Culture conditions for primary human limbal epithelial cells.

abstract：:Professor Coffey joined the faculty at the University of Oxford in 1987 on completing his doctoral work. In 1989, he was awarded a personal Royal Society Research Fellowship, at the same time moving to the University of Sheffield to establish a new laboratory for retinal transplantation. After 14 years at the Universi...

journal_title：Regenerative medicine

authors： Coffey P

更新日期：2009-07-01 00:00:00

abstract：:Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...

journal_title：Regenerative medicine

authors： Yang ZG,Tang RF,Qi YY,Chen WP,Xiong Y,Wu LD

更新日期：2020-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have tremendous potential for regenerative medicine, and have been researched for the treatment of cardiovascular diseases. MSCs are a promising cell type because of their ease of isolation and expansion, their multipotency and their low immunogenicity. However, in order to fully utilize ...

journal_title：Regenerative medicine

authors： Huang NF,Li S

更新日期：2008-11-01 00:00:00

abstract：:In June 2013, the US Supreme Court ruled that naturally occurring genes were unpatentable in the case Association for Molecular Pathology v. Myriad Genetics. Up until this decision, Myriad Genetics was the only company in the USA that could legally conduct diagnostic testing for BRCA1 and 2, genes that are linked to f...

journal_title：Regenerative medicine

authors： Matthews KR,Cuchiara ML

更新日期：2014-03-01 00:00:00

abstract：:Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in March 2020. ...

journal_title：Regenerative medicine

authors： Ilic D,Liovic M

更新日期：2020-07-01 00:00:00

abstract：:Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...

journal_title：Regenerative medicine

authors： Hoffmann A,Gross G

更新日期：2006-07-01 00:00:00

abstract：:Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...

journal_title：Regenerative medicine

authors： Buzhor E,Leshansky L,Blumenthal J,Barash H,Warshawsky D,Mazor Y,Shtrichman R

更新日期：2014-01-01 00:00:00

abstract：:Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tiss...

journal_title：Regenerative medicine

authors： Ma Z,Lu Y,Yang Y,Wang J,Kang X

更新日期：2019-09-01 00:00:00

abstract：AIM:Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). MATERIALS & METHODS:AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a de...

journal_title：Regenerative medicine

authors： Blose KJ,Ennis TL,Arif B,Weinbaum JS,Curci JA,Vorp DA

更新日期：2014-01-01 00:00:00

abstract：:Aim: To determine the potential of mesenchymal stem cells (MSC) for corneal epithelial regeneration in vitro. Materials & methods: Bone marrow MSC (BM-MSC) and adipose tissue MSC were analyzed for corneal epithelial and mesenchymal markers, using limbal stem cells and corneal cells as controls. MSC with better potenti...

journal_title：Regenerative medicine

authors： Nieto-Nicolau N,Martín-Antonio B,Müller-Sánchez C,Casaroli-Marano RP

更新日期：2020-03-01 00:00:00

abstract：:Among the many international conferences in the field of stem cells and regenerative medicine, WSCS is distinct in focusing its efforts to serve as the meeting point by multisector communities of research, clinics, industry, regulation, policy making and ethics. All are aiming at advancing stem cell innovation and new...

journal_title：Regenerative medicine

authors： Hasegawa K,Asada T,Sengoku S,Nakatsuji N

更新日期：2015-05-01 00:00:00

abstract：AIM:This paper aims to map the trends and analyze key institutional dynamics that constitute the policies for reimbursement of regenerative medicine (RM), especially in the UK. MATERIALS & METHODS:Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi-stru...

journal_title：Regenerative medicine

authors： Mahalatchimy A,Faulkner A

更新日期：2017-09-01 00:00:00

abstract：:Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...

journal_title：Regenerative medicine

authors： De Bie C

更新日期：2007-01-01 00:00:00

abstract：:Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...

journal_title：Regenerative medicine

authors： Mantripragada VP,Piuzzi NS,George J,Bova W,Ng M,Boehm C,Muschler GF

更新日期：2019-07-01 00:00:00

abstract：:Background: Bone marrow aspiration (BMA) is among a group of autologous cell-based therapies currently being explored to treat osteoarthritis (OA). Materials & methods: This retrospective case study observed ten patients (13 knees) with severe knee OA who failed extensive conservative treatment and were treated with B...

journal_title：Regenerative medicine

authors： Colberg RE,Jurado Vélez JA,Walsh KP,Fleisig G

更新日期：2020-07-01 00:00:00

abstract：AIM:It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. MATERIALS & METHODS:The effects of ...

journal_title：Regenerative medicine

authors： Herencia C,Almadén Y,Martínez-Moreno JM,Espejo I,Herrera C,Pérez-Sánchez C,Guerrero F,Ciria R,Briceño FJ,Ferrín G,de la Mata M,Muñoz-Castañeda JR

