Recombinant human thioredoxin-1 becomes oxidized in circulation and suppresses bleomycin-induced neutrophil recruitment in the rat airway.

abstract：OBJECTIVES:The aim of the present study was to investigate the potential importance of oxidative stress, measured by isoprostanes-related compounds, as non-traditional risk factor for cardiovascular disease. We planned to examine the relationship between concentrations of plasma F₂-isoprostanes (F₂-IsoPs), isofurans (I...

journal_title：Free radical research

authors： Alkazemi D,Egeland GM,Roberts LJ 2nd,Kubow S

更新日期：2012-10-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis. The most common technique for measuring the oxidation of lipoproteins is the continuous measurement of the formation of conjugated diene at OD 234 nm. The concept of "lag time", derived from such measurements, has be...

journal_title：Free radical research

authors： Parthasarathy S,Augé N,Santanam N

更新日期：1998-06-01 00:00:00

abstract：:Heme oxygenase is the rate limiting enzyme in heme degradation to carbon monoxide (CO), iron and bilirubin. The inducible isoform of the protein, heme oxygenase-1 (HO-1), is susceptible to up-regulation by a diverse variety of conditions and agents in mammalian tissue, leading to the common conception that HO-1 is a s...

journal_title：Free radical research

authors： Foresti R,Motterlini R

更新日期：1999-12-01 00:00:00

abstract：:Anxiety disorders are the most common mental illness in the USA affecting 18% of the population. The cause(s) of anxiety disorders is/are not completely clear, and research in the neurobiology of anxiety at the molecular level is still rather limited. Although mounting clinical and preclinical evidence now indicates t...

journal_title：Free radical research

authors： Fedoce ADG,Ferreira F,Bota RG,Bonet-Costa V,Sun PY,Davies KJA

更新日期：2018-07-01 00:00:00

abstract：:A small part of cellular iron, usually called 'labile iron pool' (LIP), is not securely stored and has the potential to catalyse the formation of highly reactive oxygen species. The present work estimated LIP levels in human white cells by using the analytical power of flow cytometry. The method relies essentially on ...

journal_title：Free radical research

authors： Doulias PT,Vlachou C,Boudouri C,Kanavaros P,Siamopoulos KC,Galaris D

更新日期：2008-03-01 00:00:00

abstract：:Sonodynamic therapy, a promising new approach to cancer treatment, is based on synergistic cell killing by combination of certain drugs (sonosensitizers) and ultrasound. Although the mechanism of sonodynamic action is not understood, the role of free radicals produced from sonosensitizers by ultrasound is implicated. ...

journal_title：Free radical research

authors： Misík V,Miyoshi N,Riesz P

更新日期：1996-07-01 00:00:00

abstract：:Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCCL) and elevates [Ca2+]i in many cells. However, how oxidative stress activates VDCCL under clinical setting and the consequenc...

journal_title：Free radical research

authors： Park HJ,Shin KC,Yoou SK,Kang M,Kim JG,Sung DJ,Yu W,Lee Y,Kim SH,Bae YM,Park SW

更新日期：2019-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterised by selective degeneration of the nigral dopaminergic neurons, and neuroinflammation and oxidative stress are believed to be involved in its pathogenesis. In the present study, we provide data that the synthetic steroid exemestane, which is currentl...

journal_title：Free radical research

authors： Son HJ,Han SH,Lee JA,Shin EJ,Hwang O

更新日期：2017-06-01 00:00:00

abstract：:Isolated Langendorff-perfused rat hearts, after 30 min of preperfusion, were submitted to increasing times of global normothermic ischemia (1, 2, 5, 10, 20 and 30 min) or to the same times of ischemia followed by 30 min of reperfusion. Analysis of malondialdehyde, ascorbic acid, oxypurines, nucleosides, nicotinic coen...

journal_title：Free radical research

authors： Tavazzi B,Di Pierro D,Bartolini M,Marino M,Distefano S,Galvano M,Villani C,Giardina B,Lazzarino G

更新日期：1998-01-01 00:00:00

abstract：:In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...

journal_title：Free radical research

authors： Chainy GBN,Sahoo DK

更新日期：2020-01-01 00:00:00

abstract：:The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated. Tubular proteinuria and oxidative stress were induced by a single injection of maleate (400 mg/kg) in rats. Maleate-induced renal injury included increase in renal v...

