Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression.

abstract：:The main challenges of cancer drugs are toxicity, effect on wound healing/patient outcome and in vivo instability. Polymeric scaffolds have been used separately for tissue regeneration in wound healing and as anticancer drug releasing devices. Bringing these two together in bifunctional scaffolds can provide a tool fo...

journal_title：Regenerative medicine

authors： Goonoo N,Boodhun A,Ziman M,Gray E,Bhaw-Luximon A

更新日期：2020-10-01 00:00:00

abstract：:Tendons and ligaments are related connective tissues that join muscle to bone and bone to bone, respectively. Tendon and ligament injuries are widely distributed clinical problems in society and while healing of such disorders can occur, the original biological properties of the tissue do not return to normal. In this...

journal_title：Regenerative medicine

authors： Hoffmann A,Gross G

更新日期：2006-07-01 00:00:00

abstract：:Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material for the generation of cellular therapeutics requires demonstration of comparability of lines derived from different individuals and in different facilities. This requires agreement on the critical quality attributes of such l...

journal_title：Regenerative medicine

authors： Sullivan S,Stacey GN,Akazawa C,Aoyama N,Baptista R,Bedford P,Bennaceur Griscelli A,Chandra A,Elwood N,Girard M,Kawamata S,Hanatani T,Latsis T,Lin S,Ludwig TE,Malygina T,Mack A,Mountford JC,Noggle S,Pereira LV,Pric

更新日期：2018-10-01 00:00:00

abstract：:Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow conce...

journal_title：Regenerative medicine

authors： Mantripragada VP,Piuzzi NS,George J,Bova W,Ng M,Boehm C,Muschler GF

更新日期：2019-07-01 00:00:00

abstract：:Nanotechnology offers significant potential in regenerative medicine, specifically with the ability to mimic tissue architecture at the nanoscale. In this perspective, we highlight key achievements in the nanotechnology field for successfully mimicking the composition and structure of different tissues, and the develo...

journal_title：Regenerative medicine

authors： Alarçin E,Guan X,Kashaf SS,Elbaradie K,Yang H,Jang HL,Khademhosseini A

更新日期：2016-12-01 00:00:00

abstract：:Finding solutions for patients with unmet needs is at the heart of Genzyme's innovative medical research. While small molecules and enzyme-replacement therapies have made significant strides in improving patients' quality of life and expectancy, the solutions to many conditions, such as heart disease or CNS diseases, ...

journal_title：Regenerative medicine

authors： De Bie C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) can differentiate into any human cell type, including CNS cells, and thus have high potential in regenerative medicine. Several protocols exist for neuronal differentiation of hESCs, which do not necessarily work for all hESC lines. MATERIALS & METHODS:We tested the differ...

journal_title：Regenerative medicine

authors： Lappalainen RS,Salomäki M,Ylä-Outinen L,Heikkilä TJ,Hyttinen JA,Pihlajamäki H,Suuronen R,Skottman H,Narkilahti S

更新日期：2010-09-01 00:00:00

abstract：:The UK Stem Cell Bank is a UK Research Council-funded initiative that aims to provide ethically sourced and quality controlled stocks of cells for researchers and also establish seed stocks of cell lines for clinical trials. Whilst the Bank is prohibited from carrying out basic stem cell research (to avoid conflicts o...

journal_title：Regenerative medicine

authors： Stacey G,Hunt CJ

更新日期：2006-01-01 00:00:00

abstract：:Since the first pioneering scientists explored the potential of using human cells for therapeutic purposes the branch of regenerative medicine has evolved to become a mature industry. The focus has switched from 'what can be done' to 'what can be commercialized'. Timely health economic evaluation supports successful m...

journal_title：Regenerative medicine

authors： Koerber F,Rolauffs B,Rogowski W

更新日期：2013-11-01 00:00:00

abstract：AIM:Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. MATERIALS & METHODS:DPSCs were differentiated with media containing 5.5 o...

journal_title：Regenerative medicine

authors： Matei IV,Ii H,Yaegaki K

更新日期：2017-03-01 00:00:00

abstract：:Research regarding the use of cord blood (CB) has focused on antigen match and the number of stem cells, with policies and networks related to its use being under researched. This article is based on fieldwork in China from 2013 to 2015 and examines ways that the studied CB bank enhances CB usage in China. This articl...

journal_title：Regenerative medicine

authors： Chang HC

更新日期：2017-09-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bo...

journal_title：Regenerative medicine

authors： Awan M,Buriak I,Fleck R,Fuller B,Goltsev A,Kerby J,Lowdell M,Mericka P,Petrenko A,Petrenko Y,Rogulska O,Stolzing A,Stacey GN

更新日期：2020-03-01 00:00:00

abstract：:Aim: We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process in vivo. Materials & methods: Defects were created surgically on the femoropatellar groove ...

journal_title：Regenerative medicine

authors： Yang ZG,Tang RF,Qi YY,Chen WP,Xiong Y,Wu LD

更新日期：2020-06-01 00:00:00

abstract：AIM:To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. METHODS:Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously publ...

journal_title：Regenerative medicine

authors： Vilsbøll AW,Mouritsen JM,Jensen LP,Bødker N,Holst AW,Pennisi CP,Ehlers L

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:Mechanisms underpinning Gram-negative bacterial vaginosis-induced birth anomalies are obscure. Ethical issues limit such studies on peri-implantation-stage human embryos. Here we have used embryoid bodies (EBs) as an in vitro model to examine the effect of Gram-negative bacterial endotoxins/lipopolysaccharid...

journal_title：Regenerative medicine

authors： Sivasubramaniyan K,Atluri RR,Sarda K,Arvind M,Balaji V,Deb KD

更新日期：2008-01-01 00:00:00

abstract：:Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the...

