Antioxidative effects of fluvastatin and its metabolites against oxidative DNA damage in mammalian cultured cells.

abstract：:Methylmercury (MeHg) is one of the ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. However, the mechanisms of MeHg-induced neuronal cell death are incompletely understood. Treatment of neuronal cells with MeHg (0-2 μM) for 0.5-12 h, or pretreated with LA (12.5-...

journal_title：Free radical research

authors： Yang T,Xu Z,Liu W,Xu B,Deng Y

更新日期：2016-01-01 00:00:00

abstract：:An involvement of oxidative stress (OS) was found in recent studies of Sjøgren's syndrome (SS) that reported significant changes in protein oxidation, myeloperoxidase activity, TNF-α, nitrotyrosine, and GSH levels in plasma from SS patients. Excess levels of OS markers, as oxidative DNA damage and propanoyl-lysine, we...

journal_title：Free radical research

authors： Pagano G,Castello G,Pallardó FV

更新日期：2013-02-01 00:00:00

abstract：:The purpose of this double clinical study was (1) to evaluate the effect of one single intake (300 ml) of red wine (RW) on the plasma antioxidant capacity (pAOC) and plasma phenolics over the 24-h time period following the intake, and (2) to compare the long-term effects of daily intakes (250 ml/d) of RW, white wine (...

journal_title：Free radical research

authors： Cartron E,Fouret G,Carbonneau MA,Lauret C,Michel F,Monnier L,Descomps B,Léger CL

更新日期：2003-09-01 00:00:00

abstract：:Cystine, an oxidized form of cysteine (Cys), is imported into cells via the protein xCT, which is also associated with the export of glutamate as the counter amino acid. In the current study, we attempted to rationalize roles of xCT in the livers of male mice. While xCT was not expressed in the livers of ordinary mice...

journal_title：Free radical research

authors： Kang ES,Lee J,Homma T,Kurahashi T,Kobayashi S,Nabeshima A,Yamada S,Seo HG,Miyata S,Sato H,Fujii J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Measurement of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) has recently become more popular as a means of assessing oxidative stress in the human body. The aim of this study is to compare the levels of urine 8-OHdG in patients with type 2 diabetes with and without nephropathy and to evaluate its role as a b...

journal_title：Free radical research

authors： Serdar M,Sertoglu E,Uyanik M,Tapan S,Akin K,Bilgi C,Kurt I

更新日期：2012-10-01 00:00:00

abstract：:Radicals from one-electron oxidation of 4-hydroxycinnamate, ferulate and 3,4-dihydroxycinnamate have been formed by reaction with the oxidising triplet state of duroquinone. All three compounds react with triplet duroquinone with second order rate constants close to the diffusion-controlled limit. The identity of the ...

journal_title：Free radical research

authors： Bisby RH,Parker AW

更新日期：2001-07-01 00:00:00

abstract：:Testing of pregnant women reveals weakening of neutrophil-mediated effector functions, such as reactive oxygen species generation. This study provides data confirming the phenomenon, gained through application of the flow cytometry technique. Key factors influencing neutrophil functional activity in blood plasma of pr...

journal_title：Free radical research

authors： Varfolomeeva EY,Semenova EV,Sokolov AV,Aplin KD,Timofeeva KE,Vasilyev VB,Filatov MV

更新日期：2016-08-01 00:00:00

abstract：:Individuals with low serum cholesterol experience greater than expected age-adjusted mortality from non-atherosclerotic diseases, including cancer, respiratory and digestive illnesses, but the basis for these associations remains unclear. The current investigation considered the hypothesis that hypocholesterolemia is ...

journal_title：Free radical research

authors： Muldoon MF,Kritchevsky SB,Evans RW,Kagan VE

更新日期：1996-09-01 00:00:00

abstract：:Brain ischemia and the following reperfusion are important causes for brain damage and leading causes of brain morbidity and human mortality. Numerous observations exist describing the neuronal damage during ischemia/reperfusion, but the outcome of such conditions towards glial cells still remains to be elucidated. Mi...

journal_title：Free radical research

authors： Widmer R,Engels M,Voss P,Grune T

更新日期：2007-02-01 00:00:00

abstract：:In human organism, the gaseous radical molecule nitric oxide (NO) is produced in various cells from L-arginine by the catalytic action of NO synthases (NOS). The metabolic fate of NO includes oxidation to nitrate by oxyhaemoglobin in red blood cells and autoxidation in haemoglobin-free media to nitrite. Nitrate and ni...

