Fibrin hydrogels to deliver dental stem cells of the apical papilla for regenerative medicine.

abstract：:The concept of stem cell therapy has engaged the attention of the public and scientists alike. Intensive research effort is focused upon understanding the biology and therapeutic potential of embryonic and adult stem cells, with the eventual goal of treating such pathologies as Parkinson's disease, diabetes, neurologi...

journal_title：Regenerative medicine

authors： Daniels JT,Secker GA,Shortt AJ,Tuft SJ,Seetharaman S

更新日期：2006-09-01 00:00:00

abstract：:Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the...

journal_title：Regenerative medicine

authors： Chan S

更新日期：2017-10-01 00:00:00

abstract：:Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β-cells, existing in the islets of Langerhans, play central roles in the progression of diabetes. An efficient strategy to produce functional pancreatic β-cells is important for both transplantation therapy...

journal_title：Regenerative medicine

authors： Kao DI,Chen S

更新日期：2012-07-01 00:00:00

abstract：:Aim: To determine the potential of mesenchymal stem cells (MSC) for corneal epithelial regeneration in vitro. Materials & methods: Bone marrow MSC (BM-MSC) and adipose tissue MSC were analyzed for corneal epithelial and mesenchymal markers, using limbal stem cells and corneal cells as controls. MSC with better potenti...

journal_title：Regenerative medicine

authors： Nieto-Nicolau N,Martín-Antonio B,Müller-Sánchez C,Casaroli-Marano RP

更新日期：2020-03-01 00:00:00

abstract：:Worldwide, tissue engineering and cellular replacement therapies are at the forefront of the regenerative medicine agenda, and researchers are addressing key diseases, including diabetes, stroke and neurological disorders. It is becoming evident that neurological cell therapy is a necessarily complex endeavor. The bra...

journal_title：Regenerative medicine

authors： Thwaites JW,Reebye V,Mintz P,Levicar N,Habib N

更新日期：2012-05-01 00:00:00

abstract：:Advances in directed differentiation of human embryonic stem cells (hESCs) toward cardiac lineages have generated much interest within the myocardial therapy field. Beyond the promise that hESCs would provide a supply of new cardiomyocytes to the damaged heart, recent studies have also shown that paracrine effects of ...

journal_title：Regenerative medicine

authors： Bernstein HS

更新日期：2012-09-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating traumatic injury resulting in paralysis or sensory deficits due to tissue damage and the poor ability of axons to regenerate across the lesion. Despite extensive research, there is still no effective treatment that would restore lost function after SCI. A possible therapeutic ...

journal_title：Regenerative medicine

authors： Kubinová S,Syková E

更新日期：2012-03-01 00:00:00

abstract：:Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...

journal_title：Regenerative medicine

authors： Carulli S,Contin R,De Rosa L,Pellegrini G,De Luca M

更新日期：2013-07-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have been shown recently to hold much promise in curing autoimmune diseases. Newly diagnosed Type 1 diabetes individuals have been successfully reverted to normoglycemia by administration of autologous HSCs in association with a nonmyeloablative regimen (antithymocyte globulin + cycloph...

journal_title：Regenerative medicine

authors： Ben Nasr M,Bassi R,Usuelli V,Valderrama-Vasquez A,Tezza S,D'Addio F,Fiorina P

更新日期：2016-06-01 00:00:00

abstract：:Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...

journal_title：Regenerative medicine

authors： De Bie C

更新日期：2007-01-01 00:00:00

abstract：:In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing beta-cells are a major cause of defective control of blood glucose and its complications. Restoration of damaged beta-cells by endocrine pancreas regeneration would be an ideal therapeutic option. The possibility of generating insulin-secreting c...

journal_title：Regenerative medicine

authors： Sordi V,Bertuzzi F,Piemonti L

更新日期：2008-05-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making them attractive for both regenerative medicine and drug discovery. Over the past 10 years, technological advances and innovative platforms have yielded first-in-man PSC-based clinical trials and opened up new approaches fo...

journal_title：Regenerative medicine

authors： Kimbrel EA,Lanza R

更新日期：2016-12-01 00:00:00

abstract：:The 6th International Symposium on Regenerative Rehabilitation, hosted by the Alliance for Regenerative Rehabilitation Research and Training (AR3T), included a preconference meeting of institutional representatives of the International Consortium of Regenerative Rehabilitation, keynote talks from distinguished scienti...

journal_title：Regenerative medicine

authors： Loghmani MT,Roche JA

更新日期：2018-06-01 00:00:00

abstract：:We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich p...

journal_title：Regenerative medicine

authors： Stafford CD 2nd,Colberg RE,Nourse AL

更新日期：2019-05-01 00:00:00

abstract：:Aim: Cell repopulation of tissue-engineered vascular grafts (TEVGs) from decellularized arterial scaffolds is limited by dense concentric tunica media layers which impede cells migrating radially between the layers. We aimed to develop and validate a new microneedle device to modify decellularized carotid arteries wit...

journal_title：Regenerative medicine

authors： Eufrásio-da-Silva T,Ruiz-Hernandez E,O'Dwyer J,Picazo-Frutos D,Duffy GP,Murphy BP

更新日期：2019-11-01 00:00:00

abstract：AIM:Current synthetic tubular conduits are inferior to nerve autograft for the repair of segmental peripheral nerve injuries. We examined motor outcomes with the use of longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber conduits for repair of nerve gap injury in a rat model. METHODS:Ten-millimeter segme...

