Abstract:
:We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich plasma injection followed by the use of a bone stimulator to enhance the bone healing. At 3 months, he was asymptomatic and had radiographic evidence of excellent bone healing. He remained asymptomatic at 1 year and had resumed full activities. This case report is the first in the literature to describe the treatment of a chronic ischial tuberosity nonunion avulsion fracture with the use of platelet-rich plasma as a bone graft.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Stafford CD 2nd,Colberg RE,Nourse ALdoi
10.2217/rme-2018-0071subject
Has Abstractpub_date
2019-05-01 00:00:00pages
353-358issue
5eissn
1746-0751issn
1746-076Xjournal_volume
14pub_type
杂志文章abstract::The concept of stem cell therapy has engaged the attention of the public and scientists alike. Intensive research effort is focused upon understanding the biology and therapeutic potential of embryonic and adult stem cells, with the eventual goal of treating such pathologies as Parkinson's disease, diabetes, neurologi...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.5.715
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:Mechanisms underpinning Gram-negative bacterial vaginosis-induced birth anomalies are obscure. Ethical issues limit such studies on peri-implantation-stage human embryos. Here we have used embryoid bodies (EBs) as an in vitro model to examine the effect of Gram-negative bacterial endotoxins/lipopolysaccharid...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.3.1.23
更新日期:2008-01-01 00:00:00
abstract::Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.33
更新日期:2013-07-01 00:00:00
abstract:AIM:To evaluate the in vitro immunogenic and immunomodulatory properties of induced pluripotent stem cells (iPSCs) compared with bone marrow-derived mesenchymal stromal cells (MSCs). MATERIALS & METHODS:Mouse embryonic fibroblasts (MEFs) were isolated from C3HeB/FeJ and C57BL/6J mice, and reprogrammed to generate iPSC...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.29
更新日期:2014-01-01 00:00:00
abstract::Background: Bone marrow aspiration (BMA) is among a group of autologous cell-based therapies currently being explored to treat osteoarthritis (OA). Materials & methods: This retrospective case study observed ten patients (13 knees) with severe knee OA who failed extensive conservative treatment and were treated with B...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0113
更新日期:2020-07-01 00:00:00
abstract::Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.62
更新日期:2011-11-01 00:00:00
abstract::Aim: The most common risk associated with intradiscal injection of platelet-rich plasma (PRP) is discitis with Cutibacterium acnes. It is hypothesized that antimicrobial activity of PRP can be enhanced through inclusion of leukocytes or antibiotics in the injectate. Materials & methods: Multiple PRP preparations of va...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0098
更新日期:2019-10-01 00:00:00
abstract::Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0145
更新日期:2020-03-01 00:00:00
abstract:AIM:This paper aims to map the trends and analyze key institutional dynamics that constitute the policies for reimbursement of regenerative medicine (RM), especially in the UK. MATERIALS & METHODS:Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi-stru...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0041
更新日期:2017-09-01 00:00:00
abstract::In soft tissue repair, there are several surgical options such as nondegradable, inert, synthetic, biodegradable implants or autologous tissue transplantation. However, the potential of using autologous adult stem cells derived from fat tissue is quickly becoming a clinical reality. The possibility of using an abundan...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.4.1.109
更新日期:2009-01-01 00:00:00
abstract:AIMS:An extensive colonization of surgical meshes with autologous fibroblasts may reduce complications. Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibrobla...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.4.2.197
更新日期:2009-03-01 00:00:00
abstract::Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0065
更新日期:2017-10-01 00:00:00
abstract::Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0151
更新日期:2020-06-01 00:00:00
abstract:AIM:Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. MATERIALS & METHODS:DPSCs were differentiated with media containing 5.5 o...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2016-0142
更新日期:2017-03-01 00:00:00
abstract:AIM:To evaluate the cost-effectiveness of autologous cell therapy manufacturing in xeno-free conditions. MATERIALS & METHODS:Published data on the isolation and expansion of mesenchymal stem/stromal cells introduced donor, multipassage and culture media variability on cell yields and process times on adherent culture ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0034
更新日期:2018-12-01 00:00:00
abstract::Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell a...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.1.6.789
