Quality control guidelines for clinical-grade human induced pluripotent stem cell lines.

abstract：AIMS:To evaluate the safety and efficacy of cell therapies administered acutely/sub-acutely after stroke. METHODS:Five databases were searched for studies examining the safety/efficacy of cell therapies administered ≤90 days post-stroke. Reporting quality and adherence to research guidelines were evaluated. Safety and...

journal_title：Regenerative medicine

authors： Unsworth DJ,Mathias JL,Dorstyn DS

更新日期：2016-10-01 00:00:00

abstract：AIM:We hypothesized that delivery of mesenchymal stem cells (MSCs) in a biomimetic collagen scaffold improves wound healing in a diabetic mouse model. MATERIALS & METHODS:Rolled collagen scaffolds containing MSCs were implanted or applied topically to diabetic C57BL/6 mice with excisional wounds. RESULTS:Rolled scaff...

journal_title：Regenerative medicine

authors： Assi R,Foster TR,He H,Stamati K,Bai H,Huang Y,Hyder F,Rothman D,Shu C,Homer-Vanniasinkam S,Cheema U,Dardik A

更新日期：2016-04-01 00:00:00

abstract：:Tissue regeneration specialist company Organogenesis Inc. was one of the first biotech companies formed. Incorporated in 1985, the company was originally a spin-off from a research program at MIT. For the first 10-15 years, Organogenesis was heavily research based, but then gradually moved into development. The compan...

journal_title：Regenerative medicine

authors： MacKay G

更新日期：2006-03-01 00:00:00

abstract：AIM:In this study, we have evaluated the therapeutic efficacy of mouse multipotent adult progenitor cells (mMAPCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, and compared it with mouse mesenchymal stem cells (mMSCs). MATERIALS & METHODS:We administered PKH26-labeled mMAP...

journal_title：Regenerative medicine

authors： Singh SP,Jadhav SH,Chaturvedi CP,Nityanand S

更新日期：2017-04-01 00:00:00

abstract：:Spinal cord injury devastates the CNS, besetting patients with symptoms including but not limited to: paralysis, autonomic nervous dysfunction, pain disorders and depression. Despite the identification of several molecular and genetic factors, a reliable regenerative therapy has yet to be produced for this terminal di...

journal_title：Regenerative medicine

authors： Finnegan J,Ye H

更新日期：2016-10-01 00:00:00

abstract：AIMS:An extensive colonization of surgical meshes with autologous fibroblasts may reduce complications. Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibrobla...

journal_title：Regenerative medicine

authors： Skala CE,Petry IB,Gebhard S,Hengstler JG,Albrich SB,Maltaris T,Naumann G,Koelbl H

更新日期：2009-03-01 00:00:00

abstract：AIM:Evaluation of survival, proliferation and neurodifferentiation of dental stem cells from the apical papilla (SCAP) in fibrin hydrogels. We hypothesized that fibrin composition will influence cell behavior. METHODS:Modulus, pore and fiber size were measured. SCAP in vitro viability, proliferation and neural differe...

journal_title：Regenerative medicine

authors： Germain L,De Berdt P,Vanacker J,Leprince J,Diogenes A,Jacobs D,Vandermeulen G,Bouzin C,Préat V,Dupont-Gillain C,des Rieux A

更新日期：2015-01-01 00:00:00

abstract：:Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...

journal_title：Regenerative medicine

authors： Yoshimura K,Eto H,Kato H,Doi K,Aoi N

更新日期：2011-11-01 00:00:00

abstract：:Human embryonic stem cells offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Characterizing these cells provides important information about their current state and affords relevant details for subsequent downstream manipulation. Prior to considering therapeutic appli...

journal_title：Regenerative medicine

authors： Pal R,Mandal A,Rao HS,Rao MS,Khanna A

更新日期：2007-03-01 00:00:00

abstract：:Professor Coffey joined the faculty at the University of Oxford in 1987 on completing his doctoral work. In 1989, he was awarded a personal Royal Society Research Fellowship, at the same time moving to the University of Sheffield to establish a new laboratory for retinal transplantation. After 14 years at the Universi...

journal_title：Regenerative medicine

authors： Coffey P

更新日期：2009-07-01 00:00:00

abstract：:In June 2013, the US Supreme Court ruled that naturally occurring genes were unpatentable in the case Association for Molecular Pathology v. Myriad Genetics. Up until this decision, Myriad Genetics was the only company in the USA that could legally conduct diagnostic testing for BRCA1 and 2, genes that are linked to f...

journal_title：Regenerative medicine

authors： Matthews KR,Cuchiara ML

更新日期：2014-03-01 00:00:00

abstract：:Aim: Cell repopulation of tissue-engineered vascular grafts (TEVGs) from decellularized arterial scaffolds is limited by dense concentric tunica media layers which impede cells migrating radially between the layers. We aimed to develop and validate a new microneedle device to modify decellularized carotid arteries wit...

journal_title：Regenerative medicine

authors： Eufrásio-da-Silva T,Ruiz-Hernandez E,O'Dwyer J,Picazo-Frutos D,Duffy GP,Murphy BP

更新日期：2019-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have tremendous potential for regenerative medicine, and have been researched for the treatment of cardiovascular diseases. MSCs are a promising cell type because of their ease of isolation and expansion, their multipotency and their low immunogenicity. However, in order to fully utilize ...

journal_title：Regenerative medicine

authors： Huang NF,Li S

更新日期：2008-11-01 00:00:00

abstract：AIM:It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. MATERIALS & METHODS:The effects of ...

