Adaptation to multiday ozone exposure is associated with a sustained increase of bronchoalveolar uric acid.

abstract：:The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...

journal_title：Free radical research

authors： Song HC,Chen Y,Chen Y,Park J,Zheng M,Surh YJ,Kim UH,Park JW,Yu R,Chung HT,Joe Y

更新日期：2020-07-28 00:00:00

abstract：:Carotenoids scavenge simple lipid-like alkylperoxyl radicals. However, the rate constant is too low to be determined directly and the mechanism is likewise not known with certainty [Mortensen, A. and Skibsted, L.H. (1998) FEBS Lett. 426, 392-396]. It is demonstrated that carotenoids react with peroxyl radicals only sl...

journal_title：Free radical research

authors： Mortensen A

更新日期：2002-02-01 00:00:00

abstract：:A zinc(II) phthalocyanine compound, tetra-alpha-(2,2,4-tirmethyl-3-pentoxy) Phthalocyanine Zinc (ZnPc(OR)(4)) was synthesized in this paper and this zinc (II) phthalocyanine compound was used as the photosensitizer in the photoinduced chemiluminescence (PCL) of lucigenin in N,N-dimethylformamide (DMF). The photoexcite...

journal_title：Free radical research

authors： Wang J,Jiang Z,Huang L,Huang J,Chen G

更新日期：2008-02-01 00:00:00

abstract：:Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly differ in their expression level by a factor of 2 or higher between the high and the low alpha-tocopherol ...

journal_title：Free radical research

authors： Nell S,Bahtz R,Bossecker A,Kipp A,Landes N,Bumke-Vogt C,Halligan E,Lunec J,Brigelius-Flohé R

更新日期：2007-08-01 00:00:00

abstract：:The possible protective effects of resveratrol (RVT) against cardiotoxicity were investigated in Wistar albino rats treated with saline, saline+doxorubicin (DOX; 20 mg/kg) or RVT (10 mg/kg)+DOX. Blood pressure and heart rate were recorded on the 1st week and on the 7th week, while cardiomyopathy was assessed using tra...

journal_title：Free radical research

authors： Tatlidede E,Sehirli O,Velioğlu-Oğünc A,Cetinel S,Yeğen BC,Yarat A,Süleymanoğlu S,Sener G

更新日期：2009-03-01 00:00:00

abstract：:A range of catechins and oligomeric procyanidins was purified by high performance liquid chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, galloylated epicatechin, glycosylated catechin, procyanidin dimers, galloylated dimers, trimer, and tetramer species were all identified, purif...

journal_title：Free radical research

authors： Plumb GW,De Pascual-Teresa S,Santos-Buelga C,Cheynier V,Williamson G

更新日期：1998-10-01 00:00:00

abstract：:Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and make nitric oxide (NO*) in amounts sufficient to affect mitochondrial respiration. However, we found that the addition of L-arginine or the NOS inhibitor L-NMMA to intact rat liver mitochondria did not have any effect on the respirat...

journal_title：Free radical research

authors： Tay YM,Lim KS,Sheu FS,Jenner A,Whiteman M,Wong KP,Halliwell B

更新日期：2004-06-01 00:00:00

abstract：:In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...

journal_title：Free radical research

authors： Chainy GBN,Sahoo DK

更新日期：2020-01-01 00:00:00

abstract：:Hydroxyl radical (*OH) generation in the kidney of mice treated with ferric nitrilotriacetate (Fe-NTA) or potassium bromate (KBrO3) in vivo was estimated by the salicylate hydroxylation method, using the optimal experimental conditions we recently reported. Induction of DNA lesions and lipid peroxidation in the kidney...

journal_title：Free radical research

authors： Ueno S,Kashimoto T,Susa N,Shiho K,Seki T,Ito N,Takeda-Homma S,Nishimura Y,Sugiyama M

更新日期：2007-11-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF alpha) cytotoxicity is mediated, at least in part, by oxidative stress and phospholipase A2 activation. The first post-receptor events to be observed in TNF alpha-sensitive lines are the generation of superoxide anion (O2-) within the mitochondria and the activation of phospholipase A...

