Abstract:
:Induced pluripotent stem (iPS) cells offer tremendous opportunity for the creation of autologous cellular therapies, in which gene correction or the avoidance of immune response issues are desirable. In addition, iPS cells avoid the ethical concerns raised by the sourcing of human embryonic stem cells (hESCs) from embryos. iPS cells share many characteristics with hESCs and it is anticipated that existing experience with hESCs will translate to rapid progress in moving iPS cell-derived products toward clinical trials. While the potential clinical value for these products is considerable, the nature of current manufacturing paradigms for autologous iPS cell products raises considerable regulatory concerns. Here, the regulatory challenges posed by autologous iPS cell-derived products are examined. We conclude that there will be considerable regulatory concerns primarily relating to reproducibility of the manufacturing process and safety testing within clinically limited time constraints. Demonstrating safety of the final cell product in an autologous setting will be the single greatest obstacle to progressing autologous iPS cell-based therapies into the clinic.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Carpenter MK,Couture LAdoi
10.2217/rme.10.55subject
Has Abstractpub_date
2010-07-01 00:00:00pages
569-79issue
4eissn
1746-0751issn
1746-076Xjournal_volume
5pub_type
杂志文章abstract::The 6th International Symposium on Regenerative Rehabilitation, hosted by the Alliance for Regenerative Rehabilitation Research and Training (AR3T), included a preconference meeting of institutional representatives of the International Consortium of Regenerative Rehabilitation, keynote talks from distinguished scienti...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0026
更新日期:2018-06-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 历史文章,杂志文章
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journal_title:Regenerative medicine
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Regenerative medicine
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doi:10.2217/rme-2016-0129
更新日期:2016-12-01 00:00:00
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journal_title:Regenerative medicine
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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更新日期:2007-07-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.13.58
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.3.2.165
更新日期:2008-03-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.6.919
更新日期:2007-11-01 00:00:00
abstract:AIM:Dendritic cell (DC)-based vaccines have a potential utility for use in the treatment of malignancy. Human embryonic stem cells (hESCs) may provide a more cost-effective and reliable source of DCs for immunotherapy purposes, providing on-demand access for patients. METHOD:We developed a protocol to generate DCs fro...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.25
更新日期:2009-07-01 00:00:00
abstract::Aim: To describe the successful treatment of a Baker's cyst in the setting of post-traumatic osteoarthritis using ultrasound-guided injection of platelet-rich plasma. Setting: Outpatient sports clinic. Patient: 29-year old male basketball player. Case description: The patient presented with 2-months history of right k...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0021
更新日期:2020-06-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.16
更新日期:2010-05-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.11.21
更新日期:2011-05-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0156
更新日期:2019-09-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.15.24
更新日期:2015-01-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.2217/rme-2019-0113
更新日期:2020-07-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 新闻
doi:10.2217/rme.09.6
更新日期:2009-05-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2015-0045
更新日期:2016-04-01 00:00:00
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journal_title:Regenerative medicine
pub_type:
doi:10.2217/rme.15.4
更新日期:2015-05-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.1.59
更新日期:2006-01-01 00:00:00
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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journal_title:Regenerative medicine
pub_type: 杂志文章
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journal_title:Regenerative medicine
pub_type: 杂志文章
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