Ubiquinol supplementation protects against renal ischemia and reperfusion injury in rats.

abstract：:Dihydrocalcein (H2-calcein) is recommended as a superior probe for intracellular radical (ROS) detection as different to dichlorodihydrofluorescein (H2-DCF), its oxidation product calcein is thought not to leak out of cells. We determined whether H2-calcein is a useful tool to measure ROS in vascular smooth muscle cel...

journal_title：Free radical research

authors： Keller A,Mohamed A,Dröse S,Brandt U,Fleming I,Brandes RP

更新日期：2004-12-01 00:00:00

abstract：:Although the primary biological function of retinal photoreceptors is to absorb light and provide visual information, extensive exposure to intense light could increase the risk of phototoxic reactions mediated by products of rhodopsin bleaching that might accumulate in photoreceptor outer segments (POS). The phototox...

journal_title：Free radical research

authors： Olchawa M,Krzysztynska-Kuleta O,Duda M,Pawlak A,Pabisz P,Czuba-Pelech B,Sarna T

更新日期：2019-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been poised at a straddled state of being beneficiary as well detrimental depending on its threshold levels. Maintaining the homeostasis of ROS is imperative for normal cellular physiology, wherein physiological concentrations of ROS are involved in cell signaling and elevated ROS co...

journal_title：Free radical research

authors： Sheshadri P,Kumar A

更新日期：2016-01-01 00:00:00

abstract：:Intracellular levels of H2O2 in BHK-21 cells are not static but decline progressively with cell growth. Exposure of cells to inhibitors of catalase, or glutathione peroxidase, not only diminishes this decline but also depresses rates of cell proliferation, suggesting important growth regulatory roles for those antioxi...

journal_title：Free radical research

authors： Burdon RH,Alliangana D,Gill V

更新日期：1995-11-01 00:00:00

abstract：:We have previously shown that Vitamin C (ascorbic acid) can trigger hydroxyl radical formation in copper contaminated household drinking water. We report here that the capacity of ascorbic acid to catalyze hydroxyl radical generation in the drinking water samples is strongly dependent on the bicarbonate concentration ...

journal_title：Free radical research

authors： Jansson PJ,Asplund KU,Mäkelä JC,Lindqvist C,Nordström T

更新日期：2003-08-01 00:00:00

abstract：:Formation of the alpha-hydroxyethyl radical (CH3 degree CHOH) has already been extensively demonstrated after ethanol metabolism in the liver. Despite favourable conditions, this formation in the brain has remained speculative since there is no direct experimental evidence in intact brain cells. In this preliminary st...

journal_title：Free radical research

authors： Gonthier B,Eysseric H,Soubeyran A,Daveloose D,Saxod R,Barret L

更新日期：1997-12-01 00:00:00

abstract：:Hypericin and pseudohypericin are polycyclic-phenolic structurally related compounds found in Hypericum perforatum L. (St John's wort). As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding ath...

journal_title：Free radical research

authors： Laggner H,Schreier S,Hermann M,Exner M,Mühl A,Gmeiner BM,Kapiotis S

更新日期：2007-02-01 00:00:00

abstract：:There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is al...

journal_title：Free radical research

authors： Closa D

更新日期：2013-11-01 00:00:00

abstract：:α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein...

journal_title：Free radical research

authors： Misaki K,Takitani K,Ogihara T,Inoue A,Kawakami C,Kuno T,Kawamura N,Miyake M,Nakagawa T,Tamai H

更新日期：2003-01-01 00:00:00

abstract：:Exposure to asbestos fiber is central to mesothelial carcinogenesis. Recent sequencing studies on human and rodent malignant mesothelioma (MM) revealed frequently mutated genes, including CDKN2A, BAP1 and NF2. Crocidolite directly or indirectly catalyses the generation of hydroxyl radicals, which appears to be the maj...

journal_title：Free radical research

authors： Funahashi S,Okazaki Y,Akatsuka S,Takahashi T,Sakumi K,Nakabeppu Y,Toyokuni S

更新日期：2020-03-01 00:00:00

abstract：:Diosgenin possesses anti-inflammatory and anticancer properties. Activated neutrophils produce high concentrations of the superoxide anion which is involved in the pathophysiology of inflammation-related diseases and cancer. In the present study, the inhibitory effect and possible mechanisms of diosgenin on superoxide...

journal_title：Free radical research

authors： Lin Y,Jia R,Liu Y,Gao Y,Zeng X,Kou J,Yu B

更新日期：2014-12-01 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:We tested the hypothesis that hypertension associated with polycythemia vera (PV) may be related to hemoglobin released from erythrocytes (cell-free hemoglobin, fHb). We assessed hematocrit, mean arterial pressure (MAP), blood viscosity, and the level of fHb and nitrite/nitrate (NOx) in the plasma of 73 PV patients an...

journal_title：Free radical research

authors： Rusak T,Misztal T,Piszcz J,Tomasiak M

更新日期：2014-02-01 00:00:00

abstract：:Proteins constitute the major 'working force' for all forms of biological work. Their exact conformation and pattern of folding are tightly connected to their activity and function. Reactive oxygen and nitrogen species (ROS and RNS) are formed during normal metabolism and in higher fluxes under pathological conditions...

journal_title：Free radical research

authors： Chevion M,Berenshtein E,Stadtman ER

更新日期：2000-11-01 00:00:00

abstract：:The mechanism of high-grade serous ovarian cancer (HGSC) development remains elusive. This review outlines recent advances in the understanding of sequential molecular changes associated with the development of HGSC, as well as describes oxidative stress-induced genomic instability and carcinogenesis. This article rev...

