The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a systematic review of the literature.

abstract：:Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the r...

journal_title：Regenerative medicine

authors： De Bari C,Pitzalis C,Dell'Accio F

更新日期：2006-01-01 00:00:00

abstract：:Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...

journal_title：Regenerative medicine

authors： Yang ZG,Tang RF,Qi YY,Chen WP,Xiong Y,Wu LD

更新日期：2020-06-01 00:00:00

abstract：:Research regarding the use of cord blood (CB) has focused on antigen match and the number of stem cells, with policies and networks related to its use being under researched. This article is based on fieldwork in China from 2013 to 2015 and examines ways that the studied CB bank enhances CB usage in China. This articl...

journal_title：Regenerative medicine

authors： Chang HC

更新日期：2017-09-01 00:00:00

abstract：:Founded in 2009 and headquartered in Glasgow, Scotland, UK, Sistemic Ltd has developed from a thought in the minds of four scientists into a company working globally to play its part in delivering the exciting opportunities for improvements in human health presented by cell therapies and regenerative medicine products...

journal_title：Regenerative medicine

authors： Reid J

更新日期：2013-09-01 00:00:00

abstract：:Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...

journal_title：Regenerative medicine

authors： Mantripragada VP,Piuzzi NS,George J,Bova W,Ng M,Boehm C,Muschler GF

更新日期：2019-07-01 00:00:00

abstract：:The thymus is required for generation of a self-tolerant, self-restricted T-cell repertoire. The capacity to manipulate or replace thymus function therapeutically would be beneficial in a variety of clinical settings, including for improving recovery following bone marrow transplantation, restoring immune system funct...

journal_title：Regenerative medicine

authors： Bredenkamp N,Jin X,Liu D,O'Neill KE,Manley NR,Blackburn CC

更新日期：2015-01-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) hold tremendous promise for tissue engineering and regenerative medicine, yet with so many sources of MSCs, what are the primary criteria for selecting leading candidates? Ideally, the cells will be multipotent, inexpensive, lack donor site morbidity, donor materials should...

journal_title：Regenerative medicine

authors： Wang L,Ott L,Seshareddy K,Weiss ML,Detamore MS

更新日期：2011-01-01 00:00:00

abstract：:Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell a...

journal_title：Regenerative medicine

authors： Shard AG,Tomlins PE

更新日期：2006-11-01 00:00:00

abstract：:Following the reversal by the court of appeals of the injunction against federal funding of human embryonic stem cell research, Judge Lamberth has held such funding to be lawful and has dismissed the lawsuit. However, the litigation is likely to continue in the court of appeals and ultimately perhaps in the Supreme Co...

journal_title：Regenerative medicine

authors： Goldfarb N

更新日期：2011-11-01 00:00:00

abstract：:The Tissue Engineering and Regenerative Medicine International Society-Asia Pacific (TERMIS-AP) annual meeting was held in Sydney, Australia from 15-17 September 2010 and highlighted the latest developments in tissue engineering and regenerative medicine in the Asia-Pacific region. Several of the plenary lectures focu...

journal_title：Regenerative medicine

authors： Frith JE,Hudson JE,Cooper-White JJ

更新日期：2011-03-01 00:00:00

abstract：AIM:It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. MATERIALS & METHODS:The effects of ...

journal_title：Regenerative medicine

authors： Herencia C,Almadén Y,Martínez-Moreno JM,Espejo I,Herrera C,Pérez-Sánchez C,Guerrero F,Ciria R,Briceño FJ,Ferrín G,de la Mata M,Muñoz-Castañeda JR

更新日期：2015-01-01 00:00:00

abstract：:The cornea at the front of the eye is covered by an epithelium. This epithelium is maintained by stem cells located at the periphery of the cornea, in a region known as the limbus. Because this region harbors the stem cells for the corneal epithelium, the so-called limbal stem cells, its culture provides considerable ...

journal_title：Regenerative medicine

authors： Osei-Bempong C,Henein C,Ahmad S

更新日期：2009-05-01 00:00:00

abstract：:Advances in directed differentiation of human embryonic stem cells (hESCs) toward cardiac lineages have generated much interest within the myocardial therapy field. Beyond the promise that hESCs would provide a supply of new cardiomyocytes to the damaged heart, recent studies have also shown that paracrine effects of ...

journal_title：Regenerative medicine

authors： Bernstein HS

更新日期：2012-09-01 00:00:00

abstract：:Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an ...

journal_title：Regenerative medicine

authors： Zhou J,Cui H,Lu H,Xu Z,Feng W,Chen L,Jin X,Yang X,Qi Z

更新日期：2017-04-01 00:00:00

abstract：AIMS:Murine 3T3 feeder cells are commonly used for stem cell expansion. Although 'feeder-free' systems are being developed for a variety of stem cells including embryonic, the use of feeder cells currently remains optimal for the expansion of epithelial stem cells. In this study, MRC-5, a human embryonic fibroblast cel...

journal_title：Regenerative medicine

authors： Notara M,Haddow DB,MacNeil S,Daniels JT

更新日期：2007-11-01 00:00:00

abstract：:In the South Korean health technology assessment system, prices of alternative medicines, incremental cost-effectiveness ratios in pharmaco-economic evaluations and patient access improvement systems such as risk-sharing agreements are the most important factors concerning the reimbursement of regenerative medicine (R...

