Singlet oxygen quenching and radical scavenging capacities of structurally-related flavonoids present in Zuccagnia punctata Cav.

abstract：:The intestinal tract, known for its capability for self-renew, represents the first barrier of defence between the organism and its luminal environment. The thiol/disulfide redox systems comprising the glutathione/glutathione disulfide (GSH/GSSG), cysteine/cystine (Cys/CySS) and reduced and oxidized thioredoxin (Trx/T...

journal_title：Free radical research

authors： Circu ML,Aw TY

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:The oxidative state has been implicated in the signaling of various vasomotor functions, yet its role regarding the vasomotor action of insulin is less known. OBJECTIVE:To investigate the insulin-evoked relaxations of consecutive arterial segments of different oxidative state and the role of extracellular si...

journal_title：Free radical research

authors： Szijártó IA,Molnár GA,Mikolás E,Fisi V,Laczy B,Gollasch M,Koller A,Wittmann I

更新日期：2014-07-01 00:00:00

abstract：:In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...

journal_title：Free radical research

authors： Chainy GBN,Sahoo DK

更新日期：2020-01-01 00:00:00

abstract：:Oxidative reactions are thought to play a role in the inflammatory condition called fatty liver. It is unclear whether oxidized lipoprotein lipids or proteins are associated with future fatty liver. In the Cardiovascular Risk in Young Finns Study, we determined the circulating levels of LDL and HDL oxidized lipids and...

journal_title：Free radical research

authors： Kaikkonen JE,Kresanov P,Ahotupa M,Jula A,Mikkilä V,Viikari JS,Juonala M,Hutri-Kähönen N,Kähönen M,Lehtimäki T,Kangas AJ,Soininen P,Ala-Korpela M,Raitakari OT

更新日期：2016-01-01 00:00:00

abstract：:The hydroxyl radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO) and 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) formed in the presence of hydrogen peroxide and FeII are normally quite stable, but in the presence of 5-20 micromolar myoglobin their ESR signals decay rapidly. This decay probably reflects furth...

journal_title：Free radical research

authors： De Bono D,Yang WD,Symons MC

更新日期：1994-05-01 00:00:00

abstract：:Oxidative DNA modification has been implicated in development of certain cancers and 8-oxodG, the most abundant and mutagenic DNA modification, has for some time been considered a biomarker of this activity. Urinary excretion of 8-oxodG over 24h has been used to estimate the rate of damage to DNA, and animal studies h...

journal_title：Free radical research

authors： Poulsen HE,Loft S,Prieme H,Vistisen K,Lykkesfeldt J,Nyyssonen K,Salonen JT

更新日期：1998-12-01 00:00:00

abstract：:Glycation of proteins or other biomolecules and their further long-term degradation result in the formation of advanced glycation end products, AGEs. AGEs and other ligands interact with their receptors, RAGEs, localized to a variety of tissues, but mainly in endothelium and vascular wall cells. This interaction trigg...

journal_title：Free radical research

authors： Guedes-Martins L,Matos L,Soares A,Silva E,Almeida H

更新日期：2013-08-01 00:00:00

abstract：:Intake of antioxidants from the diet has been recognized to have beneficial health effects, but the potential benefit of taking antioxidants such as β-carotene as supplements is controversial. The aim of the present study was to evaluate the potential protective effects of a physiologically relevant concentration (2 μ...

journal_title：Free radical research

authors： Åsgård R,Hellman B

更新日期：2013-09-01 00:00:00

abstract：:Gamma-glutamylcysteine synthetase (GCS; also referred to as glutamate-cysteine ligase, GLCL) catalyzes the rate-limiting reaction in glutathione (GSH) biosynthesis. The GCS holoenzyme is composed of a catalytic and regulatory subunit, each encoded by a unique gene. In addition to some conditions which specifically upr...

journal_title：Free radical research

authors： Wild AC,Mulcahy RT

更新日期：2000-04-01 00:00:00

abstract：:The radiation-induced reactions of a water-soluble coumarin derivative, coumarin-3-carboxyl acid (C3CA), have been investigated in aqueous solutions by pulse radiolysis with a 35 MeV electron beam, final product analysis following (60)Co γ-irradiations and deterministic model simulations. Pulse radiolysis revealed tha...

journal_title：Free radical research

authors： Yamashita S,Baldacchino G,Maeyama T,Taguchi M,Muroya Y,Lin M,Kimura A,Murakami T,Katsumura Y

