Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model.

abstract：:Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...

journal_title：Regenerative medicine

authors： Hoffmann A,Gross G

更新日期：2006-07-01 00:00:00

abstract：AIM:This study presents an interim safety and feasibility analysis of the REGENERATE-IHD randomized controlled trial, which is examining the safety and efficacy of three different delivery routes of bone marrow-derived stem cells (BMSCs) in patients with ischemic heart failure. METHODS & RESULTS:The first 58 patients ...

journal_title：Regenerative medicine

authors： Mozid A,Yeo C,Arnous S,Ako E,Saunders N,Locca D,Brookman P,Archbold RA,Rothman M,Mills P,Agrawal S,Martin J,Mathur A

更新日期：2014-05-01 00:00:00

abstract：:Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β-cells, existing in the islets of Langerhans, play central roles in the progression of diabetes. An efficient strategy to produce functional pancreatic β-cells is important for both transplantation therapy...

journal_title：Regenerative medicine

authors： Kao DI,Chen S

更新日期：2012-07-01 00:00:00

abstract：:Diabetes mellitus represents a global epidemic affecting over 350 million patients worldwide and projected by the WHO to surpass the 500 million patient mark within the next two decades. Besides Type 1 and Type 2 diabetes mellitus, the study of the endocrine compartment of the pancreas is of great translational intere...

journal_title：Regenerative medicine

authors： Ricordi C,Inverardi L,Domínguez-Bendala J

更新日期：2012-11-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...

journal_title：Regenerative medicine

authors： Awan M,Buriak I,Fleck R,Fuller B,Goltsev A,Kerby J,Lowdell M,Mericka P,Petrenko A,Petrenko Y,Rogulska O,Stolzing A,Stacey GN

更新日期：2020-03-01 00:00:00

abstract：:Spinal cord injury devastates the CNS, besetting patients with symptoms including but not limited to: paralysis, autonomic nervous dysfunction, pain disorders and depression. Despite the identification of several molecular and genetic factors, a reliable regenerative therapy has yet to be produced for this terminal di...

journal_title：Regenerative medicine

authors： Finnegan J,Ye H

更新日期：2016-10-01 00:00:00

abstract：:Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in March 2020. ...

journal_title：Regenerative medicine

authors： Ilic D,Liovic M

更新日期：2020-07-01 00:00:00

abstract：:Aging is defined as the progressive and generalized impairment of function, resulting in an increasing vulnerability to environmental challenges and a growing risk of disease and death. The decline in the regenerative capacity of resident stem cells across different tissues is a central mediator of aging. In this pape...

journal_title：Regenerative medicine

authors： Stochaj U,Kodiha M,Shum-Tim D,Colmegna I

更新日期：2013-03-01 00:00:00

abstract：:Tissue regeneration specialist company Organogenesis Inc. was one of the first biotech companies formed. Incorporated in 1985, the company was originally a spin-off from a research program at MIT. For the first 10-15 years, Organogenesis was heavily research based, but then gradually moved into development. The compan...

journal_title：Regenerative medicine

authors： MacKay G

更新日期：2006-03-01 00:00:00

abstract：:Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tiss...

journal_title：Regenerative medicine

authors： Ma Z,Lu Y,Yang Y,Wang J,Kang X

更新日期：2019-09-01 00:00:00

abstract：:Human embryonic stem cells (ESCs) can be induced to differentiate into a wide range of tissues that soon could be used for therapeutic applications in regenerative medicine. Despite their developmental potential, sources used to generate human ESC lines raise serious ethical concerns, which recently prompted efforts t...

journal_title：Regenerative medicine

authors： Lee H,Park J,Forget BG,Gaines P

更新日期：2009-09-01 00:00:00

abstract：:Aim: The present study evaluated the effects of polydeoxyribonucleotide (PDRN) on tissue regeneration, paying special attention to the molecular mechanisms that underlie its tissue remodeling actions to better identify its effective therapeutic potential in wound healing. Materials & methods: Strategic searches were c...

journal_title：Regenerative medicine

authors： Colangelo MT,Galli C,Guizzardi S

更新日期：2020-08-06 00:00:00

abstract：:Clinical application of autologous cells by businesses promoting unproven stem cell treatments represents the largest growth sector in this problematic industry, but also presents special challenges to regulators. Patients frequently identify autologous cells as personal property, using the language of 'ownership'. Th...

journal_title：Regenerative medicine

authors： Sipp D

更新日期：2017-10-01 00:00:00

abstract：:Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...

journal_title：Regenerative medicine

authors： Carulli S,Contin R,De Rosa L,Pellegrini G,De Luca M

更新日期：2013-07-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making them attractive for both regenerative medicine and drug discovery. Over the past 10 years, technological advances and innovative platforms have yielded first-in-man PSC-based clinical trials and opened up new approaches fo...

journal_title：Regenerative medicine

authors： Kimbrel EA,Lanza R

更新日期：2016-12-01 00:00:00

abstract：:Founded in 2009 and headquartered in Glasgow, Scotland, UK, Sistemic Ltd has developed from a thought in the minds of four scientists into a company working globally to play its part in delivering the exciting opportunities for improvements in human health presented by cell therapies and regenerative medicine products...

