Hormones and oxidative stress: an overview.

Abstract:

:In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzymatic and nonenzymatic antioxidant defences to protect themselves from OS. Although hormones as means of biological coordination involve in regulation of physiological activities of tissues by regulating metabolism, any change in their normal titre leads to pathophysiological states. While, hormones such as melatonin, insulin, oestrogen, progesterone display antioxidant features, thyroid hormone, corticosteroids and catecholamines elicit free radical generation and OS, and the role of testosterone in inducing OS is debateable. This review is an attempt to understand the impact of free radical generation and cross talk between the hormones modulating antioxidant defence system under various pathophysiological conditions.

journal_name

Free Radic Res

journal_title

Free radical research

authors

Chainy GBN,Sahoo DK

doi

10.1080/10715762.2019.1702656

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

1-26

issue

1

eissn

1071-5762

issn

1029-2470

journal_volume

54

pub_type

杂志文章,评审
  • Effective inhibition by beta-carotene of cellular DNA breaking induced by peroxynitrous acid.

    abstract::Peroxynitrous acid synthesized by reaction of hydrogen peroxide and nitrite and generated from 3-morpholinosydononimine (SIN-1) induced cellular DNA breaking of human promyelocytic leukemia HL-60 cells in phosphate buffer (pH 7.5) as assessed by alkaline single cell gel electrophoresis (comet) assay and quantification...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715769900300031

    authors: Hiramoto K,Tomiyama S,Kikugawa K

    更新日期:1999-01-01 00:00:00

  • alpha-Phenyl N-tert-butyl nitrone (PBN) increases the cortical cerebral blood flow by inhibiting the breakdown of nitric oxide in anesthetized rats.

    abstract::The effects of intravenous administration of alpha-phenyl N-tert-butyl nitrone (PBN) on cortical cerebral blood flow (CBF) were examined in Wistar rats under pentobarbital anesthesia and artificial ventilation. The cortical CBF in parietal cortex was measured by laser Doppler flowmetry. Intravenous administrations of ...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715769509064017

    authors: Inanami O,Kuwabara M

    更新日期:1995-07-01 00:00:00

  • Protein oxidative damage and redox imbalance induced by ionising radiation in CHO cells.

    abstract::Reactive oxygen species (ROS) are important mediators of the cytotoxicity induced by the direct reaction of ionising radiation (IR) with all critical cellular components, such as proteins, lipids, and nucleic acids. The derived oxidative damage may propagate in exposed tissues in a dose- and spatiotemporal dependent m...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715762.2018.1446529

    authors: Pietraforte D,Paulicelli E,Patrono C,Gambardella L,Scorza G,Testa A,Fattibene P

    更新日期:2018-04-01 00:00:00

  • In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles.

    abstract::The antioxidant properties of protoporphyrin IX and related tetrapyrroles are poorly characterized. Therefore, eight tetrapyrroles, five of which are produced in vivo, were tested to assess their antioxidant capacities in the Salmonella reverse mutation, TEAC, FRAP and ORAC assays. Tertiary-butyl hydroperoxide (tert-B...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715762.2012.715371

    authors: Mölzer C,Huber H,Steyrer A,Ziesel G,Ertl A,Plavotic A,Wallner M,Bulmer AC,Wagner KH

    更新日期:2012-11-01 00:00:00

  • AGEs, contributors to placental bed vascular changes leading to preeclampsia.

    abstract::Glycation of proteins or other biomolecules and their further long-term degradation result in the formation of advanced glycation end products, AGEs. AGEs and other ligands interact with their receptors, RAGEs, localized to a variety of tissues, but mainly in endothelium and vascular wall cells. This interaction trigg...

    journal_title:Free radical research

    pub_type: 杂志文章,评审

    doi:10.3109/10715762.2013.815347

    authors: Guedes-Martins L,Matos L,Soares A,Silva E,Almeida H

    更新日期:2013-08-01 00:00:00

  • Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutella...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715762.2017.1422602

    authors: Zhang X,Ji R,Sun H,Peng J,Ma X,Wang C,Fu Y,Bao L,Jin Y

    更新日期:2018-02-01 00:00:00

  • Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance.

