A novel method using 8-hydroperoxy-2'-deoxyguanosine formation for evaluating antioxidative potency.

abstract：:Radicals from one-electron oxidation of 4-hydroxycinnamate, ferulate and 3,4-dihydroxycinnamate have been formed by reaction with the oxidising triplet state of duroquinone. All three compounds react with triplet duroquinone with second order rate constants close to the diffusion-controlled limit. The identity of the ...

journal_title：Free radical research

authors： Bisby RH,Parker AW

更新日期：2001-07-01 00:00:00

abstract：:Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...

journal_title：Free radical research

authors： Dutta A,Gupta ML,Verma S

更新日期：2018-01-01 00:00:00

abstract：:Neopterin and its reduced form, 7,8 dihydroneopterin are pteridines released from macrophages and monocytes when stimulated with interferon gamma in vivo. The function of this response is unknown though there is an enormous amount of information available on the use of these compounds as clinical markers of monocyte/m...

journal_title：Free radical research

authors： Gieseg SP,Reibnegger G,Wachter H,Esterbauer H

更新日期：1995-08-01 00:00:00

abstract：:The synproportionation reaction between ferryl leghemoglobin and oxyleghemoglobin does not occur, at least under conditions where this process could be clearly demonstrated with myoglobin and hemoglobin. In contrast, a cross synproportionation can occur between oxyleghemoglobin and ferryl myoglobin or between ferryl l...

journal_title：Free radical research

authors： Mathieu C,Swaraj K,Davies MJ,Trinchant JC,Puppo A

更新日期：1997-08-01 00:00:00

abstract：:Curcumin is a polyphenol derived from the plant Curcuma longa that induces apoptotic cell death in malignant cancer cell lines. It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidan...

journal_title：Free radical research

authors： Jung KH,Park JW

更新日期：2011-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important mediators of the cytotoxicity induced by the direct reaction of ionising radiation (IR) with all critical cellular components, such as proteins, lipids, and nucleic acids. The derived oxidative damage may propagate in exposed tissues in a dose- and spatiotemporal dependent m...

journal_title：Free radical research

authors： Pietraforte D,Paulicelli E,Patrono C,Gambardella L,Scorza G,Testa A,Fattibene P

更新日期：2018-04-01 00:00:00

abstract：:To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and a...

journal_title：Free radical research

authors： Crohns M,Saarelainen S,Kankaanranta H,Moilanen E,Alho H,Kellokumpu-Lehtinen P

更新日期：2009-07-01 00:00:00

abstract：:To study the role of oxidative stress in hypertension and pre-hypertension, this study analysed plasma levels of reactive carbonyl species (RCS) in 1204 Chinese Han adults. Results showed a statistically significant positive correlation (p < 0.001) between blood pressure and plasma RCS levels with or without being adj...

journal_title：Free radical research

authors： Chen K,Xie F,Liu S,Li G,Chen Y,Shi W,Hu H,Liu L,Yin D

更新日期：2011-05-01 00:00:00

abstract：:In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action was optimized by meas...

journal_title：Free radical research

authors： Rathee JS,Patro BS,Brown L,Chattopadhyay S

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is known to be activated via exercise-associated transient increases in oxidative stress. However, the precise mechanism(s) triggering PPARγ activation in monocytes during/following exercise remain to be confirmed. Here, two cohorts of five healthy male individu...

journal_title：Free radical research

authors： Davies NA,Watkeys L,Butcher L,Potter S,Hughes MG,Moir H,Morris K,Thomas AW,Webb R

更新日期：2015-01-01 00:00:00

abstract：:The cyanidin-3-O-beta-glucopyranoside (C-3-G) antioxidant capacity towards reactive oxygen species (ROS)-mediated damages was assessed in tissue and cells submitted to increased oxidative stress. In the isolated ischemic and reperfused rat heart, 10 or 30 degreesM C-3-G protected from both lipid peroxidation (66.7 and...

