Sherley v. Sebelius.

abstract：:Multipotent mesenchymal stromal cells (MSCs) hold tremendous promise for tissue engineering and regenerative medicine, yet with so many sources of MSCs, what are the primary criteria for selecting leading candidates? Ideally, the cells will be multipotent, inexpensive, lack donor site morbidity, donor materials should...

journal_title：Regenerative medicine

authors： Wang L,Ott L,Seshareddy K,Weiss ML,Detamore MS

更新日期：2011-01-01 00:00:00

abstract：:Human embryonic stem cells offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Characterizing these cells provides important information about their current state and affords relevant details for subsequent downstream manipulation. Prior to considering therapeutic appli...

journal_title：Regenerative medicine

authors： Pal R,Mandal A,Rao HS,Rao MS,Khanna A

更新日期：2007-03-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...

journal_title：Regenerative medicine

authors： Awan M,Buriak I,Fleck R,Fuller B,Goltsev A,Kerby J,Lowdell M,Mericka P,Petrenko A,Petrenko Y,Rogulska O,Stolzing A,Stacey GN

更新日期：2020-03-01 00:00:00

abstract：:Cell therapies aim to repair the mechanisms underlying disease initiation and progression, achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. This review covers the current state of cell therapies designed for the ...

journal_title：Regenerative medicine

authors： Buzhor E,Leshansky L,Blumenthal J,Barash H,Warshawsky D,Mazor Y,Shtrichman R

更新日期：2014-01-01 00:00:00

abstract：:Since the first pioneering scientists explored the potential of using human cells for therapeutic purposes the branch of regenerative medicine has evolved to become a mature industry. The focus has switched from 'what can be done' to 'what can be commercialized'. Timely health economic evaluation supports successful m...

journal_title：Regenerative medicine

authors： Koerber F,Rolauffs B,Rogowski W

更新日期：2013-11-01 00:00:00

abstract：:We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich p...

journal_title：Regenerative medicine

authors： Stafford CD 2nd,Colberg RE,Nourse AL

更新日期：2019-05-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cells offer tremendous opportunity for the creation of autologous cellular therapies, in which gene correction or the avoidance of immune response issues are desirable. In addition, iPS cells avoid the ethical concerns raised by the sourcing of human embryonic stem cells (hESCs) from emb...

journal_title：Regenerative medicine

authors： Carpenter MK,Couture LA

更新日期：2010-07-01 00:00:00

abstract：:Nanotechnology offers significant potential in regenerative medicine, specifically with the ability to mimic tissue architecture at the nanoscale. In this perspective, we highlight key achievements in the nanotechnology field for successfully mimicking the composition and structure of different tissues, and the develo...

journal_title：Regenerative medicine

authors： Alarçin E,Guan X,Kashaf SS,Elbaradie K,Yang H,Jang HL,Khademhosseini A

更新日期：2016-12-01 00:00:00

abstract：:Founded in 2009 and headquartered in Glasgow, Scotland, UK, Sistemic Ltd has developed from a thought in the minds of four scientists into a company working globally to play its part in delivering the exciting opportunities for improvements in human health presented by cell therapies and regenerative medicine products...

journal_title：Regenerative medicine

authors： Reid J

更新日期：2013-09-01 00:00:00

abstract：:Cautious approaches in the clinic are currently proposed, supported by relevant in vitro, in vivo and published data. Key to developing our understanding of the risks of immune rejection of stem cell based therapies will be the inclusion of immunological endpoints in clinical trials and the sharing of data. There is l...

journal_title：Regenerative medicine

authors： Haworth R,Sharpe M

更新日期：2015-01-01 00:00:00

abstract：AIM:Current synthetic tubular conduits are inferior to nerve autograft for the repair of segmental peripheral nerve injuries. We examined motor outcomes with the use of longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber conduits for repair of nerve gap injury in a rat model. METHODS:Ten-millimeter segme...

journal_title：Regenerative medicine

authors： Jin J,Park M,Rengarajan A,Zhang Q,Limburg S,Joshi SK,Patel S,Kim HT,Kuo AC

更新日期：2012-11-01 00:00:00

abstract：AIMS:Therapeutic replacement of organs with healthy cells requires disease-specific strategies. As copper toxicosis due to ATP7B deficiency in Wilson disease produces significant liver injury, disease-specific study of transplanted cell proliferation will offer insights into cell and gene therapy mechanisms. MATERIALS...

journal_title：Regenerative medicine

authors： Malhi H,Joseph B,Schilsky ML,Gupta S

更新日期：2008-03-01 00:00:00

abstract：:Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep ...

journal_title：Regenerative medicine

authors： Bisceglia G,Santodirocco M,Faienza A,Mastrodonato N,Urbano F,Totaro A,Bazzocchi F,Mauro LD

更新日期：2020-01-01 00:00:00

abstract：:The neurological and physiological basis of brain function and disease has been a significant focus of investigation throughout the history of medical research. Recent advances in understanding have led to the development of new treatments for diseases of the brain and defects of cognitive and behavioral function: pha...

journal_title：Regenerative medicine

authors： Chan S,Harris J

更新日期：2006-05-01 00:00:00

abstract：:Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...

journal_title：Regenerative medicine

authors： Mantripragada VP,Piuzzi NS,George J,Bova W,Ng M,Boehm C,Muschler GF

更新日期：2019-07-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have tremendous potential for regenerative medicine, and have been researched for the treatment of cardiovascular diseases. MSCs are a promising cell type because of their ease of isolation and expansion, their multipotency and their low immunogenicity. However, in order to fully utilize ...