journal_title：Regenerative medicine

authors： Chan S

更新日期：2017-10-01 00:00:00

abstract：:In soft tissue repair, there are several surgical options such as nondegradable, inert, synthetic, biodegradable implants or autologous tissue transplantation. However, the potential of using autologous adult stem cells derived from fat tissue is quickly becoming a clinical reality. The possibility of using an abundan...

journal_title：Regenerative medicine

authors： Cherubino M,Marra KG

更新日期：2009-01-01 00:00:00

abstract：:In the South Korean health technology assessment system, prices of alternative medicines, incremental cost-effectiveness ratios in pharmaco-economic evaluations and patient access improvement systems such as risk-sharing agreements are the most important factors concerning the reimbursement of regenerative medicine (R...

journal_title：Regenerative medicine

authors： Cho E,Yoo SL,Kang Y,Lee JH

更新日期：2020-04-01 00:00:00

abstract：:Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the r...

journal_title：Regenerative medicine

authors： De Bari C,Pitzalis C,Dell'Accio F

更新日期：2006-01-01 00:00:00

abstract：:Among the many international conferences in the field of stem cells and regenerative medicine, WSCS is distinct in focusing its efforts to serve as the meeting point by multisector communities of research, clinics, industry, regulation, policy making and ethics. All are aiming at advancing stem cell innovation and new...

journal_title：Regenerative medicine

authors： Hasegawa K,Asada T,Sengoku S,Nakatsuji N

更新日期：2015-05-01 00:00:00

abstract：:Osteoarthritis is a common disorder in which there is not only extensive degeneration but also an aberrant attempt at repair in joints. Stem cell therapy could provide a permanent, biological solution, with all sources of stem cells (embryonic, fetal and adult) showing some degree of potential. Mesenchymal stromal/ste...

journal_title：Regenerative medicine

authors： Roberts S,Genever P,McCaskie A,De Bari C

更新日期：2011-05-01 00:00:00

abstract：:Launched in June 2011, CCRM is a unique, Canadian, not-for-profit group that is solely focused on developing and commercializing regenerative medicine, cell and gene therapy technologies. Its mission is to generate sustainable health and economic benefits through global collaborations, and its vision is to be the pref...

journal_title：Regenerative medicine

authors： Evans A,Johnson S

更新日期：2016-12-01 00:00:00

abstract：:Cautious approaches in the clinic are currently proposed, supported by relevant in vitro, in vivo and published data. Key to developing our understanding of the risks of immune rejection of stem cell based therapies will be the inclusion of immunological endpoints in clinical trials and the sharing of data. There is l...

journal_title：Regenerative medicine

authors： Haworth R,Sharpe M

更新日期：2015-01-01 00:00:00

abstract：AIMS:To investigate neural stem cell (NSC) interactions with striatal tissue following engraftment and the effects of growth factors. MATERIALS & METHODS:Organotypic striatal slice cultures established from neonatal rats were used as an ex vivo model system. Survival, integration and differentiation of grafted NSCs fr...

journal_title：Regenerative medicine

authors： Jäderstad LM,Jäderstad J,Herlenius E

更新日期：2010-11-01 00:00:00

abstract：:Inherited epidermolysis bullosa (EB) is a family of rare genetic skin disorders characterized by structural and mechanical fragility of skin and mucosal membranes. The main feature of EB is the presence of recurrent skin blistering or erosions, which have a profound impact in the quality of life of EB patients and, in...

journal_title：Regenerative medicine

authors： Carulli S,Contin R,De Rosa L,Pellegrini G,De Luca M

更新日期：2013-07-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have been shown recently to hold much promise in curing autoimmune diseases. Newly diagnosed Type 1 diabetes individuals have been successfully reverted to normoglycemia by administration of autologous HSCs in association with a nonmyeloablative regimen (antithymocyte globulin + cycloph...

journal_title：Regenerative medicine

authors： Ben Nasr M,Bassi R,Usuelli V,Valderrama-Vasquez A,Tezza S,D'Addio F,Fiorina P

更新日期：2016-06-01 00:00:00

abstract：:Background: Bone marrow aspiration (BMA) is among a group of autologous cell-based therapies currently being explored to treat osteoarthritis (OA). Materials & methods: This retrospective case study observed ten patients (13 knees) with severe knee OA who failed extensive conservative treatment and were treated with B...

journal_title：Regenerative medicine

authors： Colberg RE,Jurado Vélez JA,Walsh KP,Fleisig G

更新日期：2020-07-01 00:00:00

abstract：AIMS:To evaluate the safety and efficacy of cell therapies administered acutely/sub-acutely after stroke. METHODS:Five databases were searched for studies examining the safety/efficacy of cell therapies administered ≤90 days post-stroke. Reporting quality and adherence to research guidelines were evaluated. Safety and...

journal_title：Regenerative medicine

authors： Unsworth DJ,Mathias JL,Dorstyn DS

更新日期：2016-10-01 00:00:00

abstract：:Diabetes mellitus represents a global epidemic affecting over 350 million patients worldwide and projected by the WHO to surpass the 500 million patient mark within the next two decades. Besides Type 1 and Type 2 diabetes mellitus, the study of the endocrine compartment of the pancreas is of great translational intere...

journal_title：Regenerative medicine

authors： Ricordi C,Inverardi L,Domínguez-Bendala J

更新日期：2012-11-01 00:00:00

abstract：:Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were used to treat a different disorder. Subsequently, several studies using cultured cells have enabled identification of hair growth modulators with similar prope...

journal_title：Regenerative medicine

authors： Higgins CA,Christiano AM

更新日期：2014-01-01 00:00:00