Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance.

abstract：:The host inflammatory response appears to be an important contributor to the pathogenesis of human viral respiratory illness. Virus-induced oxidative stress appears to mediate an early phase of elaboration of the proinflammatory cytokine interleukin-8 by respiratory epithelial cells. The purpose of these studies was t...

journal_title：Free radical research

authors： Kaul P,Singh I,Turner RB

更新日期：2002-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterised by selective degeneration of the nigral dopaminergic neurons, and neuroinflammation and oxidative stress are believed to be involved in its pathogenesis. In the present study, we provide data that the synthetic steroid exemestane, which is currentl...

journal_title：Free radical research

authors： Son HJ,Han SH,Lee JA,Shin EJ,Hwang O

更新日期：2017-06-01 00:00:00

abstract：:An increasing incidence of unresponsiveness to antimonials in Leishmaniasis has led to identification of plant-derived anti-leishmanial compounds like Artemisinin. Since iron-mediated generation of free radicals sustains the anti-malarial activity of Artemisinin, this study investigated whether similar mechanisms acco...

journal_title：Free radical research

authors： Sen R,Saha P,Sarkar A,Ganguly S,Chatterjee M

更新日期：2010-11-01 00:00:00

abstract：:Thioredoxin-1 (TRX) is a redox-active protein with anti-inflammatory effects. This study investigated the optimal delivery method and the mechanisms of recombinant human TRX (rhTRX) to suppress neutrophil recruitment in a rat bleomycin (BLM)-induced sustained acute lung injury model. In male Wister rats intratracheall...

journal_title：Free radical research

authors： Nakamura T,Hoshino Y,Yamada A,Teratani A,Furukawa S,Okuyama H,Ueda S,Wada H,Yodoi J,Nakamura H

更新日期：2007-10-01 00:00:00

abstract：:The cytologically active secondary lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) have been detected as their 2,4-dinitrophenylhydrazone (DNP) derivatives in plant tissue cultures using LC-MS. This paper reports, for the first time, the use of LC-MS methodology to definitively identif...

journal_title：Free radical research

authors： Deighton N,Magill WJ,Bremner DH,Benson EE

更新日期：1997-09-01 00:00:00

abstract：:Hemopexin, a heme-binding serum glycoprotein, is thought to play an important role in the prevention of oxidative damage that may be catalysed by free heme. Through the use of EPR techniques, the generation of free radicals from organic hydroperoxides by heme and heme-hemopexin complexes, and the concomitant formation...

journal_title：Free radical research

authors： Timmins GS,Davies MJ,Song DX,Muller-Eberhard U

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:Aspiration pneumonia is infection of the respiratory tract resulting from accumulation of sputum in the larynx. N-acetyl-L-cysteine (NAC) might regulate mucin (MUC) expression and activate inherent anti-infective system in bronchiolar epithelial cells after cellular uptake, and therefore, serve as the preventat...

journal_title：Free radical research

authors： Koizumi C,Yamada M,Ishizaki K,Ueda T,Sakurai K

更新日期：2015-01-01 00:00:00

abstract：:Effects of vitamins B, C, E, K and P, as well as coenzymes Q, on formation of final products of radiation-induced free-radical transformations of ethanol, ethylene glycol, alpha-methylglycoside and glucose in aqueous solutions were studied. Based on the obtained results, it can be concluded that there are substances a...

journal_title：Free radical research

authors： Shadyro OI,Sosnovskaya AA,Edimecheva IP,Grintsevich IB,Lagutin PY,Alekseev AV,Kazem K

更新日期：2005-07-01 00:00:00

abstract：:The effect of antioxidants on ammonia induced CNS and renal pathobiology in 10 sheep infested by L. Cuprina larvae was investigated. The condition produces severe dermatitis, proliferation of macrophages and hyperammonaemia, and free radicals may therefore be involved in the pathogenesis. Five of the sheep (treated gr...

journal_title：Free radical research

authors： Guerrini VH

更新日期：1994-07-01 00:00:00

abstract：:Hyperthermia-induced apoptosis and its enhancement in the presence of a temperature-dependent free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride (AAPH) were examined in human uterine cervical cancer cell lines, CaSki and HeLa. When both cell lines were treated with hyperthermia at 44 degrees C for 60...