journal_title：Regenerative medicine

authors： Jin J,Park M,Rengarajan A,Zhang Q,Limburg S,Joshi SK,Patel S,Kim HT,Kuo AC

更新日期：2012-11-01 00:00:00

abstract：:Professor Coffey joined the faculty at the University of Oxford in 1987 on completing his doctoral work. In 1989, he was awarded a personal Royal Society Research Fellowship, at the same time moving to the University of Sheffield to establish a new laboratory for retinal transplantation. After 14 years at the Universi...

journal_title：Regenerative medicine

authors： Coffey P

更新日期：2009-07-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...

journal_title：Regenerative medicine

authors： Awan M,Buriak I,Fleck R,Fuller B,Goltsev A,Kerby J,Lowdell M,Mericka P,Petrenko A,Petrenko Y,Rogulska O,Stolzing A,Stacey GN

更新日期：2020-03-01 00:00:00

abstract：:The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, b...

journal_title：Regenerative medicine

authors： El-Jawhari JJ,Brockett CL,Ktistakis I,Jones E,Giannoudis PV

更新日期：2018-03-19 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) hold tremendous promise for tissue engineering and regenerative medicine, yet with so many sources of MSCs, what are the primary criteria for selecting leading candidates? Ideally, the cells will be multipotent, inexpensive, lack donor site morbidity, donor materials should...

journal_title：Regenerative medicine

authors： Wang L,Ott L,Seshareddy K,Weiss ML,Detamore MS

更新日期：2011-01-01 00:00:00

abstract：:Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...

journal_title：Regenerative medicine

authors： Yang ZG,Tang RF,Qi YY,Chen WP,Xiong Y,Wu LD

更新日期：2020-06-01 00:00:00

abstract：:Aim: The most common risk associated with intradiscal injection of platelet-rich plasma (PRP) is discitis with Cutibacterium acnes. It is hypothesized that antimicrobial activity of PRP can be enhanced through inclusion of leukocytes or antibiotics in the injectate. Materials & methods: Multiple PRP preparations of va...

journal_title：Regenerative medicine

authors： Prysak MH,Lutz CG,Zukofsky TA,Katz JM,Everts PA,Lutz GE

更新日期：2019-10-01 00:00:00

abstract：AIMS:Therapeutic replacement of organs with healthy cells requires disease-specific strategies. As copper toxicosis due to ATP7B deficiency in Wilson disease produces significant liver injury, disease-specific study of transplanted cell proliferation will offer insights into cell and gene therapy mechanisms. MATERIALS...

journal_title：Regenerative medicine

authors： Malhi H,Joseph B,Schilsky ML,Gupta S

更新日期：2008-03-01 00:00:00

abstract：:Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...

journal_title：Regenerative medicine

authors： Buzhor E,Leshansky L,Blumenthal J,Barash H,Warshawsky D,Mazor Y,Shtrichman R

更新日期：2014-01-01 00:00:00

abstract：:Researchers are working on key issues in regenerative medicine in many of the over 280 academic institutions in Germany. Moreover, nonuniversity research institutions such as Helmholtz-, Max-Planck-, Fraunhofer- and Leibniz-Centers provide important contributions to the field of regenerative medicine in Germany. Resea...

journal_title：Regenerative medicine

authors： Lauter FR,Wirsching S

更新日期：2011-11-01 00:00:00

abstract：AIMS:To assess the potential of electrospun poly(lactide-co-glycolide) membranes to provide a biodegradable cell carrier system for limbal epithelial cells. MATERIAL & METHODS:50:50 poly(lactide-co-glycolide) scaffolds were spun, sterilized and seeded with primary rabbit limbal epithelial cells. Cells were cultured on...

journal_title：Regenerative medicine

authors： Deshpande P,McKean R,Blackwood KA,Senior RA,Ogunbanjo A,Ryan AJ,MacNeil S

更新日期：2010-05-01 00:00:00

abstract：AIM:This paper aims to map the trends and analyze key institutional dynamics that constitute the policies for reimbursement of regenerative medicine (RM), especially in the UK. MATERIALS & METHODS:Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi-stru...

journal_title：Regenerative medicine

authors： Mahalatchimy A,Faulkner A

更新日期：2017-09-01 00:00:00

abstract：:Medicinal signaling cell (MSC)-based products represent emerging treatments in various therapeutic areas including cardiometabolic, inflammation, autoimmunity, orthopedics, wound healing and oncology. Exploring innovation beyond minimally manipulated plastic-adherent ex vivo expanded allogeneic MSCs enables product de...

journal_title：Regenerative medicine

authors： Vertès AA

更新日期：2017-12-01 00:00:00

abstract：:Background: Bone marrow aspiration (BMA) is among a group of autologous cell-based therapies currently being explored to treat osteoarthritis (OA). Materials & methods: This retrospective case study observed ten patients (13 knees) with severe knee OA who failed extensive conservative treatment and were treated with B...

journal_title：Regenerative medicine

authors： Colberg RE,Jurado Vélez JA,Walsh KP,Fleisig G

更新日期：2020-07-01 00:00:00

abstract：:Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...

journal_title：Regenerative medicine

authors： Siegel B

更新日期：2009-05-01 00:00:00