Plasma reactive carbonyl species: Potential risk factor for hypertension.

abstract：:The singlet oxygen (1O2) quenching and free radical (DPPH(*), ABTS(* +) and O2(* -)) scavenging ability of three structurally-related flavonoids (7-hydroxyflavanone HF, 2',4'-dihydroxychalcone DHC and 3,7-dihydroxyflavone DHF) present in the Argentinean native shrub Zuccagnia punctata Cav. were studied in solution by ...

journal_title：Free radical research

authors： Vieyra FE,Boggetti HJ,Zampini IC,Ordoñez RM,Isla MI,Alvarez RM,De Rosso V,Mercadante AZ,Borsarelli CD

更新日期：2009-06-01 00:00:00

abstract：:The review deals with impairment of Ca(2+)-ATPases by high glucose or its derivatives in vitro, as well as in human diabetes and experimental animal models. Acute increases in glucose level strongly correlate with oxidative stress. Dysfunction of Ca(2+)-ATPases in diabetic and in some cases even in nondiabetic conditi...

journal_title：Free radical research

authors： Horáková L,Strosova MK,Spickett CM,Blaskovic D

更新日期：2013-08-01 00:00:00

abstract：:In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who under...

journal_title：Free radical research

authors： Bustamante V,Casanova J,López de Santamaría E,Mas S,Sellarés J,Gea J,Gáldiz JB,Barreiro E

更新日期：2008-11-01 00:00:00

abstract：:Hypericin and pseudohypericin are polycyclic-phenolic structurally related compounds found in Hypericum perforatum L. (St John's wort). As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding ath...

journal_title：Free radical research

authors： Laggner H,Schreier S,Hermann M,Exner M,Mühl A,Gmeiner BM,Kapiotis S

更新日期：2007-02-01 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:We have investigated the toxicity to human monocytemacrophages, and susceptibility to oxidation, of different individual dietary fatty acids in cholesterol esters and triglycerides, added to the cell cultures as coacervates with bovine serum albumin. Toxicity was assessed using release of radioactivity from cells prel...

journal_title：Free radical research

authors： Hardwick SJ,Carpenter KL,Law NS,Van Der Veen C,Marchant CE,Hird R,Mitchinson MJ

更新日期：1997-04-01 00:00:00

abstract：:Assessment of oxidative stress status (OSS) in human tissues is still troublesome. Using an innovative EPR-radical-probe we successfully measured the instantaneous concentration of ROS directly in peripheral blood of athletes and normally active workers during 60 min controlled exercise. The probe employed was bis(1-h...

journal_title：Free radical research

authors： Paolini M,Valgimigli L,Marchesi E,Trespidi S,Pedulli GF

更新日期：2003-05-01 00:00:00

abstract：:Effects of 12 wk exercise training on oxidative stress were examined in elderly humans. We measured oxidative stress during a 45 min cycling test by using antipyrine hydroxylation products. Antipyrine breakdown is independent of blood flow to the liver, which is important during exercise. Furthermore, antipyrine react...

journal_title：Free radical research

authors： Meijer EP,Coolen SA,Bast A,Westerterp KR

更新日期：2001-10-01 00:00:00

abstract：:8-Oxoguanine (8-oxoG) is the most common DNA base modification in the mammalian genome, associated with oxidative stress. Here we analysed the alterations in the distribution of 8-oxoG across the entire murine genome, before and after an elevation of oxidative stress by the use of ferric nitrilotriacetate (Fe-NTA) as ...

journal_title：Free radical research

authors： Akatsuka S,Li GH,Kawaguchi S,Takahashi T,Yoshihara M,Suyama M,Toyokuni S

更新日期：2020-04-16 00:00:00

abstract：:In addition to insulin, glycemic control involves thyroid hormones. However, an excess of thyroid hormone can disturb the blood glucose equilibrium, leading to alterations of carbohydrate metabolism and, eventually, diabetes. Indeed, experimental and clinical hyperthyroidism is often accompanied by abnormal glucose to...