journal_title：Free radical research

authors： Yuki H,Kondo T,Zhao QL,Fujiwara Y,Tanabe K,Ogawa R,Nakashima A,Fushiki H,Fujimura M,Saito S

更新日期：2003-06-01 00:00:00

abstract：:In the present study we tested the ability of different antioxidant agents, used alone or in combination, to reduce the reactive oxygen species (ROS) levels and to increase the glutathione peroxidase (GPx) activity. Moreover, we tested the ability of such antioxidant agents to reduce the serum levels of proinflammator...

journal_title：Free radical research

authors： Mantovani G,Macciò A,Madeddu C,Mura L,Gramignano G,Lusso MR,Murgia V,Camboni P,Ferreli L,Mocci M,Massa E

更新日期：2003-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important mediators of the cytotoxicity induced by the direct reaction of ionising radiation (IR) with all critical cellular components, such as proteins, lipids, and nucleic acids. The derived oxidative damage may propagate in exposed tissues in a dose- and spatiotemporal dependent m...

journal_title：Free radical research

authors： Pietraforte D,Paulicelli E,Patrono C,Gambardella L,Scorza G,Testa A,Fattibene P

更新日期：2018-04-01 00:00:00

abstract：:Sublytic levels (microM) of hemin destabilized RBC membrane as indicated by ghost fragmentation pattern using a laser viscodiffractometer. Furthermore, electron microscopic study shows that 5 microM of hemin induced echinocytic transformation whereas higher hemin concentration (40 microM) induced spherocytic transform...

journal_title：Free radical research

authors： Chiu DT,Huang TY,Hung IJ,Wei JS,Liu TZ,Stern A

更新日期：1997-07-01 00:00:00

abstract：:Methylmercury (MeHg) is one of the ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. However, the mechanisms of MeHg-induced neuronal cell death are incompletely understood. Treatment of neuronal cells with MeHg (0-2 μM) for 0.5-12 h, or pretreated with LA (12.5-...

journal_title：Free radical research

authors： Yang T,Xu Z,Liu W,Xu B,Deng Y

更新日期：2016-01-01 00:00:00

abstract：:We investigated effect of aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE) on prostaglandin (PG) E2 receptors of liver plasma membranes. The modification of the membranes by MDA diminished PGE2 binding, decreasing receptor affinity for PGE2 and receptor density whereas HNE inc...

journal_title：Free radical research

authors： Buko VU,Artsukevich A,Zavodnik I,Maltsev A,Sushko L,Zimmermann T,Dianzani MU

更新日期：1996-11-01 00:00:00

abstract：:Creatol (CTL) is a product resulting from the reaction of creatinine (Cr) with the hydroxyl radical and is identified as a precursor of methylguanidine (MG), a uremic toxin. In this study, we investigated serum CTL levels together with those of Cr and MG in 66 patients who were on maintenance hemodialysis (HD). Prior ...

journal_title：Free radical research

authors： Tomida C,Aoyagi K,Nagase S,Gotoh M,Yamagata K,Takemura K,Koyama A

更新日期：2000-01-01 00:00:00

abstract：:Sonodynamic therapy, a promising new approach to cancer treatment, is based on synergistic cell killing by combination of certain drugs (sonosensitizers) and ultrasound. Although the mechanism of sonodynamic action is not understood, the role of free radicals produced from sonosensitizers by ultrasound is implicated. ...

journal_title：Free radical research

authors： Misík V,Miyoshi N,Riesz P

更新日期：1996-07-01 00:00:00

abstract：:Pyruvate is a well-known scavenger of hydrogen peroxide (H2O2). In addition, it scavenges superoxide radical (O2.-). However, evidence on its intracellular antioxidant function is meager at present. Hence, we have examined the effectiveness of this metabolite and its ethyl ester against intracellular oxidative damage ...

journal_title：Free radical research

authors： Varma SD,Devamanoharan PS,Ali AH

更新日期：1998-02-01 00:00:00

abstract：:The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 ...

journal_title：Free radical research

authors： Borrás C,Gómez-Cabrera MC,Viña J

更新日期：2011-06-01 00:00:00

abstract：:Antioxidants are important species which possess the ability to protect the body from damage caused by free radical-induced oxidative stress. A variety of free radical-scavenging antioxidants exist within the body many of which are derived from dietary sources. There is currently much interest in the antioxidant role ...

