Serum total antioxidant activity in relative hypo- and hypercholesterolemia.

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00

abstract：:Oxidized low density lipoprotein (LDL) has a major impact in the development of atherosclerosis. Risk for oxidative modification of LDL is usually determined indirectly by measuring the capability of LDL to resist radical insult. We compared three different methods quantifying the antioxidative capacity of LDL ex vivo...

journal_title：Free radical research

authors： Malminiemi K,Palomäki A,Malminiemi O

更新日期：2000-11-01 00:00:00

abstract：:The oxidized intermediates generated upon exposure of Aspergillus niger catalase to hydrogen peroxide and superoxide radical fluxes were examined with UV-visible spectrophotometry. Hydrogen peroxide and superoxide radical were generated by means of glucose/glucose oxidase and xanthine/xanthine oxidase systems. Serial ...

journal_title：Free radical research

authors： Lardinois OM,Rouxhet PG

更新日期：1994-01-01 00:00:00

abstract：:Gamma-glutamylcysteine synthetase (GCS; also referred to as glutamate-cysteine ligase, GLCL) catalyzes the rate-limiting reaction in glutathione (GSH) biosynthesis. The GCS holoenzyme is composed of a catalytic and regulatory subunit, each encoded by a unique gene. In addition to some conditions which specifically upr...

journal_title：Free radical research

authors： Wild AC,Mulcahy RT

更新日期：2000-04-01 00:00:00

abstract：:The purpose of the present study was to investigate the protective effect of esculetin (ES) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the lung epithelial A549 cells. Mice were intragastrically administered with ES (20 and 40 mg/kg) 1 h prior to LPS challenge. ES pretreatment at doses of 20 and 40...

journal_title：Free radical research

authors： Chen T,Guo Q,Wang H,Zhang H,Wang C,Zhang P,Meng S,Li Y,Ji H,Yan T

更新日期：2015-01-01 00:00:00

abstract：:In this study, three rapid assay techniques for the determination of glutathione, one enzymatic, one fluorometric and one newly patented colorimetric method, were compared by measuring reduced (GSH) and oxidized (GSSG) glutathione in guinea-pig heart and liver. The HPLC technique was used as a standard, since it is co...

journal_title：Free radical research

authors： Floreani M,Petrone M,Debetto P,Palatini P

更新日期：1997-05-01 00:00:00

abstract：:The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for 4 years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defenses, and WG4 - Bio-inspired synthetic stra...

journal_title：Free radical research

authors： Ferreri C,Golding BT,Jahn U,Ravanat JL

更新日期：2016-11-01 00:00:00

abstract：:The cytologically active secondary lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) have been detected as their 2,4-dinitrophenylhydrazone (DNP) derivatives in plant tissue cultures using LC-MS. This paper reports, for the first time, the use of LC-MS methodology to definitively identif...

journal_title：Free radical research

authors： Deighton N,Magill WJ,Bremner DH,Benson EE

更新日期：1997-09-01 00:00:00

abstract：:We studied the effects of a single post whole-body low-dose irradiation (50 cGy of gamma-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, g...

journal_title：Free radical research

authors： Yamaoka K,Kojima S,Nomura T

更新日期：2000-03-01 00:00:00

abstract：:In human organism, the gaseous radical molecule nitric oxide (NO) is produced in various cells from L-arginine by the catalytic action of NO synthases (NOS). The metabolic fate of NO includes oxidation to nitrate by oxyhaemoglobin in red blood cells and autoxidation in haemoglobin-free media to nitrite. Nitrate and ni...

journal_title：Free radical research

authors： Tsikas D

更新日期：2005-08-01 00:00:00

abstract：:Adriamycin (ADR) is nephrotoxic. One component of ADR-induced nephropathy may be oxidative stress. This study used a recently developed line of transgenic mice (Nmt) on the FVB background strain, which over-express the antioxidant protein metallothionein (MT) in podocytes. Cultured podocytes from Nmt mice were resista...

journal_title：Free radical research

authors： Yang L,Zheng S,Epstein PN

更新日期：2009-02-01 00:00:00

abstract：:Curcumin is a polyphenol derived from the plant Curcuma longa that induces apoptotic cell death in malignant cancer cell lines. It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidan...

journal_title：Free radical research

authors： Jung KH,Park JW

更新日期：2011-04-01 00:00:00

abstract：:Generation of toxic oxygen metabolites followed by oxidant- and inflammatory-mediated tissue injury plays a crucial role in the pathogenesis of ischemia and reperfusion (IR). Ubiquinol, the reduced form of coenzyme Q10, is recognized for its potent antioxidant and anti-inflammatory properties in biological membranes. ...

journal_title：Free radical research

authors： Peerapanyasut W,Thamprasert K,Wongmekiat O

更新日期：2014-02-01 00:00:00

abstract：:The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...

journal_title：Free radical research

authors： Song HC,Chen Y,Chen Y,Park J,Zheng M,Surh YJ,Kim UH,Park JW,Yu R,Chung HT,Joe Y

更新日期：2020-07-28 00:00:00

abstract：:Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly differ in their expression level by a factor of 2 or higher between the high and the low alpha-tocopherol ...

journal_title：Free radical research

authors： Nell S,Bahtz R,Bossecker A,Kipp A,Landes N,Bumke-Vogt C,Halligan E,Lunec J,Brigelius-Flohé R

更新日期：2007-08-01 00:00:00

abstract：:The production of reactive oxygen species, including hydrogen peroxide (H(2)O(2)), is increased in diseased blood vessels. Although H(2)O(2) leads to impairment of the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP signaling pathway, it is not clear whether this reactive molecule affects the redox state of sGC...

