Vitamin E-coated filter decreases levels of free 4-hydroxyl-2-nonenal during haemodialysis sessions.

abstract：:α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein...

journal_title：Free radical research

authors： Misaki K,Takitani K,Ogihara T,Inoue A,Kawakami C,Kuno T,Kawamura N,Miyake M,Nakagawa T,Tamai H

更新日期：2003-01-01 00:00:00

abstract：:Oxidative stress appears to be implicated in the pathogenesis of various diseases including hepatotoxicity. Although intracellular Ca2+ signals have been suggested to play a role in the oxidative damage of hepatocytes, the sources and effects of oxidant-induced intracellular Ca2+ increases are currently debatable. Thu...

journal_title：Free radical research

authors： Kim JA,Kang YS,Lee SH,Lee YS

更新日期：2000-09-01 00:00:00

abstract：:The capacity of non-illuminated nephrotoxin orellanine ([2,2'-bipyridine]-3,3',4,4'-tetrol-1,1'-dioxide) to induce DNA damage in the presence of ferrous iron and dioxygen has been evaluated. Maximal single-strand breaks in plasmid DNA were obtained with a metal to ligand ratio 1:3. Instantaneous oxidation of Fe2+ in p...

journal_title：Free radical research

authors： Cantin-Esnault D,Oubrahim H,Richard JM

更新日期：2000-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) released from polymorphonuclear leukocytes and macrophages could cause DNA damage, but also induce cell death. Therefore inhibition of cell death must be an important issue for accumulation of genetic changes in lymphoid cells in inflammatory foci. Scavengers in the post culture medium of...

journal_title：Free radical research

authors： Miwa H,Fujii J,Kanno H,Taniguchi N,Aozasa K

更新日期：2000-07-01 00:00:00

abstract：:Methylmercury (MeHg) is one of the ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. However, the mechanisms of MeHg-induced neuronal cell death are incompletely understood. Treatment of neuronal cells with MeHg (0-2 μM) for 0.5-12 h, or pretreated with LA (12.5-...

journal_title：Free radical research

authors： Yang T,Xu Z,Liu W,Xu B,Deng Y

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Aspiration pneumonia is infection of the respiratory tract resulting from accumulation of sputum in the larynx. N-acetyl-L-cysteine (NAC) might regulate mucin (MUC) expression and activate inherent anti-infective system in bronchiolar epithelial cells after cellular uptake, and therefore, serve as the preventat...

journal_title：Free radical research

authors： Koizumi C,Yamada M,Ishizaki K,Ueda T,Sakurai K

更新日期：2015-01-01 00:00:00

abstract：:Copper Fenton systems (Cu(II)/H2O2 and Cu(II)/Asc) inactivated the lipoamide reductase and enhanced the diaphorase activity of pig-heart lipoamide dehydrogenase (LADH). Cupric ions alone were less effective. As a result of Cu(II)/H2O2 treatment, the number of titrated thiols in LADH decreased from 6 to 1 per subunit. ...

journal_title：Free radical research

authors： Gutierrez-Correa J,Stoppani AO

更新日期：1995-03-01 00:00:00

abstract：:Hemopexin, a heme-binding serum glycoprotein, is thought to play an important role in the prevention of oxidative damage that may be catalysed by free heme. Through the use of EPR techniques, the generation of free radicals from organic hydroperoxides by heme and heme-hemopexin complexes, and the concomitant formation...

journal_title：Free radical research

authors： Timmins GS,Davies MJ,Song DX,Muller-Eberhard U

更新日期：1995-12-01 00:00:00

abstract：:An involvement of oxidative stress (OS) was found in recent studies of Sjøgren's syndrome (SS) that reported significant changes in protein oxidation, myeloperoxidase activity, TNF-α, nitrotyrosine, and GSH levels in plasma from SS patients. Excess levels of OS markers, as oxidative DNA damage and propanoyl-lysine, we...

journal_title：Free radical research

authors： Pagano G,Castello G,Pallardó FV

更新日期：2013-02-01 00:00:00

abstract：:In this study, three rapid assay techniques for the determination of glutathione, one enzymatic, one fluorometric and one newly patented colorimetric method, were compared by measuring reduced (GSH) and oxidized (GSSG) glutathione in guinea-pig heart and liver. The HPLC technique was used as a standard, since it is co...

