Abstract:
:Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the stem cell therapy landscape and argue that while the sale of unproven therapies undoubtedly poses ethical concerns, it must be understood as part of a larger problem at the interface between biomedicine, healthcare, publics, policy and the market. Addressing this will require a broader perspective incorporating the shifting relationships between different stakeholder groups, the global politics of research and innovation, and the evolving role of publics and patients with respect to science.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Chan Sdoi
10.2217/rme-2017-0065subject
Has Abstractpub_date
2017-10-01 00:00:00pages
839-851issue
7eissn
1746-0751issn
1746-076Xjournal_volume
12pub_type
杂志文章abstract::Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β-cells, existing in the islets of Langerhans, play central roles in the progression of diabetes. An efficient strategy to produce functional pancreatic β-cells is important for both transplantation therapy...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.27
更新日期:2012-07-01 00:00:00
abstract:AIMS:To assess the potential of electrospun poly(lactide-co-glycolide) membranes to provide a biodegradable cell carrier system for limbal epithelial cells. MATERIAL & METHODS:50:50 poly(lactide-co-glycolide) scaffolds were spun, sterilized and seeded with primary rabbit limbal epithelial cells. Cells were cultured on...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.16
更新日期:2010-05-01 00:00:00
abstract::Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0151
更新日期:2020-06-01 00:00:00
abstract::Regenerative medicine is an evolving, cross-disciplinary, international field that, as a result, uses terms that are either not widely understood, or may have a number of different meanings. Many stakeholders have identified this lack of clarity as a potential barrier to effective communication within the field. To ad...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.34
更新日期:2009-07-01 00:00:00
abstract::The neurological and physiological basis of brain function and disease has been a significant focus of investigation throughout the history of medical research. Recent advances in understanding have led to the development of new treatments for diseases of the brain and defects of cognitive and behavioral function: pha...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.3.361
更新日期:2006-05-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have tremendous potential for regenerative medicine, and have been researched for the treatment of cardiovascular diseases. MSCs are a promising cell type because of their ease of isolation and expansion, their multipotency and their low immunogenicity. However, in order to fully utilize ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.3.6.877
更新日期:2008-11-01 00:00:00
abstract::Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...
journal_title:Regenerative medicine
pub_type: 临床试验,杂志文章
doi:10.2217/rme-2018-0173
更新日期:2019-07-01 00:00:00
abstract::The cornea at the front of the eye is covered by an epithelium. This epithelium is maintained by stem cells located at the periphery of the cornea, in a region known as the limbus. Because this region harbors the stem cells for the corneal epithelium, the so-called limbal stem cells, its culture provides considerable ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.7
更新日期:2009-05-01 00:00:00
abstract::Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, liga...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2016-0125
更新日期:2016-12-01 00:00:00
abstract::Since the first pioneering scientists explored the potential of using human cells for therapeutic purposes the branch of regenerative medicine has evolved to become a mature industry. The focus has switched from 'what can be done' to 'what can be commercialized'. Timely health economic evaluation supports successful m...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.13.69
更新日期:2013-11-01 00:00:00
abstract:AIMS:Murine 3T3 feeder cells are commonly used for stem cell expansion. Although 'feeder-free' systems are being developed for a variety of stem cells including embryonic, the use of feeder cells currently remains optimal for the expansion of epithelial stem cells. In this study, MRC-5, a human embryonic fibroblast cel...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.6.919
更新日期:2007-11-01 00:00:00
abstract::Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.1.4.563
更新日期:2006-07-01 00:00:00
abstract::In the South Korean health technology assessment system, prices of alternative medicines, incremental cost-effectiveness ratios in pharmaco-economic evaluations and patient access improvement systems such as risk-sharing agreements are the most important factors concerning the reimbursement of regenerative medicine (R...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0035
更新日期:2020-04-01 00:00:00
abstract:AIM:Dendritic cell (DC)-based vaccines have a potential utility for use in the treatment of malignancy. Human embryonic stem cells (hESCs) may provide a more cost-effective and reliable source of DCs for immunotherapy purposes, providing on-demand access for patients. METHOD:We developed a protocol to generate DCs fro...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.25
更新日期:2009-07-01 00:00:00
abstract::In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing beta-cells are a major cause of defective control of blood glucose and its complications. Restoration of damaged beta-cells by endocrine pancreas regeneration would be an ideal therapeutic option. The possibility of generating insulin-secreting c...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.3.3.377
更新日期:2008-05-01 00:00:00
abstract::Background: Bone marrow aspiration (BMA) is among a group of autologous cell-based therapies currently being explored to treat osteoarthritis (OA). Materials & methods: This retrospective case study observed ten patients (13 knees) with severe knee OA who failed extensive conservative treatment and were treated with B...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0113
更新日期:2020-07-01 00:00:00
abstract::We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich p...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0071
更新日期:2019-05-01 00:00:00
abstract::Following the reversal by the court of appeals of the injunction against federal funding of human embryonic stem cell research, Judge Lamberth has held such funding to be lawful and has dismissed the lawsuit. However, the litigation is likely to continue in the court of appeals and ultimately perhaps in the Supreme Co...