    abstract::Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces ...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715762.2018.1460749

    authors: Hou C,Peng Y,Qin C,Fan F,Liu J,Long J

    更新日期:2018-12-01 00:00:00

  • Placental NFE2L2 is discordantly activated in monochorionic twins with selective intrauterine growth restriction and possibly regulated by hypoxia.

    abstract:INTRODUCTION:Nuclear factor, erythroid 2 like 2 (NFE2L2) is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 deficiency in placentas is associated with pregnancy complications. We have demonstrated that elevated OS existed in placental shares of the smaller fetus in selective int...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715762.2017.1315113

    authors: Wu J,He Z,Gao Y,Zhang G,Huang X,Fang Q

    更新日期:2017-04-01 00:00:00

  • Increase in insulin-induced relaxation of consecutive arterial segments toward the periphery: Role of vascular oxidative state.

    abstract:RATIONALE:The oxidative state has been implicated in the signaling of various vasomotor functions, yet its role regarding the vasomotor action of insulin is less known. OBJECTIVE:To investigate the insulin-evoked relaxations of consecutive arterial segments of different oxidative state and the role of extracellular si...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715762.2014.904507

    authors: Szijártó IA,Molnár GA,Mikolás E,Fisi V,Laczy B,Gollasch M,Koller A,Wittmann I

    更新日期:2014-07-01 00:00:00

  • Sex-dependent antioxidant enzyme activities and lipid peroxidation in ageing mouse brain.

    abstract::We investigated whether oxidant status and antioxidant enzyme activities during ageing of mouse brain are regulated in sex-dependent manner. In the homogenate from the brain of 1, 4, 10 and 18 months old male and female CBA mice, lipid peroxidation (LPO), total superoxide dismutase (tSOD), catalase (CAT) and glutathio...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/1071576031000102178

    authors: Sobocanec S,Balog T,Sverko V,Marotti T

    更新日期:2003-07-01 00:00:00

  • Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin.

    abstract::Neopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with gamma-interferon in vivo. The role of 78NP in inflammatory response is unknown though neopterin has been used clinically as a marker of immune cell activation, due to its very fluorescent nature. U...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760100300121

    authors: Gieseg SP,Maghzal G,Glubb D

    更新日期:2001-02-01 00:00:00

  • SOD2 gene polymorphism and response of oxidative stress parameters in young wrestlers to a three-month training.

    abstract::The aim of the study was to analyse the effect of Val 16Ala polymorphism in SOD2 gene on oxidative stress parameters and lipid profile of the blood during a three-month wrestling training. The study included 53 Polish young wrestlers. Blood samples were collected at the beginning of the programme and following three m...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715762.2017.1327716

    authors: Jówko E,Gierczuk D,Cieśliński I,Kotowska J

    更新日期:2017-05-01 00:00:00

  • Status of antioxidants in brain microvessels of monkey and rat.

    abstract::Levels of certain antioxidants namely reduced glutathione (GSH), ascorbic acid (Vit C), alpha-tocopherol (Vit E) and antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were compared in monkey and rat brain microvessels which constitute the blood...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715769509145642

    authors: Shukla A,Dikshit M,Srimal RC

    更新日期:1995-04-01 00:00:00

  • Effect of complexation with randomly methylated beta-cyclodextrin on the aqueous solubility, photostability and antioxidant activity of an indolinonic nitroxide radical.

    abstract::The interaction between the hydrophobic indolinonic nitroxide radical, 1,2-dihydro-2-methyl-2-phenyl-3H-indole-3-one-1-oxyl and hydrophilic alpha-, beta- and gamma-cyclodextrin derivatives was investigated in water by phase-solubility analysis. Among the studied cyclodextrins, random methyl-beta-cyclodextrin (RM-beta-...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760400023689

    authors: Damiani E,Tursilli R,Casolari A,Astolfi P,Greci L,Scalia S

    更新日期:2005-01-01 00:00:00

  • Aldehyde adducts generated during lipid peroxidation modification of proteins.

    abstract::Various lines of evidence indicate that an important part in the pathogenesis of atherosclerosis is the modification of the plasma low-density lipoproteins (LDLs). A large number of pro-inflammatory and pro-atherogenic properties have been ascribed to the oxidatively modified LDLs and their components. There is consid...

