Inactivation of heart dihydrolipoamide dehydrogenase by copper Fenton systems. Effect of thiol compounds and metal chelators.

abstract：:Because hepatic fibrosis usually involves more than one pathological process, combination therapy with modalities that target aberrant signaling cascade in activated hepatic stellate cells (HSCs) represents an alternative strategy. This study evaluates the hypothesis that astragaloside IV (AS-IV) and ferulic acid (FA)...

journal_title：Free radical research

authors： Dong H,Guo H,Liang Y,Wang X,Niu Y

更新日期：2017-02-01 00:00:00

abstract：:The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...

journal_title：Free radical research

authors： Song HC,Chen Y,Chen Y,Park J,Zheng M,Surh YJ,Kim UH,Park JW,Yu R,Chung HT,Joe Y

更新日期：2020-07-28 00:00:00

abstract：:Thioredoxin-1 (TRX) is a redox-active protein with anti-inflammatory effects. This study investigated the optimal delivery method and the mechanisms of recombinant human TRX (rhTRX) to suppress neutrophil recruitment in a rat bleomycin (BLM)-induced sustained acute lung injury model. In male Wister rats intratracheall...

journal_title：Free radical research

authors： Nakamura T,Hoshino Y,Yamada A,Teratani A,Furukawa S,Okuyama H,Ueda S,Wada H,Yodoi J,Nakamura H

更新日期：2007-10-01 00:00:00

abstract：:N-nitroso species have recently been detected in animal tissues. Protein N-nitrosotryptophan is the best candidate for this N-nitroso pool. N-nitrosation of N-blocked trytophan derivatives like melatonin (MelH) by N2O3 or peroxynitrite (ONOOH/ONOO- ) has been observed under conditions of pH and reagent concentrations ...

journal_title：Free radical research

authors： Peyrot F,Houée-Levin C,Ducrocq C

更新日期：2006-09-01 00:00:00

abstract：:Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut industrial estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-gr...

journal_title：Free radical research

authors： Peluso M,Munnia A,Piro S,Jedpiyawongse A,Sangrajrang S,Giese RW,Ceppi M,Boffetta P,Srivatanakul P

更新日期：2012-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important mediators of the cytotoxicity induced by the direct reaction of ionising radiation (IR) with all critical cellular components, such as proteins, lipids, and nucleic acids. The derived oxidative damage may propagate in exposed tissues in a dose- and spatiotemporal dependent m...

journal_title：Free radical research

authors： Pietraforte D,Paulicelli E,Patrono C,Gambardella L,Scorza G,Testa A,Fattibene P

更新日期：2018-04-01 00:00:00

abstract：:Generation of toxic oxygen metabolites followed by oxidant- and inflammatory-mediated tissue injury plays a crucial role in the pathogenesis of ischemia and reperfusion (IR). Ubiquinol, the reduced form of coenzyme Q10, is recognized for its potent antioxidant and anti-inflammatory properties in biological membranes. ...

journal_title：Free radical research

authors： Peerapanyasut W,Thamprasert K,Wongmekiat O

更新日期：2014-02-01 00:00:00

abstract：:We evaluated whether nutritional vitamin A deficiency generates oxidative stress and inflammation in aorta. Wistar male rats (21 days old) were given free access to a control (8 mg retinol as retinyl palmitate/kg) or a vitamin A- deficient diet for three months. One group of deficient animals was fed with the control ...

journal_title：Free radical research

authors： Gatica L,Alvarez S,Gomez N,Zago MP,Oteiza P,Oliveros L,Gimenez MS

更新日期：2005-06-01 00:00:00

abstract：:Liposomes composed of soybean phosphatidylcholine were peroxidized using the reagent sodium hypochlorite or the myeloperoxidase-hydrogen peroxide-Cl- system. Linoleic acid hydroperoxide previously prepared from linoleic acid by means of lipoxidase was incorporated into liposomes. The yield of thiobarbituric acid react...

journal_title：Free radical research

authors： Panasenko OM,Arnhold J

更新日期：1999-06-01 00:00:00

abstract：:Microcystin-LR (MCLR) is a potent hepatotoxin. Oxidative stress is thought to be implicated in the cytotoxicity of MCLR, but the mechanisms by which MCLR produces reactive oxygen species (ROS) are still unclear. This study investigated the role and possible sources of ROS generation in MCLR-induced cytogenotoxicity in...

