解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::India, resembling other developing nations, is confronting a hastening demographic switch to non-communicable diseases. Inborn errors of metabolism (IEM) constitute a varied heterogeneous group of disorders with variable clinical appearance, primarily in the pediatric populace. Congenital deformities and genetic disor...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2021.1877286
更新日期:2021-01-27 00:00:00
abstract::Cholesterol is an essential component of mammalian plasma membrane. Alterations in sterol metabolism or oxidation have been linked to various pathological conditions, including cardiovascular diseases, cancer, and neurodegenerative disorders. Unsaturated sterols are vulnerable to oxidation induced by singlet oxygen an...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2021.1879387
更新日期:2021-01-26 00:00:00
abstract::Silver nanoparticles (AgNPs) are the most widely used nanomaterials as antimicrobial agents. AgNPs have been shown to inhibit the growth of and induce apoptosis-like death in Escherichia coli. However, the precise mechanism of AgNPs-induced apoptosis-like death and association with DNA damage-inducible protein F (dinF...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1866178
更新日期:2021-01-06 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Radioresistance is a significant obstacle in NSCLC radiotherapy. Long non-coding RNA LINC00473 has been found to impact the radiotherapy in several malignant tumours. This study aimed to investigate the underlying role and mechanism of LINC0047...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1841900
更新日期:2020-10-01 00:00:00
abstract::The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1791843
更新日期:2020-07-28 00:00:00
abstract::7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and concentrative forms. Therefore, the objective of this study was to...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1764948
更新日期:2020-05-01 00:00:00
abstract::The ubiquitin-proteasome system (UPS) and autophagy are two major intracellular proteolytic systems that are closely associated with each other. Because UPS and autophagy are involved in the clearance of oxidised and/or aggregated proteins, it would be logical to assume that alterations in proteolysis would accompany ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1734588
更新日期:2020-04-20 00:00:00
abstract::8-Oxoguanine (8-oxoG) is the most common DNA base modification in the mammalian genome, associated with oxidative stress. Here we analysed the alterations in the distribution of 8-oxoG across the entire murine genome, before and after an elevation of oxidative stress by the use of ferric nitrilotriacetate (Fe-NTA) as ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1733548
更新日期:2020-04-16 00:00:00
abstract::Amphotericin B has been the gold standard for the treatment of invasive mycosis for many years. Its resistance mechanisms are reported to be mainly related to the decrease of ergosterol content or the changes of cell wall. Previous study has shown that Saccharomyces cerevisiae strain lack of BSC2 was sensitive signifi...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1751151
更新日期:2020-04-01 00:00:00
abstract::Exposure to asbestos fiber is central to mesothelial carcinogenesis. Recent sequencing studies on human and rodent malignant mesothelioma (MM) revealed frequently mutated genes, including CDKN2A, BAP1 and NF2. Crocidolite directly or indirectly catalyses the generation of hydroxyl radicals, which appears to be the maj...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1743285
更新日期:2020-03-01 00:00:00
abstract::In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2019.1702656
更新日期:2020-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a lung disease caused by an inflammatory response to various inhaled toxins, especially cigarette smoke. Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histo...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1696965
更新日期:2019-12-06 00:00:00
abstract::Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS)...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1677902
更新日期:2019-12-01 00:00:00
abstract::Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were develop...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1683171
更新日期:2019-12-01 00:00:00
abstract::Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a systemic inflammatory response, resulting in proinflammatory cells recruitm...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1668936
更新日期:2019-10-01 00:00:00
abstract::Peroxiredoxin 1 (PRDX1) is an antioxidant enzyme that, when secreted, can act as a proinflammatory signal. Here we studied the regulation of intracellular PRDX1 by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) in the RAW 264.7 mouse macrophage cell line. While LPS or IFN-γ alone did not affect PRDX1 protein le...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1637863
更新日期:2019-08-01 00:00:00
abstract::Cerebrovascular diseases (CBD) are one of the most dangerous complications of atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the prognosis of patients. Atherosclerosis is the main cause of CBD development. Hypertension, dyslipidemia, diabetes, smoking, obesity, and other risk facto...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2019.1620939
更新日期:2019-06-01 00:00:00
abstract::Although the primary biological function of retinal photoreceptors is to absorb light and provide visual information, extensive exposure to intense light could increase the risk of phototoxic reactions mediated by products of rhodopsin bleaching that might accumulate in photoreceptor outer segments (POS). The phototox...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1603377
更新日期:2019-04-01 00:00:00
abstract::Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A total of 407 participants chronically exposed to arsenic via drinking water from ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1595613
更新日期:2019-04-01 00:00:00
abstract::In addition to insulin, glycemic control involves thyroid hormones. However, an excess of thyroid hormone can disturb the blood glucose equilibrium, leading to alterations of carbohydrate metabolism and, eventually, diabetes. Indeed, experimental and clinical hyperthyroidism is often accompanied by abnormal glucose to...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2019.1590567
更新日期:2019-03-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, t...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1572888
