Abstract:
:Inflammation plays a critical role in the secondary degenerative response to spinal cord injury (SCI). The influx of inflammatory cells following SCI is preceded by the expression of specific chemoattractants, including chemokines. The chemokine CXCL10 is a potent T lymphocyte recruiter and has been strongly implicated in the pathology of many CNS disorders. We have previously demonstrated that CXCL10 exacerbates secondary degeneration by blocking the function of CXCL10 prior to SCI. Here we administered neutralizing antibodies against CXCL10 1 h after SCI in order to investigate the efficacy of this therapeutic intervention in abating histologic and functional deficit following acute SCI and further assess the functional role of CXCL10 in secondary degeneration. Neutralization of CXCL10 significantly reduced inflammation, apoptosis, neuronal loss and whole tissue loss. Notably, this therapeutic treatment also promoted revascularization of the injured spinal cord and functional recovery. These data suggest that anti-CXCL10 antibody treatment is a viable therapeutic strategy for acute SCI.
journal_name
Regen Medjournal_title
Regenerative medicineauthors
Gonzalez R,Hickey MJ,Espinosa JM,Nistor G,Lane TE,Keirstead HSdoi
10.2217/17460751.2.5.771subject
Has Abstractpub_date
2007-09-01 00:00:00pages
771-83issue
5eissn
1746-0751issn
1746-076Xjournal_volume
2pub_type
杂志文章abstract::Promising new medical technologies and approaches to treatment offer the potential to substantially improve the lives of patients who need help, and in some cases transform the way medicine is practiced. In recent years, the biotechnology industry has generated many examples of new approaches that are having a profoun...
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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journal_title:Regenerative medicine
pub_type: 杂志文章
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journal_title:Regenerative medicine
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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journal_title:Regenerative medicine
pub_type: 杂志文章
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journal_title:Regenerative medicine
pub_type: 杂志文章,评审
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journal_title:Regenerative medicine
pub_type: 历史文章,杂志文章
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