journal_title：Free radical research

authors： Nong Q,Komatsu M,Izumo K,Indo HP,Xu B,Aoyama K,Majima HJ,Horiuchi M,Morimoto K,Takeuchi T

更新日期：2007-12-01 00:00:00

abstract：:The toxic effect of copper was evaluated in sunflower plants by means of root elongation, lipid peroxidation and antioxidative enzyme activities. Plants were grown under controlled environmental conditions in hydroponic culture for two weeks and exposed to different copper concentrations for an additional week. Determ...

journal_title：Free radical research

authors： García A,Baquedano FJ,Navarro P,Castillo FJ

更新日期：1999-12-01 00:00:00

abstract：:Oxidative stress may initiate lipid peroxidation that generates ethane. Ethane, at low concentrations, is eliminated by pulmonary exhalation. Previous methods have not allowed frequent sampling, thus ethane kinetics has not been studied in man. A validated method over the range 3.8-100,000 ppb with a limit of quantita...

journal_title：Free radical research

authors： Dale O,Bergum H,Lund T,Nilsen T,Aadahl P,Stenseth R

更新日期：2003-08-01 00:00:00

abstract：:S-Nitrosation plays an important role in regulation of protein function and signal transduction. Discovering S-nitrosated targets is a prerequisite for further functional study. However, current proteomic methods used to quantify S-nitrosation are limited in their applicability to certain types of samples, or by the n...

journal_title：Free radical research

authors： Zhang X,Huang B,Chen C

更新日期：2012-08-01 00:00:00

abstract：:Proteins are subject to various posttranslational modifications, some of them being undesired from the point of view of metabolic efficiency. Prevention of such modifications is expected to provide new means of therapy of diseases and decelerate the process of aging. In this review, modifications of proteins by reacti...

journal_title：Free radical research

authors： Sadowska-Bartosz I,Ott C,Grune T,Bartosz G

更新日期：2014-11-01 00:00:00

abstract：:Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and make nitric oxide (NO*) in amounts sufficient to affect mitochondrial respiration. However, we found that the addition of L-arginine or the NOS inhibitor L-NMMA to intact rat liver mitochondria did not have any effect on the respirat...

journal_title：Free radical research

authors： Tay YM,Lim KS,Sheu FS,Jenner A,Whiteman M,Wong KP,Halliwell B

更新日期：2004-06-01 00:00:00

abstract：:The cytologically active secondary lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) have been detected as their 2,4-dinitrophenylhydrazone (DNP) derivatives in plant tissue cultures using LC-MS. This paper reports, for the first time, the use of LC-MS methodology to definitively identif...

journal_title：Free radical research

authors： Deighton N,Magill WJ,Bremner DH,Benson EE

更新日期：1997-09-01 00:00:00

abstract：:We studied the effects of a single post whole-body low-dose irradiation (50 cGy of gamma-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, g...

journal_title：Free radical research

authors： Yamaoka K,Kojima S,Nomura T

更新日期：2000-03-01 00:00:00

abstract：:The antioxidant properties of protoporphyrin IX and related tetrapyrroles are poorly characterized. Therefore, eight tetrapyrroles, five of which are produced in vivo, were tested to assess their antioxidant capacities in the Salmonella reverse mutation, TEAC, FRAP and ORAC assays. Tertiary-butyl hydroperoxide (tert-B...

journal_title：Free radical research

authors： Mölzer C,Huber H,Steyrer A,Ziesel G,Ertl A,Plavotic A,Wallner M,Bulmer AC,Wagner KH

更新日期：2012-11-01 00:00:00

abstract：:Curcumin is a polyphenol derived from the plant Curcuma longa that induces apoptotic cell death in malignant cancer cell lines. It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidan...

journal_title：Free radical research

authors： Jung KH,Park JW

更新日期：2011-04-01 00:00:00

abstract：:A small part of cellular iron, usually called 'labile iron pool' (LIP), is not securely stored and has the potential to catalyse the formation of highly reactive oxygen species. The present work estimated LIP levels in human white cells by using the analytical power of flow cytometry. The method relies essentially on ...

journal_title：Free radical research

authors： Doulias PT,Vlachou C,Boudouri C,Kanavaros P,Siamopoulos KC,Galaris D

更新日期：2008-03-01 00:00:00

abstract：:To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and a...

