Abstract:
:Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were developed to detect free radicals under flow conditions. A continuous flow EPR technique was used to evaluate the spin trapping properties of these tethered nitrones. While both resins trapped radicals, polymer supported nitrone Resin-2-PFDMPO with a longer and more flexible linker showed a more information rich spectrum than Resin-2-HFDMPO.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Earla A,Walter ED,Braslau Rdoi
10.1080/10715762.2019.1683171subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1084-1100issue
11-12eissn
1071-5762issn
1029-2470journal_volume
53pub_type
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