APE1/Ref-1 regulates PTEN expression mediated by Egr-1.

abstract：BACKGROUND AND AIM:Previous studies have shown that preventive treatment with the antioxidant, ebselen, in experimental models of type 1 diabetic nephropathy resulted in an attenuation of structural and functional damage in the kidney. However, evidence for the effectiveness of ebselen in late-intervention studies is l...

journal_title：Free radical research

authors： Tan SM,Sharma A,Stefanovic N,de Haan JB

更新日期：2015-03-01 00:00:00

abstract：:The cyanidin-3-O-beta-glucopyranoside (C-3-G) antioxidant capacity towards reactive oxygen species (ROS)-mediated damages was assessed in tissue and cells submitted to increased oxidative stress. In the isolated ischemic and reperfused rat heart, 10 or 30 degreesM C-3-G protected from both lipid peroxidation (66.7 and...

journal_title：Free radical research

authors： Amorini AM,Lazzarino G,Galvano F,Fazzina G,Tavazzi B,Galvano G

更新日期：2003-04-01 00:00:00

abstract：:Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases. Neurodegenerative diseases are characterized by progressive dysfunction and death of neurons. Oxidative stress is associated with dysfunction of the mitochondria and endoplasmic reticulum, inducing apoptosis and protein misfold...

journal_title：Free radical research

authors： Ghosh N,Ghosh R,Mandal SC

更新日期：2011-08-01 00:00:00

abstract：:We have here investigated possible occurrence of bicarbonate-dependent, carbonate radical anion (CO(3)(•-))-driven tocopherol-mediated human LDL peroxidation (TMP) in vitro and in vivo. CO(3)(•-), generated in vitro by the SOD1/H(2)O(2)/bicarbonate system, readily promoted TMP, which was dependent on α-tocopherol and ...

journal_title：Free radical research

authors： Lapenna D,Ciofani G,Cuccurullo C,Neri M,Giamberardino MA,Cuccurullo F

更新日期：2012-11-01 00:00:00

abstract：:Tropolones, the naturally occurring compounds responsible for the durability of heartwood of several cupressaceous trees, have been shown to possess both metal chelating and antioxidant properties. However, little is known about the ability of tropolone and its derivatives to protect cultured cells from oxidative stre...

journal_title：Free radical research

authors： Doulias PT,Nousis L,Zhu BZ,Frei B,Galaris D

更新日期：2005-02-01 00:00:00

abstract：:Involvement of oxidative stress is implicated in the progression of complication of diabetes mellitus. With respect to heart diseases, we have studied role of oxidative stress/antioxidants using rats treated with streptozotocin to induce diabetes (DM). Hemodynamic and echocardiographic measurements showed thickening o...

journal_title：Free radical research

authors： Doi K,Sawada F,Toda G,Yamachika S,Seto S,Urata Y,Ihara Y,Sakata N,Taniguchi N,Kondo T,Yano K

更新日期：2001-03-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF alpha) cytotoxicity is mediated, at least in part, by oxidative stress and phospholipase A2 activation. The first post-receptor events to be observed in TNF alpha-sensitive lines are the generation of superoxide anion (O2-) within the mitochondria and the activation of phospholipase A...

journal_title：Free radical research

authors： Polla BS,Jacquier-Sarlin MR,Kantengwa S,Mariéthoz E,Hennet T,Russo-Marie F,Cossarizza A

更新日期：1996-08-01 00:00:00

abstract：:The intracellular superoxide and glutathione disulphide concentrations increased in Penicillium chrysogeum treated with 50, 250 or 500 microM menadione (MQ). A significant increase in the intracellular peroxide concentration was also observed when mycelia were exposed to 250 or 500 microM MQ. The specific activity of ...

journal_title：Free radical research

authors： Emri T,Pócsi I,Szentirmai A

更新日期：1999-02-01 00:00:00

abstract：:Pyruvate is a well-known scavenger of hydrogen peroxide (H2O2). In addition, it scavenges superoxide radical (O2.-). However, evidence on its intracellular antioxidant function is meager at present. Hence, we have examined the effectiveness of this metabolite and its ethyl ester against intracellular oxidative damage ...

journal_title：Free radical research

authors： Varma SD,Devamanoharan PS,Ali AH

更新日期：1998-02-01 00:00:00

abstract：:Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCCL) and elevates [Ca2+]i in many cells. However, how oxidative stress activates VDCCL under clinical setting and the consequenc...

