Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway.

abstract：:India, resembling other developing nations, is confronting a hastening demographic switch to non-communicable diseases. Inborn errors of metabolism (IEM) constitute a varied heterogeneous group of disorders with variable clinical appearance, primarily in the pediatric populace. Congenital deformities and genetic disor...

journal_title：Free radical research

authors： Ray SK,Mukherjee S

更新日期：2021-01-27 00:00:00

abstract：:Ribonucleotide reductases catalyze the irreversible reductive formation of 2'-deoxyribonucleotides required for DNA replication and cell proliferation, and a radical mechanism was assumed to be involved in this reaction. In order to search for a radical in the aerobic manganese ribonucleotide reductase (Mn-RRase) by e...

journal_title：Free radical research

authors： Griepenburg U,Lassmann G,Auling G

更新日期：1996-06-01 00:00:00

abstract：:Creatol (CTL) is a product resulting from the reaction of creatinine (Cr) with the hydroxyl radical and is identified as a precursor of methylguanidine (MG), a uremic toxin. In this study, we investigated serum CTL levels together with those of Cr and MG in 66 patients who were on maintenance hemodialysis (HD). Prior ...

journal_title：Free radical research

authors： Tomida C,Aoyagi K,Nagase S,Gotoh M,Yamagata K,Takemura K,Koyama A

更新日期：2000-01-01 00:00:00

abstract：:The preventive effect of 20(S)-ginsenoside Rg(3) (20(S)-Rg(3)) on lipopolysaccharide (LPS)-induced oxidative tissue injury in rats was investigated in this study. The elevated serum nitrite/nitrate, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and creatinine levels in LPS-treated control rats were ...

journal_title：Free radical research

authors： Kang KS,Kim HY,Yamabe N,Park JH,Yokozawa T

更新日期：2007-10-01 00:00:00

abstract：:The mechanism of high-grade serous ovarian cancer (HGSC) development remains elusive. This review outlines recent advances in the understanding of sequential molecular changes associated with the development of HGSC, as well as describes oxidative stress-induced genomic instability and carcinogenesis. This article rev...

journal_title：Free radical research

authors： Kobayashi H,Ogawa K,Kawahara N,Iwai K,Niiro E,Morioka S,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:The production of reactive oxygen species, including hydrogen peroxide (H(2)O(2)), is increased in diseased blood vessels. Although H(2)O(2) leads to impairment of the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP signaling pathway, it is not clear whether this reactive molecule affects the redox state of sGC...

journal_title：Free radical research

authors： Tawa M,Shimosato T,Iwasaki H,Imamura T,Okamura T

更新日期：2015-01-01 00:00:00

abstract：:Flavonoids are components of fruit and vegetables that may be beneficial in the prevention of disease such as cancer and cardiovascular diseases. Their beneficial effects will be dependent upon their uptake and disposition in tissues and cells. The metabolism and pharmacokinetics of flavonoids has been an area of acti...

journal_title：Free radical research

authors： Manach C,Donovan JL

更新日期：2004-08-01 00:00:00

abstract：:Several substances related to the neurodegenerative diseases of Alzheimer and Parkinson, such as hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42, have been shown to induce apoptosis in tumoral cell lines and rat neurons but not in human neurons. Moreover, the role of mitochondria...

journal_title：Free radical research

authors： Medina S,Martínez M,Hernanz A

更新日期：2002-11-01 00:00:00

abstract：:Iron or oxygen regulates the stability of hypoxia inducible factor-1α (HIF-1α). We investigated whether ferrous glycinate would affect HIF-1α accumulation, aerobic glycolysis and mitochondrial energy metabolism in human A549 lung cancer cells. Incubation of A549 cells with ferrous glycinate decreased the protein level...

journal_title：Free radical research

authors： Kuo YT,Jheng JH,Lo MC,Chen WL,Wang SG,Lee HM

更新日期：2018-12-01 00:00:00

abstract：:The hydroxyl radical (.OH)-scavenging activity of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a novel nonsteroidal anti-inflammatory drug (NSAID), and that of several other NSAIDs were investigated by the hyaluronic acid (HA) degradation method and the electron spin resonance (ESR) spin-trapping techniq...

