Abstract:
:Medicinal signaling cell (MSC)-based products represent emerging treatments in various therapeutic areas including cardiometabolic, inflammation, autoimmunity, orthopedics, wound healing and oncology. Exploring innovation beyond minimally manipulated plastic-adherent ex vivo expanded allogeneic MSCs enables product delineation. Product delineation is on the critical path to maximize clinical benefits and market access. An innovation framework is presented here along various innovation dimensions comprising composition-of-matter by means of positive cell surface markers, formulation varying for example the cell dose or the preservation mode and medium, manufacturing to adapt the secretome of MSCs to the condition of interest, the mode of delivery and corresponding delivery devices, as well as molecular engineering and biomarkers. The rationale of the innovation space thus described applies generally to all cell-based therapies.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Vertès AAdoi
10.2217/rme-2017-0093subject
Has Abstractpub_date
2017-12-01 00:00:00pages
997-1013issue
8eissn
1746-0751issn
1746-076Xjournal_volume
12pub_type
杂志文章abstract::Multipotent mesenchymal stromal cells (MSCs) hold tremendous promise for tissue engineering and regenerative medicine, yet with so many sources of MSCs, what are the primary criteria for selecting leading candidates? Ideally, the cells will be multipotent, inexpensive, lack donor site morbidity, donor materials should...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.10.98
更新日期:2011-01-01 00:00:00
abstract:AIM:This paper aims to map the trends and analyze key institutional dynamics that constitute the policies for reimbursement of regenerative medicine (RM), especially in the UK. MATERIALS & METHODS:Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi-stru...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0041
更新日期:2017-09-01 00:00:00
abstract::In the South Korean health technology assessment system, prices of alternative medicines, incremental cost-effectiveness ratios in pharmaco-economic evaluations and patient access improvement systems such as risk-sharing agreements are the most important factors concerning the reimbursement of regenerative medicine (R...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0035
更新日期:2020-04-01 00:00:00
abstract::Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.1.95
更新日期:2007-01-01 00:00:00
abstract::Among the many international conferences in the field of stem cells and regenerative medicine, WSCS is distinct in focusing its efforts to serve as the meeting point by multisector communities of research, clinics, industry, regulation, policy making and ethics. All are aiming at advancing stem cell innovation and new...
journal_title:Regenerative medicine
pub_type:
doi:10.2217/rme.15.4
更新日期:2015-05-01 00:00:00
abstract:AIMS:Murine 3T3 feeder cells are commonly used for stem cell expansion. Although 'feeder-free' systems are being developed for a variety of stem cells including embryonic, the use of feeder cells currently remains optimal for the expansion of epithelial stem cells. In this study, MRC-5, a human embryonic fibroblast cel...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.6.919
更新日期:2007-11-01 00:00:00
abstract::Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...
journal_title:Regenerative medicine
pub_type: 新闻
doi:10.2217/rme.09.6
更新日期:2009-05-01 00:00:00
abstract::Following the reversal by the court of appeals of the injunction against federal funding of human embryonic stem cell research, Judge Lamberth has held such funding to be lawful and has dismissed the lawsuit. However, the litigation is likely to continue in the court of appeals and ultimately perhaps in the Supreme Co...
journal_title:Regenerative medicine
pub_type: 历史文章,杂志文章
doi:10.2217/rme.11.70
更新日期:2011-11-01 00:00:00
abstract::Dr Jane Lebkowski joined Geron Corporation in 1998 and is currently Senior Vice President and Chief Scientific Officer of the Regenerative Medicine Division. Dr Lebkowski heads Geron's human embryonic stem cell program, and is responsible for all research, preclinical development, product development, manufacturing an...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/rme.09.49
更新日期:2009-09-01 00:00:00
abstract::Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β-cells, existing in the islets of Langerhans, play central roles in the progression of diabetes. An efficient strategy to produce functional pancreatic β-cells is important for both transplantation therapy...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.27
更新日期:2012-07-01 00:00:00
abstract::Cautious approaches in the clinic are currently proposed, supported by relevant in vitro, in vivo and published data. Key to developing our understanding of the risks of immune rejection of stem cell based therapies will be the inclusion of immunological endpoints in clinical trials and the sharing of data. There is l...
