Free radicals and acute pancreatitis: much ado about … something.

abstract：:Curcumin is a polyphenol derived from the plant Curcuma longa that induces apoptotic cell death in malignant cancer cell lines. It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidan...

journal_title：Free radical research

authors： Jung KH,Park JW

更新日期：2011-04-01 00:00:00

abstract：:Ceruloplasmin (CP) is a blue copper glycoprotein with multiple physiological functions including ferroxidase and oxidase activities. CP is also an important serum oxygen free radical (OFR) scavenger and antioxidant, exerting cardioprotective and antifibrillatory actions. Although it has been reported that CP activitie...

journal_title：Free radical research

authors： Aouffen M,Paquin J,Furtos A,Waldron KC,Mateescu MA

更新日期：2004-01-01 00:00:00

abstract：:The markers 3-nitrotyrosine and 3-chlorotyrosine are measured as surrogates for reactive nitrogen species and hypochlorous acid respectively, which are both elevated in inflamed human tissues. Previous studies reported a loss of 3-nitrotyrosine when exposed to hypochlorous acid, suggesting that observations of 3-nitro...

journal_title：Free radical research

authors： Curtis MP,Neidigh JW

更新日期：2014-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces ...

journal_title：Free radical research

authors： Hou C,Peng Y,Qin C,Fan F,Liu J,Long J

更新日期：2018-12-01 00:00:00

abstract：:Peroxynitrite anion is a reactive and short-lived species and its formation in vivo has been implicated in several human diseases. In view of the potential usefulness of compounds that can protect against peroxynitrite or their reactive intermediates, a study focused on flavonoid compounds was carried out. Since the r...

journal_title：Free radical research

authors： Santos MR,Mira L

更新日期：2004-09-01 00:00:00

abstract：:We investigated hepatoprotective activity and antioxidant effect of the 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene that purified from Morus bombycis Koidzumi roots against CCl4-induced liver damage in rats. The 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene displayed dose-dependent ...

journal_title：Free radical research

authors： Jin YS,Lee MJ,Han W,Heo SI,Sohn SI,Wang MH

更新日期：2006-09-01 00:00:00

abstract：:The singlet oxygen (1O2) quenching and free radical (DPPH(*), ABTS(* +) and O2(* -)) scavenging ability of three structurally-related flavonoids (7-hydroxyflavanone HF, 2',4'-dihydroxychalcone DHC and 3,7-dihydroxyflavone DHF) present in the Argentinean native shrub Zuccagnia punctata Cav. were studied in solution by ...

journal_title：Free radical research

authors： Vieyra FE,Boggetti HJ,Zampini IC,Ordoñez RM,Isla MI,Alvarez RM,De Rosso V,Mercadante AZ,Borsarelli CD

更新日期：2009-06-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Radioresistance is a significant obstacle in NSCLC radiotherapy. Long non-coding RNA LINC00473 has been found to impact the radiotherapy in several malignant tumours. This study aimed to investigate the underlying role and mechanism of LINC0047...

journal_title：Free radical research

authors： Qin P,Li Y,Liu J,Wang N

更新日期：2020-10-01 00:00:00

abstract：:The cyanidin-3-O-beta-glucopyranoside (C-3-G) antioxidant capacity towards reactive oxygen species (ROS)-mediated damages was assessed in tissue and cells submitted to increased oxidative stress. In the isolated ischemic and reperfused rat heart, 10 or 30 degreesM C-3-G protected from both lipid peroxidation (66.7 and...

journal_title：Free radical research

authors： Amorini AM,Lazzarino G,Galvano F,Fazzina G,Tavazzi B,Galvano G

更新日期：2003-04-01 00:00:00

abstract：:Human serum samples were evaluated for oxidative stress with the d-ROMs test. The ceruloplasmin (CP) and copper contents of the samples was independently measured and compared to those calculated on the basis of the d-ROMs test results for pure CP solutions. The d-ROMs readings did not show any significant correlation...

journal_title：Free radical research

authors： Colombini F,Carratelli M,Alberti A

更新日期：2016-01-01 00:00:00

abstract：:Generation of toxic oxygen metabolites followed by oxidant- and inflammatory-mediated tissue injury plays a crucial role in the pathogenesis of ischemia and reperfusion (IR). Ubiquinol, the reduced form of coenzyme Q10, is recognized for its potent antioxidant and anti-inflammatory properties in biological membranes. ...

