Global update: Germany.

abstract：:The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, b...

journal_title：Regenerative medicine

authors： El-Jawhari JJ,Brockett CL,Ktistakis I,Jones E,Giannoudis PV

更新日期：2018-03-19 00:00:00

abstract：:Induced pluripotent stem (iPS) cells offer tremendous opportunity for the creation of autologous cellular therapies, in which gene correction or the avoidance of immune response issues are desirable. In addition, iPS cells avoid the ethical concerns raised by the sourcing of human embryonic stem cells (hESCs) from emb...

journal_title：Regenerative medicine

authors： Carpenter MK,Couture LA

更新日期：2010-07-01 00:00:00

abstract：AIM:Secondary lymphedema is observed in common after postmalignancy treatment of the breast and the gynecologic organs but effective therapies are not established. Adipose-derived stem cells (ADSCs), which are pluripotent, regenerative in local injection, are tested for murine hindlimb secondary lymphedema by regenerat...

journal_title：Regenerative medicine

authors： Yoshida S,Hamuy R,Hamada Y,Yoshimoto H,Hirano A,Akita S

更新日期：2015-01-01 00:00:00

abstract：:The neurological and physiological basis of brain function and disease has been a significant focus of investigation throughout the history of medical research. Recent advances in understanding have led to the development of new treatments for diseases of the brain and defects of cognitive and behavioral function: pha...

journal_title：Regenerative medicine

authors： Chan S,Harris J

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:Mechanisms underpinning Gram-negative bacterial vaginosis-induced birth anomalies are obscure. Ethical issues limit such studies on peri-implantation-stage human embryos. Here we have used embryoid bodies (EBs) as an in vitro model to examine the effect of Gram-negative bacterial endotoxins/lipopolysaccharid...

journal_title：Regenerative medicine

authors： Sivasubramaniyan K,Atluri RR,Sarda K,Arvind M,Balaji V,Deb KD

更新日期：2008-01-01 00:00:00

abstract：AIM:To evaluate the in vitro immunogenic and immunomodulatory properties of induced pluripotent stem cells (iPSCs) compared with bone marrow-derived mesenchymal stromal cells (MSCs). MATERIALS & METHODS:Mouse embryonic fibroblasts (MEFs) were isolated from C3HeB/FeJ and C57BL/6J mice, and reprogrammed to generate iPSC...

journal_title：Regenerative medicine

authors： Schnabel LV,Abratte CM,Schimenti JC,Felippe MJ,Cassano JM,Southard TL,Cross JA,Fortier LA

更新日期：2014-01-01 00:00:00

abstract：AIM:This study presents an interim safety and feasibility analysis of the REGENERATE-IHD randomized controlled trial, which is examining the safety and efficacy of three different delivery routes of bone marrow-derived stem cells (BMSCs) in patients with ischemic heart failure. METHODS & RESULTS:The first 58 patients ...

journal_title：Regenerative medicine

authors： Mozid A,Yeo C,Arnous S,Ako E,Saunders N,Locca D,Brookman P,Archbold RA,Rothman M,Mills P,Agrawal S,Martin J,Mathur A

更新日期：2014-05-01 00:00:00

abstract：:The olfactory mucosa contains cells that enable it to generate new neurons and other supporting cells throughout life, allowing it to replace cells of the mucosa that have been damaged by exposure to various insults. In this article, we discuss the different types of stem cell found within the olfactory mucosa and the...

journal_title：Regenerative medicine

authors： Young E,Westerberg B,Yanai A,Gregory-Evans K

更新日期：2018-07-01 00:00:00

abstract：:In June 2013, the US Supreme Court ruled that naturally occurring genes were unpatentable in the case Association for Molecular Pathology v. Myriad Genetics. Up until this decision, Myriad Genetics was the only company in the USA that could legally conduct diagnostic testing for BRCA1 and 2, genes that are linked to f...

journal_title：Regenerative medicine

authors： Matthews KR,Cuchiara ML

更新日期：2014-03-01 00:00:00

abstract：:Aim: The present study evaluated the effects of polydeoxyribonucleotide (PDRN) on tissue regeneration, paying special attention to the molecular mechanisms that underlie its tissue remodeling actions to better identify its effective therapeutic potential in wound healing. Materials & methods: Strategic searches were c...

journal_title：Regenerative medicine

authors： Colangelo MT,Galli C,Guizzardi S

更新日期：2020-08-06 00:00:00

abstract：:Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, liga...

journal_title：Regenerative medicine

authors： Mengsteab PY,Nair LS,Laurencin CT

更新日期：2016-12-01 00:00:00

abstract：:Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an ...

journal_title：Regenerative medicine

authors： Zhou J,Cui H,Lu H,Xu Z,Feng W,Chen L,Jin X,Yang X,Qi Z

更新日期：2017-04-01 00:00:00

abstract：:Following the reversal by the court of appeals of the injunction against federal funding of human embryonic stem cell research, Judge Lamberth has held such funding to be lawful and has dismissed the lawsuit. However, the litigation is likely to continue in the court of appeals and ultimately perhaps in the Supreme Co...

journal_title：Regenerative medicine

authors： Goldfarb N

更新日期：2011-11-01 00:00:00

abstract：:Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...

journal_title：Regenerative medicine

authors： De Bie C

更新日期：2007-01-01 00:00:00

abstract：:Aim: Cell repopulation of tissue-engineered vascular grafts (TEVGs) from decellularized arterial scaffolds is limited by dense concentric tunica media layers which impede cells migrating radially between the layers. We aimed to develop and validate a new microneedle device to modify decellularized carotid arteries wit...

