Abstract:
AIM:Placental allografts used for tissue regeneration differ in membrane compositions and processing techniques. A uniquely folded dehydrated binate amniotic membrane (DBAM) was biochemically characterized to evaluate its potential role in wound healing. METHODS:Histology, Luminex-based immunoassay and standard in vitro cell biology techniques were employed. RESULTS:Histological staining confirmed that the DBAM was chorion free with epithelial cell layer of the respective amnion membranes facing outward. DBAM had quantifiable levels of relevant cytokines that induced proliferation and migration while bolstering secretory activity of the cells. DBAM retained biological efficacy at a broad range of temperatures. CONCLUSION:Cytokines in DBAM stimulate bone marrow stromal and stem cells that may lead to tissue regeneration and wound healing in a clinical setup.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Sane MS,Misra N,Quintanar NM,Jones CD,Mustafi SBdoi
10.2217/rme-2018-0085subject
Has Abstractpub_date
2018-09-01 00:00:00pages
689-703issue
6eissn
1746-0751issn
1746-076Xjournal_volume
13pub_type
杂志文章abstract::The determinants of adoption of regenerative medicine therapies are currently poorly understood. This study aims to draw comparison between the UK and Canada in terms of factors likely to affect healthcare adoption of future regenerative therapies in ophthalmology. Conducting semi-structured interviews with senior oph...
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