journal_title：Free radical research

authors： Polla BS,Jacquier-Sarlin MR,Kantengwa S,Mariéthoz E,Hennet T,Russo-Marie F,Cossarizza A

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Measurement of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) has recently become more popular as a means of assessing oxidative stress in the human body. The aim of this study is to compare the levels of urine 8-OHdG in patients with type 2 diabetes with and without nephropathy and to evaluate its role as a b...

journal_title：Free radical research

authors： Serdar M,Sertoglu E,Uyanik M,Tapan S,Akin K,Bilgi C,Kurt I

更新日期：2012-10-01 00:00:00

abstract：:The increasing knowledge on the participation of free radicals in many diverse clinical and pathological conditions, has consequently expanded the search for new and versatile antioxidants aimed at combating oxidative stress. Our interest in this field concerns aromatic indolinonic aminoxyls (nitroxides) which efficie...

journal_title：Free radical research

authors： Damiani E,Carloni P,Stipa P,Greci L

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND AND AIM:Previous studies have shown that preventive treatment with the antioxidant, ebselen, in experimental models of type 1 diabetic nephropathy resulted in an attenuation of structural and functional damage in the kidney. However, evidence for the effectiveness of ebselen in late-intervention studies is l...

journal_title：Free radical research

authors： Tan SM,Sharma A,Stefanovic N,de Haan JB

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Nuclear factor, erythroid 2 like 2 (NFE2L2) is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 deficiency in placentas is associated with pregnancy complications. We have demonstrated that elevated OS existed in placental shares of the smaller fetus in selective int...

journal_title：Free radical research

authors： Wu J,He Z,Gao Y,Zhang G,Huang X,Fang Q

更新日期：2017-04-01 00:00:00

abstract：:Oxidized low density lipoprotein (LDL) plays an important role in atherogenesis. It is generally thought that LDL is mainly oxidized in the intima of vessel walls, surrounded by hydrophilic antioxidants and proteins such as albumin. The aim of this study was to investigate the possible interrelationships between oxida...

journal_title：Free radical research

authors： Carbonneau MA,Cartron E,Leger CL,Senglat C,Descomps B

更新日期：2002-02-01 00:00:00

abstract：:Hispidulin (6-methoxy-5,7,4'-trihydroxyflavone) and eupafolin (6-methoxy-5,7,3',4'-tetrahydroxyflavone), are flavonoids found in the leaves of Eupatorium litoralle. They have recognized antioxidant and antineoplastic properties, although their action mechanisms have not been previously described. We now report the eff...

journal_title：Free radical research

authors： Dabaghi-Barbosa P,Mariante Rocha A,Franco da Cruz Lima A,Heleno de Oliveira B,Benigna Martinelli de Oliveira M,Gunilla Skare Carnieri E,Cadena SM,Eliane Merlin Rocha M

更新日期：2005-12-01 00:00:00

abstract：:Sublytic levels (microM) of hemin destabilized RBC membrane as indicated by ghost fragmentation pattern using a laser viscodiffractometer. Furthermore, electron microscopic study shows that 5 microM of hemin induced echinocytic transformation whereas higher hemin concentration (40 microM) induced spherocytic transform...

journal_title：Free radical research

authors： Chiu DT,Huang TY,Hung IJ,Wei JS,Liu TZ,Stern A

更新日期：1997-07-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, t...

journal_title：Free radical research

authors： Ben Anes A,Ben Nasr H,Garrouche A,Bchir S,Dhaouefi Z,Chabchoub E,Tabka Z,Chahed K

更新日期：2019-03-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a ubiquitous pteridine metabolite that serves as a NOS cofactor. Recently, we showed that BH4 efficiently inhibits superoxide generation from the heme group at the oxygenase domain of eNOS. This role indicates that BH4 acts as a redox switch in the catalytic mechanism of the enzyme, which ...

journal_title：Free radical research

authors： Vásquez-Vivar J,Kalyanaraman B,Martásek P

更新日期：2003-02-01 00:00:00

abstract：:α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein...

journal_title：Free radical research

authors： Misaki K,Takitani K,Ogihara T,Inoue A,Kawakami C,Kuno T,Kawamura N,Miyake M,Nakagawa T,Tamai H

