Abstract:
:The UK Stem Cell Bank is a UK Research Council-funded initiative that aims to provide ethically sourced and quality controlled stocks of cells for researchers and also establish seed stocks of cell lines for clinical trials. Whilst the Bank is prohibited from carrying out basic stem cell research (to avoid conflicts of interest) it is working to improve stem cell banking procedures including cryopreservation, characterization and quality control. The Bank also supports training activities and has provided the hub for the International Stem Cell Initiative, which includes 17 expert stem cell centers aiming to characterize a large number of human embryonic stem cell lines in a standardized way to improve our understanding of the characteristics of these cells.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Stacey G,Hunt CJdoi
10.2217/17460751.1.1.139subject
Has Abstractpub_date
2006-01-01 00:00:00pages
139-42issue
1eissn
1746-0751issn
1746-076Xjournal_volume
1pub_type
杂志文章abstract::Worldwide, tissue engineering and cellular replacement therapies are at the forefront of the regenerative medicine agenda, and researchers are addressing key diseases, including diabetes, stroke and neurological disorders. It is becoming evident that neurological cell therapy is a necessarily complex endeavor. The bra...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.2
更新日期:2012-05-01 00:00:00
abstract::Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β-cells, existing in the islets of Langerhans, play central roles in the progression of diabetes. An efficient strategy to produce functional pancreatic β-cells is important for both transplantation therapy...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.27
更新日期:2012-07-01 00:00:00
abstract::Advances in directed differentiation of human embryonic stem cells (hESCs) toward cardiac lineages have generated much interest within the myocardial therapy field. Beyond the promise that hESCs would provide a supply of new cardiomyocytes to the damaged heart, recent studies have also shown that paracrine effects of ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.46
更新日期:2012-09-01 00:00:00
abstract::Tissue regeneration specialist company Organogenesis Inc. was one of the first biotech companies formed. Incorporated in 1985, the company was originally a spin-off from a research program at MIT. For the first 10-15 years, Organogenesis was heavily research based, but then gradually moved into development. The compan...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/17460751.1.2.169
更新日期:2006-03-01 00:00:00
abstract:AIM:Current synthetic tubular conduits are inferior to nerve autograft for the repair of segmental peripheral nerve injuries. We examined motor outcomes with the use of longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber conduits for repair of nerve gap injury in a rat model. METHODS:Ten-millimeter segme...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.12.87
更新日期:2012-11-01 00:00:00
abstract:AIMS:An extensive colonization of surgical meshes with autologous fibroblasts may reduce complications. Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibrobla...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.4.2.197
更新日期:2009-03-01 00:00:00
abstract::Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tiss...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0156
更新日期:2019-09-01 00:00:00
abstract:AIMS:To evaluate the safety and efficacy of cell therapies administered acutely/sub-acutely after stroke. METHODS:Five databases were searched for studies examining the safety/efficacy of cell therapies administered ≤90 days post-stroke. Reporting quality and adherence to research guidelines were evaluated. Safety and...
