The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications.

abstract：:Mammalian odorant-binding proteins (OBPs) are soluble lipocalins produced in the nasal mucosa and in other epithelial tissues of several animal species, where they are supposed to serve as scavengers for small structurally unrelated hydrophobic molecules. These would include odorants and toxic aldehydes like 4-hydroxy...

journal_title：Free radical research

authors： Macedo-Márquez A,Vázquez-Acevedo M,Ongay-Larios L,Miranda-Astudillo H,Hernández-Muñoz R,González-Halphen D,Grolli S,Ramoni R

更新日期：2014-07-01 00:00:00

abstract：:Guanidinosuccinic acid (GSA) is noted for its nitric oxide (NO) mimicking actions such as vasodilatation and activation of the N-methyl-D-aspartate (NMDA) receptor. We have reported that GSA is the product of argininosuccinate (ASA) and some reactive oxygen species, mainly the hydroxyl radical. We tested for GSA synth...

journal_title：Free radical research

authors： Aoyagi K,Akiyama K,Shahrzad S,Tomida C,Hirayama A,Nagase S,Takemura K,Koyama A,Ohba S,Narita M

更新日期：1999-07-01 00:00:00

abstract：:Along with differentiation of mouse stromal preadipocytes OP9 into adipocytes, intracellular ROS, especially superoxide anion radicals detected by NBT reduction assay, were found to appreciably increase, mainly in cytoplasmic area, parallelling with increases in intracellular lipid-droplet accumulation, whereas undiff...

journal_title：Free radical research

authors： Saitoh Y,Xiao L,Mizuno H,Kato S,Aoshima H,Taira H,Kokubo K,Miwa N

更新日期：2010-09-01 00:00:00

abstract：:p38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress. The most abundant family member is p38α, which helps to couple cell proliferation and growth in response to ce...

journal_title：Free radical research

authors： Tormos AM,Taléns-Visconti R,Nebreda AR,Sastre J

更新日期：2013-11-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) reproduces a multiple sclerosis (MS)-like experimental model. The main objective was to evaluate the effect of extremely low-frequency electromagnetic fields (EL-EMF) application, like a paradigm of transcranial magnetic stimulation (TMS) in the development of EAE. Rats ...

journal_title：Free radical research

authors： Medina-Fernandez FJ,Escribano BM,Agüera E,Aguilar-Luque M,Feijoo M,Luque E,Garcia-Maceira FI,Pascual-Leone A,Drucker-Colin R,Tunez I

更新日期：2017-05-01 00:00:00

abstract：:Oxidatively generated damage to nucleic acids may play an important role in the pathophysiological processes of a variety of diseases. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) are oxidatively generated products of DNA and RNA, respectively. Our previous studies have s...

journal_title：Free radical research

authors： Mao YH,Weng QH,Xu LN,Li XY,Zhao B,Sun Y,Nie JJ,Hu JH,Zhou Q,Zhang LQ,Guo J,Zuo MZ,Ito S,Cai JP

更新日期：2017-06-01 00:00:00

abstract：:Multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive metabolic disorder of fatty acid metabolism, is mostly caused by mutations in the ETFA, ETFB or ETFDH genes that result in dysfunctions in electron transfer flavoprotein (ETF) or electron transfer flavoprotein-ubiquinone dehydrogenase (ETFDH). I...

journal_title：Free radical research

authors： Chokchaiwong S,Kuo YT,Lin SH,Hsu YC,Hsu SP,Liu YT,Chou AJ,Kao SH

更新日期：2018-12-01 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) induces Mv1Lu cell senescence through inactivating glycogen synthase kinase 3 (GSK3), thereby inactivating complex IV and increasing intracellular ROS. In the present study, we identified protein kinase C delta (PKCδ) as an upstream regulator of GSK3 inactivation in this mechanis...