journal_title：Free radical research

authors： Tsikas D

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Nuclear factor, erythroid 2 like 2 (NFE2L2) is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 deficiency in placentas is associated with pregnancy complications. We have demonstrated that elevated OS existed in placental shares of the smaller fetus in selective int...

journal_title：Free radical research

authors： Wu J,He Z,Gao Y,Zhang G,Huang X,Fang Q

更新日期：2017-04-01 00:00:00

abstract：:India, resembling other developing nations, is confronting a hastening demographic switch to non-communicable diseases. Inborn errors of metabolism (IEM) constitute a varied heterogeneous group of disorders with variable clinical appearance, primarily in the pediatric populace. Congenital deformities and genetic disor...

journal_title：Free radical research

authors： Ray SK,Mukherjee S

更新日期：2021-01-27 00:00:00

abstract：:Prostaglandin E2 (PGE2) has been reported to play critical roles in cell fate decision by interacting with four types of prostanoid receptors such as EP1, EP2, EP3 and EP4. The present study was aimed at investigating the effect of the EP4-specific agonist CAY10598 in human colon cancer HCT116 cells. Our study reveale...

journal_title：Free radical research

authors： Chae IG,Kim DH,Kundu J,Jeong CH,Kundu JK,Chun KS

更新日期：2014-11-01 00:00:00

abstract：:APE1/Ref-1, the mammalian ortholog of E. coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has dual role in controlling cellular response to oxidative stress. It is rate-limiting in repair of oxidative DNA damage including strand breaks and also has co-transc...

journal_title：Free radical research

authors： Fantini D,Vascotto C,Deganuto M,Bivi N,Gustincich S,Marcon G,Quadrifoglio F,Damante G,Bhakat KK,Mitra S,Tell G

更新日期：2008-01-01 00:00:00

abstract：:The effects of intravenous administration of alpha-phenyl N-tert-butyl nitrone (PBN) on cortical cerebral blood flow (CBF) were examined in Wistar rats under pentobarbital anesthesia and artificial ventilation. The cortical CBF in parietal cortex was measured by laser Doppler flowmetry. Intravenous administrations of ...

journal_title：Free radical research

authors： Inanami O,Kuwabara M

更新日期：1995-07-01 00:00:00

abstract：:C-phycocyanins, major biliproteins of blue green algae (cyanobacteria), widely used as colourants in food and cosmetics are known for their antioxidant as well as therapeutic potential. Recent claims indicating phycobiliproteins exert stronger photodynamic action on tumor cells than clinically approved hematoporphyrin...

journal_title：Free radical research

authors： Paul BT,Patel A,Selvam GS,Mishra S,Ghosh PK,Murugesan R

更新日期：2006-08-01 00:00:00

abstract：:The aim of the study was to investigate whether there is transmembrane transport of intact glutathione ([3H]-GSH, 0.1 microCi) in rat and human type II pneumocytes (T2P), and if this transport might be dependent on the redox state of the extracellular fluid. The T2P were pretreated with acivicin (250 microM) to inhibi...

journal_title：Free radical research

authors： van Klaveren RJ,Hoet PH,Demedts M,Nemery B

更新日期：1999-05-01 00:00:00

abstract：:In addition to insulin, glycemic control involves thyroid hormones. However, an excess of thyroid hormone can disturb the blood glucose equilibrium, leading to alterations of carbohydrate metabolism and, eventually, diabetes. Indeed, experimental and clinical hyperthyroidism is often accompanied by abnormal glucose to...

journal_title：Free radical research

authors： Venditti P,Reed TT,Victor VM,Di Meo S

更新日期：2019-03-01 00:00:00

abstract：:The imbalance between the reactive oxygen (ROS) and nitrogen (RNS) species production and their handling by the antioxidant machinery (low molecular weight antioxidant molecules and antioxidant enzymes), also known as oxidative stress, is a condition caused by physiological and pathological processes. Moreover, oxidat...

journal_title：Free radical research

authors： Gorini G,Gamberi T,Fiaschi T,Mannelli M,Modesti A,Magherini F

更新日期：2019-02-01 00:00:00

abstract：:Myeoloperoxidase catalyses the formation of hypochlorous acid (HOCl) via reaction of H(2)O(2) with Cl(-) ion. Although HOCl is known to play a major role in the human immune system by killing bacteria and other invading pathogens, excessive generation of this oxidant is known to cause damage to tissue. Recently, it wa...

