The neurotoxic effect of sickle cell hemoglobin.

abstract：:Phospholipids (PLs) are important biomolecules that not only constitute structural building blocks and scaffolds of cell and organelle membranes but also play a vital role in cell biochemistry and physiology. Moreover, dietary exogenous PLs are characterised by high nutritional value and other beneficial health effect...

journal_title：Free radical research

authors： Parchem K,Sasson S,Ferreri C,Bartoszek A

更新日期：2019-01-01 00:00:00

abstract：:Free radical oxidation of cholesterol and its precursors contribute significantly to the pathophysiology of a number of human diseases. This review intends to summarize recent developments and provide a perspective on the reactivities of sterols toward free radical oxidation, the free radical reaction mechanism, and t...

journal_title：Free radical research

authors： Xu L,Porter NA

更新日期：2015-01-01 00:00:00

abstract：:Ceruloplasmin (CP) is a blue copper glycoprotein with multiple physiological functions including ferroxidase and oxidase activities. CP is also an important serum oxygen free radical (OFR) scavenger and antioxidant, exerting cardioprotective and antifibrillatory actions. Although it has been reported that CP activitie...

journal_title：Free radical research

authors： Aouffen M,Paquin J,Furtos A,Waldron KC,Mateescu MA

更新日期：2004-01-01 00:00:00

abstract：:Gastric inflammation is a highly complex biochemical protective response to cellular/tissue injury. When this process occurs in an uncontrolled manner, the result is excessive cellular/tissue damage that results chronic inflammation and destruction of normal tissue. Current evidence suggests that Helicobacter pylori (...

journal_title：Free radical research

authors： Yoshikawa T,Naito Y

更新日期：2000-12-01 00:00:00

abstract：:We have previously reported that H2O2-induced apoptosis in HL-60 human leukemia cells takes place in the presence of chloride, requires myeloperoxidase (MPO), and occurs through oxidative reactions involving hypochlorous acid and chloramines. We now report that when chloride is replaced by the pseudohalide thiocyanate...

journal_title：Free radical research

authors： Wagner BA,Reszka KJ,McCormick ML,Britigan BE,Evig CB,Burns CP

更新日期：2004-02-01 00:00:00

abstract：:The present study was designed to determine whether hydroxymethylglutaryl-CoA reductase inhibitors (statins) modulate the NO production via iNOS in adipocytes stimulated by lipopolysaccharide (L) and tumour necrosis factor-alpha (T). Well-differentiated 3T3-L1 adipocytes significantly produced NO by LT-treatment. Pre-...

journal_title：Free radical research

authors： Araki S,Dobashi K,Asayama K,Shirahata A

更新日期：2007-09-01 00:00:00

abstract：:Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly differ in their expression level by a factor of 2 or higher between the high and the low alpha-tocopherol ...

journal_title：Free radical research

authors： Nell S,Bahtz R,Bossecker A,Kipp A,Landes N,Bumke-Vogt C,Halligan E,Lunec J,Brigelius-Flohé R

更新日期：2007-08-01 00:00:00

abstract：:Thioredoxin-1 (TRX) is a redox-active protein with anti-inflammatory effects. This study investigated the optimal delivery method and the mechanisms of recombinant human TRX (rhTRX) to suppress neutrophil recruitment in a rat bleomycin (BLM)-induced sustained acute lung injury model. In male Wister rats intratracheall...

journal_title：Free radical research

authors： Nakamura T,Hoshino Y,Yamada A,Teratani A,Furukawa S,Okuyama H,Ueda S,Wada H,Yodoi J,Nakamura H

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Aspiration pneumonia is infection of the respiratory tract resulting from accumulation of sputum in the larynx. N-acetyl-L-cysteine (NAC) might regulate mucin (MUC) expression and activate inherent anti-infective system in bronchiolar epithelial cells after cellular uptake, and therefore, serve as the preventat...

journal_title：Free radical research

authors： Koizumi C,Yamada M,Ishizaki K,Ueda T,Sakurai K

更新日期：2015-01-01 00:00:00

abstract：:The effects of various free radicals derived from 6-formylpterin (6-FP), alpha-phenyl-tert-butyl nitrone (PBN) and 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) combined with hyperthermia, on gene expression in similarly enhanced apoptosis of human lymphoma U937 cells were investigated using cDNA microarrays c...

journal_title：Free radical research

authors： Wada S,Tabuchi Y,Kondo T,Cui ZG,Zhao QL,Takasaki I,Salunga TL,Ogawa R,Arai T,Makino K,Furuta I