journal_title：Regenerative medicine

authors： Eufrásio-da-Silva T,Ruiz-Hernandez E,O'Dwyer J,Picazo-Frutos D,Duffy GP,Murphy BP

更新日期：2019-11-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) hold tremendous promise for tissue engineering and regenerative medicine, yet with so many sources of MSCs, what are the primary criteria for selecting leading candidates? Ideally, the cells will be multipotent, inexpensive, lack donor site morbidity, donor materials should...

journal_title：Regenerative medicine

authors： Wang L,Ott L,Seshareddy K,Weiss ML,Detamore MS

更新日期：2011-01-01 00:00:00

abstract：:Human embryonic stem cells (ESCs) can be induced to differentiate into a wide range of tissues that soon could be used for therapeutic applications in regenerative medicine. Despite their developmental potential, sources used to generate human ESC lines raise serious ethical concerns, which recently prompted efforts t...

journal_title：Regenerative medicine

authors： Lee H,Park J,Forget BG,Gaines P

更新日期：2009-09-01 00:00:00

abstract：:Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...

journal_title：Regenerative medicine

authors： Carulli S,Contin R,De Rosa L,Pellegrini G,De Luca M

更新日期：2013-07-01 00:00:00

abstract：:Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep ...

journal_title：Regenerative medicine

authors： Bisceglia G,Santodirocco M,Faienza A,Mastrodonato N,Urbano F,Totaro A,Bazzocchi F,Mauro LD

更新日期：2020-01-01 00:00:00

abstract：:Dr Jane Lebkowski joined Geron Corporation in 1998 and is currently Senior Vice President and Chief Scientific Officer of the Regenerative Medicine Division. Dr Lebkowski heads Geron's human embryonic stem cell program, and is responsible for all research, preclinical development, product development, manufacturing an...

journal_title：Regenerative medicine

authors： Lebkowski JS

更新日期：2009-09-01 00:00:00

abstract：:Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material for the generation of cellular therapeutics requires demonstration of comparability of lines derived from different individuals and in different facilities. This requires agreement on the critical quality attributes of such l...

journal_title：Regenerative medicine

authors： Sullivan S,Stacey GN,Akazawa C,Aoyama N,Baptista R,Bedford P,Bennaceur Griscelli A,Chandra A,Elwood N,Girard M,Kawamata S,Hanatani T,Latsis T,Lin S,Ludwig TE,Malygina T,Mack A,Mountford JC,Noggle S,Pereira LV,Pric

更新日期：2018-10-01 00:00:00

abstract：:Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...

journal_title：Regenerative medicine

authors： Hoffmann A,Gross G

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) can differentiate into any human cell type, including CNS cells, and thus have high potential in regenerative medicine. Several protocols exist for neuronal differentiation of hESCs, which do not necessarily work for all hESC lines. MATERIALS & METHODS:We tested the differ...

journal_title：Regenerative medicine

authors： Lappalainen RS,Salomäki M,Ylä-Outinen L,Heikkilä TJ,Hyttinen JA,Pihlajamäki H,Suuronen R,Skottman H,Narkilahti S

更新日期：2010-09-01 00:00:00

abstract：:Ross Macdonald is the CEO and Managing Director of Cynata Therapeutics Limited (Australia). He has over 30 years of experience and a track record of success in pharmaceuticals and biotechnology businesses. His career history includes positions as Vice President of Business Development for Sinclair Pharmaceuticals Ltd ...

journal_title：Regenerative medicine

authors： Macdonald R

更新日期：2019-11-01 00:00:00

abstract：:Background: To evaluate whether subtenon injection of platelet-rich plasma (PRP) with retinal electromagnetic stimulation (rEMS) is effective in therapy-resistant chronic central serous chorioretinopathy (CSCR). Design: Prospective, sequential. Materials & methods: The study included 22 eyes with resistant chronic CSC...

journal_title：Regenerative medicine

authors： Arslan U,Özmert E

更新日期：2020-08-01 00:00:00

abstract：:Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...

journal_title：Regenerative medicine

authors： Buzhor E,Leshansky L,Blumenthal J,Barash H,Warshawsky D,Mazor Y,Shtrichman R

更新日期：2014-01-01 00:00:00

abstract：:Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell a...

journal_title：Regenerative medicine

authors： Shard AG,Tomlins PE

更新日期：2006-11-01 00:00:00

abstract：:Cautious approaches in the clinic are currently proposed, supported by relevant in vitro, in vivo and published data. Key to developing our understanding of the risks of immune rejection of stem cell based therapies will be the inclusion of immunological endpoints in clinical trials and the sharing of data. There is l...

journal_title：Regenerative medicine

authors： Haworth R,Sharpe M

更新日期：2015-01-01 00:00:00

abstract：:The cornea at the front of the eye is covered by an epithelium. This epithelium is maintained by stem cells located at the periphery of the cornea, in a region known as the limbus. Because this region harbors the stem cells for the corneal epithelium, the so-called limbal stem cells, its culture provides considerable ...

journal_title：Regenerative medicine

authors： Osei-Bempong C,Henein C,Ahmad S

更新日期：2009-05-01 00:00:00

abstract：:Aim: The most common risk associated with intradiscal injection of platelet-rich plasma (PRP) is discitis with Cutibacterium acnes. It is hypothesized that antimicrobial activity of PRP can be enhanced through inclusion of leukocytes or antibiotics in the injectate. Materials & methods: Multiple PRP preparations of va...

journal_title：Regenerative medicine

authors： Prysak MH,Lutz CG,Zukofsky TA,Katz JM,Everts PA,Lutz GE

更新日期：2019-10-01 00:00:00