journal_title:Regenerative medicine
pub_type: 历史文章,杂志文章
doi:10.2217/rme.11.70
更新日期:2011-11-01 00:00:00
abstract:AIMS:To investigate neural stem cell (NSC) interactions with striatal tissue following engraftment and the effects of growth factors. MATERIALS & METHODS:Organotypic striatal slice cultures established from neonatal rats were used as an ex vivo model system. Survival, integration and differentiation of grafted NSCs fr...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.80
更新日期:2010-11-01 00:00:00
abstract:AIM:We hypothesized that delivery of mesenchymal stem cells (MSCs) in a biomimetic collagen scaffold improves wound healing in a diabetic mouse model. MATERIALS & METHODS:Rolled collagen scaffolds containing MSCs were implanted or applied topically to diabetic C57BL/6 mice with excisional wounds. RESULTS:Rolled scaff...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2015-0045
更新日期:2016-04-01 00:00:00
abstract::Human embryonic stem cells offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Characterizing these cells provides important information about their current state and affords relevant details for subsequent downstream manipulation. Prior to considering therapeutic appli...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.2.179
更新日期:2007-03-01 00:00:00
abstract::Aim: We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat™, Lipogems®) is a viable alternative for treatment of joint pain and inflammation associated dysfunction in shoulder osteoarthritis (OA). Materials & methods: A total of 25 subjects with OA received an injection of MFat™ and were fol...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0069
更新日期:2020-10-01 00:00:00
abstract::Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the r...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.1.59
更新日期:2006-01-01 00:00:00
abstract::The 6th International Symposium on Regenerative Rehabilitation, hosted by the Alliance for Regenerative Rehabilitation Research and Training (AR3T), included a preconference meeting of institutional representatives of the International Consortium of Regenerative Rehabilitation, keynote talks from distinguished scienti...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0026
更新日期:2018-06-01 00:00:00
abstract::Parkinson's disease and Alzheimer's disease are the most common neurodegenerative diseases in the elderly population. Given that age is the most important risk factor in these diseases, the number of patients is expected to rise dramatically in the coming years. Therefore, an effective therapy for these diseases is hi...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.2.4.425
更新日期:2007-07-01 00:00:00
abstract::Advances in directed differentiation of human embryonic stem cells (hESCs) toward cardiac lineages have generated much interest within the myocardial therapy field. Beyond the promise that hESCs would provide a supply of new cardiomyocytes to the damaged heart, recent studies have also shown that paracrine effects of ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.12.46
更新日期:2012-09-01 00:00:00
abstract::Aging is defined as the progressive and generalized impairment of function, resulting in an increasing vulnerability to environmental challenges and a growing risk of disease and death. The decline in the regenerative capacity of resident stem cells across different tissues is a central mediator of aging. In this pape...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.10
更新日期:2013-03-01 00:00:00
abstract::Aim: To describe the successful treatment of a Baker's cyst in the setting of post-traumatic osteoarthritis using ultrasound-guided injection of platelet-rich plasma. Setting: Outpatient sports clinic. Patient: 29-year old male basketball player. Case description: The patient presented with 2-months history of right k...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0021
更新日期:2020-06-01 00:00:00
abstract::Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0145
更新日期:2020-03-01 00:00:00
abstract::Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0074
更新日期:2020-01-01 00:00:00