Optimizing the safety of intradiscal platelet-rich plasma: an in vitro study with Cutibacterium acnes.

abstract：:Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an ...

journal_title：Regenerative medicine

authors： Zhou J,Cui H,Lu H,Xu Z,Feng W,Chen L,Jin X,Yang X,Qi Z

更新日期：2017-04-01 00:00:00

abstract：AIMS:Murine 3T3 feeder cells are commonly used for stem cell expansion. Although 'feeder-free' systems are being developed for a variety of stem cells including embryonic, the use of feeder cells currently remains optimal for the expansion of epithelial stem cells. In this study, MRC-5, a human embryonic fibroblast cel...

journal_title：Regenerative medicine

authors： Notara M,Haddow DB,MacNeil S,Daniels JT

更新日期：2007-11-01 00:00:00

abstract：:The thymus is required for generation of a self-tolerant, self-restricted T-cell repertoire. The capacity to manipulate or replace thymus function therapeutically would be beneficial in a variety of clinical settings, including for improving recovery following bone marrow transplantation, restoring immune system funct...

journal_title：Regenerative medicine

authors： Bredenkamp N,Jin X,Liu D,O'Neill KE,Manley NR,Blackburn CC

更新日期：2015-01-01 00:00:00

abstract：:In soft tissue repair, there are several surgical options such as nondegradable, inert, synthetic, biodegradable implants or autologous tissue transplantation. However, the potential of using autologous adult stem cells derived from fat tissue is quickly becoming a clinical reality. The possibility of using an abundan...

journal_title：Regenerative medicine

authors： Cherubino M,Marra KG

更新日期：2009-01-01 00:00:00

abstract：:Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...

journal_title：Regenerative medicine

authors： Siegel B

更新日期：2009-05-01 00:00:00

abstract：:Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the...

journal_title：Regenerative medicine

authors： Chan S

更新日期：2017-10-01 00:00:00

abstract：:Clinical application of autologous cells by businesses promoting unproven stem cell treatments represents the largest growth sector in this problematic industry, but also presents special challenges to regulators. Patients frequently identify autologous cells as personal property, using the language of 'ownership'. Th...

journal_title：Regenerative medicine

authors： Sipp D

更新日期：2017-10-01 00:00:00

abstract：:Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tiss...

journal_title：Regenerative medicine

authors： Ma Z,Lu Y,Yang Y,Wang J,Kang X

更新日期：2019-09-01 00:00:00

abstract：:The 6th International Symposium on Regenerative Rehabilitation, hosted by the Alliance for Regenerative Rehabilitation Research and Training (AR3T), included a preconference meeting of institutional representatives of the International Consortium of Regenerative Rehabilitation, keynote talks from distinguished scienti...

journal_title：Regenerative medicine

authors： Loghmani MT,Roche JA

更新日期：2018-06-01 00:00:00

abstract：AIMS:To evaluate the safety and efficacy of cell therapies administered acutely/sub-acutely after stroke. METHODS:Five databases were searched for studies examining the safety/efficacy of cell therapies administered ≤90 days post-stroke. Reporting quality and adherence to research guidelines were evaluated. Safety and...

journal_title：Regenerative medicine

authors： Unsworth DJ,Mathias JL,Dorstyn DS

更新日期：2016-10-01 00:00:00

abstract：:Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...

journal_title：Regenerative medicine

authors： Yoshimura K,Eto H,Kato H,Doi K,Aoi N

更新日期：2011-11-01 00:00:00

abstract：:Medicinal signaling cell (MSC)-based products represent emerging treatments in various therapeutic areas including cardiometabolic, inflammation, autoimmunity, orthopedics, wound healing and oncology. Exploring innovation beyond minimally manipulated plastic-adherent ex vivo expanded allogeneic MSCs enables product de...

journal_title：Regenerative medicine

authors： Vertès AA

更新日期：2017-12-01 00:00:00

abstract：:Background: To evaluate whether subtenon injection of platelet-rich plasma (PRP) with retinal electromagnetic stimulation (rEMS) is effective in therapy-resistant chronic central serous chorioretinopathy (CSCR). Design: Prospective, sequential. Materials & methods: The study included 22 eyes with resistant chronic CSC...

journal_title：Regenerative medicine

authors： Arslan U,Özmert E

更新日期：2020-08-01 00:00:00

abstract：:Aim: To determine the potential of mesenchymal stem cells (MSC) for corneal epithelial regeneration in vitro. Materials & methods: Bone marrow MSC (BM-MSC) and adipose tissue MSC were analyzed for corneal epithelial and mesenchymal markers, using limbal stem cells and corneal cells as controls. MSC with better potenti...

journal_title：Regenerative medicine

authors： Nieto-Nicolau N,Martín-Antonio B,Müller-Sánchez C,Casaroli-Marano RP

更新日期：2020-03-01 00:00:00

abstract：AIM:Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). MATERIALS & METHODS:AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a de...

journal_title：Regenerative medicine

authors： Blose KJ,Ennis TL,Arif B,Weinbaum JS,Curci JA,Vorp DA

更新日期：2014-01-01 00:00:00

abstract：:Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...