更新日期：2003-01-01 00:00:00

abstract：:Hypericin and pseudohypericin are polycyclic-phenolic structurally related compounds found in Hypericum perforatum L. (St John's wort). As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding ath...

journal_title：Free radical research

authors： Laggner H,Schreier S,Hermann M,Exner M,Mühl A,Gmeiner BM,Kapiotis S

更新日期：2007-02-01 00:00:00

abstract：:Amphotericin B has been the gold standard for the treatment of invasive mycosis for many years. Its resistance mechanisms are reported to be mainly related to the decrease of ergosterol content or the changes of cell wall. Previous study has shown that Saccharomyces cerevisiae strain lack of BSC2 was sensitive signifi...

journal_title：Free radical research

authors： Kong Y,Wang Q,Cao F,Zhang X,Fang Z,Shi P,Wang H,Shen Y,Huang Z

更新日期：2020-04-01 00:00:00

abstract：:Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS)...

journal_title：Free radical research

authors： Guo J,Xu H,Liu S,Wang Z,Dai Y,Lu J,Zheng S,Xu D,Zhou J,Ke L,Cheng X,Xu M,Zhang X,Guo Y,Lin Y,Ding W,Gao G,Wang H,Chen Q,Yu X,Chen H,Qin L,Sun X,Li Z,Zheng S,Wang J,Cheng Y,Qiu S,Hu Y,Huang P,Li

更新日期：2019-12-01 00:00:00

abstract：:Human serum samples were evaluated for oxidative stress with the d-ROMs test. The ceruloplasmin (CP) and copper contents of the samples was independently measured and compared to those calculated on the basis of the d-ROMs test results for pure CP solutions. The d-ROMs readings did not show any significant correlation...

journal_title：Free radical research

authors： Colombini F,Carratelli M,Alberti A

更新日期：2016-01-01 00:00:00

abstract：:Subjecting selected peptides to in vitro analyses covering their ability to interfere with the lipid oxidation chain reaction as well as to protect proteins from direct and indirect oxidation has provided the basis for a more detailed understanding of peptide-mediated protection in biological systems. The efficiency o...

journal_title：Free radical research

authors： Jongberg S,Carlsen CU,Skibsted LH

更新日期：2009-10-01 00:00:00

abstract：:Orellanine is the tetrahydroxylated and di-N-oxidized bipyridine toxin extracted from several Cortinarius mushrooms among them C. orellanus. The pathogenic mechanism involved in the C. orellanus-poisoning by orellanine leading to kidney impairment is not yet fully understood until now. Electron spin resonance (ESR) sp...

journal_title：Free radical research

authors： Oubrahim H,Richard JM,Cantin-Esnault D

更新日期：1998-05-01 00:00:00

abstract：:The effects of inorganic phosphate (Pi), the main intracellular membrane permeable anion capable of altering mitochondrial pH gradients (Delta pH), were measured on mitochondrial H2O2 release. As expected, Pi decreased Delta pH and increased the electric membrane potential (Delta Psi). Mitochondrial H2O2 release was s...

journal_title：Free radical research

authors： Oliveira GA,Kowaltowski AJ

更新日期：2004-10-01 00:00:00

abstract：:The biomimetic model of micelles of linoleic acid containing 2-mercaptoethanol and the antioxidant was examined under gamma irradiation up to 400 Gy in aerobic or deoxygenated conditions where thiyl radicals are the main reactive species. Lipid peroxidation was retarded by ascorbic acid and α-tocopherol, whereas this ...

journal_title：Free radical research

authors： Tartaro Bujak I,Mihaljević B,Ferreri C,Chatgilialoglu C

更新日期：2016-11-01 00:00:00

abstract：:The capacity of non-illuminated nephrotoxin orellanine ([2,2'-bipyridine]-3,3',4,4'-tetrol-1,1'-dioxide) to induce DNA damage in the presence of ferrous iron and dioxygen has been evaluated. Maximal single-strand breaks in plasmid DNA were obtained with a metal to ligand ratio 1:3. Instantaneous oxidation of Fe2+ in p...

journal_title：Free radical research

authors： Cantin-Esnault D,Oubrahim H,Richard JM

更新日期：2000-08-01 00:00:00

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00