Abstract:
:The neurological and physiological basis of brain function and disease has been a significant focus of investigation throughout the history of medical research. Recent advances in understanding have led to the development of new treatments for diseases of the brain and defects of cognitive and behavioral function: pharmacological, cell-based and even gene therapy may all provide keys to cognitive regeneration. Such therapies, however, might be applied not only towards restoring brain function in the case of disease but to enhance cognitive function for healthy individuals. The concept of cognitive enhancement raises many ethical issues: whether brain-enhancing treatments should be developed and made available and to whom; and what potential consequences might arise? This paper explores some of the ethical arguments associated with cognitive enhancement and concludes that although the technology involved is as yet uncertain and issues of social equity remain to be addressed, the potential benefit of enhancing human brain function is clear.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Chan S,Harris Jdoi
10.2217/17460751.1.3.361subject
Has Abstractpub_date
2006-05-01 00:00:00pages
361-6issue
3eissn
1746-0751issn
1746-076Xjournal_volume
1pub_type
杂志文章abstract::Dr Jane Lebkowski joined Geron Corporation in 1998 and is currently Senior Vice President and Chief Scientific Officer of the Regenerative Medicine Division. Dr Lebkowski heads Geron's human embryonic stem cell program, and is responsible for all research, preclinical development, product development, manufacturing an...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/rme.09.49
更新日期:2009-09-01 00:00:00
abstract::Aim: The most common risk associated with intradiscal injection of platelet-rich plasma (PRP) is discitis with Cutibacterium acnes. It is hypothesized that antimicrobial activity of PRP can be enhanced through inclusion of leukocytes or antibiotics in the injectate. Materials & methods: Multiple PRP preparations of va...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0098
更新日期:2019-10-01 00:00:00
abstract::Since the first pioneering scientists explored the potential of using human cells for therapeutic purposes the branch of regenerative medicine has evolved to become a mature industry. The focus has switched from 'what can be done' to 'what can be commercialized'. Timely health economic evaluation supports successful m...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.13.69
更新日期:2013-11-01 00:00:00
abstract:AIM:Dendritic cell (DC)-based vaccines have a potential utility for use in the treatment of malignancy. Human embryonic stem cells (hESCs) may provide a more cost-effective and reliable source of DCs for immunotherapy purposes, providing on-demand access for patients. METHOD:We developed a protocol to generate DCs fro...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.09.25
更新日期:2009-07-01 00:00:00
abstract::The concept of stem cell therapy has engaged the attention of the public and scientists alike. Intensive research effort is focused upon understanding the biology and therapeutic potential of embryonic and adult stem cells, with the eventual goal of treating such pathologies as Parkinson's disease, diabetes, neurologi...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.5.715
更新日期:2006-09-01 00:00:00
abstract::Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0145
更新日期:2020-03-01 00:00:00
abstract:AIMS:An extensive colonization of surgical meshes with autologous fibroblasts may reduce complications. Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibrobla...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.4.2.197
更新日期:2009-03-01 00:00:00
abstract:AIM:Current synthetic tubular conduits are inferior to nerve autograft for the repair of segmental peripheral nerve injuries. We examined motor outcomes with the use of longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber conduits for repair of nerve gap injury in a rat model. METHODS:Ten-millimeter segme...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.12.87
更新日期:2012-11-01 00:00:00
abstract:AIM:To evaluate the cost-effectiveness of autologous cell therapy manufacturing in xeno-free conditions. MATERIALS & METHODS:Published data on the isolation and expansion of mesenchymal stem/stromal cells introduced donor, multipassage and culture media variability on cell yields and process times on adherent culture ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0034
更新日期:2018-12-01 00:00:00
abstract::Osteoarthritis is a common disorder in which there is not only extensive degeneration but also an aberrant attempt at repair in joints. Stem cell therapy could provide a permanent, biological solution, with all sources of stem cells (embryonic, fetal and adult) showing some degree of potential. Mesenchymal stromal/ste...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.11.21
更新日期:2011-05-01 00:00:00
abstract::Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme-2016-0165
更新日期:2017-04-01 00:00:00
abstract::The thymus is required for generation of a self-tolerant, self-restricted T-cell repertoire. The capacity to manipulate or replace thymus function therapeutically would be beneficial in a variety of clinical settings, including for improving recovery following bone marrow transplantation, restoring immune system funct...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.15.8
更新日期:2015-01-01 00:00:00
abstract::We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich p...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2018-0071
更新日期:2019-05-01 00:00:00
abstract::Tissue regeneration specialist company Organogenesis Inc. was one of the first biotech companies formed. Incorporated in 1985, the company was originally a spin-off from a research program at MIT. For the first 10-15 years, Organogenesis was heavily research based, but then gradually moved into development. The compan...