journal_title：Free radical research

authors： Tawa M,Shimosato T,Iwasaki H,Imamura T,Okamura T

更新日期：2015-01-01 00:00:00

abstract：:There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is al...

journal_title：Free radical research

authors： Closa D

更新日期：2013-11-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning in Asian countries, that has high antioxidant activity in vitro and some antioxidant activity in vivo. We attempted to identify the major antioxidants present, using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay as a guide. 3-Hydroxy-2-methyl-4H-p...

journal_title：Free radical research

authors： Wang H,Jenner AM,Lee CY,Shui G,Tang SY,Whiteman M,Wenk MR,Halliwell B

更新日期：2007-04-01 00:00:00

abstract：:The phenomenon of ozone tolerance is described, but the underlying mechanisms remain unknown. We tested whether adaptation to multiday ozone exposure was related to an upregulated pulmonary antioxidant defence. Six calves were exposed to 0.75 ppm ozone, 12 h day(-1) for seven consecutive days. Pulmonary function tests...

journal_title：Free radical research

authors： Kirschvink N,Fiévez L,Bureau F,Degand G,Maghuin-Rogister G,Smith N,Art T,Lekeux P

更新日期：2002-01-01 00:00:00

abstract：:Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...

journal_title：Free radical research

authors： Dutta A,Gupta ML,Verma S

更新日期：2018-01-01 00:00:00

abstract：:A small part of cellular iron, usually called 'labile iron pool' (LIP), is not securely stored and has the potential to catalyse the formation of highly reactive oxygen species. The present work estimated LIP levels in human white cells by using the analytical power of flow cytometry. The method relies essentially on ...

journal_title：Free radical research

authors： Doulias PT,Vlachou C,Boudouri C,Kanavaros P,Siamopoulos KC,Galaris D

更新日期：2008-03-01 00:00:00

abstract：:2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) has been identified as a major water-soluble metabolite of vitamin E, which circulates in the blood and is excreted with the urine. The aim of this study was to assess the antioxidant activity of alpha-CEHC using several methods with different proox...

journal_title：Free radical research

authors： Betancor-Fernandez A,Sies H,Stahl W,Polidori MC

更新日期：2002-08-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF alpha) cytotoxicity is mediated, at least in part, by oxidative stress and phospholipase A2 activation. The first post-receptor events to be observed in TNF alpha-sensitive lines are the generation of superoxide anion (O2-) within the mitochondria and the activation of phospholipase A...

journal_title：Free radical research

authors： Polla BS,Jacquier-Sarlin MR,Kantengwa S,Mariéthoz E,Hennet T,Russo-Marie F,Cossarizza A

更新日期：1996-08-01 00:00:00

abstract：:Gamma-glutamyltransferase (GGT) plays a central role in the homeostasis of the antioxidant glutathione (GSH). The expression of GGT has been shown to be upregulated after oxidative stress, but the signalling pathways implicated remain poorly characterized. The results here show that acute exposure of CC531 cells to ox...

journal_title：Free radical research

authors： Pandur S,Pankiv S,Johannessen M,Moens U,Huseby NE

更新日期：2007-12-01 00:00:00

abstract：:Obesity enhances the frequency and severity of acute kidney injury (AKI). Telmisartan pre-treatment was used experimentally in the amelioration of ischemia/reperfusion (IR)-induced AKI. However, there is a lack of evidence regarding its beneficial effects on AKI in obese animals. The present study, therefore, aimed to...

journal_title：Free radical research

authors： Ali SI,Alhusseini NF,Atteia HH,Idris RA,Hasan RA

更新日期：2016-09-01 00:00:00

abstract：:Oxidative DNA modification has been implicated in development of certain cancers and 8-oxodG, the most abundant and mutagenic DNA modification, has for some time been considered a biomarker of this activity. Urinary excretion of 8-oxodG over 24h has been used to estimate the rate of damage to DNA, and animal studies h...

journal_title：Free radical research

authors： Poulsen HE,Loft S,Prieme H,Vistisen K,Lykkesfeldt J,Nyyssonen K,Salonen JT

更新日期：1998-12-01 00:00:00

abstract：:Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut industrial estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-gr...

journal_title：Free radical research

authors： Peluso M,Munnia A,Piro S,Jedpiyawongse A,Sangrajrang S,Giese RW,Ceppi M,Boffetta P,Srivatanakul P

更新日期：2012-01-01 00:00:00

abstract：:Neopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with gamma-interferon in vivo. The role of 78NP in inflammatory response is unknown though neopterin has been used clinically as a marker of immune cell activation, due to its very fluorescent nature. U...

journal_title：Free radical research

authors： Gieseg SP,Maghzal G,Glubb D

更新日期：2001-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutella...

journal_title：Free radical research

authors： Zhang X,Ji R,Sun H,Peng J,Ma X,Wang C,Fu Y,Bao L,Jin Y

更新日期：2018-02-01 00:00:00

abstract：:The brain is highly susceptible to oxidative stress due to its high metabolic demand. Increased oxidative stress and depletion of glutathione (GSH) are observed with aging and many neurological diseases. Exercise training has the potential to reduce oxidative stress in the brain. In this study, nine healthy sedentary ...

journal_title：Free radical research

authors： Rai S,Chowdhury A,Reniers RLEP,Wood SJ,Lucas SJE,Aldred S

更新日期：2018-01-01 00:00:00