressing the regulation of myelin formation and maintenance by Schwann cells, the sympathetic nervous system of young adult rodents has served a key role as an essentially nonmyelinated yet modifiable control tissue. Nevertheless there is clear evidence of substantial myelination in the super...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:It is well known that large pyroninophilic cell proliferation in regional lymphoid tissue preceds and accompanies cell-mediated immunological reactions. In the present study of lymph node responses in the pregnant rat it was found that there were no significant differences between large pyronionphilic cell counts from...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-07-01 00:00:00
abstract：:The entire lengths of central and peripheral myelin sheaths on the same ventral motoneuron axons of young rats were studied during the rapid early phase of myelination which occurs during the first 2 weeks after birth. Sheath thickness varied along central internodes at all ages, though this variation was less in the ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：:Signalling interactions between the polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. However, mechanisms that mediate translation of early positional information of cells into anatomy remain largely unknown. In ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00134.x
更新日期：2003-01-01 00:00:00
abstract：:The kinematics of swings at joints can be described fully by means of two simple ratios and the angle at which the total operative force vector pulls upon a bone. The ratios can be applied to individual muscles, thus linking structural and functional myology in an exact way. The 'spurt' and 'shunt' types of muscle are...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric proteins, such as alpha myosin heavy chain and cardiac alpha actin, have no...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12486
更新日期：2016-09-01 00:00:00
abstract：:The ligamentous attachments of the lumbar spinous processes were studied by dissection and histological examination in seven dogs, three cats and six baboons. Unlike man, the lumbar spines of these animals do not possess a supraspinous ligament and there is no decussation of the erector spinae tendons in the lower lum...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Due to conflicting data from previous studies a new methodological approach to evaluate heel pad stiffness and soft tissue deformation has been developed. The purpose of this study was to compare heel pad (HP) stiffness in both limbs between males and females during a dynamic unloading and loading activity. Ten males ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13207
更新日期：2020-09-01 00:00:00
abstract：:The total number of muscle fibres, as well as the numbers of Type I, Type II and intermediate muscle fibre types, in transverse sections of the pectineus muscles of dogs of 2 and 12 months of age was determined by an indirect fibre counting method. The total nubmers of fibres in all muscles decreased very significantl...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The structure of the sinuatrial nodal artery has been investigated in young and old rats. The nodal artery is derived from the internal thoracic artery, runs centrally though the node and supplies it by several branches. An extensive cuff of nodal cells is seen within the adventitia of the artery and its branches adja...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:The structure of the gonad primordia is described in the embryos of three species of poeciliid fish. Prior to the sexualisation of the germ cells, a dimorphism exists based upon the gonadal somatic features. This serves as a basis for distinguishing between male and female specimens. Presumptive males are characterise...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:We present a simple and quick system for accurately scoring the developmental progress of mouse embryos harvested on embryonic day 14 (E14.5). Based solely on the external appearance of the maturing forelimb, we provide a convenient way to distinguish six developmental sub-stages. Using a variety of objective morphome...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12590
更新日期：2017-05-01 00:00:00
abstract：:In the infant the region lateral to the sella turcica which is traditionally termed the 'cavernous sinus' is composed of 3 individual compartments. The aim of this study was to demonstrate a similar compartmentation of the adult cavernous sinus and to identify and quantify the adipose bodies which are located within t...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19740681.x
更新日期：2000-11-01 00:00:00
abstract：:An immuno-epifluorescence microscopic study of first trimester human chorionic villi has revealed different patterns of distribution for intermediate filament proteins. Keratin staining was restricted to the trophoblastic epithelium. The protein was shown to be concentrated into desmosome-containing apical and basal c...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