journal_title：Free radical research

authors： Robinson EE,Maxwell SR,Thorpe GH

更新日期：1997-03-01 00:00:00

abstract：:Cellular exposure to ionising radiation leads to oxidative stress events, which refer to elevated intracellular levels of reactive oxygen species (ROS). The elevated levels of ROS significantly contributed to γ-radiation (IR) induced cytotoxicity. In an attempt to minimise these cytotoxic effects, antioxidant compound...

journal_title：Free radical research

authors： Abozaid OAR,Moawed FSM,Farrag MA,Abdel Aziz AAA

更新日期：2017-12-01 00:00:00

abstract：:The markers 3-nitrotyrosine and 3-chlorotyrosine are measured as surrogates for reactive nitrogen species and hypochlorous acid respectively, which are both elevated in inflamed human tissues. Previous studies reported a loss of 3-nitrotyrosine when exposed to hypochlorous acid, suggesting that observations of 3-nitro...

journal_title：Free radical research

authors： Curtis MP,Neidigh JW

更新日期：2014-11-01 00:00:00

abstract：:The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for 4 years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defenses, and WG4 - Bio-inspired synthetic stra...

journal_title：Free radical research

authors： Ferreri C,Golding BT,Jahn U,Ravanat JL

更新日期：2016-11-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is an essential cofactor of the electron transport gene as well as an important antioxidant, which is particularly effective within mitochondria. A number of prior studies have shown that it can exert efficacy in treating patients with known mitochondrial disorders. We investigated the potential u...

journal_title：Free radical research

authors： Beal MF

更新日期：2002-04-01 00:00:00

abstract：:We investigated the effect of curcumin on liver injury in diabetic rats induced by streptozotocin (STZ) through modulation of endoplasmic reticulum stress (ERS) and unfolded protein response (UPR). Experimental diabetes was induced by a single intraperitoneal injection of STZ (55 mg/kg), and curcumin was given at 100 ...

journal_title：Free radical research

authors： Afrin R,Arumugam S,Soetikno V,Thandavarayan RA,Pitchaimani V,Karuppagounder V,Sreedhar R,Harima M,Suzuki H,Miyashita S,Nomoto M,Suzuki K,Watanabe K

更新日期：2015-03-01 00:00:00

abstract：:The metabolism of paraquat generates oxygen radicals. Paraquat has thus been suggested as a model compound to induce oxidative damage to DNA, lipids and proteins in different cells and tissues, although experimental data are inconsistent. In order to explore the possibilities for an animal model of oxidative DNA damag...

journal_title：Free radical research

authors： Sørensen M,Loft S

更新日期：2000-05-01 00:00:00

abstract：:Radicals from one-electron oxidation of 4-hydroxycinnamate, ferulate and 3,4-dihydroxycinnamate have been formed by reaction with the oxidising triplet state of duroquinone. All three compounds react with triplet duroquinone with second order rate constants close to the diffusion-controlled limit. The identity of the ...

journal_title：Free radical research

authors： Bisby RH,Parker AW

更新日期：2001-07-01 00:00:00

abstract：:Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and make nitric oxide (NO*) in amounts sufficient to affect mitochondrial respiration. However, we found that the addition of L-arginine or the NOS inhibitor L-NMMA to intact rat liver mitochondria did not have any effect on the respirat...

journal_title：Free radical research

authors： Tay YM,Lim KS,Sheu FS,Jenner A,Whiteman M,Wong KP,Halliwell B

更新日期：2004-06-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a ubiquitous pteridine metabolite that serves as a NOS cofactor. Recently, we showed that BH4 efficiently inhibits superoxide generation from the heme group at the oxygenase domain of eNOS. This role indicates that BH4 acts as a redox switch in the catalytic mechanism of the enzyme, which ...

journal_title：Free radical research

authors： Vásquez-Vivar J,Kalyanaraman B,Martásek P

更新日期：2003-02-01 00:00:00

abstract：:This work describes the synthesis and characterisation of some novel hybrid molecules which contains in the same molecule a free radical moiety of hydrazyl type and a spin-trap moiety of nitrone type. The new compounds synthesized have multiple and easy to follow spectroscopic properties, making them useful as sensors...

journal_title：Free radical research

authors： Ionita P

更新日期：2006-01-01 00:00:00