journal_title：Free radical research

authors： Park SY,Lee SM,Shin SW,Park JW

更新日期：2008-05-01 00:00:00

abstract：:Several substances related to the neurodegenerative diseases of Alzheimer and Parkinson, such as hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42, have been shown to induce apoptosis in tumoral cell lines and rat neurons but not in human neurons. Moreover, the role of mitochondria...

journal_title：Free radical research

authors： Medina S,Martínez M,Hernanz A

更新日期：2002-11-01 00:00:00

abstract：:The hydroxyl radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO) and 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) formed in the presence of hydrogen peroxide and FeII are normally quite stable, but in the presence of 5-20 micromolar myoglobin their ESR signals decay rapidly. This decay probably reflects furth...

journal_title：Free radical research

authors： De Bono D,Yang WD,Symons MC

更新日期：1994-05-01 00:00:00

abstract：:Multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive metabolic disorder of fatty acid metabolism, is mostly caused by mutations in the ETFA, ETFB or ETFDH genes that result in dysfunctions in electron transfer flavoprotein (ETF) or electron transfer flavoprotein-ubiquinone dehydrogenase (ETFDH). I...

journal_title：Free radical research

authors： Chokchaiwong S,Kuo YT,Lin SH,Hsu YC,Hsu SP,Liu YT,Chou AJ,Kao SH

更新日期：2018-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, t...

journal_title：Free radical research

authors： Ben Anes A,Ben Nasr H,Garrouche A,Bchir S,Dhaouefi Z,Chabchoub E,Tabka Z,Chahed K

更新日期：2019-03-01 00:00:00

abstract：:Oxidative DNA modification has been implicated in development of certain cancers and 8-oxodG, the most abundant and mutagenic DNA modification, has for some time been considered a biomarker of this activity. Urinary excretion of 8-oxodG over 24h has been used to estimate the rate of damage to DNA, and animal studies h...

journal_title：Free radical research

authors： Poulsen HE,Loft S,Prieme H,Vistisen K,Lykkesfeldt J,Nyyssonen K,Salonen JT

更新日期：1998-12-01 00:00:00

abstract：:The preventive effect of 20(S)-ginsenoside Rg(3) (20(S)-Rg(3)) on lipopolysaccharide (LPS)-induced oxidative tissue injury in rats was investigated in this study. The elevated serum nitrite/nitrate, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and creatinine levels in LPS-treated control rats were ...

journal_title：Free radical research

authors： Kang KS,Kim HY,Yamabe N,Park JH,Yokozawa T

更新日期：2007-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) released from polymorphonuclear leukocytes and macrophages could cause DNA damage, but also induce cell death. Therefore inhibition of cell death must be an important issue for accumulation of genetic changes in lymphoid cells in inflammatory foci. Scavengers in the post culture medium of...

journal_title：Free radical research

authors： Miwa H,Fujii J,Kanno H,Taniguchi N,Aozasa K

更新日期：2000-07-01 00:00:00

abstract：:Human serum samples were evaluated for oxidative stress with the d-ROMs test. The ceruloplasmin (CP) and copper contents of the samples was independently measured and compared to those calculated on the basis of the d-ROMs test results for pure CP solutions. The d-ROMs readings did not show any significant correlation...

journal_title：Free radical research

authors： Colombini F,Carratelli M,Alberti A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Although cis-diamminedichloroplatinum (II) (cisplatin) is an effective anticancer agent, its clinical use is highly limited predominantly due to its adverse effects on renal functions. The present work examined the therapeutic potential of edaravone, a free radical scavenger, for inhibiting cisplatin-induced...

journal_title：Free radical research

authors： Iguchi T,Nishikawa M,Chang B,Muroya O,Sato EF,Nakatani T,Inoue M

更新日期：2004-04-01 00:00:00

abstract：:Lipid peroxidation generates reactive aldehydes, most notably hydroxynonenal (HNE), which covalently binds amino acid residue side chains leading to protein inactivation and insolubility. Specific adducts of lipid peroxidation have been demonstrated to be intimately associated with pathological lesions of Alzheimer's ...

journal_title：Free radical research

authors： Perry EA,Castellani RJ,Moreira PI,Nunomura A,Lui Q,Harris PL,Sayre LM,Szweda PA,Szweda LI,Zhu X,Smith MA,Perry G

更新日期：2013-07-01 00:00:00