journal_title：Regenerative medicine

authors： Huang NF,Li S

更新日期：2008-11-01 00:00:00

abstract：:Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...

journal_title：Regenerative medicine

authors： Carulli S,Contin R,De Rosa L,Pellegrini G,De Luca M

更新日期：2013-07-01 00:00:00

abstract：:In the past decade, stem cell therapy has been increasingly employed for the treatment of various diseases. Subsequently, there has been a great interest in the manufacture of stem cells under good manufacturing practice, which is required by law for their use in humans. The cells for sight Stem Cell Therapy Research ...

journal_title：Regenerative medicine

authors： Sheth-Shah R,Vernon AJ,Seetharaman S,Neale MH,Daniels JT

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) can differentiate into any human cell type, including CNS cells, and thus have high potential in regenerative medicine. Several protocols exist for neuronal differentiation of hESCs, which do not necessarily work for all hESC lines. MATERIALS & METHODS:We tested the differ...

journal_title：Regenerative medicine

authors： Lappalainen RS,Salomäki M,Ylä-Outinen L,Heikkilä TJ,Hyttinen JA,Pihlajamäki H,Suuronen R,Skottman H,Narkilahti S

更新日期：2010-09-01 00:00:00

abstract：:Regenerative medicine is an evolving, cross-disciplinary, international field that, as a result, uses terms that are either not widely understood, or may have a number of different meanings. Many stakeholders have identified this lack of clarity as a potential barrier to effective communication within the field. To ad...

journal_title：Regenerative medicine

authors： Sheridan B,Harris N

更新日期：2009-07-01 00:00:00

abstract：:Tissue engineering is a field of study unto itself, but in reality, it is a fusion of medicine, pharmacology, chemistry, cell biology, molecular biology and engineering. The field has been developing at an ever-increasing pace and already provides benefits to regenerative medicine in areas such as the skin and cornea....

journal_title：Regenerative medicine

authors： Sekiya S,Shimizu T,Okano T

更新日期：2013-05-01 00:00:00

abstract：:Promising new medical technologies and approaches to treatment offer the potential to substantially improve the lives of patients who need help, and in some cases transform the way medicine is practiced. In recent years, the biotechnology industry has generated many examples of new approaches that are having a profoun...

journal_title：Regenerative medicine

authors： Werner M,Mayleben T,Van Bokkelen G

更新日期：2012-11-01 00:00:00

abstract：AIM:Secondary lymphedema is observed in common after postmalignancy treatment of the breast and the gynecologic organs but effective therapies are not established. Adipose-derived stem cells (ADSCs), which are pluripotent, regenerative in local injection, are tested for murine hindlimb secondary lymphedema by regenerat...

journal_title：Regenerative medicine

authors： Yoshida S,Hamuy R,Hamada Y,Yoshimoto H,Hirano A,Akita S

更新日期：2015-01-01 00:00:00

abstract：:Dr Jane Lebkowski joined Geron Corporation in 1998 and is currently Senior Vice President and Chief Scientific Officer of the Regenerative Medicine Division. Dr Lebkowski heads Geron's human embryonic stem cell program, and is responsible for all research, preclinical development, product development, manufacturing an...

journal_title：Regenerative medicine

authors： Lebkowski JS

更新日期：2009-09-01 00:00:00

abstract：:Medicinal signaling cell (MSC)-based products represent emerging treatments in various therapeutic areas including cardiometabolic, inflammation, autoimmunity, orthopedics, wound healing and oncology. Exploring innovation beyond minimally manipulated plastic-adherent ex vivo expanded allogeneic MSCs enables product de...

journal_title：Regenerative medicine

authors： Vertès AA

更新日期：2017-12-01 00:00:00

abstract：:Many features of adipose stem/progenitor cells, including their physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly, with perivascular progenitor cells differentiating into new adipocytes to replace dead adipocytes. A number of clinical trials using f...

journal_title：Regenerative medicine

authors： Yoshimura K,Eto H,Kato H,Doi K,Aoi N

更新日期：2011-11-01 00:00:00

abstract：:In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing beta-cells are a major cause of defective control of blood glucose and its complications. Restoration of damaged beta-cells by endocrine pancreas regeneration would be an ideal therapeutic option. The possibility of generating insulin-secreting c...

journal_title：Regenerative medicine

authors： Sordi V,Bertuzzi F,Piemonti L

更新日期：2008-05-01 00:00:00

abstract：:Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an ...

journal_title：Regenerative medicine

authors： Zhou J,Cui H,Lu H,Xu Z,Feng W,Chen L,Jin X,Yang X,Qi Z

更新日期：2017-04-01 00:00:00

abstract：:Aim: We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat™, Lipogems®) is a viable alternative for treatment of joint pain and inflammation associated dysfunction in shoulder osteoarthritis (OA). Materials & methods: A total of 25 subjects with OA received an injection of MFat™ and were fol...

journal_title：Regenerative medicine

authors： Vinet-Jones H,F Darr K

更新日期：2020-10-01 00:00:00

abstract：:Genetics Policy Institute (GPI) is a nonprofit, public interest organization recognized as a leading promoter and defender of stem cell research and other cutting-edge medical research targeting cures. Since GPI's inception in 2003, its mission has focused on establishing a positive policy, regulatory and societal fra...

journal_title：Regenerative medicine

authors： Siegel B

更新日期：2009-05-01 00:00:00