journal_title:Regenerative medicine
pub_type: 社论
doi:10.2217/rme.14.50
更新日期:2015-01-01 00:00:00
abstract::Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0065
更新日期:2017-10-01 00:00:00
abstract::Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell a...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.1.6.789
更新日期:2006-11-01 00:00:00
abstract::Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in March 2020. ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0052
更新日期:2020-07-01 00:00:00
abstract:AIM:In this study, we have evaluated the therapeutic efficacy of mouse multipotent adult progenitor cells (mMAPCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, and compared it with mouse mesenchymal stem cells (mMSCs). MATERIALS & METHODS:We administered PKH26-labeled mMAP...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2016-0109
更新日期:2017-04-01 00:00:00
abstract:AIMS:Therapeutic replacement of organs with healthy cells requires disease-specific strategies. As copper toxicosis due to ATP7B deficiency in Wilson disease produces significant liver injury, disease-specific study of transplanted cell proliferation will offer insights into cell and gene therapy mechanisms. MATERIALS...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.3.2.165
更新日期:2008-03-01 00:00:00
abstract::Launched in June 2011, CCRM is a unique, Canadian, not-for-profit group that is solely focused on developing and commercializing regenerative medicine, cell and gene therapy technologies. Its mission is to generate sustainable health and economic benefits through global collaborations, and its vision is to be the pref...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2016-0129
更新日期:2016-12-01 00:00:00
abstract::Nanotechnology offers significant potential in regenerative medicine, specifically with the ability to mimic tissue architecture at the nanoscale. In this perspective, we highlight key achievements in the nanotechnology field for successfully mimicking the composition and structure of different tissues, and the develo...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2016-0120
更新日期:2016-12-01 00:00:00
abstract:AIM:Dendritic cell (DC)-based vaccines have a potential utility for use in the treatment of malignancy. Human embryonic stem cells (hESCs) may provide a more cost-effective and reliable source of DCs for immunotherapy purposes, providing on-demand access for patients. METHOD:We developed a protocol to generate DCs fro...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.25
更新日期:2009-07-01 00:00:00
abstract::Background: Bone marrow aspiration (BMA) is among a group of autologous cell-based therapies currently being explored to treat osteoarthritis (OA). Materials & methods: This retrospective case study observed ten patients (13 knees) with severe knee OA who failed extensive conservative treatment and were treated with B...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0113
更新日期:2020-07-01 00:00:00
abstract::Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were used to treat a different disorder. Subsequently, several studies using cultured cells have enabled identification of hair growth modulators with similar prope...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.87
更新日期:2014-01-01 00:00:00
abstract:AIM:Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). MATERIALS & METHODS:AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a de...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.61
更新日期:2014-01-01 00:00:00
abstract::Aim: We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat™, Lipogems®) is a viable alternative for treatment of joint pain and inflammation associated dysfunction in shoulder osteoarthritis (OA). Materials & methods: A total of 25 subjects with OA received an injection of MFat™ and were fol...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0069
更新日期:2020-10-01 00:00:00
abstract::Induced pluripotent stem (iPS) cells offer tremendous opportunity for the creation of autologous cellular therapies, in which gene correction or the avoidance of immune response issues are desirable. In addition, iPS cells avoid the ethical concerns raised by the sourcing of human embryonic stem cells (hESCs) from emb...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.55
更新日期:2010-07-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have tremendous potential for regenerative medicine, and have been researched for the treatment of cardiovascular diseases. MSCs are a promising cell type because of their ease of isolation and expansion, their multipotency and their low immunogenicity. However, in order to fully utilize ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.3.6.877
更新日期:2008-11-01 00:00:00
abstract::Human embryonic stem cells offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Characterizing these cells provides important information about their current state and affords relevant details for subsequent downstream manipulation. Prior to considering therapeutic appli...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.2.179
更新日期:2007-03-01 00:00:00
abstract::The cornea at the front of the eye is covered by an epithelium. This epithelium is maintained by stem cells located at the periphery of the cornea, in a region known as the limbus. Because this region harbors the stem cells for the corneal epithelium, the so-called limbal stem cells, its culture provides considerable ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.7
更新日期:2009-05-01 00:00:00
abstract::Professor Coffey joined the faculty at the University of Oxford in 1987 on completing his doctoral work. In 1989, he was awarded a personal Royal Society Research Fellowship, at the same time moving to the University of Sheffield to establish a new laboratory for retinal transplantation. After 14 years at the Universi...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/rme.09.33
更新日期:2009-07-01 00:00:00
abstract::Clinical application of autologous cells by businesses promoting unproven stem cell treatments represents the largest growth sector in this problematic industry, but also presents special challenges to regulators. Patients frequently identify autologous cells as personal property, using the language of 'ownership'. Th...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0063
更新日期:2017-10-01 00:00:00
abstract::The thymus is required for generation of a self-tolerant, self-restricted T-cell repertoire. The capacity to manipulate or replace thymus function therapeutically would be beneficial in a variety of clinical settings, including for improving recovery following bone marrow transplantation, restoring immune system funct...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.15.8
更新日期:2015-01-01 00:00:00