journal_title：Free radical research

authors： Kobayashi H,Ogawa K,Kawahara N,Iwai K,Niiro E,Morioka S,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:Peroxynitrous acid synthesized by reaction of hydrogen peroxide and nitrite and generated from 3-morpholinosydononimine (SIN-1) induced cellular DNA breaking of human promyelocytic leukemia HL-60 cells in phosphate buffer (pH 7.5) as assessed by alkaline single cell gel electrophoresis (comet) assay and quantification...

journal_title：Free radical research

authors： Hiramoto K,Tomiyama S,Kikugawa K

更新日期：1999-01-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) are the most widely used nanomaterials as antimicrobial agents. AgNPs have been shown to inhibit the growth of and induce apoptosis-like death in Escherichia coli. However, the precise mechanism of AgNPs-induced apoptosis-like death and association with DNA damage-inducible protein F (dinF...

journal_title：Free radical research

authors： Kim S,Lee DG

更新日期：2021-01-06 00:00:00

abstract：:p38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress. The most abundant family member is p38α, which helps to couple cell proliferation and growth in response to ce...

journal_title：Free radical research

authors： Tormos AM,Taléns-Visconti R,Nebreda AR,Sastre J

更新日期：2013-11-01 00:00:00

abstract：:Capacitation of spermatozoa is an essential procedure for fertilization. Capacitated spermatozoa have an increase in the intracellular cAMP and acrosome reaction (AR) occurs immediately. The effect of exogenous superoxide anion (O2-) on the level of intracellular cAMP and the percentages of both spontaneous AR and lys...

journal_title：Free radical research

authors： Zhang H,Zheng RL

更新日期：1996-04-01 00:00:00

abstract：INTRODUCTION:Nuclear factor, erythroid 2 like 2 (NFE2L2) is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 deficiency in placentas is associated with pregnancy complications. We have demonstrated that elevated OS existed in placental shares of the smaller fetus in selective int...

journal_title：Free radical research

authors： Wu J,He Z,Gao Y,Zhang G,Huang X,Fang Q

更新日期：2017-04-01 00:00:00

abstract：:To study the role of oxidative stress in hypertension and pre-hypertension, this study analysed plasma levels of reactive carbonyl species (RCS) in 1204 Chinese Han adults. Results showed a statistically significant positive correlation (p < 0.001) between blood pressure and plasma RCS levels with or without being adj...

journal_title：Free radical research

authors： Chen K,Xie F,Liu S,Li G,Chen Y,Shi W,Hu H,Liu L,Yin D

更新日期：2011-05-01 00:00:00

abstract：:8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect. ...

journal_title：Free radical research

authors： Turk PW,Weitzman SA

更新日期：1995-09-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by synovial proliferation and migration which is induced by proinflammatory cytokines or oxidative stress, followed by joint destruction. Edaravone, clinically available free radical scavenger in Japan, is confirmed to be beneficial in the acute stage of cerebral infarction. ...

journal_title：Free radical research

authors： Arii K,Kumon Y,Ikeda Y,Suehiro T,Hashimoto K

更新日期：2006-02-01 00:00:00

abstract：:In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...

journal_title：Free radical research

authors： Chainy GBN,Sahoo DK

更新日期：2020-01-01 00:00:00

abstract：:The metabolism of paraquat generates oxygen radicals. Paraquat has thus been suggested as a model compound to induce oxidative damage to DNA, lipids and proteins in different cells and tissues, although experimental data are inconsistent. In order to explore the possibilities for an animal model of oxidative DNA damag...

journal_title：Free radical research

authors： Sørensen M,Loft S

更新日期：2000-05-01 00:00:00

abstract：:After minimal sample preparation, two different HPLC methodologies, one based on a single gradient reversed-phase HPLC step, the other on multiple HPLC runs each optimised for specific components, were used to investigate the composition of flavonoids and phenolic acids in apple and tomato juices. The principal compon...

journal_title：Free radical research

authors： Bremner PD,Blacklock CJ,Paganga G,Mullen W,Rice-Evans CA,Crozier A

更新日期：2000-06-01 00:00:00

abstract：:The response of HeLa cells to subcellular spatially localized two-photon irradiation of a singlet oxygen photosensitizer (protoporphyrin IX, PpIX) using a focused laser was assessed. Upon irradiation under these conditions, a localized population of PpIX excited states can be produced with meaningful intracellular spa...

journal_title：Free radical research

authors： Gollmer A,Besostri F,Breitenbach T,Ogilby PR

更新日期：2013-09-01 00:00:00

abstract：:The aim of the study was to investigate whether there is transmembrane transport of intact glutathione ([3H]-GSH, 0.1 microCi) in rat and human type II pneumocytes (T2P), and if this transport might be dependent on the redox state of the extracellular fluid. The T2P were pretreated with acivicin (250 microM) to inhibi...

journal_title：Free radical research

authors： van Klaveren RJ,Hoet PH,Demedts M,Nemery B

更新日期：1999-05-01 00:00:00

abstract：:Testing of pregnant women reveals weakening of neutrophil-mediated effector functions, such as reactive oxygen species generation. This study provides data confirming the phenomenon, gained through application of the flow cytometry technique. Key factors influencing neutrophil functional activity in blood plasma of pr...

journal_title：Free radical research

authors： Varfolomeeva EY,Semenova EV,Sokolov AV,Aplin KD,Timofeeva KE,Vasilyev VB,Filatov MV

更新日期：2016-08-01 00:00:00

abstract：:Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a systemic inflammatory response, resulting in proinflammatory cells recruitm...

journal_title：Free radical research

authors： Rossi M,Delbauve S,Roumeguère T,Wespes E,Leo O,Flamand V,Le Moine A,Hougardy JM

更新日期：2019-10-01 00:00:00