更新日期：2012-07-01 00:00:00

abstract：:Silibinin is an active constituent extracted from blessed milk thistle (Silybum marianum). Our previous study demonstrated that silibinin induced autophagy and apoptosis via reactive oxygen species (ROS) generation in HeLa cells. In this study, we investigated whether the autophagy- and apoptosis-associated molecules ...

journal_title：Free radical research

authors： Fan S,Qi M,Yu Y,Li L,Yao G,Tashiro S,Onodera S,Ikejima T

更新日期：2012-03-01 00:00:00

abstract：:Anxiety disorders are the most common mental illness in the USA affecting 18% of the population. The cause(s) of anxiety disorders is/are not completely clear, and research in the neurobiology of anxiety at the molecular level is still rather limited. Although mounting clinical and preclinical evidence now indicates t...

journal_title：Free radical research

authors： Fedoce ADG,Ferreira F,Bota RG,Bonet-Costa V,Sun PY,Davies KJA

更新日期：2018-07-01 00:00:00

abstract：:A study of peroxyl radical-mediated bovine serum albumin oxidation in the presence of the quinolinic aminoxyl 1,2-dihydro-2,2-diphenyl-4-ethoxy-quinoline-1-oxyl (QAO) was carried out in order to test its efficiency as a protein antioxidant. Albumin oxidation was induced by the tert-butylhydroperoxide/PbO2 system. The ...

journal_title：Free radical research

authors： Tanfani F,Carloni P,Damiani E,Greci L,Wozniak M,Kulawiak D,Jankowski K,Kaczor J,Matuszkiewics A

更新日期：1994-10-01 00:00:00

abstract：:The mechanism of high-grade serous ovarian cancer (HGSC) development remains elusive. This review outlines recent advances in the understanding of sequential molecular changes associated with the development of HGSC, as well as describes oxidative stress-induced genomic instability and carcinogenesis. This article rev...

journal_title：Free radical research

authors： Kobayashi H,Ogawa K,Kawahara N,Iwai K,Niiro E,Morioka S,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:The effect of antioxidants on ammonia induced CNS and renal pathobiology in 10 sheep infested by L. Cuprina larvae was investigated. The condition produces severe dermatitis, proliferation of macrophages and hyperammonaemia, and free radicals may therefore be involved in the pathogenesis. Five of the sheep (treated gr...

journal_title：Free radical research

authors： Guerrini VH

更新日期：1994-07-01 00:00:00

abstract：:Methylmercury (MeHg) is one of the ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. However, the mechanisms of MeHg-induced neuronal cell death are incompletely understood. Treatment of neuronal cells with MeHg (0-2 μM) for 0.5-12 h, or pretreated with LA (12.5-...

journal_title：Free radical research

authors： Yang T,Xu Z,Liu W,Xu B,Deng Y

更新日期：2016-01-01 00:00:00

abstract：:Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O(2)(•-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O(2)(•-) determinants in this population. O(2)(•-) production was evaluated using chemi...

journal_title：Free radical research

authors： Morena M,Patrier L,Jaussent I,Bargnoux AS,Dupuy AM,Badiou S,Leray-Moragues H,Klouche K,Canaud B,Cristol JP

更新日期：2011-06-01 00:00:00

abstract：:This work describes the synthesis and characterisation of some novel hybrid molecules which contains in the same molecule a free radical moiety of hydrazyl type and a spin-trap moiety of nitrone type. The new compounds synthesized have multiple and easy to follow spectroscopic properties, making them useful as sensors...

journal_title：Free radical research

authors： Ionita P

更新日期：2006-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are involved in the mechanism of photoaging and carcinogenesis. Skin is endowed with antioxidant enzymes including superoxide dismutases (SOD): cytosolic copper zinc SOD and mitochondrial manganese SOD. The aim of our study was to estimate the protective effect of manganese against oxidat...

journal_title：Free radical research

authors： Parat MO,Richard MJ,Leccia MT,Amblard P,Favier A,Beani JC

更新日期：1995-10-01 00:00:00

abstract：:The capacity of non-illuminated nephrotoxin orellanine ([2,2'-bipyridine]-3,3',4,4'-tetrol-1,1'-dioxide) to induce DNA damage in the presence of ferrous iron and dioxygen has been evaluated. Maximal single-strand breaks in plasmid DNA were obtained with a metal to ligand ratio 1:3. Instantaneous oxidation of Fe2+ in p...