journal_title：Free radical research

authors： Crohns M,Saarelainen S,Kankaanranta H,Moilanen E,Alho H,Kellokumpu-Lehtinen P

更新日期：2009-07-01 00:00:00

abstract：:In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who under...

journal_title：Free radical research

authors： Bustamante V,Casanova J,López de Santamaría E,Mas S,Sellarés J,Gea J,Gáldiz JB,Barreiro E

更新日期：2008-11-01 00:00:00

abstract：:The ability of a range of dietary flavonoids to inhibit low-density lipoprotein (LDL) oxidation in vitro was tested using a number of different methods to assess oxidative damage to LDL. Overall quercetin was the most effective inhibitor of oxidative damage to LDL in vitro. On this basis, a diet enriched with onions a...

journal_title：Free radical research

authors： O'Reilly JD,Sanders TA,Wiseman H

更新日期：2000-10-01 00:00:00

abstract：:Proteins constitute the major 'working force' for all forms of biological work. Their exact conformation and pattern of folding are tightly connected to their activity and function. Reactive oxygen and nitrogen species (ROS and RNS) are formed during normal metabolism and in higher fluxes under pathological conditions...

journal_title：Free radical research

authors： Chevion M,Berenshtein E,Stadtman ER

更新日期：2000-11-01 00:00:00

abstract：:Uraemic subjects undergoing chronic haemodialysis show increased oxidative stress. The use of non-biocompatible filters and reduced antioxidative defences are important sources of reactive oxygen species (ROS) release. The highly oxidative environment accelerates the onset and progression of tissue damage and atherosc...

journal_title：Free radical research

authors： Odetti P,Traverso N,Monacelli F,Menini S,Vazzana J,Tasso B,Pronzato MA,Robaudo C,Deferrari G

更新日期：2006-02-01 00:00:00

abstract：:Glutathione plays a central role in the maintenance of cellular antioxidant defense. The alterations in the glutathione and associated recyclic enzymes caused by both exercise training and ethanol are well documented; however, their interactive effects with age are not well understood. Therefore, the influence of agei...

journal_title：Free radical research

authors： Kakarla P,Kesireddy S,Christiaan L

更新日期：2008-05-01 00:00:00

abstract：:A study of peroxyl radical-mediated bovine serum albumin oxidation in the presence of the quinolinic aminoxyl 1,2-dihydro-2,2-diphenyl-4-ethoxy-quinoline-1-oxyl (QAO) was carried out in order to test its efficiency as a protein antioxidant. Albumin oxidation was induced by the tert-butylhydroperoxide/PbO2 system. The ...

journal_title：Free radical research

authors： Tanfani F,Carloni P,Damiani E,Greci L,Wozniak M,Kulawiak D,Jankowski K,Kaczor J,Matuszkiewics A

更新日期：1994-10-01 00:00:00

abstract：:Silibinin is an active constituent extracted from blessed milk thistle (Silybum marianum). Our previous study demonstrated that silibinin induced autophagy and apoptosis via reactive oxygen species (ROS) generation in HeLa cells. In this study, we investigated whether the autophagy- and apoptosis-associated molecules ...

journal_title：Free radical research

authors： Fan S,Qi M,Yu Y,Li L,Yao G,Tashiro S,Onodera S,Ikejima T

更新日期：2012-03-01 00:00:00

abstract：:Oxidative stress is suggested as a potential mechanism in impaired foetal growth, smaller birth size and thus subsequently adult chronic diseases. We have investigated associations between oxidative stress in pregnancy and birth anthropometry (weight, height, head and chest circumferences). In the MINIMat-trial (Mater...

journal_title：Free radical research

authors： Lindström E,Persson LÅ,Raqib R,El Arifeen S,Basu S,Ekström EC

更新日期：2012-03-01 00:00:00

abstract：:We investigated the effects of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on reactive oxygen species (ROS) and on oxidative DNA damage in vitro, as well as the effects of the main fluvastatin metabolites (M2, M3, and M4) and other inhibitors of the same enzyme, pravastatin and simvastati...

journal_title：Free radical research

authors： Imaeda A,Tanigawa T,Aoki T,Kondo Y,Nakamura N,Yoshikawa T

更新日期：2001-12-01 00:00:00