journal_title：Free radical research

authors： Byun HO,Jung HJ,Kim MJ,Yoon G

更新日期：2014-09-01 00:00:00

abstract：:Globular adiponectin (gAd) induces the generation of reactive oxygen species (ROS) and nitric oxide (NO) in the murine macrophage cell line RAW 264. This study investigated the role of the mammalian target of rapamycin (mTOR) in gAd-induced ROS and NO generation. gAd stimulation induced phosphorylation of mTOR, which ...

journal_title：Free radical research

authors： Fujimoto A,Akifusa S,Kamio N,Hirofuji T,Nonaka K,Yamashita Y

更新日期：2010-02-01 00:00:00

abstract：:The present study has been designed and carried out to investigate the protective role of taurine (2-aminoethanesulphonic acid) against NaAsO(2) induced nephrotoxicity. Oral administration of arsenic increased the productions of ROS and RNS, enhanced lipid peroxidation, protein carbonylation and decreased intracellula...

journal_title：Free radical research

authors： Roy A,Manna P,Sil PC

更新日期：2009-10-01 00:00:00

abstract：:We investigated the effect of curcumin on liver injury in diabetic rats induced by streptozotocin (STZ) through modulation of endoplasmic reticulum stress (ERS) and unfolded protein response (UPR). Experimental diabetes was induced by a single intraperitoneal injection of STZ (55 mg/kg), and curcumin was given at 100 ...

journal_title：Free radical research

authors： Afrin R,Arumugam S,Soetikno V,Thandavarayan RA,Pitchaimani V,Karuppagounder V,Sreedhar R,Harima M,Suzuki H,Miyashita S,Nomoto M,Suzuki K,Watanabe K

更新日期：2015-03-01 00:00:00

abstract：:Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered ...

journal_title：Free radical research

authors： Dorigan de Matos Furlanetto AL,Valente C,Martinez GR,Merlin Rocha ME,Maurer JBB,Cadena SMSC

更新日期：2019-01-01 00:00:00

abstract：:8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect. ...

journal_title：Free radical research

authors： Turk PW,Weitzman SA

更新日期：1995-09-01 00:00:00

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00

abstract：:We investigated the effects of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on reactive oxygen species (ROS) and on oxidative DNA damage in vitro, as well as the effects of the main fluvastatin metabolites (M2, M3, and M4) and other inhibitors of the same enzyme, pravastatin and simvastati...

journal_title：Free radical research

authors： Imaeda A,Tanigawa T,Aoki T,Kondo Y,Nakamura N,Yoshikawa T

更新日期：2001-12-01 00:00:00

abstract：:Retinal mitochondria become dysfunctional in diabetes and the production of superoxide radicals is increased; over-expression of MnSOD abrogates mitochondrial dysfunction and prevents the development of diabetic retinopathy. The mitochondrial DNA (mtDNA) is particularly prone to oxidative damage. The aim of this study...

journal_title：Free radical research

authors： Madsen-Bouterse SA,Zhong Q,Mohammad G,Ho YS,Kowluru RA

更新日期：2010-03-01 00:00:00

abstract：:The effects of inorganic phosphate (Pi), the main intracellular membrane permeable anion capable of altering mitochondrial pH gradients (Delta pH), were measured on mitochondrial H2O2 release. As expected, Pi decreased Delta pH and increased the electric membrane potential (Delta Psi). Mitochondrial H2O2 release was s...

journal_title：Free radical research

authors： Oliveira GA,Kowaltowski AJ

更新日期：2004-10-01 00:00:00

abstract：:Heme oxygenase is the rate limiting enzyme in heme degradation to carbon monoxide (CO), iron and bilirubin. The inducible isoform of the protein, heme oxygenase-1 (HO-1), is susceptible to up-regulation by a diverse variety of conditions and agents in mammalian tissue, leading to the common conception that HO-1 is a s...

journal_title：Free radical research

authors： Foresti R,Motterlini R

更新日期：1999-12-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutella...