journal_title：Regenerative medicine

authors： Buzhor E,Leshansky L,Blumenthal J,Barash H,Warshawsky D,Mazor Y,Shtrichman R

更新日期：2014-01-01 00:00:00

abstract：:Researchers are working on key issues in regenerative medicine in many of the over 280 academic institutions in Germany. Moreover, nonuniversity research institutions such as Helmholtz-, Max-Planck-, Fraunhofer- and Leibniz-Centers provide important contributions to the field of regenerative medicine in Germany. Resea...

journal_title：Regenerative medicine

authors： Lauter FR,Wirsching S

更新日期：2011-11-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making them attractive for both regenerative medicine and drug discovery. Over the past 10 years, technological advances and innovative platforms have yielded first-in-man PSC-based clinical trials and opened up new approaches fo...

journal_title：Regenerative medicine

authors： Kimbrel EA,Lanza R

更新日期：2016-12-01 00:00:00

abstract：:Aim: The present study evaluated the effects of polydeoxyribonucleotide (PDRN) on tissue regeneration, paying special attention to the molecular mechanisms that underlie its tissue remodeling actions to better identify its effective therapeutic potential in wound healing. Materials & methods: Strategic searches were c...

journal_title：Regenerative medicine

authors： Colangelo MT,Galli C,Guizzardi S

更新日期：2020-08-06 00:00:00

abstract：:The neurological and physiological basis of brain function and disease has been a significant focus of investigation throughout the history of medical research. Recent advances in understanding have led to the development of new treatments for diseases of the brain and defects of cognitive and behavioral function: pha...

journal_title：Regenerative medicine

authors： Chan S,Harris J

更新日期：2006-05-01 00:00:00

abstract：AIM:Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. MATERIALS & METHODS:DPSCs were differentiated with media containing 5.5 o...

journal_title：Regenerative medicine

authors： Matei IV,Ii H,Yaegaki K

更新日期：2017-03-01 00:00:00

abstract：AIMS:An extensive colonization of surgical meshes with autologous fibroblasts may reduce complications. Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibrobla...

journal_title：Regenerative medicine

authors： Skala CE,Petry IB,Gebhard S,Hengstler JG,Albrich SB,Maltaris T,Naumann G,Koelbl H

更新日期：2009-03-01 00:00:00

abstract：:Aging is defined as the progressive and generalized impairment of function, resulting in an increasing vulnerability to environmental challenges and a growing risk of disease and death. The decline in the regenerative capacity of resident stem cells across different tissues is a central mediator of aging. In this pape...

journal_title：Regenerative medicine

authors： Stochaj U,Kodiha M,Shum-Tim D,Colmegna I

更新日期：2013-03-01 00:00:00

abstract：:In the past decade, stem cell therapy has been increasingly employed for the treatment of various diseases. Subsequently, there has been a great interest in the manufacture of stem cells under good manufacturing practice, which is required by law for their use in humans. The cells for sight Stem Cell Therapy Research ...

journal_title：Regenerative medicine

authors： Sheth-Shah R,Vernon AJ,Seetharaman S,Neale MH,Daniels JT

更新日期：2016-04-01 00:00:00

abstract：:Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep ...

journal_title：Regenerative medicine

authors： Bisceglia G,Santodirocco M,Faienza A,Mastrodonato N,Urbano F,Totaro A,Bazzocchi F,Mauro LD

更新日期：2020-01-01 00:00:00

abstract：AIM:It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. MATERIALS & METHODS:The effects of ...

journal_title：Regenerative medicine

authors： Herencia C,Almadén Y,Martínez-Moreno JM,Espejo I,Herrera C,Pérez-Sánchez C,Guerrero F,Ciria R,Briceño FJ,Ferrín G,de la Mata M,Muñoz-Castañeda JR

更新日期：2015-01-01 00:00:00

abstract：:Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...

journal_title：Regenerative medicine

authors： Mantripragada VP,Piuzzi NS,George J,Bova W,Ng M,Boehm C,Muschler GF

更新日期：2019-07-01 00:00:00

abstract：:Human embryonic stem cells offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Characterizing these cells provides important information about their current state and affords relevant details for subsequent downstream manipulation. Prior to considering therapeutic appli...

journal_title：Regenerative medicine

authors： Pal R,Mandal A,Rao HS,Rao MS,Khanna A

更新日期：2007-03-01 00:00:00

abstract：:The UK Stem Cell Bank is a UK Research Council-funded initiative that aims to provide ethically sourced and quality controlled stocks of cells for researchers and also establish seed stocks of cell lines for clinical trials. Whilst the Bank is prohibited from carrying out basic stem cell research (to avoid conflicts o...

journal_title：Regenerative medicine

authors： Stacey G,Hunt CJ

更新日期：2006-01-01 00:00:00

abstract：:The Tissue Engineering and Regenerative Medicine International Society-Asia Pacific (TERMIS-AP) annual meeting was held in Sydney, Australia from 15-17 September 2010 and highlighted the latest developments in tissue engineering and regenerative medicine in the Asia-Pacific region. Several of the plenary lectures focu...

journal_title：Regenerative medicine

authors： Frith JE,Hudson JE,Cooper-White JJ

更新日期：2011-03-01 00:00:00