First endocavitary treatment with cord blood platelet gel for perianal fistula.

Abstract:

:Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics and developed an application technique of platelet gel in liquid form. This semi-activated form provides for the activation of the coagulation process but not the gelification of the platelet concentrate. In this way, it can be easily inoculated in an endocavitary space, and then complete in vivo the gelification process. We report the successful use of this procedure to heal a recurrent perianal fistula.

journal_name

Regen Med

journal_title

Regenerative medicine

authors

Bisceglia G,Santodirocco M,Faienza A,Mastrodonato N,Urbano F,Totaro A,Bazzocchi F,Mauro LD

doi

10.2217/rme-2019-0074

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

1171-1176

issue

1

eissn

1746-0751

issn

1746-076X

journal_volume

15

pub_type

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