更新日期:2006-11-01 00:00:00
abstract::A major challenge to commercializing cell-based therapies is developing scalable manufacturing processes while maintaining the critical quality parameters (identity, potency, purity, safety) of the final live cell product. Process development activities such as extended passaging and serum reduction/elimination can fa...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.105
更新日期:2012-01-01 00:00:00
abstract:AIM:Secondary lymphedema is observed in common after postmalignancy treatment of the breast and the gynecologic organs but effective therapies are not established. Adipose-derived stem cells (ADSCs), which are pluripotent, regenerative in local injection, are tested for murine hindlimb secondary lymphedema by regenerat...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.15.24
更新日期:2015-01-01 00:00:00
abstract::Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the r...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.1.59
更新日期:2006-01-01 00:00:00
abstract::The cornea at the front of the eye is covered by an epithelium. This epithelium is maintained by stem cells located at the periphery of the cornea, in a region known as the limbus. Because this region harbors the stem cells for the corneal epithelium, the so-called limbal stem cells, its culture provides considerable ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.7
更新日期:2009-05-01 00:00:00
abstract::Spinal cord injury (SCI) is a devastating traumatic injury resulting in paralysis or sensory deficits due to tissue damage and the poor ability of axons to regenerate across the lesion. Despite extensive research, there is still no effective treatment that would restore lost function after SCI. A possible therapeutic ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.121
更新日期:2012-03-01 00:00:00
abstract::Aim: To describe the successful treatment of a Baker's cyst in the setting of post-traumatic osteoarthritis using ultrasound-guided injection of platelet-rich plasma. Setting: Outpatient sports clinic. Patient: 29-year old male basketball player. Case description: The patient presented with 2-months history of right k...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0021
更新日期:2020-06-01 00:00:00
abstract::Dr Jane Lebkowski joined Geron Corporation in 1998 and is currently Senior Vice President and Chief Scientific Officer of the Regenerative Medicine Division. Dr Lebkowski heads Geron's human embryonic stem cell program, and is responsible for all research, preclinical development, product development, manufacturing an...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/rme.09.49
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Human embryonic stem cells (hESCs) can differentiate into any human cell type, including CNS cells, and thus have high potential in regenerative medicine. Several protocols exist for neuronal differentiation of hESCs, which do not necessarily work for all hESC lines. MATERIALS & METHODS:We tested the differ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.58
更新日期:2010-09-01 00:00:00
abstract::Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...
journal_title:Regenerative medicine
pub_type: 新闻
doi:10.2217/rme.09.6
更新日期:2009-05-01 00:00:00
abstract:AIM:We hypothesized that delivery of mesenchymal stem cells (MSCs) in a biomimetic collagen scaffold improves wound healing in a diabetic mouse model. MATERIALS & METHODS:Rolled collagen scaffolds containing MSCs were implanted or applied topically to diabetic C57BL/6 mice with excisional wounds. RESULTS:Rolled scaff...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2015-0045
更新日期:2016-04-01 00:00:00
abstract::Promising new medical technologies and approaches to treatment offer the potential to substantially improve the lives of patients who need help, and in some cases transform the way medicine is practiced. In recent years, the biotechnology industry has generated many examples of new approaches that are having a profoun...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.12.90
更新日期:2012-11-01 00:00:00
abstract::Among the many international conferences in the field of stem cells and regenerative medicine, WSCS is distinct in focusing its efforts to serve as the meeting point by multisector communities of research, clinics, industry, regulation, policy making and ethics. All are aiming at advancing stem cell innovation and new...
journal_title:Regenerative medicine
pub_type:
doi:10.2217/rme.15.4
更新日期:2015-05-01 00:00:00
abstract::Researchers are working on key issues in regenerative medicine in many of the over 280 academic institutions in Germany. Moreover, nonuniversity research institutions such as Helmholtz-, Max-Planck-, Fraunhofer- and Leibniz-Centers provide important contributions to the field of regenerative medicine in Germany. Resea...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.64
更新日期:2011-11-01 00:00:00
abstract::Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.1.4.563
更新日期:2006-07-01 00:00:00