Abstract:
:Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell attachment and behavior, to biocompatibility, is traced. Although these processes are studied and reported widely, there is, as yet, little published evidence that implant biocompatibility can be enhanced in the long term by surface engineering. This lack of evidence does not necessarily imply a lack of effect, but may be ascribed to a lack of robust characterization and poor modeling of the implant environment.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Shard AG,Tomlins PEdoi
10.2217/17460751.1.6.789subject
Has Abstractpub_date
2006-11-01 00:00:00pages
789-800issue
6eissn
1746-0751issn
1746-076Xjournal_volume
1pub_type
杂志文章,评审abstract::In the South Korean health technology assessment system, prices of alternative medicines, incremental cost-effectiveness ratios in pharmaco-economic evaluations and patient access improvement systems such as risk-sharing agreements are the most important factors concerning the reimbursement of regenerative medicine (R...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0035
更新日期:2020-04-01 00:00:00
abstract::Regenerative medicine is an evolving, cross-disciplinary, international field that, as a result, uses terms that are either not widely understood, or may have a number of different meanings. Many stakeholders have identified this lack of clarity as a potential barrier to effective communication within the field. To ad...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.34
更新日期:2009-07-01 00:00:00
abstract:AIM:Evaluation of survival, proliferation and neurodifferentiation of dental stem cells from the apical papilla (SCAP) in fibrin hydrogels. We hypothesized that fibrin composition will influence cell behavior. METHODS:Modulus, pore and fiber size were measured. SCAP in vitro viability, proliferation and neural differe...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.81
更新日期:2015-01-01 00:00:00
abstract::In the past decade, stem cell therapy has been increasingly employed for the treatment of various diseases. Subsequently, there has been a great interest in the manufacture of stem cells under good manufacturing practice, which is required by law for their use in humans. The cells for sight Stem Cell Therapy Research ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2015-0020
更新日期:2016-04-01 00:00:00
abstract::Hematopoietic stem cells (HSCs) have been shown recently to hold much promise in curing autoimmune diseases. Newly diagnosed Type 1 diabetes individuals have been successfully reverted to normoglycemia by administration of autologous HSCs in association with a nonmyeloablative regimen (antithymocyte globulin + cycloph...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2015-0057
更新日期:2016-06-01 00:00:00
abstract::Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0074
更新日期:2020-01-01 00:00:00
abstract::Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material for the generation of cellular therapeutics requires demonstration of comparability of lines derived from different individuals and in different facilities. This requires agreement on the critical quality attributes of such l...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0095
更新日期:2018-10-01 00:00:00
abstract::Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.62
更新日期:2011-11-01 00:00:00
abstract:AIMS:To evaluate the safety and efficacy of cell therapies administered acutely/sub-acutely after stroke. METHODS:Five databases were searched for studies examining the safety/efficacy of cell therapies administered ≤90 days post-stroke. Reporting quality and adherence to research guidelines were evaluated. Safety and...
journal_title:Regenerative medicine
pub_type: 杂志文章,meta分析,评审
doi:10.2217/rme-2016-0063
更新日期:2016-10-01 00:00:00
abstract::The thymus is required for generation of a self-tolerant, self-restricted T-cell repertoire. The capacity to manipulate or replace thymus function therapeutically would be beneficial in a variety of clinical settings, including for improving recovery following bone marrow transplantation, restoring immune system funct...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.15.8
更新日期:2015-01-01 00:00:00
abstract:AIM:Placental allografts used for tissue regeneration differ in membrane compositions and processing techniques. A uniquely folded dehydrated binate amniotic membrane (DBAM) was biochemically characterized to evaluate its potential role in wound healing. METHODS:Histology, Luminex-based immunoassay and standard in vit...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0085
更新日期:2018-09-01 00:00:00
abstract::Aim: To determine the potential of mesenchymal stem cells (MSC) for corneal epithelial regeneration in vitro. Materials & methods: Bone marrow MSC (BM-MSC) and adipose tissue MSC were analyzed for corneal epithelial and mesenchymal markers, using limbal stem cells and corneal cells as controls. MSC with better potenti...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0067
更新日期:2020-03-01 00:00:00
abstract::Dr Jane Lebkowski joined Geron Corporation in 1998 and is currently Senior Vice President and Chief Scientific Officer of the Regenerative Medicine Division. Dr Lebkowski heads Geron's human embryonic stem cell program, and is responsible for all research, preclinical development, product development, manufacturing an...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/rme.09.49
更新日期:2009-09-01 00:00:00
abstract::Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0151
更新日期:2020-06-01 00:00:00