journal_title：Regenerative medicine

authors： Herencia C,Almadén Y,Martínez-Moreno JM,Espejo I,Herrera C,Pérez-Sánchez C,Guerrero F,Ciria R,Briceño FJ,Ferrín G,de la Mata M,Muñoz-Castañeda JR

更新日期：2015-01-01 00:00:00

abstract：:Founded in 2009 and headquartered in Glasgow, Scotland, UK, Sistemic Ltd has developed from a thought in the minds of four scientists into a company working globally to play its part in delivering the exciting opportunities for improvements in human health presented by cell therapies and regenerative medicine products...

journal_title：Regenerative medicine

authors： Reid J

更新日期：2013-09-01 00:00:00

abstract：AIMS:Therapeutic replacement of organs with healthy cells requires disease-specific strategies. As copper toxicosis due to ATP7B deficiency in Wilson disease produces significant liver injury, disease-specific study of transplanted cell proliferation will offer insights into cell and gene therapy mechanisms. MATERIALS...

journal_title：Regenerative medicine

authors： Malhi H,Joseph B,Schilsky ML,Gupta S

更新日期：2008-03-01 00:00:00

abstract：:Clinical application of autologous cells by businesses promoting unproven stem cell treatments represents the largest growth sector in this problematic industry, but also presents special challenges to regulators. Patients frequently identify autologous cells as personal property, using the language of 'ownership'. Th...

journal_title：Regenerative medicine

authors： Sipp D

更新日期：2017-10-01 00:00:00

abstract：:Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...

journal_title：Regenerative medicine

authors： Mantripragada VP,Piuzzi NS,George J,Bova W,Ng M,Boehm C,Muschler GF

更新日期：2019-07-01 00:00:00

abstract：:Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...

journal_title：Regenerative medicine

authors： Buzhor E,Leshansky L,Blumenthal J,Barash H,Warshawsky D,Mazor Y,Shtrichman R

更新日期：2014-01-01 00:00:00

abstract：:Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, liga...

journal_title：Regenerative medicine

authors： Mengsteab PY,Nair LS,Laurencin CT

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) can differentiate into any human cell type, including CNS cells, and thus have high potential in regenerative medicine. Several protocols exist for neuronal differentiation of hESCs, which do not necessarily work for all hESC lines. MATERIALS & METHODS:We tested the differ...

journal_title：Regenerative medicine

authors： Lappalainen RS,Salomäki M,Ylä-Outinen L,Heikkilä TJ,Hyttinen JA,Pihlajamäki H,Suuronen R,Skottman H,Narkilahti S

更新日期：2010-09-01 00:00:00

abstract：AIM:Current synthetic tubular conduits are inferior to nerve autograft for the repair of segmental peripheral nerve injuries. We examined motor outcomes with the use of longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber conduits for repair of nerve gap injury in a rat model. METHODS:Ten-millimeter segme...

journal_title：Regenerative medicine

authors： Jin J,Park M,Rengarajan A,Zhang Q,Limburg S,Joshi SK,Patel S,Kim HT,Kuo AC

更新日期：2012-11-01 00:00:00

abstract：:In the past decade, stem cell therapy has been increasingly employed for the treatment of various diseases. Subsequently, there has been a great interest in the manufacture of stem cells under good manufacturing practice, which is required by law for their use in humans. The cells for sight Stem Cell Therapy Research ...

journal_title：Regenerative medicine

authors： Sheth-Shah R,Vernon AJ,Seetharaman S,Neale MH,Daniels JT

更新日期：2016-04-01 00:00:00

abstract：AIM:To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. METHODS:Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously publ...

journal_title：Regenerative medicine

authors： Vilsbøll AW,Mouritsen JM,Jensen LP,Bødker N,Holst AW,Pennisi CP,Ehlers L

更新日期：2018-04-01 00:00:00

abstract：:The concept of stem cell therapy has engaged the attention of the public and scientists alike. Intensive research effort is focused upon understanding the biology and therapeutic potential of embryonic and adult stem cells, with the eventual goal of treating such pathologies as Parkinson's disease, diabetes, neurologi...

journal_title：Regenerative medicine

authors： Daniels JT,Secker GA,Shortt AJ,Tuft SJ,Seetharaman S

更新日期：2006-09-01 00:00:00

abstract：AIM:This paper aims to map the trends and analyze key institutional dynamics that constitute the policies for reimbursement of regenerative medicine (RM), especially in the UK. MATERIALS & METHODS:Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi-stru...

journal_title：Regenerative medicine

authors： Mahalatchimy A,Faulkner A

更新日期：2017-09-01 00:00:00

abstract：:Background: To evaluate whether subtenon injection of platelet-rich plasma (PRP) with retinal electromagnetic stimulation (rEMS) is effective in therapy-resistant chronic central serous chorioretinopathy (CSCR). Design: Prospective, sequential. Materials & methods: The study included 22 eyes with resistant chronic CSC...

journal_title：Regenerative medicine

authors： Arslan U,Özmert E

更新日期：2020-08-01 00:00:00

abstract：:Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...

journal_title：Regenerative medicine

authors： De Bie C

更新日期：2007-01-01 00:00:00

abstract：:Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the r...

journal_title：Regenerative medicine

authors： De Bari C,Pitzalis C,Dell'Accio F

更新日期：2006-01-01 00:00:00

abstract：:Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...

journal_title：Regenerative medicine

authors： Siegel B

更新日期：2009-05-01 00:00:00