journal_title：Regenerative medicine

authors： Cho E,Yoo SL,Kang Y,Lee JH

更新日期：2020-04-01 00:00:00

abstract：:Aim: To determine the potential of mesenchymal stem cells (MSC) for corneal epithelial regeneration in vitro. Materials & methods: Bone marrow MSC (BM-MSC) and adipose tissue MSC were analyzed for corneal epithelial and mesenchymal markers, using limbal stem cells and corneal cells as controls. MSC with better potenti...

journal_title：Regenerative medicine

authors： Nieto-Nicolau N,Martín-Antonio B,Müller-Sánchez C,Casaroli-Marano RP

更新日期：2020-03-01 00:00:00

abstract：:Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...

journal_title：Regenerative medicine

authors： De Bie C

更新日期：2007-01-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making them attractive for both regenerative medicine and drug discovery. Over the past 10 years, technological advances and innovative platforms have yielded first-in-man PSC-based clinical trials and opened up new approaches fo...

journal_title：Regenerative medicine

authors： Kimbrel EA,Lanza R

更新日期：2016-12-01 00:00:00

abstract：:Medicinal signaling cell (MSC)-based products represent emerging treatments in various therapeutic areas including cardiometabolic, inflammation, autoimmunity, orthopedics, wound healing and oncology. Exploring innovation beyond minimally manipulated plastic-adherent ex vivo expanded allogeneic MSCs enables product de...

journal_title：Regenerative medicine

authors： Vertès AA

更新日期：2017-12-01 00:00:00

abstract：:Background: To evaluate whether subtenon injection of platelet-rich plasma (PRP) with retinal electromagnetic stimulation (rEMS) is effective in therapy-resistant chronic central serous chorioretinopathy (CSCR). Design: Prospective, sequential. Materials & methods: The study included 22 eyes with resistant chronic CSC...

journal_title：Regenerative medicine

authors： Arslan U,Özmert E

更新日期：2020-08-01 00:00:00

abstract：:In the past decade, stem cell therapy has been increasingly employed for the treatment of various diseases. Subsequently, there has been a great interest in the manufacture of stem cells under good manufacturing practice, which is required by law for their use in humans. The cells for sight Stem Cell Therapy Research ...

journal_title：Regenerative medicine

authors： Sheth-Shah R,Vernon AJ,Seetharaman S,Neale MH,Daniels JT

更新日期：2016-04-01 00:00:00

abstract：:Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...

journal_title：Regenerative medicine

authors： Carulli S,Contin R,De Rosa L,Pellegrini G,De Luca M

更新日期：2013-07-01 00:00:00

abstract：:The determinants of adoption of regenerative medicine therapies are currently poorly understood. This study aims to draw comparison between the UK and Canada in terms of factors likely to affect healthcare adoption of future regenerative therapies in ophthalmology. Conducting semi-structured interviews with senior oph...

journal_title：Regenerative medicine

authors： Rose JB,May M,Williams DJ

更新日期：2015-05-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...

journal_title：Regenerative medicine

authors： Awan M,Buriak I,Fleck R,Fuller B,Goltsev A,Kerby J,Lowdell M,Mericka P,Petrenko A,Petrenko Y,Rogulska O,Stolzing A,Stacey GN

更新日期：2020-03-01 00:00:00

abstract：:Diabetes mellitus represents a global epidemic affecting over 350 million patients worldwide and projected by the WHO to surpass the 500 million patient mark within the next two decades. Besides Type 1 and Type 2 diabetes mellitus, the study of the endocrine compartment of the pancreas is of great translational intere...

journal_title：Regenerative medicine

authors： Ricordi C,Inverardi L,Domínguez-Bendala J

更新日期：2012-11-01 00:00:00

abstract：:Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in March 2020. ...

journal_title：Regenerative medicine

authors： Ilic D,Liovic M

更新日期：2020-07-01 00:00:00

abstract：:Aim: Cell repopulation of tissue-engineered vascular grafts (TEVGs) from decellularized arterial scaffolds is limited by dense concentric tunica media layers which impede cells migrating radially between the layers. We aimed to develop and validate a new microneedle device to modify decellularized carotid arteries wit...

journal_title：Regenerative medicine

authors： Eufrásio-da-Silva T,Ruiz-Hernandez E,O'Dwyer J,Picazo-Frutos D,Duffy GP,Murphy BP

更新日期：2019-11-01 00:00:00

abstract：:Cautious approaches in the clinic are currently proposed, supported by relevant in vitro, in vivo and published data. Key to developing our understanding of the risks of immune rejection of stem cell based therapies will be the inclusion of immunological endpoints in clinical trials and the sharing of data. There is l...

journal_title：Regenerative medicine

authors： Haworth R,Sharpe M

更新日期：2015-01-01 00:00:00

abstract：AIM:This study presents an interim safety and feasibility analysis of the REGENERATE-IHD randomized controlled trial, which is examining the safety and efficacy of three different delivery routes of bone marrow-derived stem cells (BMSCs) in patients with ischemic heart failure. METHODS & RESULTS:The first 58 patients ...

journal_title：Regenerative medicine

authors： Mozid A,Yeo C,Arnous S,Ako E,Saunders N,Locca D,Brookman P,Archbold RA,Rothman M,Mills P,Agrawal S,Martin J,Mathur A

更新日期：2014-05-01 00:00:00