journal_title：Free radical research

authors： Floreani M,Petrone M,Debetto P,Palatini P

更新日期：1997-05-01 00:00:00

abstract：:Pyruvate is a well-known scavenger of hydrogen peroxide (H2O2). In addition, it scavenges superoxide radical (O2.-). However, evidence on its intracellular antioxidant function is meager at present. Hence, we have examined the effectiveness of this metabolite and its ethyl ester against intracellular oxidative damage ...

journal_title：Free radical research

authors： Varma SD,Devamanoharan PS,Ali AH

更新日期：1998-02-01 00:00:00

abstract：:A soluble protein from Saccharomyces cerevisiae acts as a peroxidase but requires a NADPH-dependent thioredoxin system and was named thioredoxin peroxidase (TPx). The role of TPx in aging of stationary cultures of S. cerevisiae was investigated in a wild-type strain and a mutant yeast strain in which the tsa gene that...

journal_title：Free radical research

authors： Lee JH,Park JW

更新日期：2004-03-01 00:00:00

abstract：:The production of microRNAs (miRNA) is influenced by various stimuli, including environmental stresses. We hypothesized that reactive oxygen species (ROS)-associated stress could regulate macrophage miRNA synthesis. miRNAs undergo unique steps of maturation processing through either one of two pathways of cytoplasmic ...

journal_title：Free radical research

authors： Ranjan R,Lee YG,Karpurapu M,Syed MA,Chung S,Deng J,Jeong JJ,Zhao G,Xiao L,Sadikot RT,Weiss MJ,Christman JW,Park GY

更新日期：2015-01-01 00:00:00

abstract：:An iodoacetamide azaadamantyl spin label was studied in fluid solution and in 9:1 trehalose:sucrose glass. In 9:1 toluene:CH2Cl2 solution at 293 K, the isotropic nitrogen hyperfine coupling is 19.2 G, T1 is 0.37 µs and T2 is 0.30-0.35 µs. Between about 80 and 150 K 1/Tm in 9:1 trehalose:sucrose is approximately indepe...

journal_title：Free radical research

authors： Eaton SS,Rajca A,Yang Z,Eaton GR

更新日期：2018-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important mediators of the cytotoxicity induced by the direct reaction of ionising radiation (IR) with all critical cellular components, such as proteins, lipids, and nucleic acids. The derived oxidative damage may propagate in exposed tissues in a dose- and spatiotemporal dependent m...

journal_title：Free radical research

authors： Pietraforte D,Paulicelli E,Patrono C,Gambardella L,Scorza G,Testa A,Fattibene P

更新日期：2018-04-01 00:00:00

abstract：:A range of catechins and oligomeric procyanidins was purified by high performance liquid chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, galloylated epicatechin, glycosylated catechin, procyanidin dimers, galloylated dimers, trimer, and tetramer species were all identified, purif...

journal_title：Free radical research

authors： Plumb GW,De Pascual-Teresa S,Santos-Buelga C,Cheynier V,Williamson G

更新日期：1998-10-01 00:00:00

abstract：:Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were develop...

journal_title：Free radical research

authors： Earla A,Walter ED,Braslau R

更新日期：2019-12-01 00:00:00

abstract：:Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered ...

journal_title：Free radical research

authors： Dorigan de Matos Furlanetto AL,Valente C,Martinez GR,Merlin Rocha ME,Maurer JBB,Cadena SMSC

更新日期：2019-01-01 00:00:00

abstract：:Macrophages produce reactive oxygen species such as O2-, H2O2 and *OH that contribute to the pathogenesis of diseases such as inflammation and atherosclerosis. The cells have multiple defense systems against those reactive oxygen species, and we describe here such an oxidative stress-inducible defense system. Upon exp...

journal_title：Free radical research

authors： Ishii T,Itoh K,Sato H,Bannai S

更新日期：1999-10-01 00:00:00

abstract：:This work describes the synthesis and characterisation of some novel hybrid molecules which contains in the same molecule a free radical moiety of hydrazyl type and a spin-trap moiety of nitrone type. The new compounds synthesized have multiple and easy to follow spectroscopic properties, making them useful as sensors...