更新日期：2007-01-01 00:00:00

abstract：:Testing of pregnant women reveals weakening of neutrophil-mediated effector functions, such as reactive oxygen species generation. This study provides data confirming the phenomenon, gained through application of the flow cytometry technique. Key factors influencing neutrophil functional activity in blood plasma of pr...

journal_title：Free radical research

authors： Varfolomeeva EY,Semenova EV,Sokolov AV,Aplin KD,Timofeeva KE,Vasilyev VB,Filatov MV

更新日期：2016-08-01 00:00:00

abstract：:The aim of the study was to investigate whether there is transmembrane transport of intact glutathione ([3H]-GSH, 0.1 microCi) in rat and human type II pneumocytes (T2P), and if this transport might be dependent on the redox state of the extracellular fluid. The T2P were pretreated with acivicin (250 microM) to inhibi...

journal_title：Free radical research

authors： van Klaveren RJ,Hoet PH,Demedts M,Nemery B

更新日期：1999-05-01 00:00:00

abstract：:Silibinin is an active constituent extracted from blessed milk thistle (Silybum marianum). Our previous study demonstrated that silibinin induced autophagy and apoptosis via reactive oxygen species (ROS) generation in HeLa cells. In this study, we investigated whether the autophagy- and apoptosis-associated molecules ...

journal_title：Free radical research

authors： Fan S,Qi M,Yu Y,Li L,Yao G,Tashiro S,Onodera S,Ikejima T

更新日期：2012-03-01 00:00:00

abstract：:Assessment of oxidative stress status (OSS) in human tissues is still troublesome. Using an innovative EPR-radical-probe we successfully measured the instantaneous concentration of ROS directly in peripheral blood of athletes and normally active workers during 60 min controlled exercise. The probe employed was bis(1-h...

journal_title：Free radical research

authors： Paolini M,Valgimigli L,Marchesi E,Trespidi S,Pedulli GF

更新日期：2003-05-01 00:00:00

abstract：:Isolated Langendorff-perfused rat hearts, after 30 min of preperfusion, were submitted to increasing times of global normothermic ischemia (1, 2, 5, 10, 20 and 30 min) or to the same times of ischemia followed by 30 min of reperfusion. Analysis of malondialdehyde, ascorbic acid, oxypurines, nucleosides, nicotinic coen...

journal_title：Free radical research

authors： Tavazzi B,Di Pierro D,Bartolini M,Marino M,Distefano S,Galvano M,Villani C,Giardina B,Lazzarino G

更新日期：1998-01-01 00:00:00

abstract：:It is well known that reperfusion damage of ischemic myocardium may be attributed to alterations in the antioxidant defense system against free radical aggression. In addition, the degree of myocardial damage may depend on the duration and severity of ischemia that precedes reperfusion. We carried out serial ischemic ...

journal_title：Free radical research

authors： Porreca E,Del Boccio G,Lapenna D,Di Febbo C,Pennelli A,Cipollone F,Di Ilio C,Cuccurullo F

更新日期：1994-03-01 00:00:00

abstract：:Reperfusion injury of the liver occurs in liver transplantation and in major hepatectomies. It triggers a severe oxidative stress that leads to increased lipid peroxidation. In our study we examined the effect of parenteral supranutritional administration of alpha-tocopherol, a vitamin that plays a key role in the end...

journal_title：Free radical research

authors： Giakoustidis D,Kontos N,Iliadis S,Papageorgiou G,Tsantilas D,Spyridis C,Papazoglou K,Botsoglou N,Dimitriadou A,Giakoustidis E

更新日期：2001-08-01 00:00:00

abstract：:A soluble protein from Saccharomyces cerevisiae acts as a peroxidase but requires a NADPH-dependent thioredoxin system and was named thioredoxin peroxidase (TPx). The role of TPx in aging of stationary cultures of S. cerevisiae was investigated in a wild-type strain and a mutant yeast strain in which the tsa gene that...

journal_title：Free radical research

authors： Lee JH,Park JW

更新日期：2004-03-01 00:00:00

abstract：:The preventive effect of 20(S)-ginsenoside Rg(3) (20(S)-Rg(3)) on lipopolysaccharide (LPS)-induced oxidative tissue injury in rats was investigated in this study. The elevated serum nitrite/nitrate, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and creatinine levels in LPS-treated control rats were ...

journal_title：Free radical research

authors： Kang KS,Kim HY,Yamabe N,Park JH,Yokozawa T

更新日期：2007-10-01 00:00:00

abstract：:The production of microRNAs (miRNA) is influenced by various stimuli, including environmental stresses. We hypothesized that reactive oxygen species (ROS)-associated stress could regulate macrophage miRNA synthesis. miRNAs undergo unique steps of maturation processing through either one of two pathways of cytoplasmic ...