journal_title:Regenerative medicine
pub_type: 面试
doi:10.2217/17460751.1.2.169
更新日期:2006-03-01 00:00:00
abstract:AIMS:To investigate neural stem cell (NSC) interactions with striatal tissue following engraftment and the effects of growth factors. MATERIALS & METHODS:Organotypic striatal slice cultures established from neonatal rats were used as an ex vivo model system. Survival, integration and differentiation of grafted NSCs fr...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme.10.80
更新日期:2010-11-01 00:00:00
abstract::Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.2.1.95
更新日期:2007-01-01 00:00:00
abstract::Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2019-0151
更新日期:2020-06-01 00:00:00
abstract::Clinical application of autologous cells by businesses promoting unproven stem cell treatments represents the largest growth sector in this problematic industry, but also presents special challenges to regulators. Patients frequently identify autologous cells as personal property, using the language of 'ownership'. Th...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0063
更新日期:2017-10-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have tremendous potential for regenerative medicine, and have been researched for the treatment of cardiovascular diseases. MSCs are a promising cell type because of their ease of isolation and expansion, their multipotency and their low immunogenicity. However, in order to fully utilize ...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.3.6.877
更新日期:2008-11-01 00:00:00
abstract::Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell a...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.1.6.789
更新日期:2006-11-01 00:00:00
abstract::Aim: We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat™, Lipogems®) is a viable alternative for treatment of joint pain and inflammation associated dysfunction in shoulder osteoarthritis (OA). Materials & methods: A total of 25 subjects with OA received an injection of MFat™ and were fol...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2020-0069
更新日期:2020-10-01 00:00:00
abstract::Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were used to treat a different disorder. Subsequently, several studies using cultured cells have enabled identification of hair growth modulators with similar prope...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.13.87
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Mechanisms underpinning Gram-negative bacterial vaginosis-induced birth anomalies are obscure. Ethical issues limit such studies on peri-implantation-stage human embryos. Here we have used embryoid bodies (EBs) as an in vitro model to examine the effect of Gram-negative bacterial endotoxins/lipopolysaccharid...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.3.1.23
更新日期:2008-01-01 00:00:00
abstract::Among the many international conferences in the field of stem cells and regenerative medicine, WSCS is distinct in focusing its efforts to serve as the meeting point by multisector communities of research, clinics, industry, regulation, policy making and ethics. All are aiming at advancing stem cell innovation and new...
journal_title:Regenerative medicine
pub_type:
doi:10.2217/rme.15.4
更新日期:2015-05-01 00:00:00
abstract::Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the r...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/17460751.1.1.59
更新日期:2006-01-01 00:00:00
abstract::Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0065
更新日期:2017-10-01 00:00:00
abstract::Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...
journal_title:Regenerative medicine
pub_type: 临床试验,杂志文章
doi:10.2217/rme-2018-0173
更新日期:2019-07-01 00:00:00
abstract::The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, b...
journal_title:Regenerative medicine
pub_type: 杂志文章
doi:10.2217/rme-2017-0104
更新日期:2018-03-19 00:00:00
abstract::Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/17460751.1.4.563
更新日期:2006-07-01 00:00:00
abstract::A major challenge to commercializing cell-based therapies is developing scalable manufacturing processes while maintaining the critical quality parameters (identity, potency, purity, safety) of the final live cell product. Process development activities such as extended passaging and serum reduction/elimination can fa...
journal_title:Regenerative medicine
pub_type: 杂志文章,评审
doi:10.2217/rme.11.105
更新日期:2012-01-01 00:00:00