journal_title：Free radical research

authors： Peerapanyasut W,Thamprasert K,Wongmekiat O

更新日期：2014-02-01 00:00:00

abstract：:Rat granulosa cells (GCs) were treated with human chorionic gonadotropin (hCG), 8-bromo-adenosine 3',5'-cyclic monophosphate (8-Br-cAMP), forskolin, phorbol 12-myristate 13-acetate (PMA), A23187 or pregnenolone in the absence or presence of hydrogen peroxide (H(2)O(2)). Different doses of trilostane were applied to GC...

journal_title：Free radical research

authors： Yu PL,Lin TM,Wang SW,Wang PS

更新日期：2012-06-01 00:00:00

abstract：:This experiment was performed to clarify the role of protein kinase C (PKC) delta in NADPH oxidase-dependent O(2-) production and actin polymerization followed by phagocytosis in neutrophils. Bovine neutrophils and human neutrophil-like differentiated HL-60 (dHL-60) cells were stimulated with serum-opsonized zymosan (...

journal_title：Free radical research

authors： Waki K,Inanami O,Yamamori T,Nagahata H,Kuwabara M

更新日期：2006-04-01 00:00:00

abstract：:Epidemiology studies have shown that consumption of fruits and vegetables is associated with the prevention of chronic diseases such as cancer and cardiovascular disease. Induction of cellular phase II detoxifying enzymes is associated with cancer preventive potential. Phenolsulfotransferases (PSTs) are traditionally ...

journal_title：Free radical research

authors： Yeh CT,Yen GC

更新日期：2005-08-01 00:00:00

abstract：:Increased reactive oxygen species (ROS) and lipid peroxidation may be implicated in the pathogenesis of preeclampsia by causing cell (membrane) damage and impaired endothelial function. Carbonyl derivatives of proteins, or protein carbonyls, may be sensitive biomarkers of ROS-mediated damage. The aim of the study was ...

journal_title：Free radical research

authors： Zusterzeel PL,Mulder TP,Peters WH,Wiseman SA,Steegers EA

更新日期：2000-11-01 00:00:00

abstract：:The purpose of the present study was to investigate the protective effect of esculetin (ES) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the lung epithelial A549 cells. Mice were intragastrically administered with ES (20 and 40 mg/kg) 1 h prior to LPS challenge. ES pretreatment at doses of 20 and 40...

journal_title：Free radical research

authors： Chen T,Guo Q,Wang H,Zhang H,Wang C,Zhang P,Meng S,Li Y,Ji H,Yan T

更新日期：2015-01-01 00:00:00

abstract：:Involvement of oxidative stress is implicated in the progression of complication of diabetes mellitus. With respect to heart diseases, we have studied role of oxidative stress/antioxidants using rats treated with streptozotocin to induce diabetes (DM). Hemodynamic and echocardiographic measurements showed thickening o...

journal_title：Free radical research

authors： Doi K,Sawada F,Toda G,Yamachika S,Seto S,Urata Y,Ihara Y,Sakata N,Taniguchi N,Kondo T,Yano K

更新日期：2001-03-01 00:00:00

abstract：:Nitration-induced protein damage in the placenta leads to impaired blood flow and deficient feto-placental exchange in diabetic pregnancies. This work studied the effect of nitric oxide and peroxynitrite on Cu/Zn SOD activity in rat placentas and evaluated whether Cu/Zn SOD is nitrated in the placenta from diabetic ra...

journal_title：Free radical research

authors： White V,Capobianco E,Higa R,Martínez N,Sosa M,Pustovrh MC,Jawerbaum A

更新日期：2010-12-01 00:00:00

abstract：:The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated. Tubular proteinuria and oxidative stress were induced by a single injection of maleate (400 mg/kg) in rats. Maleate-induced renal injury included increase in renal v...

journal_title：Free radical research

authors： Tapia E,Sánchez-Lozada LG,García-Niño WR,García E,Cerecedo A,García-Arroyo FE,Osorio H,Arellano A,Cristóbal-García M,Loredo ML,Molina-Jijón E,Hernández-Damián J,Negrette-Guzmán M,Zazueta C,Huerta-Yepez S,Reyes JL,Madero M