journal_title：Free radical research

authors： Ranjan R,Lee YG,Karpurapu M,Syed MA,Chung S,Deng J,Jeong JJ,Zhao G,Xiao L,Sadikot RT,Weiss MJ,Christman JW,Park GY

更新日期：2015-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are critically important chemical intermediates in biological studies, due to their multiple physiologically essential functions and their often pathologically deleterious effects. Consequently, it is vital that their presence in biological samples has to be quantifiable. However, their h...

journal_title：Free radical research

authors： Chen X,Zhong Z,Xu Z,Chen L,Wang Y

更新日期：2010-06-01 00:00:00

abstract：:APE1/Ref-1, the mammalian ortholog of E. coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has dual role in controlling cellular response to oxidative stress. It is rate-limiting in repair of oxidative DNA damage including strand breaks and also has co-transc...

journal_title：Free radical research

authors： Fantini D,Vascotto C,Deganuto M,Bivi N,Gustincich S,Marcon G,Quadrifoglio F,Damante G,Bhakat KK,Mitra S,Tell G

更新日期：2008-01-01 00:00:00

abstract：:Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS)...

journal_title：Free radical research

authors： Guo J,Xu H,Liu S,Wang Z,Dai Y,Lu J,Zheng S,Xu D,Zhou J,Ke L,Cheng X,Xu M,Zhang X,Guo Y,Lin Y,Ding W,Gao G,Wang H,Chen Q,Yu X,Chen H,Qin L,Sun X,Li Z,Zheng S,Wang J,Cheng Y,Qiu S,Hu Y,Huang P,Li

更新日期：2019-12-01 00:00:00

abstract：:The purpose of this double clinical study was (1) to evaluate the effect of one single intake (300 ml) of red wine (RW) on the plasma antioxidant capacity (pAOC) and plasma phenolics over the 24-h time period following the intake, and (2) to compare the long-term effects of daily intakes (250 ml/d) of RW, white wine (...

journal_title：Free radical research

authors： Cartron E,Fouret G,Carbonneau MA,Lauret C,Michel F,Monnier L,Descomps B,Léger CL

更新日期：2003-09-01 00:00:00

abstract：:Lectin-like oxidized low-density lipoprotein (LOX-1) has been identified in endothelial cells as the main receptor of oxidized low-density lipoprotein (OxLDL). LOX-1 is upregulated in the presence of pathological conditions including atherosclerosis, hypertension, and diabetes because it acts as a mediator of "endothe...

journal_title：Free radical research

authors： Lubrano V,Balzan S

更新日期：2014-08-01 00:00:00

abstract：:Adenosine is an endogenous cardioprotective substance. The present study examines whether exogenous adenosine attenuates cardiac injury induced by oxidative stress. Rat hearts (Langendorff model) were perfused with H2O2 (180 microM) for 10 min, then recovered for 60 min (n = 10). In other groups adenosine 55 microM, 1...

journal_title：Free radical research

authors： Valen G,Vaage J

更新日期：1996-01-01 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:Glucose at pathophysiological concentrations was able to accelerate copper-induced oxidation of isolated low-density lipoprotein (LDL) and whole serum. The efficiency of glucose was favored under the following circumstances: (a) when LDL oxidation was induced by low copper concentration, (b) when LDL was partly oxidiz...

journal_title：Free radical research

authors： Leoni V,Albertini R,Passi A,Abuja PM,Borroni P,D'Eril GM,De Luca G

更新日期：2002-05-01 00:00:00

abstract：:Cellular exposure to ionising radiation leads to oxidative stress events, which refer to elevated intracellular levels of reactive oxygen species (ROS). The elevated levels of ROS significantly contributed to γ-radiation (IR) induced cytotoxicity. In an attempt to minimise these cytotoxic effects, antioxidant compound...

journal_title：Free radical research

authors： Abozaid OAR,Moawed FSM,Farrag MA,Abdel Aziz AAA

更新日期：2017-12-01 00:00:00

abstract：:Formation of the alpha-hydroxyethyl radical (CH3 degree CHOH) has already been extensively demonstrated after ethanol metabolism in the liver. Despite favourable conditions, this formation in the brain has remained speculative since there is no direct experimental evidence in intact brain cells. In this preliminary st...

journal_title：Free radical research

authors： Gonthier B,Eysseric H,Soubeyran A,Daveloose D,Saxod R,Barret L

更新日期：1997-12-01 00:00:00