journal_title：Free radical research

authors： Kataoka M,Tonooka K,Ando T,Imai K,Aimoto T

更新日期：1997-10-01 00:00:00

abstract：:It is well known that antioxidants such as AA (reduced ascorbate), glutathione (GSH) (reduced glutathione) and melatonin can delay seed ageing. Can they recover aged seed? Artificial aged maize seeds were obtained and their reduced germination rate (GR) and high lipid peroxidation were recorded. Exogenous melatonin wa...

journal_title：Free radical research

authors： Deng B,Yang K,Zhang Y,Li Z

更新日期：2017-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung disease caused by an inflammatory response to various inhaled toxins, especially cigarette smoke. Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histo...

journal_title：Free radical research

authors： Chikuma K,Arima K,Asaba Y,Kubota R,Asayama S,Sato K,Kawakami H

更新日期：2019-12-06 00:00:00

abstract：:Methylmercury (MeHg) is one of the ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. However, the mechanisms of MeHg-induced neuronal cell death are incompletely understood. Treatment of neuronal cells with MeHg (0-2 μM) for 0.5-12 h, or pretreated with LA (12.5-...

journal_title：Free radical research

authors： Yang T,Xu Z,Liu W,Xu B,Deng Y

更新日期：2016-01-01 00:00:00

abstract：:Glutathione plays a central role in the maintenance of cellular antioxidant defense. The alterations in the glutathione and associated recyclic enzymes caused by both exercise training and ethanol are well documented; however, their interactive effects with age are not well understood. Therefore, the influence of agei...

journal_title：Free radical research

authors： Kakarla P,Kesireddy S,Christiaan L

更新日期：2008-05-01 00:00:00

abstract：:Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to the airflow limitations and airway hyperresponsiveness (AHR). The involvement of oxidative stress in this process is well-established, but the specific role of the superoxide anion...

journal_title：Free radical research

authors： Nesi RT,Barroso MV,Souza Muniz V,de Arantes AC,Martins MA,Brito Gitirana L,Neves JS,Benjamim CF,Lanzetti M,Valenca SS

更新日期：2017-07-01 00:00:00

abstract：:Neopterin and its reduced form, 7,8 dihydroneopterin are pteridines released from macrophages and monocytes when stimulated with interferon gamma in vivo. The function of this response is unknown though there is an enormous amount of information available on the use of these compounds as clinical markers of monocyte/m...

journal_title：Free radical research

authors： Gieseg SP,Reibnegger G,Wachter H,Esterbauer H

更新日期：1995-08-01 00:00:00

abstract：:Oxidative stress is associated with a range of inflammatory lung diseases including asthma, adult respiratory distress syndrome, idiopathic pulmonary fibrosis, pneumonia, lung transplantation, chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis and lung cancer. Increased concentrations of reactive o...

journal_title：Free radical research

authors： Rahman I,Kelly F

更新日期：2003-12-01 00:00:00

abstract：:Proteins constitute the major 'working force' for all forms of biological work. Their exact conformation and pattern of folding are tightly connected to their activity and function. Reactive oxygen and nitrogen species (ROS and RNS) are formed during normal metabolism and in higher fluxes under pathological conditions...

journal_title：Free radical research

authors： Chevion M,Berenshtein E,Stadtman ER

更新日期：2000-11-01 00:00:00

abstract：:The purpose of this double clinical study was (1) to evaluate the effect of one single intake (300 ml) of red wine (RW) on the plasma antioxidant capacity (pAOC) and plasma phenolics over the 24-h time period following the intake, and (2) to compare the long-term effects of daily intakes (250 ml/d) of RW, white wine (...

journal_title：Free radical research

authors： Cartron E,Fouret G,Carbonneau MA,Lauret C,Michel F,Monnier L,Descomps B,Léger CL

更新日期：2003-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterised by selective degeneration of the nigral dopaminergic neurons, and neuroinflammation and oxidative stress are believed to be involved in its pathogenesis. In the present study, we provide data that the synthetic steroid exemestane, which is currentl...

journal_title：Free radical research

authors： Son HJ,Han SH,Lee JA,Shin EJ,Hwang O

更新日期：2017-06-01 00:00:00

abstract：:Diosgenin possesses anti-inflammatory and anticancer properties. Activated neutrophils produce high concentrations of the superoxide anion which is involved in the pathophysiology of inflammation-related diseases and cancer. In the present study, the inhibitory effect and possible mechanisms of diosgenin on superoxide...