更新日期:2019-03-01 00:00:00
abstract::The imbalance between the reactive oxygen (ROS) and nitrogen (RNS) species production and their handling by the antioxidant machinery (low molecular weight antioxidant molecules and antioxidant enzymes), also known as oxidative stress, is a condition caused by physiological and pathological processes. Moreover, oxidat...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2018.1542141
更新日期:2019-02-01 00:00:00
abstract::Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1548767
更新日期:2019-01-01 00:00:00
abstract::Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCCL) and elevates [Ca2+]i in many cells. However, how oxidative stress activates VDCCL under clinical setting and the consequenc...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1556394
更新日期:2019-01-01 00:00:00
abstract::Phospholipids (PLs) are important biomolecules that not only constitute structural building blocks and scaffolds of cell and organelle membranes but also play a vital role in cell biochemistry and physiology. Moreover, dietary exogenous PLs are characterised by high nutritional value and other beneficial health effect...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2019.1657573
更新日期:2019-01-01 00:00:00
abstract::Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1460749
更新日期:2018-12-01 00:00:00
abstract::Iron or oxygen regulates the stability of hypoxia inducible factor-1α (HIF-1α). We investigated whether ferrous glycinate would affect HIF-1α accumulation, aerobic glycolysis and mitochondrial energy metabolism in human A549 lung cancer cells. Incubation of A549 cells with ferrous glycinate decreased the protein level...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1476691
更新日期:2018-12-01 00:00:00
abstract::Multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive metabolic disorder of fatty acid metabolism, is mostly caused by mutations in the ETFA, ETFB or ETFDH genes that result in dysfunctions in electron transfer flavoprotein (ETF) or electron transfer flavoprotein-ubiquinone dehydrogenase (ETFDH). I...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1500695
更新日期:2018-12-01 00:00:00
abstract::It has been reported that haem oxygenase-1 (Hmox1) induction attenuates neointimal thickening. Here we further investigated the potential mechanisms regulating this important pathological process. We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this in...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1524578
更新日期:2018-10-01 00:00:00
abstract::G72 has been characterised as a susceptibility gene that can have wide-ranging effects in a number of neurodegenerative diseases, including schizophrenia and major depression. Indeed, its product, pLG72, is a potential serum biomarker for schizophrenia. Previous transcriptomic and biochemical studies have indicated th...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1504293
更新日期:2018-09-01 00:00:00
abstract::Autophagy modulation is a potential therapeutic strategy for breast cancer, and a previous study indicated that metformin exhibits significant anti-carcinogenic activity. However, the ability of metformin to induce autophagy and its role in breast cancer cell death remains unclear. In this study, we exposed MCF-7 cell...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1485075
更新日期:2018-08-01 00:00:00
abstract::Anxiety disorders are the most common mental illness in the USA affecting 18% of the population. The cause(s) of anxiety disorders is/are not completely clear, and research in the neurobiology of anxiety at the molecular level is still rather limited. Although mounting clinical and preclinical evidence now indicates t...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2018.1475733
更新日期:2018-07-01 00:00:00
abstract::Over the last decade, a dual character of cell response to oxidative stress, eustress versus distress, has become increasingly recognized. A growing body of evidence indicates that under physiological conditions, low concentrations of reactive oxygen and nitrogen species (RONS) maintained by the activity of endogenous...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2018.1457217
更新日期:2018-05-01 00:00:00
abstract::Reactive oxygen species (ROS) are important mediators of the cytotoxicity induced by the direct reaction of ionising radiation (IR) with all critical cellular components, such as proteins, lipids, and nucleic acids. The derived oxidative damage may propagate in exposed tissues in a dose- and spatiotemporal dependent m...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1446529
更新日期:2018-04-01 00:00:00
abstract::Hepatic sinusoidal obstruction syndrome (HSOS) is a rare and life-threatening liver disease. (+)-Catechin is a natural dietary flavonol with high antioxidant capacity. This study aims to investigate the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signalling pathway in the protection o...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1437914
更新日期:2018-04-01 00:00:00
abstract::An iodoacetamide azaadamantyl spin label was studied in fluid solution and in 9:1 trehalose:sucrose glass. In 9:1 toluene:CH2Cl2 solution at 293 K, the isotropic nitrogen hyperfine coupling is 19.2 G, T1 is 0.37 µs and T2 is 0.30-0.35 µs. Between about 80 and 150 K 1/Tm in 9:1 trehalose:sucrose is approximately indepe...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1384954
更新日期:2018-03-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutella...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1422602
更新日期:2018-02-01 00:00:00
abstract::Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1418982
更新日期:2018-01-01 00:00:00
abstract::The brain is highly susceptible to oxidative stress due to its high metabolic demand. Increased oxidative stress and depletion of glutathione (GSH) are observed with aging and many neurological diseases. Exercise training has the potential to reduce oxidative stress in the brain. In this study, nine healthy sedentary ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1411594
更新日期:2018-01-01 00:00:00
abstract::Cellular exposure to ionising radiation leads to oxidative stress events, which refer to elevated intracellular levels of reactive oxygen species (ROS). The elevated levels of ROS significantly contributed to γ-radiation (IR) induced cytotoxicity. In an attempt to minimise these cytotoxic effects, antioxidant compound...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1395025
更新日期:2017-12-01 00:00:00