    journal_title:Free radical research

    pub_type: 杂志文章,评审

    doi:10.3109/10715762.2015.1036052

    authors: Uchida K

    更新日期:2015-01-01 00:00:00

  • Free radicals and acute pancreatitis: much ado about … something.

    abstract::There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is al...

    journal_title:Free radical research

    pub_type: 杂志文章,评审

    doi:10.3109/10715762.2013.829571

    authors: Closa D

    更新日期:2013-11-01 00:00:00

  • Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.

    abstract::Oxidative modifications are a hallmark of oxidative imbalance in the brains of individuals with Alzheimer's, Parkinson's and prion diseases and their respective animal models. While the causes of oxidative stress are relatively well-documented, the effects of chronically reducing oxidative stress on cognition, patholo...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760802644694

    authors: Siedlak SL,Casadesus G,Webber KM,Pappolla MA,Atwood CS,Smith MA,Perry G

    更新日期:2009-02-01 00:00:00

  • Sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis.

    abstract::The widely used anti-cancer drug cisplatin imparts various toxic manifestations in the host, with nephrotoxicity being the most severe one. The trace element selenium shows antioxidant activity in both human and animals. The present study was designed to assess the chemoprotecting and chemoenhancing efficacy of a naph...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715762.2015.1012079

    authors: Ghosh P,Singha Roy S,Basu A,Bhattacharjee A,Bhattacharya S

    更新日期:2015-04-01 00:00:00

  • Postanoxic damage of microglial cells is mediated by xanthine oxidase and cyclooxygenase.

    abstract::Brain ischemia and the following reperfusion are important causes for brain damage and leading causes of brain morbidity and human mortality. Numerous observations exist describing the neuronal damage during ischemia/reperfusion, but the outcome of such conditions towards glial cells still remains to be elucidated. Mi...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760600978807

    authors: Widmer R,Engels M,Voss P,Grune T

    更新日期:2007-02-01 00:00:00

  • Serum total antioxidant activity in relative hypo- and hypercholesterolemia.

    abstract::Individuals with low serum cholesterol experience greater than expected age-adjusted mortality from non-atherosclerotic diseases, including cancer, respiratory and digestive illnesses, but the basis for these associations remains unclear. The current investigation considered the hypothesis that hypocholesterolemia is ...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715769609149049

    authors: Muldoon MF,Kritchevsky SB,Evans RW,Kagan VE

    更新日期:1996-09-01 00:00:00

  • Quinolinic aminoxyl protects albumin against peroxyl radical mediated damage.

    abstract::A study of peroxyl radical-mediated bovine serum albumin oxidation in the presence of the quinolinic aminoxyl 1,2-dihydro-2,2-diphenyl-4-ethoxy-quinoline-1-oxyl (QAO) was carried out in order to test its efficiency as a protein antioxidant. Albumin oxidation was induced by the tert-butylhydroperoxide/PbO2 system. The ...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715769409056583

    authors: Tanfani F,Carloni P,Damiani E,Greci L,Wozniak M,Kulawiak D,Jankowski K,Kaczor J,Matuszkiewics A

    更新日期:1994-10-01 00:00:00

  • Bicarbonate-dependent, carbonate radical anion-driven tocopherol-mediated human LDL peroxidation: an in vitro and in vivo study.

    abstract::We have here investigated possible occurrence of bicarbonate-dependent, carbonate radical anion (CO(3)(•-))-driven tocopherol-mediated human LDL peroxidation (TMP) in vitro and in vivo. CO(3)(•-), generated in vitro by the SOD1/H(2)O(2)/bicarbonate system, readily promoted TMP, which was dependent on α-tocopherol and ...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715762.2012.719613

    authors: Lapenna D,Ciofani G,Cuccurullo C,Neri M,Giamberardino MA,Cuccurullo F

    更新日期:2012-11-01 00:00:00

  • Alteration of antioxidants during the progression of heart disease in streptozotocin-induced diabetic rats.

