Prospects of stem cell therapy in osteoarthritis.

Abstract:

:Osteoarthritis is a common disorder in which there is not only extensive degeneration but also an aberrant attempt at repair in joints. Stem cell therapy could provide a permanent, biological solution, with all sources of stem cells (embryonic, fetal and adult) showing some degree of potential. Mesenchymal stromal/stem cells, however, appear to be the leading candidates because of their ability to be sourced from many or all joint tissues. They may also modulate the immune response of individuals, in a manner influenced by local factors. This biological behavior of stem cells renders the application of regulatory standardizations challenging in comparison to pharmaceutical therapies. However, this would not be an issue if endogenous stem cells were activated to effect repair of an arthritic joint.

journal_name

Regen Med

journal_title

Regenerative medicine

authors

Roberts S,Genever P,McCaskie A,De Bari C

doi

10.2217/rme.11.21

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

351-66

issue

3

eissn

1746-0751

issn

1746-076X

journal_volume

6

pub_type

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