journal_title：Free radical research

authors： Ionita P

更新日期：2006-01-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) induces expression of the proinflammatory and profibrotic cytokine monocyte chemoattractant protein-1 (MCP-1) in tubular epithelial cells (TECs) and thereby contributes to the tubular epithelial-mesenchymal transition (EMT), which in turn leads to the progression of tubulointerst...

journal_title：Free radical research

authors： Li A,Wang J,Zhu D,Zhang X,Pan R,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly differ in their expression level by a factor of 2 or higher between the high and the low alpha-tocopherol ...

journal_title：Free radical research

authors： Nell S,Bahtz R,Bossecker A,Kipp A,Landes N,Bumke-Vogt C,Halligan E,Lunec J,Brigelius-Flohé R

更新日期：2007-08-01 00:00:00

abstract：:To define the molecular mechanism(s) of carvedilol inhibition of lipid peroxidation we have utilized model systems that allow us to study the different reactions involved in this complex process. Carvedilol inhibits the peroxidation of sonicated phosphatidylcholine liposomes triggered by FeCl2 addition whereas atenolo...

journal_title：Free radical research

authors： Tadolini B,Franconi F

更新日期：1998-11-01 00:00:00

abstract：:Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS)...

journal_title：Free radical research

authors： Guo J,Xu H,Liu S,Wang Z,Dai Y,Lu J,Zheng S,Xu D,Zhou J,Ke L,Cheng X,Xu M,Zhang X,Guo Y,Lin Y,Ding W,Gao G,Wang H,Chen Q,Yu X,Chen H,Qin L,Sun X,Li Z,Zheng S,Wang J,Cheng Y,Qiu S,Hu Y,Huang P,Li

更新日期：2019-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung disease caused by an inflammatory response to various inhaled toxins, especially cigarette smoke. Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histo...

journal_title：Free radical research

authors： Chikuma K,Arima K,Asaba Y,Kubota R,Asayama S,Sato K,Kawakami H

更新日期：2019-12-06 00:00:00

abstract：:Orellanine is the tetrahydroxylated and di-N-oxidized bipyridine toxin extracted from several Cortinarius mushrooms among them C. orellanus. The pathogenic mechanism involved in the C. orellanus-poisoning by orellanine leading to kidney impairment is not yet fully understood until now. Electron spin resonance (ESR) sp...

journal_title：Free radical research

authors： Oubrahim H,Richard JM,Cantin-Esnault D

更新日期：1998-05-01 00:00:00

abstract：:Cerebrovascular diseases (CBD) are one of the most dangerous complications of atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the prognosis of patients. Atherosclerosis is the main cause of CBD development. Hypertension, dyslipidemia, diabetes, smoking, obesity, and other risk facto...

journal_title：Free radical research

authors： Scicchitano P,Cortese F,Gesualdo M,De Palo M,Massari F,Giordano P,Ciccone MM

更新日期：2019-06-01 00:00:00

abstract：:Myeloperoxidase (MPO), a major constituent of neutrophils, catalyzes the production of hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride anion. We have previously reported that MPO-deficient (MPO(-/-)) neutrophils produce greater amount of macrophage inflammatory protein-2 (MIP-2) in vitro than do wi...

journal_title：Free radical research

authors： Tateno N,Matsumoto N,Motowaki T,Suzuki K,Aratani Y

更新日期：2013-05-01 00:00:00

abstract：:The phenomenon of ozone tolerance is described, but the underlying mechanisms remain unknown. We tested whether adaptation to multiday ozone exposure was related to an upregulated pulmonary antioxidant defence. Six calves were exposed to 0.75 ppm ozone, 12 h day(-1) for seven consecutive days. Pulmonary function tests...

journal_title：Free radical research

authors： Kirschvink N,Fiévez L,Bureau F,Degand G,Maghuin-Rogister G,Smith N,Art T,Lekeux P

更新日期：2002-01-01 00:00:00

abstract：:3-Nitrotyrosine (3NT) is known as an important indicator of nitrosative stress and has been linked to various diseases. Our aim was to develop an indirect ELISA (enzyme-linked immunosorbent assay) method suitable for the detection of protein-bound 3NT in clinical plasma and serum samples. Nitrated protein standards an...

journal_title：Free radical research

authors： Weber D,Kneschke N,Grimm S,Bergheim I,Breusing N,Grune T

更新日期：2012-03-01 00:00:00