Abstract:
AIM:Secondary lymphedema is observed in common after postmalignancy treatment of the breast and the gynecologic organs but effective therapies are not established. Adipose-derived stem cells (ADSCs), which are pluripotent, regenerative in local injection, are tested for murine hindlimb secondary lymphedema by regenerative method. METHODS & RESULTS:Mice were divided into four groups: no ADSCs, 1 × 10(6) ADSCs, 1 × 10(5) ADSCs and 1 × 10(4) ADSCs (each group, n = 20) in a stringent surgical resection and irradiation. Circumferential measurement, lymphatic flow assessment and quantification of lymphatic vessels were performed. RESULTS:The numbers of lymphatic vessels by LYVE-1 immunohistochemistry, and VEGF-C- or VEGFR3-expressing cells were significantly increased in transplanted groups (p < 0.05). CONCLUSION:ADSCs can restore the lymphatic vascular network in secondary lymphedema with increased collecting vessels.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Yoshida S,Hamuy R,Hamada Y,Yoshimoto H,Hirano A,Akita Sdoi
10.2217/rme.15.24subject
Has Abstractpub_date
2015-01-01 00:00:00pages
549-62issue
5eissn
1746-0751issn
1746-076Xjournal_volume
10pub_type
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