journal_title：Regenerative medicine

authors： Reid J

更新日期：2013-09-01 00:00:00

abstract：:Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an ...

journal_title：Regenerative medicine

authors： Zhou J,Cui H,Lu H,Xu Z,Feng W,Chen L,Jin X,Yang X,Qi Z

更新日期：2017-04-01 00:00:00

abstract：:Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...

journal_title：Regenerative medicine

authors： Yoshimura K,Eto H,Kato H,Doi K,Aoi N

更新日期：2011-11-01 00:00:00

abstract：:Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material for the generation of cellular therapeutics requires demonstration of comparability of lines derived from different individuals and in different facilities. This requires agreement on the critical quality attributes of such l...

journal_title：Regenerative medicine

authors： Sullivan S,Stacey GN,Akazawa C,Aoyama N,Baptista R,Bedford P,Bennaceur Griscelli A,Chandra A,Elwood N,Girard M,Kawamata S,Hanatani T,Latsis T,Lin S,Ludwig TE,Malygina T,Mack A,Mountford JC,Noggle S,Pereira LV,Pric

更新日期：2018-10-01 00:00:00

abstract：AIM:To evaluate the cost-effectiveness of autologous cell therapy manufacturing in xeno-free conditions. MATERIALS & METHODS:Published data on the isolation and expansion of mesenchymal stem/stromal cells introduced donor, multipassage and culture media variability on cell yields and process times on adherent culture ...

journal_title：Regenerative medicine

authors： Bandeiras C,Cabral JM,Finkelstein SN,Ferreira FC

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) can differentiate into any human cell type, including CNS cells, and thus have high potential in regenerative medicine. Several protocols exist for neuronal differentiation of hESCs, which do not necessarily work for all hESC lines. MATERIALS & METHODS:We tested the differ...

journal_title：Regenerative medicine

authors： Lappalainen RS,Salomäki M,Ylä-Outinen L,Heikkilä TJ,Hyttinen JA,Pihlajamäki H,Suuronen R,Skottman H,Narkilahti S

更新日期：2010-09-01 00:00:00

abstract：:The determinants of adoption of regenerative medicine therapies are currently poorly understood. This study aims to draw comparison between the UK and Canada in terms of factors likely to affect healthcare adoption of future regenerative therapies in ophthalmology. Conducting semi-structured interviews with senior oph...

journal_title：Regenerative medicine

authors： Rose JB,May M,Williams DJ

更新日期：2015-05-01 00:00:00

abstract：:A major challenge to commercializing cell-based therapies is developing scalable manufacturing processes while maintaining the critical quality parameters (identity, potency, purity, safety) of the final live cell product. Process development activities such as extended passaging and serum reduction/elimination can fa...

journal_title：Regenerative medicine

authors： Carmen J,Burger SR,McCaman M,Rowley JA

更新日期：2012-01-01 00:00:00

abstract：:Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell a...

journal_title：Regenerative medicine

authors： Shard AG,Tomlins PE

更新日期：2006-11-01 00:00:00

abstract：:The Tissue Engineering and Regenerative Medicine International Society-Asia Pacific (TERMIS-AP) annual meeting was held in Sydney, Australia from 15-17 September 2010 and highlighted the latest developments in tissue engineering and regenerative medicine in the Asia-Pacific region. Several of the plenary lectures focu...

journal_title：Regenerative medicine

authors： Frith JE,Hudson JE,Cooper-White JJ

更新日期：2011-03-01 00:00:00

abstract：:Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...

journal_title：Regenerative medicine

authors： De Bie C

更新日期：2007-01-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cells offer tremendous opportunity for the creation of autologous cellular therapies, in which gene correction or the avoidance of immune response issues are desirable. In addition, iPS cells avoid the ethical concerns raised by the sourcing of human embryonic stem cells (hESCs) from emb...

journal_title：Regenerative medicine

authors： Carpenter MK,Couture LA

更新日期：2010-07-01 00:00:00

abstract：:Research regarding the use of cord blood (CB) has focused on antigen match and the number of stem cells, with policies and networks related to its use being under researched. This article is based on fieldwork in China from 2013 to 2015 and examines ways that the studied CB bank enhances CB usage in China. This articl...

journal_title：Regenerative medicine

authors： Chang HC

更新日期：2017-09-01 00:00:00

abstract：:Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...

journal_title：Regenerative medicine

authors： Siegel B

更新日期：2009-05-01 00:00:00

abstract：:Nanotechnology offers significant potential in regenerative medicine, specifically with the ability to mimic tissue architecture at the nanoscale. In this perspective, we highlight key achievements in the nanotechnology field for successfully mimicking the composition and structure of different tissues, and the develo...

journal_title：Regenerative medicine

authors： Alarçin E,Guan X,Kashaf SS,Elbaradie K,Yang H,Jang HL,Khademhosseini A

更新日期：2016-12-01 00:00:00