Abstract:
:The hydroxyl radical (.OH)-scavenging activity of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a novel nonsteroidal anti-inflammatory drug (NSAID), and that of several other NSAIDs were investigated by the hyaluronic acid (HA) degradation method and the electron spin resonance (ESR) spin-trapping technique. The superoxide anion (.O2-)-scavenging activity of M-5011 was also measured by the ESR technique. (1) M-5011 and the other NSAIDs examined inhibited the degradation of HA induced by the Fenton reaction system in a dose-dependent manner. (2) M-5011 and the other NSAIDs scavenged .OH directly in a dose-dependent manner. (3) M-5011 was the most potent drug among the NSAIDs tested regarding the scavenging activity of .OH as follows; M-5011 > indomethacin > ketoprofen = suprofen > aspirin. The .OH-scavenging activity of M-5011 was potent in comparison with that of oxidized glutathione (GSSG), an endogenous .OH scavenger. (4) M-5011 did not scavenge .O2-; nor did GSSG. These results suggest that M-5011 acts as a scavenger of .OH at sites with inflammatory lesions.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Kataoka M,Tonooka K,Ando T,Imai K,Aimoto Tdoi
10.3109/10715769709065781subject
Has Abstractpub_date
1997-10-01 00:00:00pages
419-27issue
4eissn
1071-5762issn
1029-2470journal_volume
27pub_type
杂志文章abstract::The bioactive flavonoid baicalein has been shown to have radioprotective activity, although the molecular mechanism is poorly understood in vivo. C57BL/6 mice were irradiated with X-rays (15 Gy) with and without baicalein treatment (5 mg/kg/day). Irradiation groups showed an increase of NF-κB-mediated inflammatory fac...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2011.555479
更新日期:2011-05-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Radioresistance is a significant obstacle in NSCLC radiotherapy. Long non-coding RNA LINC00473 has been found to impact the radiotherapy in several malignant tumours. This study aimed to investigate the underlying role and mechanism of LINC0047...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1841900
更新日期:2020-10-01 00:00:00
abstract::Silibinin is an active constituent extracted from blessed milk thistle (Silybum marianum). Our previous study demonstrated that silibinin induced autophagy and apoptosis via reactive oxygen species (ROS) generation in HeLa cells. In this study, we investigated whether the autophagy- and apoptosis-associated molecules ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.655244
更新日期:2012-03-01 00:00:00
abstract::Ascorbic acid (vitamin C) induced hydrogen peroxide (H(2)O(2)) formation was measured in household drinking water and metal supplemented Milli-Q water by using the FOX assay. Here we show that ascorbic acid readily induces H(2)O(2) formation in Cu(II) supplemented Milli-Q water and poorly buffered household drinking w...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760500249861
更新日期:2005-11-01 00:00:00
abstract::p38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress. The most abundant family member is p38α, which helps to couple cell proliferation and growth in response to ce...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2013.821200
更新日期:2013-11-01 00:00:00
abstract::Diosgenin possesses anti-inflammatory and anticancer properties. Activated neutrophils produce high concentrations of the superoxide anion which is involved in the pathophysiology of inflammation-related diseases and cancer. In the present study, the inhibitory effect and possible mechanisms of diosgenin on superoxide...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.966705
更新日期:2014-12-01 00:00:00
abstract::Oxidative stress is suggested as a potential mechanism in impaired foetal growth, smaller birth size and thus subsequently adult chronic diseases. We have investigated associations between oxidative stress in pregnancy and birth anthropometry (weight, height, head and chest circumferences). In the MINIMat-trial (Mater...
journal_title:Free radical research
pub_type: 临床试验,杂志文章
doi:10.3109/10715762.2011.651467
更新日期:2012-03-01 00:00:00
abstract::Recent findings have suggested that oxidative damage might contribute to the cytotoxicity and carcinogenicity of aflatoxin B1 (AFB1). Salvia miltiorrhiza (Sm), a herbal plant that has been used extensively in traditional Chinese medicine for treating cardiovascular and liver diseases, is believed to have some antioxid...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900301131
更新日期:1999-12-01 00:00:00
abstract::S-Nitrosation plays an important role in regulation of protein function and signal transduction. Discovering S-nitrosated targets is a prerequisite for further functional study. However, current proteomic methods used to quantify S-nitrosation are limited in their applicability to certain types of samples, or by the n...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.684244
更新日期:2012-08-01 00:00:00
abstract::α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760310001600426
更新日期:2003-01-01 00:00:00
abstract::Cystine, an oxidized form of cysteine (Cys), is imported into cells via the protein xCT, which is also associated with the export of glutamate as the counter amino acid. In the current study, we attempted to rationalize roles of xCT in the livers of male mice. While xCT was not expressed in the livers of ordinary mice...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1282157
更新日期:2017-01-01 00:00:00
abstract::We studied the effects of a single post whole-body low-dose irradiation (50 cGy of gamma-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, g...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760000300221
更新日期:2000-03-01 00:00:00
abstract::Tumour necrosis factor alpha (TNF alpha) cytotoxicity is mediated, at least in part, by oxidative stress and phospholipase A2 activation. The first post-receptor events to be observed in TNF alpha-sensitive lines are the generation of superoxide anion (O2-) within the mitochondria and the activation of phospholipase A...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609149917
更新日期:1996-08-01 00:00:00
abstract:RATIONALE:The oxidative state has been implicated in the signaling of various vasomotor functions, yet its role regarding the vasomotor action of insulin is less known. OBJECTIVE:To investigate the insulin-evoked relaxations of consecutive arterial segments of different oxidative state and the role of extracellular si...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.904507