journal_title:Regenerative medicine
pub_type: 杂志文章,meta分析,评审
doi:10.2217/rme-2016-0063
更新日期:2016-10-01 00:00:00
abstract::Diabetes mellitus represents a global epidemic affecting over 350 million patients worldwide and projected by the WHO to surpass the 500 million patient mark within the next two decades. Besides Type 1 and Type 2 diabetes mellitus, the study of the endocrine compartment of the pancreas is of great translational intere...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.70
更新日期:2012-11-01 00:00:00
abstract::Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in March 2020. ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0052
更新日期:2020-07-01 00:00:00
abstract::Aim: The most common risk associated with intradiscal injection of platelet-rich plasma (PRP) is discitis with Cutibacterium acnes. It is hypothesized that antimicrobial activity of PRP can be enhanced through inclusion of leukocytes or antibiotics in the injectate. Materials & methods: Multiple PRP preparations of va...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0098
更新日期:2019-10-01 00:00:00
abstract::Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.62
更新日期:2011-11-01 00:00:00
abstract::In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing beta-cells are a major cause of defective control of blood glucose and its complications. Restoration of damaged beta-cells by endocrine pancreas regeneration would be an ideal therapeutic option. The possibility of generating insulin-secreting c...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.3.3.377
更新日期:2008-05-01 00:00:00
abstract:AIM:Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). MATERIALS & METHODS:AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a de...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.61
更新日期:2014-01-01 00:00:00
abstract::Human embryonic stem cells (ESCs) can be induced to differentiate into a wide range of tissues that soon could be used for therapeutic applications in regenerative medicine. Despite their developmental potential, sources used to generate human ESC lines raise serious ethical concerns, which recently prompted efforts t...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.09.46
更新日期:2009-09-01 00:00:00
abstract::The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, b...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0104
更新日期:2018-03-19 00:00:00
abstract::Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.14.35
更新日期:2014-01-01 00:00:00
abstract::The Tissue Engineering and Regenerative Medicine International Society-Asia Pacific (TERMIS-AP) annual meeting was held in Sydney, Australia from 15-17 September 2010 and highlighted the latest developments in tissue engineering and regenerative medicine in the Asia-Pacific region. Several of the plenary lectures focu...
journal_title:Regenerative medicine
pub_type:
doi:10.2217/rme.11.7
更新日期:2011-03-01 00:00:00
abstract::Medicinal signaling cell (MSC)-based products represent emerging treatments in various therapeutic areas including cardiometabolic, inflammation, autoimmunity, orthopedics, wound healing and oncology. Exploring innovation beyond minimally manipulated plastic-adherent ex vivo expanded allogeneic MSCs enables product de...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0093
更新日期:2017-12-01 00:00:00
abstract::Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0074
更新日期:2020-01-01 00:00:00
abstract:AIM:It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. MATERIALS & METHODS:The effects of ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.59
更新日期:2015-01-01 00:00:00
abstract:AIM:To evaluate the in vitro immunogenic and immunomodulatory properties of induced pluripotent stem cells (iPSCs) compared with bone marrow-derived mesenchymal stromal cells (MSCs). MATERIALS & METHODS:Mouse embryonic fibroblasts (MEFs) were isolated from C3HeB/FeJ and C57BL/6J mice, and reprogrammed to generate iPSC...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.29
更新日期:2014-01-01 00:00:00
abstract::Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0065
更新日期:2017-10-01 00:00:00
abstract:AIM:Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. MATERIALS & METHODS:DPSCs were differentiated with media containing 5.5 o...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2016-0142
更新日期:2017-03-01 00:00:00
abstract::Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.33
更新日期:2013-07-01 00:00:00
abstract::Aging is defined as the progressive and generalized impairment of function, resulting in an increasing vulnerability to environmental challenges and a growing risk of disease and death. The decline in the regenerative capacity of resident stem cells across different tissues is a central mediator of aging. In this pape...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.10
更新日期:2013-03-01 00:00:00
abstract::Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.1.95
更新日期:2007-01-01 00:00:00
abstract::The concept of stem cell therapy has engaged the attention of the public and scientists alike. Intensive research effort is focused upon understanding the biology and therapeutic potential of embryonic and adult stem cells, with the eventual goal of treating such pathologies as Parkinson's disease, diabetes, neurologi...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.5.715
更新日期:2006-09-01 00:00:00
abstract::The 6th International Symposium on Regenerative Rehabilitation, hosted by the Alliance for Regenerative Rehabilitation Research and Training (AR3T), included a preconference meeting of institutional representatives of the International Consortium of Regenerative Rehabilitation, keynote talks from distinguished scienti...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0026
更新日期:2018-06-01 00:00:00
abstract::We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich p...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0071
更新日期:2019-05-01 00:00:00