abstract::Clinical application of autologous cells by businesses promoting unproven stem cell treatments represents the largest growth sector in this problematic industry, but also presents special challenges to regulators. Patients frequently identify autologous cells as personal property, using the language of 'ownership'. Th...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0063
更新日期:2017-10-01 00:00:00
abstract::Aging is defined as the progressive and generalized impairment of function, resulting in an increasing vulnerability to environmental challenges and a growing risk of disease and death. The decline in the regenerative capacity of resident stem cells across different tissues is a central mediator of aging. In this pape...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.10
更新日期:2013-03-01 00:00:00
abstract::In June 2013, the US Supreme Court ruled that naturally occurring genes were unpatentable in the case Association for Molecular Pathology v. Myriad Genetics. Up until this decision, Myriad Genetics was the only company in the USA that could legally conduct diagnostic testing for BRCA1 and 2, genes that are linked to f...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.93
更新日期:2014-03-01 00:00:00
abstract::Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.1.4.563
更新日期:2006-07-01 00:00:00
abstract::The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, b...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0104
更新日期:2018-03-19 00:00:00
abstract::The cornea at the front of the eye is covered by an epithelium. This epithelium is maintained by stem cells located at the periphery of the cornea, in a region known as the limbus. Because this region harbors the stem cells for the corneal epithelium, the so-called limbal stem cells, its culture provides considerable ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.7
更新日期:2009-05-01 00:00:00
abstract::Founded in 2009 and headquartered in Glasgow, Scotland, UK, Sistemic Ltd has developed from a thought in the minds of four scientists into a company working globally to play its part in delivering the exciting opportunities for improvements in human health presented by cell therapies and regenerative medicine products...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.13.58
更新日期:2013-09-01 00:00:00
abstract::Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...
journal_title:Regenerative medicine
pub_type: 新闻
doi:10.2217/rme.09.6
更新日期:2009-05-01 00:00:00
abstract::Induced pluripotent stem (iPS) cells offer tremendous opportunity for the creation of autologous cellular therapies, in which gene correction or the avoidance of immune response issues are desirable. In addition, iPS cells avoid the ethical concerns raised by the sourcing of human embryonic stem cells (hESCs) from emb...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.55
更新日期:2010-07-01 00:00:00
abstract:AIM:To evaluate the in vitro immunogenic and immunomodulatory properties of induced pluripotent stem cells (iPSCs) compared with bone marrow-derived mesenchymal stromal cells (MSCs). MATERIALS & METHODS:Mouse embryonic fibroblasts (MEFs) were isolated from C3HeB/FeJ and C57BL/6J mice, and reprogrammed to generate iPSC...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.29
更新日期:2014-01-01 00:00:00
abstract:AIM:In this study, we have evaluated the therapeutic efficacy of mouse multipotent adult progenitor cells (mMAPCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, and compared it with mouse mesenchymal stem cells (mMSCs). MATERIALS & METHODS:We administered PKH26-labeled mMAP...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2016-0109
更新日期:2017-04-01 00:00:00
abstract::Worldwide, tissue engineering and cellular replacement therapies are at the forefront of the regenerative medicine agenda, and researchers are addressing key diseases, including diabetes, stroke and neurological disorders. It is becoming evident that neurological cell therapy is a necessarily complex endeavor. The bra...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.2
更新日期:2012-05-01 00:00:00
abstract::Spinal cord injury (SCI) is a devastating traumatic injury resulting in paralysis or sensory deficits due to tissue damage and the poor ability of axons to regenerate across the lesion. Despite extensive research, there is still no effective treatment that would restore lost function after SCI. A possible therapeutic ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.121
更新日期:2012-03-01 00:00:00
abstract:AIM:This paper aims to map the trends and analyze key institutional dynamics that constitute the policies for reimbursement of regenerative medicine (RM), especially in the UK. MATERIALS & METHODS:Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi-stru...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0041
更新日期:2017-09-01 00:00:00
abstract:AIMS:To investigate neural stem cell (NSC) interactions with striatal tissue following engraftment and the effects of growth factors. MATERIALS & METHODS:Organotypic striatal slice cultures established from neonatal rats were used as an ex vivo model system. Survival, integration and differentiation of grafted NSCs fr...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.80
更新日期:2010-11-01 00:00:00
abstract:AIM:Dendritic cell (DC)-based vaccines have a potential utility for use in the treatment of malignancy. Human embryonic stem cells (hESCs) may provide a more cost-effective and reliable source of DCs for immunotherapy purposes, providing on-demand access for patients. METHOD:We developed a protocol to generate DCs fro...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.25
更新日期:2009-07-01 00:00:00