journal_title：Free radical research

authors： Amorini AM,Lazzarino G,Galvano F,Fazzina G,Tavazzi B,Galvano G

更新日期：2003-04-01 00:00:00

abstract：:Gamma-glutamyltransferase (GGT) plays a central role in the homeostasis of the antioxidant glutathione (GSH). The expression of GGT has been shown to be upregulated after oxidative stress, but the signalling pathways implicated remain poorly characterized. The results here show that acute exposure of CC531 cells to ox...

journal_title：Free radical research

authors： Pandur S,Pankiv S,Johannessen M,Moens U,Huseby NE

更新日期：2007-12-01 00:00:00

abstract：:Brain ischemia and the following reperfusion are important causes for brain damage and leading causes of brain morbidity and human mortality. Numerous observations exist describing the neuronal damage during ischemia/reperfusion, but the outcome of such conditions towards glial cells still remains to be elucidated. Mi...

journal_title：Free radical research

authors： Widmer R,Engels M,Voss P,Grune T

更新日期：2007-02-01 00:00:00

abstract：:The intestinal tract, known for its capability for self-renew, represents the first barrier of defence between the organism and its luminal environment. The thiol/disulfide redox systems comprising the glutathione/glutathione disulfide (GSH/GSSG), cysteine/cystine (Cys/CySS) and reduced and oxidized thioredoxin (Trx/T...

journal_title：Free radical research

authors： Circu ML,Aw TY

更新日期：2011-11-01 00:00:00

abstract：:Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCCL) and elevates [Ca2+]i in many cells. However, how oxidative stress activates VDCCL under clinical setting and the consequenc...

journal_title：Free radical research

authors： Park HJ,Shin KC,Yoou SK,Kang M,Kim JG,Sung DJ,Yu W,Lee Y,Kim SH,Bae YM,Park SW

更新日期：2019-01-01 00:00:00

abstract：:Weaning mice were fed a diet supplemented with beef tallow (BT) or BT plus docosahexaenoic acid (DHA) containing 100 mg alpha-tocopherol/kg (alpha-Toc100) or 500 mg alpha-tocopherol/kg (alpha-Toc500) for 4 wk to modify membrane fatty acid unsaturation, and then were administered ferric nitrilotriacetate (Fe-NTA). The ...

journal_title：Free radical research

authors： Yasuda S,Watanabe S,Kobayashi T,Hata N,Misawa Y,Utsumi H,Okuyama H

更新日期：1999-03-01 00:00:00

abstract：:Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to the airflow limitations and airway hyperresponsiveness (AHR). The involvement of oxidative stress in this process is well-established, but the specific role of the superoxide anion...

journal_title：Free radical research

authors： Nesi RT,Barroso MV,Souza Muniz V,de Arantes AC,Martins MA,Brito Gitirana L,Neves JS,Benjamim CF,Lanzetti M,Valenca SS

更新日期：2017-07-01 00:00:00

abstract：:Peroxynitrite anion is a reactive and short-lived species and its formation in vivo has been implicated in several human diseases. In view of the potential usefulness of compounds that can protect against peroxynitrite or their reactive intermediates, a study focused on flavonoid compounds was carried out. Since the r...

journal_title：Free radical research

authors： Santos MR,Mira L

更新日期：2004-09-01 00:00:00

abstract：:The preventive effect of 20(S)-ginsenoside Rg(3) (20(S)-Rg(3)) on lipopolysaccharide (LPS)-induced oxidative tissue injury in rats was investigated in this study. The elevated serum nitrite/nitrate, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and creatinine levels in LPS-treated control rats were ...

journal_title：Free radical research

authors： Kang KS,Kim HY,Yamabe N,Park JH,Yokozawa T

更新日期：2007-10-01 00:00:00

abstract：:We have determined the effects of chronic vitamin C intake on neutrophil and lymphocyte antioxidant defences during the acute phase immune response induced by intense exercise. Blood samples were taken from 16 voluntary athletes in basal conditions, both immediately after and 1 h after a duathlon competition. Sportsme...