更新日期：2015-01-01 00:00:00

abstract：:Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were used to treat a different disorder. Subsequently, several studies using cultured cells have enabled identification of hair growth modulators with similar prope...

journal_title：Regenerative medicine

authors： Higgins CA,Christiano AM

更新日期：2014-01-01 00:00:00

abstract：:A major challenge to commercializing cell-based therapies is developing scalable manufacturing processes while maintaining the critical quality parameters (identity, potency, purity, safety) of the final live cell product. Process development activities such as extended passaging and serum reduction/elimination can fa...

journal_title：Regenerative medicine

authors： Carmen J,Burger SR,McCaman M,Rowley JA

更新日期：2012-01-01 00:00:00

abstract：:We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich p...

journal_title：Regenerative medicine

authors： Stafford CD 2nd,Colberg RE,Nourse AL

更新日期：2019-05-01 00:00:00

abstract：AIMS:An extensive colonization of surgical meshes with autologous fibroblasts may reduce complications. Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibrobla...

journal_title：Regenerative medicine

authors： Skala CE,Petry IB,Gebhard S,Hengstler JG,Albrich SB,Maltaris T,Naumann G,Koelbl H

更新日期：2009-03-01 00:00:00

abstract：AIM:In this study, we have evaluated the therapeutic efficacy of mouse multipotent adult progenitor cells (mMAPCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, and compared it with mouse mesenchymal stem cells (mMSCs). MATERIALS & METHODS:We administered PKH26-labeled mMAP...

journal_title：Regenerative medicine

authors： Singh SP,Jadhav SH,Chaturvedi CP,Nityanand S

更新日期：2017-04-01 00:00:00

abstract：:Diabetes mellitus represents a global epidemic affecting over 350 million patients worldwide and projected by the WHO to surpass the 500 million patient mark within the next two decades. Besides Type 1 and Type 2 diabetes mellitus, the study of the endocrine compartment of the pancreas is of great translational intere...

journal_title：Regenerative medicine

authors： Ricordi C,Inverardi L,Domínguez-Bendala J

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Mechanisms underpinning Gram-negative bacterial vaginosis-induced birth anomalies are obscure. Ethical issues limit such studies on peri-implantation-stage human embryos. Here we have used embryoid bodies (EBs) as an in vitro model to examine the effect of Gram-negative bacterial endotoxins/lipopolysaccharid...

journal_title：Regenerative medicine

authors： Sivasubramaniyan K,Atluri RR,Sarda K,Arvind M,Balaji V,Deb KD

更新日期：2008-01-01 00:00:00

abstract：:Inflammation plays a critical role in the secondary degenerative response to spinal cord injury (SCI). The influx of inflammatory cells following SCI is preceded by the expression of specific chemoattractants, including chemokines. The chemokine CXCL10 is a potent T lymphocyte recruiter and has been strongly implicate...

journal_title：Regenerative medicine

authors： Gonzalez R,Hickey MJ,Espinosa JM,Nistor G,Lane TE,Keirstead HS

更新日期：2007-09-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making them attractive for both regenerative medicine and drug discovery. Over the past 10 years, technological advances and innovative platforms have yielded first-in-man PSC-based clinical trials and opened up new approaches fo...

journal_title：Regenerative medicine

authors： Kimbrel EA,Lanza R

更新日期：2016-12-01 00:00:00

abstract：:In soft tissue repair, there are several surgical options such as nondegradable, inert, synthetic, biodegradable implants or autologous tissue transplantation. However, the potential of using autologous adult stem cells derived from fat tissue is quickly becoming a clinical reality. The possibility of using an abundan...

journal_title：Regenerative medicine

authors： Cherubino M,Marra KG

更新日期：2009-01-01 00:00:00

abstract：AIM:Current synthetic tubular conduits are inferior to nerve autograft for the repair of segmental peripheral nerve injuries. We examined motor outcomes with the use of longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber conduits for repair of nerve gap injury in a rat model. METHODS:Ten-millimeter segme...

journal_title：Regenerative medicine

authors： Jin J,Park M,Rengarajan A,Zhang Q,Limburg S,Joshi SK,Patel S,Kim HT,Kuo AC

更新日期：2012-11-01 00:00:00

abstract：:Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...

journal_title：Regenerative medicine

authors： Carulli S,Contin R,De Rosa L,Pellegrini G,De Luca M

更新日期：2013-07-01 00:00:00

abstract：:The UK Stem Cell Bank is a UK Research Council-funded initiative that aims to provide ethically sourced and quality controlled stocks of cells for researchers and also establish seed stocks of cell lines for clinical trials. Whilst the Bank is prohibited from carrying out basic stem cell research (to avoid conflicts o...

journal_title：Regenerative medicine

authors： Stacey G,Hunt CJ

更新日期：2006-01-01 00:00:00

abstract：:Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...

journal_title：Regenerative medicine

authors： Siegel B

更新日期：2009-05-01 00:00:00