journal_title：Free radical research

authors： Cantin-Esnault D,Oubrahim H,Richard JM

更新日期：2000-08-01 00:00:00

abstract：:The concentration of taurine is high in the lens. However, its function therein remains unknown. Studies from other tissues suggest that in addition to several other modes of action, it acts as an antioxidant. We therefore hypothesize that taurine may be a part of the antioxidant defense mechanisms involved in protect...

journal_title：Free radical research

authors： Devamanoharan PS,Ali AH,Varma SD

更新日期：1998-09-01 00:00:00

abstract：:The risk of developing breast cancer increases after long term use of oestrogen and progestagen, and carcinogenesis in the breast is partly due to oxidative damage to DNA bases. Therefore, we studied the effects of 17 beta-oestradiol and progesterone on the antioxidative status and the vulnerability to oxidative stres...

journal_title：Free radical research

authors： Dabrosin C,Hammar M,Ollinger K

更新日期：1998-03-01 00:00:00

abstract：:The aim of the study was to investigate whether there is transmembrane transport of intact glutathione ([3H]-GSH, 0.1 microCi) in rat and human type II pneumocytes (T2P), and if this transport might be dependent on the redox state of the extracellular fluid. The T2P were pretreated with acivicin (250 microM) to inhibi...

journal_title：Free radical research

authors： van Klaveren RJ,Hoet PH,Demedts M,Nemery B

更新日期：1999-05-01 00:00:00

abstract：:The imbalance between the reactive oxygen (ROS) and nitrogen (RNS) species production and their handling by the antioxidant machinery (low molecular weight antioxidant molecules and antioxidant enzymes), also known as oxidative stress, is a condition caused by physiological and pathological processes. Moreover, oxidat...

journal_title：Free radical research

authors： Gorini G,Gamberi T,Fiaschi T,Mannelli M,Modesti A,Magherini F

更新日期：2019-02-01 00:00:00

abstract：:Oxidative stress is associated with a range of inflammatory lung diseases including asthma, adult respiratory distress syndrome, idiopathic pulmonary fibrosis, pneumonia, lung transplantation, chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis and lung cancer. Increased concentrations of reactive o...

journal_title：Free radical research

authors： Rahman I,Kelly F

更新日期：2003-12-01 00:00:00

abstract：:Amphotericin B has been the gold standard for the treatment of invasive mycosis for many years. Its resistance mechanisms are reported to be mainly related to the decrease of ergosterol content or the changes of cell wall. Previous study has shown that Saccharomyces cerevisiae strain lack of BSC2 was sensitive signifi...

journal_title：Free radical research

authors： Kong Y,Wang Q,Cao F,Zhang X,Fang Z,Shi P,Wang H,Shen Y,Huang Z

更新日期：2020-04-01 00:00:00

abstract：:Cardiolipin (CL) is a mitochondria-specific phospholipid and is critical for maintaining the integrity of mitochondrial membrane and mitochondrial function. CL also plays an active role in mitochondria-dependent apoptosis by interacting with cytochrome c (cyt c), tBid and other important Bcl-2 proteins. The unique str...

journal_title：Free radical research

authors： Yin H,Zhu M

更新日期：2012-08-01 00:00:00

abstract：:The oxidized intermediates generated upon exposure of Aspergillus niger catalase to hydrogen peroxide and superoxide radical fluxes were examined with UV-visible spectrophotometry. Hydrogen peroxide and superoxide radical were generated by means of glucose/glucose oxidase and xanthine/xanthine oxidase systems. Serial ...

journal_title：Free radical research

authors： Lardinois OM,Rouxhet PG

更新日期：1994-01-01 00:00:00

abstract：:A soluble protein from Saccharomyces cerevisiae acts as a peroxidase but requires a NADPH-dependent thioredoxin system and was named thioredoxin peroxidase (TPx). The role of TPx in aging of stationary cultures of S. cerevisiae was investigated in a wild-type strain and a mutant yeast strain in which the tsa gene that...

journal_title：Free radical research

authors： Lee JH,Park JW

更新日期：2004-03-01 00:00:00

abstract：:The present study was designed to determine whether hydroxymethylglutaryl-CoA reductase inhibitors (statins) modulate the NO production via iNOS in adipocytes stimulated by lipopolysaccharide (L) and tumour necrosis factor-alpha (T). Well-differentiated 3T3-L1 adipocytes significantly produced NO by LT-treatment. Pre-...

journal_title：Free radical research

authors： Araki S,Dobashi K,Asayama K,Shirahata A

更新日期：2007-09-01 00:00:00