journal_title：Free radical research

authors： Tauler P,Aguiló A,Gimeno I,Noguera A,Agustí A,Tur JA,Pons A

更新日期：2003-09-01 00:00:00

abstract：:Nitronyl nitroxides (NNs) are the paramagnetic probes that are capable of scavenging physiologically relevant reactive oxygen (ROS) and nitrogen (RNS) species, namely superoxide, nitric oxide (NO), and nitroxyl (HNO). NNs are increasingly considered as potent antioxidants and potential therapeutic agents. Understandin...

journal_title：Free radical research

authors： Bobko AA,Khramtsov VV

更新日期：2015-01-01 00:00:00

abstract：:The effects of intravenous administration of alpha-phenyl N-tert-butyl nitrone (PBN) on cortical cerebral blood flow (CBF) were examined in Wistar rats under pentobarbital anesthesia and artificial ventilation. The cortical CBF in parietal cortex was measured by laser Doppler flowmetry. Intravenous administrations of ...

journal_title：Free radical research

authors： Inanami O,Kuwabara M

更新日期：1995-07-01 00:00:00

abstract：:A small part of cellular iron, usually called 'labile iron pool' (LIP), is not securely stored and has the potential to catalyse the formation of highly reactive oxygen species. The present work estimated LIP levels in human white cells by using the analytical power of flow cytometry. The method relies essentially on ...

journal_title：Free radical research

authors： Doulias PT,Vlachou C,Boudouri C,Kanavaros P,Siamopoulos KC,Galaris D

更新日期：2008-03-01 00:00:00

abstract：:The effect of antioxidants on ammonia induced CNS and renal pathobiology in 10 sheep infested by L. Cuprina larvae was investigated. The condition produces severe dermatitis, proliferation of macrophages and hyperammonaemia, and free radicals may therefore be involved in the pathogenesis. Five of the sheep (treated gr...

journal_title：Free radical research

authors： Guerrini VH

更新日期：1994-07-01 00:00:00

abstract：:Guanidinosuccinic acid (GSA) is noted for its nitric oxide (NO) mimicking actions such as vasodilatation and activation of the N-methyl-D-aspartate (NMDA) receptor. We have reported that GSA is the product of argininosuccinate (ASA) and some reactive oxygen species, mainly the hydroxyl radical. We tested for GSA synth...

journal_title：Free radical research

authors： Aoyagi K,Akiyama K,Shahrzad S,Tomida C,Hirayama A,Nagase S,Takemura K,Koyama A,Ohba S,Narita M

更新日期：1999-07-01 00:00:00

abstract：:Endothelial dysfunction is an early pathophysiological feature and independent predictor of poor prognosis in most forms of cardiovascular diseases. Epidemiological studies report an inverse association between dietary flavonoid consumption and mortality from cardiovascular diseases. In the present paper, we review th...

journal_title：Free radical research

authors： Perez-Vizcaino F,Duarte J,Andriantsitohaina R

更新日期：2006-10-01 00:00:00

abstract：:The hydroxyl radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO) and 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) formed in the presence of hydrogen peroxide and FeII are normally quite stable, but in the presence of 5-20 micromolar myoglobin their ESR signals decay rapidly. This decay probably reflects furth...

journal_title：Free radical research

authors： De Bono D,Yang WD,Symons MC

更新日期：1994-05-01 00:00:00

abstract：:The cytologically active secondary lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) have been detected as their 2,4-dinitrophenylhydrazone (DNP) derivatives in plant tissue cultures using LC-MS. This paper reports, for the first time, the use of LC-MS methodology to definitively identif...

journal_title：Free radical research

authors： Deighton N,Magill WJ,Bremner DH,Benson EE

更新日期：1997-09-01 00:00:00

abstract：:Myeloperoxidase (MPO), a major constituent of neutrophils, catalyzes the production of hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride anion. We have previously reported that MPO-deficient (MPO(-/-)) neutrophils produce greater amount of macrophage inflammatory protein-2 (MIP-2) in vitro than do wi...

journal_title：Free radical research

authors： Tateno N,Matsumoto N,Motowaki T,Suzuki K,Aratani Y

更新日期：2013-05-01 00:00:00

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00