journal_title：Free radical research

authors： Lin Y,Jia R,Liu Y,Gao Y,Zeng X,Kou J,Yu B

更新日期：2014-12-01 00:00:00

abstract：:Hydroxyl and 1-hydroxyethyl radical adducts of 5,5-dimethylpyrroline N-oxide (DMPO) were prepared by photolysis, and mechanisms for loss of their EPR signals in rat liver microsomal suspensions were evaluated. Rates of NADPH-dependent EPR signal loss were more rapid in phosphate buffer than in Tris buffer. Addition of...

journal_title：Free radical research

authors： Reinke LA,Moore DR,McCay PB

更新日期：1996-12-01 00:00:00

abstract：INTRODUCTION:Nuclear factor, erythroid 2 like 2 (NFE2L2) is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 deficiency in placentas is associated with pregnancy complications. We have demonstrated that elevated OS existed in placental shares of the smaller fetus in selective int...

journal_title：Free radical research

authors： Wu J,He Z,Gao Y,Zhang G,Huang X,Fang Q

更新日期：2017-04-01 00:00:00

abstract：:Nerve growth factor (NGF) is one of the several structurally related proteins, named neurotrophins (NTs), that regulate neuronal survival, development, function, and plasticity. Moreover, NGF is an important activator of antioxidant mechanisms. These NGF functions are mediated by tropomyosin-related kinase receptor A ...

journal_title：Free radical research

authors： Valdovinos-Flores C,Gonsebatt ME

更新日期：2013-05-01 00:00:00

abstract：:Cerebrovascular diseases (CBD) are one of the most dangerous complications of atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the prognosis of patients. Atherosclerosis is the main cause of CBD development. Hypertension, dyslipidemia, diabetes, smoking, obesity, and other risk facto...

journal_title：Free radical research

authors： Scicchitano P,Cortese F,Gesualdo M,De Palo M,Massari F,Giordano P,Ciccone MM

更新日期：2019-06-01 00:00:00

abstract：:Oxidatively generated damage to nucleic acids may play an important role in the pathophysiological processes of a variety of diseases. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) are oxidatively generated products of DNA and RNA, respectively. Our previous studies have s...

journal_title：Free radical research

authors： Mao YH,Weng QH,Xu LN,Li XY,Zhao B,Sun Y,Nie JJ,Hu JH,Zhou Q,Zhang LQ,Guo J,Zuo MZ,Ito S,Cai JP

更新日期：2017-06-01 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) induces Mv1Lu cell senescence through inactivating glycogen synthase kinase 3 (GSK3), thereby inactivating complex IV and increasing intracellular ROS. In the present study, we identified protein kinase C delta (PKCδ) as an upstream regulator of GSK3 inactivation in this mechanis...

journal_title：Free radical research

authors： Byun HO,Jung HJ,Kim MJ,Yoon G

更新日期：2014-09-01 00:00:00

abstract：:Formation of the alpha-hydroxyethyl radical (CH3 degree CHOH) has already been extensively demonstrated after ethanol metabolism in the liver. Despite favourable conditions, this formation in the brain has remained speculative since there is no direct experimental evidence in intact brain cells. In this preliminary st...

journal_title：Free radical research

authors： Gonthier B,Eysseric H,Soubeyran A,Daveloose D,Saxod R,Barret L

更新日期：1997-12-01 00:00:00

abstract：:Nitronyl nitroxides (NNs) are the paramagnetic probes that are capable of scavenging physiologically relevant reactive oxygen (ROS) and nitrogen (RNS) species, namely superoxide, nitric oxide (NO), and nitroxyl (HNO). NNs are increasingly considered as potent antioxidants and potential therapeutic agents. Understandin...

journal_title：Free radical research

authors： Bobko AA,Khramtsov VV

更新日期：2015-01-01 00:00:00

abstract：:An increasing incidence of unresponsiveness to antimonials in Leishmaniasis has led to identification of plant-derived anti-leishmanial compounds like Artemisinin. Since iron-mediated generation of free radicals sustains the anti-malarial activity of Artemisinin, this study investigated whether similar mechanisms acco...

journal_title：Free radical research

authors： Sen R,Saha P,Sarkar A,Ganguly S,Chatterjee M

更新日期：2010-11-01 00:00:00