journal_title：Free radical research

authors： Zhang X,Ji R,Sun H,Peng J,Ma X,Wang C,Fu Y,Bao L,Jin Y

更新日期：2018-02-01 00:00:00

abstract：:The interaction between the hydrophobic indolinonic nitroxide radical, 1,2-dihydro-2-methyl-2-phenyl-3H-indole-3-one-1-oxyl and hydrophilic alpha-, beta- and gamma-cyclodextrin derivatives was investigated in water by phase-solubility analysis. Among the studied cyclodextrins, random methyl-beta-cyclodextrin (RM-beta-...

journal_title：Free radical research

authors： Damiani E,Tursilli R,Casolari A,Astolfi P,Greci L,Scalia S

更新日期：2005-01-01 00:00:00

abstract：:Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were develop...

journal_title：Free radical research

authors： Earla A,Walter ED,Braslau R

更新日期：2019-12-01 00:00:00

abstract：:Oxidative stress is suggested as a potential mechanism in impaired foetal growth, smaller birth size and thus subsequently adult chronic diseases. We have investigated associations between oxidative stress in pregnancy and birth anthropometry (weight, height, head and chest circumferences). In the MINIMat-trial (Mater...

journal_title：Free radical research

authors： Lindström E,Persson LÅ,Raqib R,El Arifeen S,Basu S,Ekström EC

更新日期：2012-03-01 00:00:00

abstract：:The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 ...

journal_title：Free radical research

authors： Borrás C,Gómez-Cabrera MC,Viña J

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Aspiration pneumonia is infection of the respiratory tract resulting from accumulation of sputum in the larynx. N-acetyl-L-cysteine (NAC) might regulate mucin (MUC) expression and activate inherent anti-infective system in bronchiolar epithelial cells after cellular uptake, and therefore, serve as the preventat...

journal_title：Free radical research

authors： Koizumi C,Yamada M,Ishizaki K,Ueda T,Sakurai K

更新日期：2015-01-01 00:00:00

abstract：:Hyperthermia-induced apoptosis and its enhancement in the presence of a temperature-dependent free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride (AAPH) were examined in human uterine cervical cancer cell lines, CaSki and HeLa. When both cell lines were treated with hyperthermia at 44 degrees C for 60...

journal_title：Free radical research

authors： Yuki H,Kondo T,Zhao QL,Fujiwara Y,Tanabe K,Ogawa R,Nakashima A,Fushiki H,Fujimura M,Saito S

更新日期：2003-06-01 00:00:00

abstract：:The hydroxyl radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO) and 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) formed in the presence of hydrogen peroxide and FeII are normally quite stable, but in the presence of 5-20 micromolar myoglobin their ESR signals decay rapidly. This decay probably reflects furth...

journal_title：Free radical research

authors： De Bono D,Yang WD,Symons MC

更新日期：1994-05-01 00:00:00

abstract：:The aim of this study was to investigate the effect of HDL oxidation on PON1 paraoxonase activity. Also, we were interested in investigating the mechanism by which PON1 could be inactivated and the correlation between its enzymatic activity and the antioxidant properties of HDL. Three different oxidation systems were ...

journal_title：Free radical research

authors： Jaouad L,Milochevitch C,Khalil A

更新日期：2003-01-01 00:00:00

abstract：:Gamma-glutamyltransferase (GGT) plays a central role in the homeostasis of the antioxidant glutathione (GSH). The expression of GGT has been shown to be upregulated after oxidative stress, but the signalling pathways implicated remain poorly characterized. The results here show that acute exposure of CC531 cells to ox...

journal_title：Free radical research

authors： Pandur S,Pankiv S,Johannessen M,Moens U,Huseby NE

更新日期：2007-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces ...

journal_title：Free radical research

authors： Hou C,Peng Y,Qin C,Fan F,Liu J,Long J

更新日期：2018-12-01 00:00:00

abstract：:The ability of a range of dietary flavonoids to inhibit low-density lipoprotein (LDL) oxidation in vitro was tested using a number of different methods to assess oxidative damage to LDL. Overall quercetin was the most effective inhibitor of oxidative damage to LDL in vitro. On this basis, a diet enriched with onions a...

journal_title：Free radical research

authors： O'Reilly JD,Sanders TA,Wiseman H

更新日期：2000-10-01 00:00:00