更新日期:2014-07-01 00:00:00
abstract::Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to the airflow limitations and airway hyperresponsiveness (AHR). The involvement of oxidative stress in this process is well-established, but the specific role of the superoxide anion...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1364377
更新日期:2017-07-01 00:00:00
abstract::Rat granulosa cells (GCs) were treated with human chorionic gonadotropin (hCG), 8-bromo-adenosine 3',5'-cyclic monophosphate (8-Br-cAMP), forskolin, phorbol 12-myristate 13-acetate (PMA), A23187 or pregnenolone in the absence or presence of hydrogen peroxide (H(2)O(2)). Different doses of trilostane were applied to GC...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.669835
更新日期:2012-06-01 00:00:00
abstract::The risk of chronic oxidative stress in the retinal pigment epithelium (RPE) increases with age due to accumulation of the photoreactive age pigment lipofuscin (LFG). Here, we asked whether sublethal and weakly lethal photic stress, induced by irradiation of ARPE-19 cells containing phagocytised LFG, affected the cell...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1380307
更新日期:2017-10-01 00:00:00
abstract::The risk of developing breast cancer increases after long term use of oestrogen and progestagen, and carcinogenesis in the breast is partly due to oxidative damage to DNA bases. Therefore, we studied the effects of 17 beta-oestradiol and progesterone on the antioxidative status and the vulnerability to oxidative stres...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769809069276
更新日期:1998-03-01 00:00:00
abstract::Approaching living systems, aqueous solutions are appropriate to characterize antioxidants, whereas the frequently used standard 1,1-diphenyl-2-picrylhydrazyl (DPPH) is insoluble in water. Therefore, mixed water-ethanol solvents were investigated using the electron paramagnetic resonance (EPR) spectroscopy. Two forms ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760600930014
更新日期:2007-04-01 00:00:00
abstract::A growing body of experimental evidence suggests that the oxidative neurotoxicity of hemoglobin A may contribute to neuronal loss after CNS hemorrhage. Several hemoglobin variants, including hemoglobin S, are more potent oxidants in cell-free systems. However, despite the increased incidence of hemorrhagic stroke asso...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760310001638010
更新日期:2004-05-01 00:00:00
abstract::Nitronyl nitroxides (NNs) are the paramagnetic probes that are capable of scavenging physiologically relevant reactive oxygen (ROS) and nitrogen (RNS) species, namely superoxide, nitric oxide (NO), and nitroxyl (HNO). NNs are increasingly considered as potent antioxidants and potential therapeutic agents. Understandin...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2015.1013951
更新日期:2015-01-01 00:00:00
abstract::Expression of multiple drug resistant (MDR) phenotype and over-expression of P-glycoprotein (P-gp) in the human hepatocellular carcinoma (HCC) cell clone P1(0.5), derived from the PLC/PRF/5 cell line (P5), are associated with strong resistance to oxidative stress and a significant (p < 0.01) increase in intracellular ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760410001705140
更新日期:2004-07-01 00:00:00
abstract::Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O(2)(•-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O(2)(•-) determinants in this population. O(2)(•-) production was evaluated using chemi...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2011.574291
更新日期:2011-06-01 00:00:00
abstract::We tested the hypothesis that hypertension associated with polycythemia vera (PV) may be related to hemoglobin released from erythrocytes (cell-free hemoglobin, fHb). We assessed hematocrit, mean arterial pressure (MAP), blood viscosity, and the level of fHb and nitrite/nitrate (NOx) in the plasma of 73 PV patients an...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2013.860225
更新日期:2014-02-01 00:00:00
abstract::The aim of this study was to investigate the effect of HDL oxidation on PON1 paraoxonase activity. Also, we were interested in investigating the mechanism by which PON1 could be inactivated and the correlation between its enzymatic activity and the antioxidant properties of HDL. Three different oxidation systems were ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576021000036614
更新日期:2003-01-01 00:00:00
abstract::Radicals from one-electron oxidation of 4-hydroxycinnamate, ferulate and 3,4-dihydroxycinnamate have been formed by reaction with the oxidising triplet state of duroquinone. All three compounds react with triplet duroquinone with second order rate constants close to the diffusion-controlled limit. The identity of the ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300621
更新日期:2001-07-01 00:00:00
abstract::Oxidative stress is a major pathogenetic event occurring in several liver disorders and is a major cause of liver damage due to Ischemia/Reperfusion (I/R) during liver transplantation. While several markers of chronic oxidative stress are well known, early protein targets of oxidative injury are not well defined. In o...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760400029603
更新日期:2005-03-01 00:00:00
abstract::Amphotericin B has been the gold standard for the treatment of invasive mycosis for many years. Its resistance mechanisms are reported to be mainly related to the decrease of ergosterol content or the changes of cell wall. Previous study has shown that Saccharomyces cerevisiae strain lack of BSC2 was sensitive signifi...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1751151
更新日期:2020-04-01 00:00:00
abstract::Myeloperoxidase (MPO), a major constituent of neutrophils, catalyzes the production of hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride anion. We have previously reported that MPO-deficient (MPO(-/-)) neutrophils produce greater amount of macrophage inflammatory protein-2 (MIP-2) in vitro than do wi...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2013.778990
更新日期:2013-05-01 00:00:00
abstract::Degenerative diseases such as cancer are induced by oxidative genetic damage. Antioxidants can scavenge reactive oxygen species, but to prevent disease, they must do so quickly, before the DNA bases are damaged. In the present study, a novel method was established for evaluating the potency of antioxidants employing 2...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760290019336
更新日期:2002-03-01 00:00:00