Abstract:
:Following the reversal by the court of appeals of the injunction against federal funding of human embryonic stem cell research, Judge Lamberth has held such funding to be lawful and has dismissed the lawsuit. However, the litigation is likely to continue in the court of appeals and ultimately perhaps in the Supreme Court. The plaintiffs' arguments against funding human embryonic stem cell research are unlikely to succeed, but unfortunately litigation is an unpredictable process in which outcomes cannot be guaranteed.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Goldfarb Ndoi
10.2217/rme.11.70subject
Has Abstractpub_date
2011-11-01 00:00:00pages
104-5issue
6 Suppleissn
1746-0751issn
1746-076Xjournal_volume
6pub_type
历史文章,杂志文章abstract:AIM:Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). MATERIALS & METHODS:AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a de...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.61
更新日期:2014-01-01 00:00:00
abstract::The concept of stem cell therapy has engaged the attention of the public and scientists alike. Intensive research effort is focused upon understanding the biology and therapeutic potential of embryonic and adult stem cells, with the eventual goal of treating such pathologies as Parkinson's disease, diabetes, neurologi...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.5.715
更新日期:2006-09-01 00:00:00
abstract::Research regarding the use of cord blood (CB) has focused on antigen match and the number of stem cells, with policies and networks related to its use being under researched. This article is based on fieldwork in China from 2013 to 2015 and examines ways that the studied CB bank enhances CB usage in China. This articl...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0050
更新日期:2017-09-01 00:00:00
abstract::The olfactory mucosa contains cells that enable it to generate new neurons and other supporting cells throughout life, allowing it to replace cells of the mucosa that have been damaged by exposure to various insults. In this article, we discuss the different types of stem cell found within the olfactory mucosa and the...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2018-0009
更新日期:2018-07-01 00:00:00
abstract::Promising new medical technologies and approaches to treatment offer the potential to substantially improve the lives of patients who need help, and in some cases transform the way medicine is practiced. In recent years, the biotechnology industry has generated many examples of new approaches that are having a profoun...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.12.90
更新日期:2012-11-01 00:00:00
abstract::Founded in 2009 and headquartered in Glasgow, Scotland, UK, Sistemic Ltd has developed from a thought in the minds of four scientists into a company working globally to play its part in delivering the exciting opportunities for improvements in human health presented by cell therapies and regenerative medicine products...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.13.58
更新日期:2013-09-01 00:00:00
abstract::Regenerative medicine is an evolving, cross-disciplinary, international field that, as a result, uses terms that are either not widely understood, or may have a number of different meanings. Many stakeholders have identified this lack of clarity as a potential barrier to effective communication within the field. To ad...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.34
更新日期:2009-07-01 00:00:00
abstract::Aging is defined as the progressive and generalized impairment of function, resulting in an increasing vulnerability to environmental challenges and a growing risk of disease and death. The decline in the regenerative capacity of resident stem cells across different tissues is a central mediator of aging. In this pape...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.10
更新日期:2013-03-01 00:00:00
abstract::Nanotechnology offers significant potential in regenerative medicine, specifically with the ability to mimic tissue architecture at the nanoscale. In this perspective, we highlight key achievements in the nanotechnology field for successfully mimicking the composition and structure of different tissues, and the develo...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2016-0120
更新日期:2016-12-01 00:00:00
abstract::Clinical application of autologous cells by businesses promoting unproven stem cell treatments represents the largest growth sector in this problematic industry, but also presents special challenges to regulators. Patients frequently identify autologous cells as personal property, using the language of 'ownership'. Th...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0063
更新日期:2017-10-01 00:00:00
abstract:AIMS:To evaluate the safety and efficacy of cell therapies administered acutely/sub-acutely after stroke. METHODS:Five databases were searched for studies examining the safety/efficacy of cell therapies administered ≤90 days post-stroke. Reporting quality and adherence to research guidelines were evaluated. Safety and...