journal_title：Free radical research

authors： Venditti P,Reed TT,Victor VM,Di Meo S

更新日期：2019-03-01 00:00:00

abstract：:Copper Fenton systems (Cu(II)/H2O2 and Cu(II)/Asc) inactivated the lipoamide reductase and enhanced the diaphorase activity of pig-heart lipoamide dehydrogenase (LADH). Cupric ions alone were less effective. As a result of Cu(II)/H2O2 treatment, the number of titrated thiols in LADH decreased from 6 to 1 per subunit. ...

journal_title：Free radical research

authors： Gutierrez-Correa J,Stoppani AO

更新日期：1995-03-01 00:00:00

abstract：:Hydroxyl and 1-hydroxyethyl radical adducts of 5,5-dimethylpyrroline N-oxide (DMPO) were prepared by photolysis, and mechanisms for loss of their EPR signals in rat liver microsomal suspensions were evaluated. Rates of NADPH-dependent EPR signal loss were more rapid in phosphate buffer than in Tris buffer. Addition of...

journal_title：Free radical research

authors： Reinke LA,Moore DR,McCay PB

更新日期：1996-12-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and autophagy are two major intracellular proteolytic systems that are closely associated with each other. Because UPS and autophagy are involved in the clearance of oxidised and/or aggregated proteins, it would be logical to assume that alterations in proteolysis would accompany ...

journal_title：Free radical research

authors： Homma T,Fujii J

更新日期：2020-04-20 00:00:00

abstract：:The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxida...

journal_title：Free radical research

authors： Fandos M,Corella D,Guillén M,Portolés O,Carrasco P,Iradi A,Martínez-González MA,Estruch R,Covas MI,Lamuela-Raventós RM,Michavilla MT,Cerdá C,Torregrosa R,Redón J,Chaves FF,Tormos MC,Ocete D,Sáez GT

更新日期：2009-12-01 00:00:00

abstract：:The risk of chronic oxidative stress in the retinal pigment epithelium (RPE) increases with age due to accumulation of the photoreactive age pigment lipofuscin (LFG). Here, we asked whether sublethal and weakly lethal photic stress, induced by irradiation of ARPE-19 cells containing phagocytised LFG, affected the cell...

journal_title：Free radical research

authors： Olchawa MM,Furso JA,Szewczyk GM,Sarna TJ

更新日期：2017-10-01 00:00:00

abstract：:It is well known that reactive oxygen species (ROS) attack several living tissues and increase the risk of development and progression of serious diseases. In neuronal level, ROS induce cell death in concentration-dependent fashion. However, little is known about the mechanisms of neuronal changes by ROS prior to indu...

journal_title：Free radical research

authors： Fukui K,Ushiki K,Takatsu H,Koike T,Urano S

更新日期：2012-02-01 00:00:00

abstract：:Nerve growth factor (NGF) is one of the several structurally related proteins, named neurotrophins (NTs), that regulate neuronal survival, development, function, and plasticity. Moreover, NGF is an important activator of antioxidant mechanisms. These NGF functions are mediated by tropomyosin-related kinase receptor A ...

journal_title：Free radical research

authors： Valdovinos-Flores C,Gonsebatt ME

更新日期：2013-05-01 00:00:00

abstract：:Ceruloplasmin (CP) is a blue copper glycoprotein with multiple physiological functions including ferroxidase and oxidase activities. CP is also an important serum oxygen free radical (OFR) scavenger and antioxidant, exerting cardioprotective and antifibrillatory actions. Although it has been reported that CP activitie...

journal_title：Free radical research

authors： Aouffen M,Paquin J,Furtos A,Waldron KC,Mateescu MA

更新日期：2004-01-01 00:00:00

abstract：:Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases. Neurodegenerative diseases are characterized by progressive dysfunction and death of neurons. Oxidative stress is associated with dysfunction of the mitochondria and endoplasmic reticulum, inducing apoptosis and protein misfold...

journal_title：Free radical research

authors： Ghosh N,Ghosh R,Mandal SC

更新日期：2011-08-01 00:00:00

abstract：:The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 ...

journal_title：Free radical research

authors： Borrás C,Gómez-Cabrera MC,Viña J

更新日期：2011-06-01 00:00:00

abstract：:To examine the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated kinase (ERK) in the oxidative stress-induced increase of permeability in endothelial cells, the effects of a p38 MAPK inhibitor (SB203580) and ERK inhibitor (PD90859) on the H2O2-induced increase of permeab...

