Abstract:
:Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS) indicators, the connective tissues of dura mater, facial fascia, pericardium, linea alba, dorsa fascia and other body parts, emitted specific and intense fluorescent signals. Moreover, the fluorescent signals along the linea alba of SD rats, did not result from the local presence of ROS but from the interaction of ROS indicators with electrons flowing through this tissue. Furthermore, the electrons travelling along the linea alba of mice were revealed to originate from mitochondria. These data suggest that mitochondrial-leaked electrons may be transported extracellularly to a hitherto undescribed system of connective tissues, which is pervasively networked, electrically conductive and metabolically related.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Guo J,Xu H,Liu S,Wang Z,Dai Y,Lu J,Zheng S,Xu D,Zhou J,Ke L,Cheng X,Xu M,Zhang X,Guo Y,Lin Y,Ding W,Gao G,Wang H,Chen Q,Yu X,Chen H,Qin L,Sun X,Li Z,Zheng S,Wang J,Cheng Y,Qiu S,Hu Y,Huang P,Lidoi
10.1080/10715762.2019.1677902subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1073-1083issue
11-12eissn
1071-5762issn
1029-2470journal_volume
53pub_type
杂志文章abstract::Ionizing radiations such as X-ray and γ-ray can directly or indirectly produce clustered or multiple damages in DNA. Previous studies have reported that overexpression of DNA glycosylases in Escherichia coli (E. coli) and human lymphoblast cells caused increased sensitivity to γ-ray and X-ray irradiation. However, the...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2015.1061186
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715769900300921
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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更新日期:1998-04-01 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:2008-03-01 00:00:00
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journal_title:Free radical research
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journal_title:Free radical research
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章,评审
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