journal_title:Regenerative medicine
pub_type: 杂志文章,meta分析,评审
doi:10.2217/rme-2016-0063
更新日期:2016-10-01 00:00:00
abstract:AIM:It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. MATERIALS & METHODS:The effects of ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.59
更新日期:2015-01-01 00:00:00
abstract::Professor Coffey joined the faculty at the University of Oxford in 1987 on completing his doctoral work. In 1989, he was awarded a personal Royal Society Research Fellowship, at the same time moving to the University of Sheffield to establish a new laboratory for retinal transplantation. After 14 years at the Universi...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/rme.09.33
更新日期:2009-07-01 00:00:00
abstract::The neurological and physiological basis of brain function and disease has been a significant focus of investigation throughout the history of medical research. Recent advances in understanding have led to the development of new treatments for diseases of the brain and defects of cognitive and behavioral function: pha...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.3.361
更新日期:2006-05-01 00:00:00
abstract:AIM:In this study, we have evaluated the therapeutic efficacy of mouse multipotent adult progenitor cells (mMAPCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, and compared it with mouse mesenchymal stem cells (mMSCs). MATERIALS & METHODS:We administered PKH26-labeled mMAP...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2016-0109
更新日期:2017-04-01 00:00:00
abstract:AIM:Dendritic cell (DC)-based vaccines have a potential utility for use in the treatment of malignancy. Human embryonic stem cells (hESCs) may provide a more cost-effective and reliable source of DCs for immunotherapy purposes, providing on-demand access for patients. METHOD:We developed a protocol to generate DCs fro...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.25
更新日期:2009-07-01 00:00:00
abstract::Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tiss...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0156
更新日期:2019-09-01 00:00:00
abstract:AIM:Evaluation of survival, proliferation and neurodifferentiation of dental stem cells from the apical papilla (SCAP) in fibrin hydrogels. We hypothesized that fibrin composition will influence cell behavior. METHODS:Modulus, pore and fiber size were measured. SCAP in vitro viability, proliferation and neural differe...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.14.81
更新日期:2015-01-01 00:00:00
abstract::Multipotent mesenchymal stromal cells (MSCs) hold tremendous promise for tissue engineering and regenerative medicine, yet with so many sources of MSCs, what are the primary criteria for selecting leading candidates? Ideally, the cells will be multipotent, inexpensive, lack donor site morbidity, donor materials should...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.10.98
更新日期:2011-01-01 00:00:00
abstract::Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.33
更新日期:2013-07-01 00:00:00
abstract::Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, liga...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2016-0125
更新日期:2016-12-01 00:00:00
abstract::Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were used to treat a different disorder. Subsequently, several studies using cultured cells have enabled identification of hair growth modulators with similar prope...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.87
更新日期:2014-01-01 00:00:00
abstract:AIMS:To investigate neural stem cell (NSC) interactions with striatal tissue following engraftment and the effects of growth factors. MATERIALS & METHODS:Organotypic striatal slice cultures established from neonatal rats were used as an ex vivo model system. Survival, integration and differentiation of grafted NSCs fr...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.80
更新日期:2010-11-01 00:00:00
abstract::Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0074
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Mechanisms underpinning Gram-negative bacterial vaginosis-induced birth anomalies are obscure. Ethical issues limit such studies on peri-implantation-stage human embryos. Here we have used embryoid bodies (EBs) as an in vitro model to examine the effect of Gram-negative bacterial endotoxins/lipopolysaccharid...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.3.1.23
更新日期:2008-01-01 00:00:00
abstract::The Tissue Engineering and Regenerative Medicine International Society-Asia Pacific (TERMIS-AP) annual meeting was held in Sydney, Australia from 15-17 September 2010 and highlighted the latest developments in tissue engineering and regenerative medicine in the Asia-Pacific region. Several of the plenary lectures focu...
journal_title:Regenerative medicine
pub_type:
doi:10.2217/rme.11.7
更新日期:2011-03-01 00:00:00
abstract::Tissue engineering is a field of study unto itself, but in reality, it is a fusion of medicine, pharmacology, chemistry, cell biology, molecular biology and engineering. The field has been developing at an ever-increasing pace and already provides benefits to regenerative medicine in areas such as the skin and cornea....
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.16
更新日期:2013-05-01 00:00:00
abstract:AIMS:Therapeutic replacement of organs with healthy cells requires disease-specific strategies. As copper toxicosis due to ATP7B deficiency in Wilson disease produces significant liver injury, disease-specific study of transplanted cell proliferation will offer insights into cell and gene therapy mechanisms. MATERIALS...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.3.2.165
更新日期:2008-03-01 00:00:00
abstract:AIMS:Murine 3T3 feeder cells are commonly used for stem cell expansion. Although 'feeder-free' systems are being developed for a variety of stem cells including embryonic, the use of feeder cells currently remains optimal for the expansion of epithelial stem cells. In this study, MRC-5, a human embryonic fibroblast cel...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.6.919
更新日期:2007-11-01 00:00:00
abstract::Spinal cord injury devastates the CNS, besetting patients with symptoms including but not limited to: paralysis, autonomic nervous dysfunction, pain disorders and depression. Despite the identification of several molecular and genetic factors, a reliable regenerative therapy has yet to be produced for this terminal di...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2016-0019
更新日期:2016-10-01 00:00:00