更新日期：2014-11-01 00:00:00

abstract：:Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O(2)(•-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O(2)(•-) determinants in this population. O(2)(•-) production was evaluated using chemi...

journal_title：Free radical research

authors： Morena M,Patrier L,Jaussent I,Bargnoux AS,Dupuy AM,Badiou S,Leray-Moragues H,Klouche K,Canaud B,Cristol JP

更新日期：2011-06-01 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:To define the molecular mechanism(s) of carvedilol inhibition of lipid peroxidation we have utilized model systems that allow us to study the different reactions involved in this complex process. Carvedilol inhibits the peroxidation of sonicated phosphatidylcholine liposomes triggered by FeCl2 addition whereas atenolo...

journal_title：Free radical research

authors： Tadolini B,Franconi F

更新日期：1998-11-01 00:00:00

abstract：:Recent findings have suggested that oxidative damage might contribute to the cytotoxicity and carcinogenicity of aflatoxin B1 (AFB1). Salvia miltiorrhiza (Sm), a herbal plant that has been used extensively in traditional Chinese medicine for treating cardiovascular and liver diseases, is believed to have some antioxid...

journal_title：Free radical research

authors： Liu J,Yang CF,Lee BL,Shen HM,Ang SG,Ong CN

更新日期：1999-12-01 00:00:00

abstract：:Oxygen radical generating systems, namely, Cu(II)/ H2O2, Cu(II)/ascorbate, Cu(II)/NAD(P)H, Cu(II)/ H2O2/catecholamine and Cu(II)/H2O2/SH-compounds irreversibly inhibited yeast glutathione reductase (GR) but Cu(II)/H2O2 enhanced the enzyme diaphorase activity. The time course of GR inactivation by Cu(II)/H2O2 dependent...

journal_title：Free radical research

authors： Gutierrez-Correa J,Stoppani AO

更新日期：1997-12-01 00:00:00

abstract：:Melatonin is an endogenous indolamine, classically known as a light/dark regulator. Besides classical functions, melatonin has also showed to have a wide range of antitumoral effects in numerous cancer experimental models. However, no definite mechanism has been described to explain the whole range of antineoplasic ef...

journal_title：Free radical research

authors： Sánchez-Sánchez AM,Martín V,García-Santos G,Rodríguez-Blanco J,Casado-Zapico S,Suarez-Garnacho S,Antolín I,Rodriguez C

更新日期：2011-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutella...

journal_title：Free radical research

authors： Zhang X,Ji R,Sun H,Peng J,Ma X,Wang C,Fu Y,Bao L,Jin Y

更新日期：2018-02-01 00:00:00

abstract：:Oxidative DNA modification has been implicated in development of certain cancers and 8-oxodG, the most abundant and mutagenic DNA modification, has for some time been considered a biomarker of this activity. Urinary excretion of 8-oxodG over 24h has been used to estimate the rate of damage to DNA, and animal studies h...

journal_title：Free radical research

authors： Poulsen HE,Loft S,Prieme H,Vistisen K,Lykkesfeldt J,Nyyssonen K,Salonen JT

更新日期：1998-12-01 00:00:00

abstract：:Lipid peroxidation generates reactive aldehydes, most notably hydroxynonenal (HNE), which covalently binds amino acid residue side chains leading to protein inactivation and insolubility. Specific adducts of lipid peroxidation have been demonstrated to be intimately associated with pathological lesions of Alzheimer's ...

journal_title：Free radical research

authors： Perry EA,Castellani RJ,Moreira PI,Nunomura A,Lui Q,Harris PL,Sayre LM,Szweda PA,Szweda LI,Zhu X,Smith MA,Perry G

更新日期：2013-07-01 00:00:00

abstract：:Cardiolipin (CL) is a mitochondria-specific phospholipid and is critical for maintaining the integrity of mitochondrial membrane and mitochondrial function. CL also plays an active role in mitochondria-dependent apoptosis by interacting with cytochrome c (cyt c), tBid and other important Bcl-2 proteins. The unique str...

journal_title：Free radical research

authors： Yin H,Zhu M

更新日期：2012-08-01 00:00:00

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00