journal_title：Free radical research

authors： Tapia E,Sánchez-Lozada LG,García-Niño WR,García E,Cerecedo A,García-Arroyo FE,Osorio H,Arellano A,Cristóbal-García M,Loredo ML,Molina-Jijón E,Hernández-Damián J,Negrette-Guzmán M,Zazueta C,Huerta-Yepez S,Reyes JL,Madero M

更新日期：2014-11-01 00:00:00

abstract：:Along with differentiation of mouse stromal preadipocytes OP9 into adipocytes, intracellular ROS, especially superoxide anion radicals detected by NBT reduction assay, were found to appreciably increase, mainly in cytoplasmic area, parallelling with increases in intracellular lipid-droplet accumulation, whereas undiff...

journal_title：Free radical research

authors： Saitoh Y,Xiao L,Mizuno H,Kato S,Aoshima H,Taira H,Kokubo K,Miwa N

更新日期：2010-09-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) reproduces a multiple sclerosis (MS)-like experimental model. The main objective was to evaluate the effect of extremely low-frequency electromagnetic fields (EL-EMF) application, like a paradigm of transcranial magnetic stimulation (TMS) in the development of EAE. Rats ...

journal_title：Free radical research

authors： Medina-Fernandez FJ,Escribano BM,Agüera E,Aguilar-Luque M,Feijoo M,Luque E,Garcia-Maceira FI,Pascual-Leone A,Drucker-Colin R,Tunez I

更新日期：2017-05-01 00:00:00

abstract：:Flavonoids, which are dietary components and have possible drug uses, inhibit lipoprotein oxidation in vitro. The present study considered whether flavonoid supplementation in humans could influence lipoprotein vulnerability to oxidation. Citrus flavonoid supplementation (about 1g/day, 3 weeks), or placebo, was given ...

journal_title：Free radical research

authors： Blostein-Fujii A,DiSilvestro RA,Frid D,Katz C

更新日期：1999-04-01 00:00:00

abstract：:Melatonin is an endogenous indolamine, classically known as a light/dark regulator. Besides classical functions, melatonin has also showed to have a wide range of antitumoral effects in numerous cancer experimental models. However, no definite mechanism has been described to explain the whole range of antineoplasic ef...

journal_title：Free radical research

authors： Sánchez-Sánchez AM,Martín V,García-Santos G,Rodríguez-Blanco J,Casado-Zapico S,Suarez-Garnacho S,Antolín I,Rodriguez C

更新日期：2011-11-01 00:00:00

abstract：:Validation of markers requires two different steps. The first one is the analytical validation including analytical procedures, definition of standard reference, and round-tests analysis. The second one is the assessment of the biological relevance of the selected marker. This biological relevance may be in the field ...

journal_title：Free radical research

authors： Antoine JM,Diplock AT

更新日期：2000-11-01 00:00:00

abstract：:Recent research about the role of free radical derivatives of oxygen and nitrogen in biological systems has highlighted the possibility that antioxidants, such as vitamin E, that prevent these processes in vitro may be capable of carrying out a similar function in living organisms in vivo. There is increasing evidence...

journal_title：Free radical research

authors： Diplock AT

更新日期：1997-06-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a ubiquitous pteridine metabolite that serves as a NOS cofactor. Recently, we showed that BH4 efficiently inhibits superoxide generation from the heme group at the oxygenase domain of eNOS. This role indicates that BH4 acts as a redox switch in the catalytic mechanism of the enzyme, which ...

journal_title：Free radical research

authors： Vásquez-Vivar J,Kalyanaraman B,Martásek P

更新日期：2003-02-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning in Asian countries, that has high antioxidant activity in vitro and some antioxidant activity in vivo. We attempted to identify the major antioxidants present, using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay as a guide. 3-Hydroxy-2-methyl-4H-p...

journal_title：Free radical research

authors： Wang H,Jenner AM,Lee CY,Shui G,Tang SY,Whiteman M,Wenk MR,Halliwell B

更新日期：2007-04-01 00:00:00

abstract：:The radiation-induced reactions of a water-soluble coumarin derivative, coumarin-3-carboxyl acid (C3CA), have been investigated in aqueous solutions by pulse radiolysis with a 35 MeV electron beam, final product analysis following (60)Co γ-irradiations and deterministic model simulations. Pulse radiolysis revealed tha...