journal_title：Free radical research

authors： Park HJ,Shin KC,Yoou SK,Kang M,Kim JG,Sung DJ,Yu W,Lee Y,Kim SH,Bae YM,Park SW

更新日期：2019-01-01 00:00:00

abstract：:Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a systemic inflammatory response, resulting in proinflammatory cells recruitm...

journal_title：Free radical research

authors： Rossi M,Delbauve S,Roumeguère T,Wespes E,Leo O,Flamand V,Le Moine A,Hougardy JM

更新日期：2019-10-01 00:00:00

abstract：:Recent research about the role of free radical derivatives of oxygen and nitrogen in biological systems has highlighted the possibility that antioxidants, such as vitamin E, that prevent these processes in vitro may be capable of carrying out a similar function in living organisms in vivo. There is increasing evidence...

journal_title：Free radical research

authors： Diplock AT

更新日期：1997-06-01 00:00:00

abstract：:Iron or oxygen regulates the stability of hypoxia inducible factor-1α (HIF-1α). We investigated whether ferrous glycinate would affect HIF-1α accumulation, aerobic glycolysis and mitochondrial energy metabolism in human A549 lung cancer cells. Incubation of A549 cells with ferrous glycinate decreased the protein level...

journal_title：Free radical research

authors： Kuo YT,Jheng JH,Lo MC,Chen WL,Wang SG,Lee HM

更新日期：2018-12-01 00:00:00

abstract：:Retinal mitochondria become dysfunctional in diabetes and the production of superoxide radicals is increased; over-expression of MnSOD abrogates mitochondrial dysfunction and prevents the development of diabetic retinopathy. The mitochondrial DNA (mtDNA) is particularly prone to oxidative damage. The aim of this study...

journal_title：Free radical research

authors： Madsen-Bouterse SA,Zhong Q,Mohammad G,Ho YS,Kowluru RA

更新日期：2010-03-01 00:00:00

abstract：:Proteins constitute the major 'working force' for all forms of biological work. Their exact conformation and pattern of folding are tightly connected to their activity and function. Reactive oxygen and nitrogen species (ROS and RNS) are formed during normal metabolism and in higher fluxes under pathological conditions...

journal_title：Free radical research

authors： Chevion M,Berenshtein E,Stadtman ER

更新日期：2000-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) are involved in the mechanism of photoaging and carcinogenesis. Skin is endowed with antioxidant enzymes including superoxide dismutases (SOD): cytosolic copper zinc SOD and mitochondrial manganese SOD. The aim of our study was to estimate the protective effect of manganese against oxidat...

journal_title：Free radical research

authors： Parat MO,Richard MJ,Leccia MT,Amblard P,Favier A,Beani JC

更新日期：1995-10-01 00:00:00

abstract：:Heme oxygenase is the rate limiting enzyme in heme degradation to carbon monoxide (CO), iron and bilirubin. The inducible isoform of the protein, heme oxygenase-1 (HO-1), is susceptible to up-regulation by a diverse variety of conditions and agents in mammalian tissue, leading to the common conception that HO-1 is a s...

journal_title：Free radical research

authors： Foresti R,Motterlini R

更新日期：1999-12-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) are the most widely used nanomaterials as antimicrobial agents. AgNPs have been shown to inhibit the growth of and induce apoptosis-like death in Escherichia coli. However, the precise mechanism of AgNPs-induced apoptosis-like death and association with DNA damage-inducible protein F (dinF...

journal_title：Free radical research

authors： Kim S,Lee DG

更新日期：2021-01-06 00:00:00

abstract：:The antioxidative activity of hydroxylamines was evaluated for the oxidation of tetralin at 61 degrees C and linoleic acid micelles in an aqueous dispersion at 37 degrees C, induced by an azo initiator. The antioxidative efficacy of the hydroxylamines for the oxidation of tetralin was smaller than that of alpha-tocoph...

journal_title：Free radical research

authors： Nishiyama T,Tamekuni H,Tachibana T,Kitamura H,Saito S

更新日期：2001-12-01 00:00:00

abstract：:Oxidative stress appears to be implicated in the pathogenesis of various diseases including hepatotoxicity. Although intracellular Ca2+ signals have been suggested to play a role in the oxidative damage of hepatocytes, the sources and effects of oxidant-induced intracellular Ca2+ increases are currently debatable. Thu...