journal_title：Free radical research

authors： Niwa K,Inanami O,Ohta T,Ito S,Karino T,Kuwabara M

更新日期：2001-11-01 00:00:00

abstract：:Uraemic subjects undergoing chronic haemodialysis show increased oxidative stress. The use of non-biocompatible filters and reduced antioxidative defences are important sources of reactive oxygen species (ROS) release. The highly oxidative environment accelerates the onset and progression of tissue damage and atherosc...

journal_title：Free radical research

authors： Odetti P,Traverso N,Monacelli F,Menini S,Vazzana J,Tasso B,Pronzato MA,Robaudo C,Deferrari G

更新日期：2006-02-01 00:00:00

abstract：:The hydroxyl radical (.OH)-scavenging activity of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a novel nonsteroidal anti-inflammatory drug (NSAID), and that of several other NSAIDs were investigated by the hyaluronic acid (HA) degradation method and the electron spin resonance (ESR) spin-trapping techniq...

journal_title：Free radical research

authors： Kataoka M,Tonooka K,Ando T,Imai K,Aimoto T

更新日期：1997-10-01 00:00:00

abstract：:Oxidative stress is suggested as a potential mechanism in impaired foetal growth, smaller birth size and thus subsequently adult chronic diseases. We have investigated associations between oxidative stress in pregnancy and birth anthropometry (weight, height, head and chest circumferences). In the MINIMat-trial (Mater...

journal_title：Free radical research

authors： Lindström E,Persson LÅ,Raqib R,El Arifeen S,Basu S,Ekström EC

更新日期：2012-03-01 00:00:00

abstract：:This study evaluated the gender differences in response to intense exercise on lymphocyte hydrogen peroxide production, nitric oxide handling and mitochondrial superoxide dismutase (MnSOD) activity and gene expression. Fifteen males and nine females participated voluntarily in the study and performed a swimming sessio...

journal_title：Free radical research

authors： Sureda A,Ferrer MD,Tauler P,Tur JA,Pons A

更新日期：2008-04-01 00:00:00

abstract：:We have determined the effects of chronic vitamin C intake on neutrophil and lymphocyte antioxidant defences during the acute phase immune response induced by intense exercise. Blood samples were taken from 16 voluntary athletes in basal conditions, both immediately after and 1 h after a duathlon competition. Sportsme...

journal_title：Free radical research

authors： Tauler P,Aguiló A,Gimeno I,Noguera A,Agustí A,Tur JA,Pons A

更新日期：2003-09-01 00:00:00

abstract：:It is well known that antioxidants such as AA (reduced ascorbate), glutathione (GSH) (reduced glutathione) and melatonin can delay seed ageing. Can they recover aged seed? Artificial aged maize seeds were obtained and their reduced germination rate (GR) and high lipid peroxidation were recorded. Exogenous melatonin wa...

journal_title：Free radical research

authors： Deng B,Yang K,Zhang Y,Li Z

更新日期：2017-10-01 00:00:00

abstract：:Capacitation of spermatozoa is an essential procedure for fertilization. Capacitated spermatozoa have an increase in the intracellular cAMP and acrosome reaction (AR) occurs immediately. The effect of exogenous superoxide anion (O2-) on the level of intracellular cAMP and the percentages of both spontaneous AR and lys...

journal_title：Free radical research

authors： Zhang H,Zheng RL

更新日期：1996-04-01 00:00:00

abstract：:It has been observed that H9c2 cardiac cells cultured in physiologic solutions exhibit delayed cell death after repeated medium replacements, of which the cause was the relatively mild osmotic challenges during the renewal of the culture medium. Interestingly, the cell damage was associated with altered intracellular ...

journal_title：Free radical research

authors： Lee JW,Ko YE,Lee IH,Lee HK,Kim HW,Kim YH

更新日期：2009-03-01 00:00:00

abstract：:7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and concentrative forms. Therefore, the objective of this study was to...

journal_title：Free radical research

authors： Janmale TV,Lindsay A,Gieseg SP

更新日期：2020-05-01 00:00:00