Abstract:
:Background: Bone marrow aspiration (BMA) is among a group of autologous cell-based therapies currently being explored to treat osteoarthritis (OA). Materials & methods: This retrospective case study observed ten patients (13 knees) with severe knee OA who failed extensive conservative treatment and were treated with BMA injection using a novel, pure bone marrow aspiration (pBMA) technique. Results: No adverse events were reported. More than 50% reduction in the visual analog scale score for pain was observed at 2- and 12-weeks post-procedure, showing statistical significance. At 64 ± 26 weeks post-procedure, average knee pain remained significantly less than pre-procedure. Conclusion: Therefore, patients with severe knee OA may achieve significant relief after a BMA injection obtained using this pure bone marrow aspiration technique.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Colberg RE,Jurado Vélez JA,Walsh KP,Fleisig Gdoi
10.2217/rme-2019-0113subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1851-1859issue
7eissn
1746-0751issn
1746-076Xjournal_volume
15pub_type
杂志文章abstract::Founded in 2009 and headquartered in Glasgow, Scotland, UK, Sistemic Ltd has developed from a thought in the minds of four scientists into a company working globally to play its part in delivering the exciting opportunities for improvements in human health presented by cell therapies and regenerative medicine products...
journal_title:Regenerative medicine
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doi:10.2217/rme.13.58
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abstract:AIMS:An extensive colonization of surgical meshes with autologous fibroblasts may reduce complications. Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibrobla...
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abstract::Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...
journal_title:Regenerative medicine
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abstract::Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...
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pub_type: 杂志文章,评审
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journal_title:Regenerative medicine
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abstract::Promising new medical technologies and approaches to treatment offer the potential to substantially improve the lives of patients who need help, and in some cases transform the way medicine is practiced. In recent years, the biotechnology industry has generated many examples of new approaches that are having a profoun...
journal_title:Regenerative medicine
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abstract:AIM:This paper aims to map the trends and analyze key institutional dynamics that constitute the policies for reimbursement of regenerative medicine (RM), especially in the UK. MATERIALS & METHODS:Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi-stru...
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pub_type: 杂志文章,meta分析,评审
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journal_title:Regenerative medicine
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journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.11.21
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更新日期:2006-11-01 00:00:00
abstract::Ross Macdonald is the CEO and Managing Director of Cynata Therapeutics Limited (Australia). He has over 30 years of experience and a track record of success in pharmaceuticals and biotechnology businesses. His career history includes positions as Vice President of Business Development for Sinclair Pharmaceuticals Ltd ...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/rme-2019-0122
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更新日期:2012-01-01 00:00:00
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更新日期:2015-05-01 00:00:00
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journal_title:Regenerative medicine
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abstract::The UK Stem Cell Bank is a UK Research Council-funded initiative that aims to provide ethically sourced and quality controlled stocks of cells for researchers and also establish seed stocks of cell lines for clinical trials. Whilst the Bank is prohibited from carrying out basic stem cell research (to avoid conflicts o...
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doi:10.2217/17460751.1.1.139
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abstract:AIM:To evaluate the in vitro immunogenic and immunomodulatory properties of induced pluripotent stem cells (iPSCs) compared with bone marrow-derived mesenchymal stromal cells (MSCs). MATERIALS & METHODS:Mouse embryonic fibroblasts (MEFs) were isolated from C3HeB/FeJ and C57BL/6J mice, and reprogrammed to generate iPSC...
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abstract::Background: To evaluate whether subtenon injection of platelet-rich plasma (PRP) with retinal electromagnetic stimulation (rEMS) is effective in therapy-resistant chronic central serous chorioretinopathy (CSCR). Design: Prospective, sequential. Materials & methods: The study included 22 eyes with resistant chronic CSC...
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journal_title:Regenerative medicine
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