journal_title：Free radical research

authors： Kim JA,Kang YS,Lee SH,Lee YS

更新日期：2000-09-01 00:00:00

abstract：:N-nitroso species have recently been detected in animal tissues. Protein N-nitrosotryptophan is the best candidate for this N-nitroso pool. N-nitrosation of N-blocked trytophan derivatives like melatonin (MelH) by N2O3 or peroxynitrite (ONOOH/ONOO- ) has been observed under conditions of pH and reagent concentrations ...

journal_title：Free radical research

authors： Peyrot F,Houée-Levin C,Ducrocq C

更新日期：2006-09-01 00:00:00

abstract：:Adenosine levels are increased in stress and act as anti-oxidant and anti-inflammatory mediators by binding to 4 G-protein-coupled receptors. Using genetically modified mice lacking A(1) and A(3) adenosine receptors, treated with ip buthionine-[S,R]-sulphoximine injections to inhibit gamma-glutamylcysteine ligase, the...

journal_title：Free radical research

authors： Conte C,Grottelli S,Prudenzi E,Bellezza I,Fredholm BB,Minelli A

更新日期：2009-03-01 00:00:00

abstract：:The intestinal tract, known for its capability for self-renew, represents the first barrier of defence between the organism and its luminal environment. The thiol/disulfide redox systems comprising the glutathione/glutathione disulfide (GSH/GSSG), cysteine/cystine (Cys/CySS) and reduced and oxidized thioredoxin (Trx/T...

journal_title：Free radical research

authors： Circu ML,Aw TY

更新日期：2011-11-01 00:00:00

abstract：:We have previously shown that Vitamin C (ascorbic acid) can trigger hydroxyl radical formation in copper contaminated household drinking water. We report here that the capacity of ascorbic acid to catalyze hydroxyl radical generation in the drinking water samples is strongly dependent on the bicarbonate concentration ...

journal_title：Free radical research

authors： Jansson PJ,Asplund KU,Mäkelä JC,Lindqvist C,Nordström T

更新日期：2003-08-01 00:00:00

abstract：:Intake of antioxidants from the diet has been recognized to have beneficial health effects, but the potential benefit of taking antioxidants such as β-carotene as supplements is controversial. The aim of the present study was to evaluate the potential protective effects of a physiologically relevant concentration (2 μ...

journal_title：Free radical research

authors： Åsgård R,Hellman B

更新日期：2013-09-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) has been reported to play critical roles in cell fate decision by interacting with four types of prostanoid receptors such as EP1, EP2, EP3 and EP4. The present study was aimed at investigating the effect of the EP4-specific agonist CAY10598 in human colon cancer HCT116 cells. Our study reveale...

journal_title：Free radical research

authors： Chae IG,Kim DH,Kundu J,Jeong CH,Kundu JK,Chun KS

更新日期：2014-11-01 00:00:00

abstract：:We investigated effect of aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE) on prostaglandin (PG) E2 receptors of liver plasma membranes. The modification of the membranes by MDA diminished PGE2 binding, decreasing receptor affinity for PGE2 and receptor density whereas HNE inc...

journal_title：Free radical research

authors： Buko VU,Artsukevich A,Zavodnik I,Maltsev A,Sushko L,Zimmermann T,Dianzani MU

更新日期：1996-11-01 00:00:00

abstract：:An iodoacetamide azaadamantyl spin label was studied in fluid solution and in 9:1 trehalose:sucrose glass. In 9:1 toluene:CH2Cl2 solution at 293 K, the isotropic nitrogen hyperfine coupling is 19.2 G, T1 is 0.37 µs and T2 is 0.30-0.35 µs. Between about 80 and 150 K 1/Tm in 9:1 trehalose:sucrose is approximately indepe...

journal_title：Free radical research

authors： Eaton SS,Rajca A,Yang Z,Eaton GR

更新日期：2018-03-01 00:00:00

abstract：:Myeloperoxidase (MPO), a major constituent of neutrophils, catalyzes the production of hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride anion. We have previously reported that MPO-deficient (MPO(-/-)) neutrophils produce greater amount of macrophage inflammatory protein-2 (MIP-2) in vitro than do wi...

journal_title：Free radical research

authors： Tateno N,Matsumoto N,Motowaki T,Suzuki K,Aratani Y

更新日期：2013-05-01 00:00:00

abstract：:The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up in 1997 to resolve methodological problems and to reach agreement on the basal level of 8-oxo-2'-deoxyguanosine (8-oxodG) in biological samples. In the present ESCODD trial 6 samples of 8-oxodG-containing oligonucleotides with different ratio...

journal_title：Free radical research

authors： Riis B

更新日期：2002-06-01 00:00:00