journal_title：Free radical research

authors： Yamashita S,Baldacchino G,Maeyama T,Taguchi M,Muroya Y,Lin M,Kimura A,Murakami T,Katsumura Y

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to determine whether single administration of the antioxidant enzyme bovine superoxide dismutase (bSOD) after radiation therapy (RT) mitigates development of pulmonary toxicity in rats. METHODS:Female F344 rats (n = 60) were divided among six experimental groups: (1) R...

journal_title：Free radical research

authors： Antonic V,Rabbani ZN,Jackson IL,Vujaskovic Z

更新日期：2015-10-01 00:00:00

abstract：:Oxidative stress is associated with a range of inflammatory lung diseases including asthma, adult respiratory distress syndrome, idiopathic pulmonary fibrosis, pneumonia, lung transplantation, chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis and lung cancer. Increased concentrations of reactive o...

journal_title：Free radical research

authors： Rahman I,Kelly F

更新日期：2003-12-01 00:00:00

abstract：:Degenerative diseases such as cancer are induced by oxidative genetic damage. Antioxidants can scavenge reactive oxygen species, but to prevent disease, they must do so quickly, before the DNA bases are damaged. In the present study, a novel method was established for evaluating the potency of antioxidants employing 2...

journal_title：Free radical research

authors： Sakakibara H,Ashida H,Kanazawa K

更新日期：2002-03-01 00:00:00

abstract：:Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly differ in their expression level by a factor of 2 or higher between the high and the low alpha-tocopherol ...

journal_title：Free radical research

authors： Nell S,Bahtz R,Bossecker A,Kipp A,Landes N,Bumke-Vogt C,Halligan E,Lunec J,Brigelius-Flohé R

更新日期：2007-08-01 00:00:00

abstract：:Gamma-glutamyltransferase (GGT) plays a central role in the homeostasis of the antioxidant glutathione (GSH). The expression of GGT has been shown to be upregulated after oxidative stress, but the signalling pathways implicated remain poorly characterized. The results here show that acute exposure of CC531 cells to ox...

journal_title：Free radical research

authors： Pandur S,Pankiv S,Johannessen M,Moens U,Huseby NE

更新日期：2007-12-01 00:00:00

abstract：:Microcystin-LR (MCLR) is a potent hepatotoxin. Oxidative stress is thought to be implicated in the cytotoxicity of MCLR, but the mechanisms by which MCLR produces reactive oxygen species (ROS) are still unclear. This study investigated the role and possible sources of ROS generation in MCLR-induced cytogenotoxicity in...

journal_title：Free radical research

authors： Nong Q,Komatsu M,Izumo K,Indo HP,Xu B,Aoyama K,Majima HJ,Horiuchi M,Morimoto K,Takeuchi T

更新日期：2007-12-01 00:00:00

abstract：:The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...

journal_title：Free radical research

authors： Song HC,Chen Y,Chen Y,Park J,Zheng M,Surh YJ,Kim UH,Park JW,Yu R,Chung HT,Joe Y

更新日期：2020-07-28 00:00:00

abstract：:Intake of antioxidants from the diet has been recognized to have beneficial health effects, but the potential benefit of taking antioxidants such as β-carotene as supplements is controversial. The aim of the present study was to evaluate the potential protective effects of a physiologically relevant concentration (2 μ...

journal_title：Free radical research

authors： Åsgård R,Hellman B

更新日期：2013-09-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Radioresistance is a significant obstacle in NSCLC radiotherapy. Long non-coding RNA LINC00473 has been found to impact the radiotherapy in several malignant tumours. This study aimed to investigate the underlying role and mechanism of LINC0047...

journal_title：Free radical research

authors： Qin P,Li Y,Liu J,Wang N

更新日期：2020-10-01 00:00:00

abstract：:Testing of pregnant women reveals weakening of neutrophil-mediated effector functions, such as reactive oxygen species generation. This study provides data confirming the phenomenon, gained through application of the flow cytometry technique. Key factors influencing neutrophil functional activity in blood plasma of pr...

journal_title：Free radical research

authors： Varfolomeeva EY,Semenova EV,Sokolov AV,Aplin KD,Timofeeva KE,Vasilyev VB,Filatov MV

更新日期：2016-08-01 00:00:00