    abstract::Involvement of oxidative stress is implicated in the progression of complication of diabetes mellitus. With respect to heart diseases, we have studied role of oxidative stress/antioxidants using rats treated with streptozotocin to induce diabetes (DM). Hemodynamic and echocardiographic measurements showed thickening o...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760100300231

    authors: Doi K,Sawada F,Toda G,Yamachika S,Seto S,Urata Y,Ihara Y,Sakata N,Taniguchi N,Kondo T,Yano K

    更新日期:2001-03-01 00:00:00

  • Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy.

    abstract::To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and a...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760902942824

    authors: Crohns M,Saarelainen S,Kankaanranta H,Moilanen E,Alho H,Kellokumpu-Lehtinen P

    更新日期:2009-07-01 00:00:00

  • Effect of pre-exposure of human erythrocytes to oxidants on the haemolytic activity of Sticholysin II. A comparison between peroxynitrite and hypochlorous acid.

    abstract::Stichodactyla heliantus II (St II) is a haemolytic toxin whose activity depends of the characteristics of red blood cells (RBC). Among the factors that may tune the response of the RBC to the toxin activity stand the oxidative status of the cell. This study investigates how pre-oxidation of RBC modifies St II activity...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.3109/10715762.2010.536838

    authors: Celedón G,González G,Lissi E,Cerda T,Bascuñant D,Lepeley M,Pazos F,Lanio ME,Alvarez C

    更新日期:2011-04-01 00:00:00

  • Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses.

    abstract::Gamma-glutamylcysteine synthetase (GCS; also referred to as glutamate-cysteine ligase, GLCL) catalyzes the rate-limiting reaction in glutathione (GSH) biosynthesis. The GCS holoenzyme is composed of a catalytic and regulatory subunit, each encoded by a unique gene. In addition to some conditions which specifically upr...

    journal_title:Free radical research

    pub_type: 杂志文章,评审

    doi:10.1080/10715760000300291

    authors: Wild AC,Mulcahy RT

    更新日期:2000-04-01 00:00:00

  • Do mitochondria make nitric oxide? no?

    abstract::Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and make nitric oxide (NO*) in amounts sufficient to affect mitochondrial respiration. However, we found that the addition of L-arginine or the NOS inhibitor L-NMMA to intact rat liver mitochondria did not have any effect on the respirat...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760410001694008

    authors: Tay YM,Lim KS,Sheu FS,Jenner A,Whiteman M,Wong KP,Halliwell B

    更新日期:2004-06-01 00:00:00

  • The effects of exercise load during development on oxidative stress levels and antioxidant potential in adulthood.

    abstract::The objective of this study was to elucidate the impact of physical activity during the growth period as well as on oxidative stress and antioxidative potential in adulthood. The experimental animals used were four-week old male Wistar rats, which were randomly divided into three groups. The exercise loads were as fol...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715762.2017.1291939

    authors: Lee S,Hashimoto J,Suzuki T,Satoh A

    更新日期:2017-02-01 00:00:00

  • Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease.

    abstract::Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases. Neurodegenerative diseases are characterized by progressive dysfunction and death of neurons. Oxidative stress is associated with dysfunction of the mitochondria and endoplasmic reticulum, inducing apoptosis and protein misfold...

    journal_title:Free radical research

    pub_type: 杂志文章,评审

    doi:10.3109/10715762.2011.574290

    authors: Ghosh N,Ghosh R,Mandal SC

    更新日期:2011-08-01 00:00:00

  • Estimation of hydroxyl radical generation by salicylate hydroxylation method in kidney of mice exposed to ferric nitrilotriacetate and potassium bromate.

    abstract::Hydroxyl radical (*OH) generation in the kidney of mice treated with ferric nitrilotriacetate (Fe-NTA) or potassium bromate (KBrO3) in vivo was estimated by the salicylate hydroxylation method, using the optimal experimental conditions we recently reported. Induction of DNA lesions and lipid peroxidation in the kidney...

    journal_title:Free radical research

    pub_type: 杂志文章

    doi:10.1080/10715760701644019

    authors: Ueno S,Kashimoto T,Susa N,Shiho K,Seki T,Ito N,Takeda-Homma S,Nishimura Y,Sugiyama M

    更新日期:2007-11-01 00:00:00